메뉴 건너뛰기




Volumn 54, Issue 1, 2000, Pages 81-87

Sex-dependent regulation of hepatic cytochrome P-450 by DDT

Author keywords

Cytochrome P450; DDT; Endocrine disrupters; Pesticides; Sex dependent regulation

Indexed keywords

CHLORPHENOTANE; CYTOCHROME P450; NITROPHENOL; PESTICIDE; RESORUFIN; TESTOSTERONE; UNSPECIFIC MONOOXYGENASE;

EID: 0343415610     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/54.1.81     Document Type: Article
Times cited : (67)

References (36)
  • 1
    • 0015122877 scopus 로고
    • Structure-activity relationships on the induction of hepatic microsomal enzymes in the mouse by 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) analogs
    • Abernathy, C. O., Hodgson, E., and Guthrie, F. E. (1971). Structure-activity relationships on the induction of hepatic microsomal enzymes in the mouse by 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) analogs. Biochem. Pharmacol. 20, 2385-2393.
    • (1971) Biochem. Pharmacol. , vol.20 , pp. 2385-2393
    • Abernathy, C.O.1    Hodgson, E.2    Guthrie, F.E.3
  • 2
    • 0001968394 scopus 로고
    • Estrogenic activity of pesticides and other xenobiotics on the uterus and male reproductive tract
    • J. A. Thomas, K. S. Korach, and J. A. McLachlan, Eds. Raven Press, New York
    • Bulger, W. H., and Kupfer, D. (1985). Estrogenic activity of pesticides and other xenobiotics on the uterus and male reproductive tract. In Endocrine Toxicology (J. A. Thomas, K. S. Korach, and J. A. McLachlan, Eds.). pp 1-33. Raven Press, New York.
    • (1985) Endocrine Toxicology , pp. 1-33
    • Bulger, W.H.1    Kupfer, D.2
  • 3
    • 0015350440 scopus 로고
    • Pesticide-induced changes in hepatic microsomal enzyme systems. Some effects of 1,1-di(p-chlorophenyl)-2,2,2-trichloroethane (DDT) and 1,1-di(p-chlorophenyl)-2,2-dichloroethylene (DDE) in the rat and Japanese quail
    • Bunyan, P. J., Townsend, M. G., and Taylor, A. (1972). Pesticide-induced changes in hepatic microsomal enzyme systems. Some effects of 1,1-di(p-chlorophenyl)-2,2,2-trichloroethane (DDT) and 1,1-di(p-chlorophenyl)-2,2-dichloroethylene (DDE) in the rat and japanese quail. Chem. Biol. Interact. 5, 13-26.
    • (1972) Chem. Biol. Interact. , vol.5 , pp. 13-26
    • Bunyan, P.J.1    Townsend, M.G.2    Taylor, A.3
  • 4
    • 0022357068 scopus 로고
    • Ethoxy-, pentoxy-and benzyloxyphenoxazones and homologues: A series of substrates to distinguish between different induced cytochromes P-450
    • Burke, M. D., Thompson, S., Elcombe, C. R., Halpert, J., Haaparanta, T., and Mayer, R. T. (1985). Ethoxy-, pentoxy-and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450. Biochem. Pharmacol. 34, 3337-3345.
    • (1985) Biochem. Pharmacol. , vol.34 , pp. 3337-3345
    • Burke, M.D.1    Thompson, S.2    Elcombe, C.R.3    Halpert, J.4    Haaparanta, T.5    Mayer, R.T.6
  • 6
    • 0028937507 scopus 로고
    • Phenytoin causes a rapid increase in 6 beta-hydroxycortisol urinary excretion in humans - A putative measure of CYP3A induction
    • Fleishaker, J. C., Pearson, L. K., and Peters, G. R. (1995). Phenytoin causes a rapid increase in 6 beta-hydroxycortisol urinary excretion in humans - a putative measure of CYP3A induction. J. Pharm. Sci. 84, 292-294.
