The flame retardants, polybrominated diphenyl ethers, are pregnane X receptor activators

Toxicological Sciences

Volumn 97, Issue 1, 2007, Pages 94-102

  Pacyniak, Erik K ^a   Cheng, Xingguo ^a   Cunningham, Michael L ^b   Crofton, Kevin ^c   Klaassen, Curtis D ^a   Guo, Grace L ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

cyp2b; cyp3a; Nuclear receptor; PBDE; PXR, induction

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; CELL NUCLEUS RECEPTOR; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2B; CYTOCHROME P450 3A; CYTOCHROME P450 3A11; FLAME RETARDANT; HORMONE RECEPTOR; LUCIFERASE; POLYBROMINATED DIPHENYL ETHER; PREGNANE X RECEPTOR; STEROID RECEPTOR; TRANSCRIPTION FACTOR; 2,2,4,4 TETRABROMODIPHENYL ETHER; 2,2,4,4-TETRABROMODIPHENYL ETHER; BROMINATED HYDROCARBON; CYP2B10 PROTEIN, MOUSE; CYP3A11 PROTEIN, MOUSE; DECABROMOBIPHENYL ETHER; DIPHENYL ETHER DERIVATIVE; MEMBRANE PROTEIN; MESSENGER RNA; PENTABROMODIPHENYL ETHER; POLYBROMINATED BIPHENYL; STEROID MONOOXYGENASE; SXR RECEPTOR; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; CONTROLLED STUDY; DATA ANALYSIS; ENZYME ASSAY; ENZYME INDUCTION; GENE EXPRESSION; GENE TARGETING; HYPOTHESIS; IN VIVO STUDY; KNOCKOUT MOUSE; MOUSE; NONHUMAN; REPORTER GENE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; DOSE RESPONSE; DRUG EFFECT; DRUG POTENTIATION; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; HUMAN; LIVER; MALE; METABOLISM; MOUSE MUTANT; PROMOTER REGION; TUMOR CELL LINE;

MUS; RATTUS;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CELL LINE, TUMOR; CYTOCHROME P-450 CYP3A; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; FLAME RETARDANTS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; HYDROCARBONS, BROMINATED; LIVER; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHENYL ETHERS; POLYBROMINATED BIPHENYLS; PROMOTER REGIONS (GENETICS); RECEPTORS, STEROID; RNA, MESSENGER; STEROID HYDROXYLASES; TRANSFECTION;

EID: 34347263448     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfm025     Document Type: Article

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