    • (1995) J. Pharm. Sci. , vol.84 , pp. 292-294
    • Fleishaker, J.C.1    Pearson, L.K.2    Peters, G.R.3
  • 7
    • 0025039665 scopus 로고
    • Promotion of altered hepatic foci development in rat liver, cytochrome P450 enzyme induction and inhibition of cell - Cell communication by DDT and some structurally related organohalogen pesticides
    • Flodström, S., Hemming, H., Wärngård, L., and Ahlborg, U. G. (1990). Promotion of altered hepatic foci development in rat liver, cytochrome P450 enzyme induction and inhibition of cell - cell communication by DDT and some structurally related organohalogen pesticides. Carcinogenesis 11, 1413-1417.
    • (1990) Carcinogenesis , vol.11 , pp. 1413-1417
    • Flodström, S.1    Hemming, H.2    Wärngård, L.3    Ahlborg, U.G.4
  • 8
    • 0026584261 scopus 로고
    • Differentiation of cytochrome P-450 inducers on the basis of 7-alkoxycoumarin O-dealkylase activities
    • Fry, J. R., Garle, M. J., and Lal, K. (1992). Differentiation of cytochrome P-450 inducers on the basis of 7-alkoxycoumarin O-dealkylase activities. Xenobiotica 22, 211-215.
    • (1992) Xenobiotica , vol.22 , pp. 211-215
    • Fry, J.R.1    Garle, M.J.2    Lal, K.3
  • 9
    • 0030221008 scopus 로고    scopus 로고
    • Induction of the male-specific cytochrome P450 3A2 in female rats by phenytoin
    • Ghosal, A., Sadrieh, N., Reik, L., Levin, W., and Thomas, P. E. (1996). Induction of the male-specific cytochrome P450 3A2 in female rats by phenytoin. Arch. Biohem. Biophys. 332, 153-162.
    • (1996) Arch. Biohem. Biophys. , vol.332 , pp. 153-162
    • Ghosal, A.1    Sadrieh, N.2    Reik, L.3    Levin, W.4    Thomas, P.E.5
  • 10
    • 0022968060 scopus 로고
    • Pregnenolone 16α-carbonitrile-inducible P-450 gene family: Gene conversion and differential regulation
    • Gonzalez, F. J., Song, B. J., and Hardwick, J. P. (1986). Pregnenolone 16α-carbonitrile-inducible P-450 gene family: gene conversion and differential regulation. Mol. Cell. Biol. 6, 2969-2976.
    • (1986) Mol. Cell. Biol. , vol.6 , pp. 2969-2976
    • Gonzalez, F.J.1    Song, B.J.2    Hardwick, J.P.3
  • 11
    • 0029002232 scopus 로고
    • Gonadal steroidogenesis in vitro from juvenile alligators obtained from contaminated or control lakes
    • Guillette, L. J., Jr., Gross, T. S., Gross, D. A., Rooney, A. A., and Percival H. F. (1995). Gonadal steroidogenesis in vitro from juvenile alligators obtained from contaminated or control lakes. Environ. Health Perspect. 103(suppl. 4), 31-36.
    • (1995) Environ. Health Perspect. , vol.103 , Issue.SUPPL. 4 , pp. 31-36
    • Guillette L.J., Jr.1    Gross, T.S.2    Gross, D.A.3    Rooney, A.A.4    Percival, H.F.5
  • 12
    • 0015222103 scopus 로고
    • DDT administered to neonatal rats induces persistent estrus syndrome
    • Heinrichs, W. L., Gellert, R. J., Bakke, J. L., Lawrence, N. L. (1971). DDT administered to neonatal rats induces persistent estrus syndrome. Science 173, 642-643.
    • (1971) Science , vol.173 , pp. 642-643
    • Heinrichs, W.L.1    Gellert, R.J.2    Bakke, J.L.3    Lawrence, N.L.4
  • 13
    • 0028281957 scopus 로고
    • Induction of cytochrome P-450 in Sigmodon hispidus (cotton rats) exposed to dietary Aroclor 1254
    • Henneman, J. R., Fox, S. D., Lubet, R. A., Ward, J. M., and Nims, R. W. (1994). Induction of cytochrome P-450 in Sigmodon hispidus (cotton rats) exposed to dietary Aroclor 1254. J. Toxicol. Environ. Health 41, 369-386.
    • (1994) J. Toxicol. Environ. Health , vol.41 , pp. 369-386
    • Henneman, J.R.1    Fox, S.D.2    Lubet, R.A.3    Ward, J.M.4    Nims, R.W.5
  • 14
    • 0000896630 scopus 로고
    • Hormonal regulation of cytochrome P450 in rat liver
    • J.B. Schenkman and H. Greim, Eds. Springer-Verlag, Berlin
    • Kato, R., and Yamazoe, Y. (1993). Hormonal regulation of cytochrome P450 in rat liver. In Handbook of Experimental Pharmacology (J.B. Schenkman and H. Greim, Eds.). Vol. 105, pp. 447-459. Springer-Verlag, Berlin.
    • (1993) Handbook of Experimental Pharmacology , vol.105 , pp. 447-459
    • Kato, R.1    Yamazoe, Y.2
  • 16
    • 0029047149 scopus 로고
    • Persistent DDT metabolite p,p′-DDE is a potent androgen receptor antagonist
    • Kelce, W. R., Stone, C. R., Laws, S., Gray, L. E., Kemppainen, J. A., and Wilson, E. M. (1995). Persistent DDT metabolite p,p′-DDE is a potent androgen receptor antagonist. Nature 375, 581-585.
    • (1995) Nature , vol.375 , pp. 581-585
    • Kelce, W.R.1    Stone, C.R.2    Laws, S.3    Gray, L.E.4    Kemppainen, J.A.5    Wilson, E.M.6
  • 17
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli, U. K. (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 18
    • 0029242428 scopus 로고
    • Induction of the hepatic CYP2B and CYP3A enzymes by the proestrogenic pesticide methoxychlor and by DDT in the rat. Effects on methoxychlor metabolism
    • Li, H. C., Dehal, S. S., and Kupfer, D. (1995). Induction of the hepatic CYP2B and CYP3A enzymes by the proestrogenic pesticide methoxychlor and by DDT in the rat. Effects on methoxychlor metabolism. J. Biochem. Toxicol. 10, 51-61.
    • (1995) J. Biochem. Toxicol. , vol.10 , pp. 51-61
    • Li, H.C.1    Dehal, S.S.2    Kupfer, D.3
  • 21
    • 0025219787 scopus 로고
    • The induction of alkoxyresorufin metabolism: A potential indicator of environmental contamination
    • Lubet, R. A., Guengerich, F. P., and Nims, R. W. (1990). The induction of alkoxyresorufin metabolism: a potential indicator of environmental contamination. Arch. Environ. Contam. Toxicol. 19, 157-163.
    • (1990) Arch. Environ. Contam. Toxicol. , vol.19 , pp. 157-163
    • Lubet, R.A.1    Guengerich, F.P.2    Nims, R.W.3
  • 22
    • 0022350885 scopus 로고
    • Dealkylation of pentoxyresorufin: A rapid and sensitive assay for measuring induction of cytochrome(s) P-450 by phenobarbital and other xenobiotics in the rat
    • Lubet, R. A., Mayer, R. T., Cameron, J. W., Nims, R. W., Burke, M. D., Wolff, T., and Guengerich, P. F. (1985). Dealkylation of pentoxyresorufin: a rapid and sensitive assay for measuring induction of cytochrome(s) P-450 by phenobarbital and other xenobiotics in the rat. Arch. Biochem. Biophys. 238, 43-48.
    • (1985) Arch. Biochem. Biophys. , vol.238 , pp. 43-48
    • Lubet, R.A.1    Mayer, R.T.2    Cameron, J.W.3    Nims, R.W.4    Burke, M.D.5    Wolff, T.6    Guengerich, P.F.7
  • 23
    • 0018750666 scopus 로고
    • Comparison of induction patterns of rat hepatic microsmal mixed-function oxidases by pesticides and related chemicals
    • Madhukar, B. V., and Matsumura, F. (1979). Comparison of induction patterns of rat hepatic microsmal mixed-function oxidases by pesticides and related chemicals. Pest. Biochem. Physiol. 11, 301-308.
    • (1979) Pest. Biochem. Physiol. , vol.11 , pp. 301-308
    • Madhukar, B.V.1    Matsumura, F.2
  • 25
    • 0027179679 scopus 로고
    • Methoxyresorufin and benzyloxyresorufin: Substrates preferentially metabolized by cytochromes P4501A2 and 2B, respectively, in the rat and mouse
    • Nerurkar, P. V., Park, S. S., Thomas, P. E., Nims, R. W., and Lubet, R. A. (1993). Methoxyresorufin and benzyloxyresorufin: substrates preferentially metabolized by cytochromes P4501A2 and 2B, respectively, in the rat and mouse. Biochem. Pharmacol. 46, 933-943.
    • (1993) Biochem. Pharmacol. , vol.46 , pp. 933-943
    • Nerurkar, P.V.1    Park, S.S.2    Thomas, P.E.3    Nims, R.W.4    Lubet, R.A.5
  • 26
    • 0024469995 scopus 로고
    • Comparison study of the sensitivities of some indices of DDT exposure in human blood and urine
    • Nhachi, C. F. B., and Loewenson, R. (1989). Comparison study of the sensitivities of some indices of DDT exposure in human blood and urine. Bull. Environ. Contam. Toxicol. 43, 493-498.
    • (1989) Bull. Environ. Contam. Toxicol. , vol.43 , pp. 493-498
    • Nhachi, C.F.B.1    Loewenson, R.2
  • 27
    • 0031594814 scopus 로고    scopus 로고
    • Comparative pharmacodynamics of CYP2B induction by DDT, DDE, and DDD in male rat liver and cultured rat hepatocytes
    • Nims, R. W., Lubet, R. A., Fox, S. D., Jones, C. R., Thomas, P.., Reddy, A. B., and Kocarek, T. A. (1998). Comparative pharmacodynamics of CYP2B induction by DDT, DDE, and DDD in male rat liver and cultured rat hepatocytes. J. Toxicol. Environ. Health 53, 455-477.
    • (1998) J. Toxicol. Environ. Health , vol.53 , pp. 455-477
    • Nims, R.W.1    Lubet, R.A.2    Fox, S.D.3    Jones, C.R.4    Thomas, P.5    Reddy, A.B.6    Kocarek, T.A.7
  • 28
    • 0028243896 scopus 로고
    • Comparative pharmacodynamics of hepatic cytochrome P450 2B induction by 5,5-diphenyl-and 5,5-diethyl-substituted barbiturates and hydantoins in the male F344/NCr rat
    • Nims, R. W., McClain, R. M., Manchand, P. S., Belica, P., Thomas, P. E., Mellini, D. W., Utermahlen, W. E., Jr., and Lubet, R. A. (1994). Comparative pharmacodynamics of hepatic cytochrome P450 2B induction by 5,5-diphenyl-and 5,5-diethyl-substituted barbiturates and hydantoins in the male F344/NCr rat. J. Pharmacol. Exp. Ther. 270, 348-355.
    • (1994) J. Pharmacol. Exp. Ther. , vol.270 , pp. 348-355
    • Nims, R.W.1    McClain, R.M.2    Manchand, P.S.3    Belica, P.4    Thomas, P.E.5    Mellini, D.W.6    Utermahlen W.E., Jr.7    Lubet, R.A.8
  • 29
    • 0015393233 scopus 로고
    • Dimethylbenzanthracene-induced mammary tumor in rats: Inhibition by DDT
    • Okey, A. B. (1972). Dimethylbenzanthracene-induced mammary tumor in rats: inhibition by DDT. Life Sci. 11, 833-843.
    • (1972) Life Sci. , vol.11 , pp. 833-843
    • Okey, A.B.1
  • 30
    • 78651165715 scopus 로고
    • The carbon monoxide-binding pigment of liver microsomes
    • Omura, T., and Sato, R. (1964). The carbon monoxide-binding pigment of liver microsomes. J. Biol. Chem. 239, 2370-2378.
    • (1964) J. Biol. Chem. , vol.239 , pp. 2370-2378
    • Omura, T.1    Sato, R.2
  • 31
    • 0014848873 scopus 로고
    • Effect of intensive occupational exposure to DDT on phenylbutazone and cortisol metabolism in human subjects
    • Poland, A., Smith, D., Kuntzman, R., Jacobson, M., and Conney, A. H. (1970). Effect of intensive occupational exposure to DDT on phenylbutazone and cortisol metabolism in human subjects. Clin. Pharmacol. Ther. 11, 724-732.
    • (1970) Clin. Pharmacol. Ther. , vol.11 , pp. 724-732
    • Poland, A.1    Smith, D.2    Kuntzman, R.3    Jacobson, M.4    Conney, A.H.5
  • 32
    • 0022117289 scopus 로고
    • p-Nitrophenol hydroxylation. A microsomal oxidation which is highly inducible by ethanol
    • Reinke, L. A., and Moyer, M. J. (1985). p-Nitrophenol hydroxylation. A microsomal oxidation which is highly inducible by ethanol. Drug Metab. Dispos. 13, 548-552.
    • (1985) Drug Metab. Dispos. , vol.13 , pp. 548-552
    • Reinke, L.A.1    Moyer, M.J.2
  • 33
    • 0026488246 scopus 로고
    • Effect of dexamethasone and phenobarbital on run-on transcription rate and CYP3A mRNA concentration in rat liver: Changes during development
    • Telhada, M. B., Pereira, T. M., and Lechner, M. C. (1992). Effect of dexamethasone and phenobarbital on run-on transcription rate and CYP3A mRNA concentration in rat liver: changes during development. Arch. Biochem. Biophys. 298, 715-725.
    • (1992) Arch. Biochem. Biophys. , vol.298 , pp. 715-725
    • Telhada, M.B.1    Pereira, T.M.2    Lechner, M.C.3
  • 35
    • 0026512675 scopus 로고
    • Phenobarbital induction of cytochrome P-450 gene expression
    • Waxman, D. J., and Azaroff, L. (1992). Phenobarbital induction of cytochrome P-450 gene expression. Biochem. J. 281(Pt 3), 577-592.
    • (1992) Biochem. J. , vol.281 , Issue.PT 3 , pp. 577-592
    • Waxman, D.J.1    Azaroff, L.2
  • 36
    • 0025267223 scopus 로고
    • Pituitary regulation of the male-specific steroid 6β-hydroxylase P-450 2a (gene product IIIA2) in adult rat liver. Suppressive influence of growth hormone and thyroxine acting at a pretranslational level
    • Waxman, D. J., Ram, P. A., Notani, G., Leblanc, G. A., Alberta, J. A., Morrissey, J. J., and Sundseth, S. S. (1990). Pituitary regulation of the male-specific steroid 6β-hydroxylase P-450 2a (gene product IIIA2) in adult rat liver. Suppressive influence of growth hormone and thyroxine acting at a pretranslational level. Mol. Endocrinol. 4, 447-454.
    • (1990) Mol. Endocrinol. , vol.4 , pp. 447-454
    • Waxman, D.J.1    Ram, P.A.2    Notani, G.3    Leblanc, G.A.4    Alberta, J.A.5    Morrissey, J.J.6    Sundseth, S.S.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.