-
1
-
-
20844443468
-
WHO-EORTC classification for cutaneous lymphomas
-
Willemze R, Jaffe ES, Burg G, Cerroni L, Berti E, Swerdlow SH, et al. WHO-EORTC classification for cutaneous lymphomas. Blood 2005; 105: 3768-85.
-
(2005)
Blood
, vol.105
, pp. 3768-3785
-
-
Willemze, R.1
Jaffe, E.S.2
Burg, G.3
Cerroni, L.4
Berti, E.5
Swerdlow, S.H.6
-
2
-
-
43549089496
-
Introduction: Cutaneous T-cell lymphoma (CTCL)- classification, staging, and treatment options
-
Bagot M. Introduction: Cutaneous T-cell lymphoma (CTCL)- classification, staging, and treatment options. Dermatol Clin 2008; 26 (Suppl 1): 3-12.
-
(2008)
Dermatol Clin
, vol.26
, Issue.SUPPL 1
, pp. 3-12
-
-
Bagot, M.1
-
3
-
-
33645634403
-
CTCL: The most common type of primary cutaneous lymphoma: Introduction
-
Foss F, Whittaker S. CTCL: The most common type of primary cutaneous lymphoma: introduction. Semin Oncol 2006; 33 (Suppl 3): 1-2.
-
(2006)
Semin Oncol
, vol.33
, Issue.SUPPL 3
, pp. 1-2
-
-
Foss, F.1
Whittaker, S.2
-
4
-
-
33644555172
-
Biological insights into the pathogenesis of cutaneous T-cell lymphomas (CTCL)
-
Whittaker S. Biological insights into the pathogenesis of cutaneous T-cell lymphomas (CTCL). Semin Oncol 2006; 33 (Suppl 3): 3-6.
-
(2006)
Semin Oncol
, vol.33
, Issue.SUPPL 3
, pp. 3-6
-
-
Whittaker, S.1
-
5
-
-
78650928058
-
-
US20050074761
-
Bensussan, A., Bagot, M., Boumsell, L., Moretta, A. Novel means for the diagnosis and therapy of CTCL. US20050074761 (2005).
-
(2005)
Novel Means For the Diagnosis and Therapy of CTCL
-
-
Bensussan, A.1
Bagot, M.2
Boumsell, L.3
Moretta, A.4
-
7
-
-
33644513696
-
Therapeutic advances in cutaneous T-cell lymphoma (CTCL)
-
Stadler R, Kremer A. Therapeutic advances in cutaneous T-cell lymphoma (CTCL): From retinoids to rexinoids. Semin Oncol 2006; 33 (Suppl 3): 7-10.
-
(2006)
From Retinoids to Rexinoids. Semin Oncol
, vol.33
, Issue.SUPPL 3
, pp. 7-10
-
-
Stadler, R.1
Kremer, A.2
-
8
-
-
0026729070
-
Regulation of gene expression by vitamin A: The role of nuclear retinoic acid receptors
-
Petkovich M. Regulation of gene expression by vitamin A: The role of nuclear retinoic acid receptors. Annu Rev of Nutr 1992; 12: 443-71.
-
(1992)
Annu Rev of Nutr
, vol.12
, pp. 443-471
-
-
Petkovich, M.1
-
9
-
-
0027662103
-
Hetero - and homodimeric receptors in thyroid hormone and vitamin A action
-
Zhang XK, Pfahl M. Hetero - and homodimeric receptors in thyroid hormone and vitamin A action. Receptor 1993; 3: 183-91.
-
(1993)
Receptor
, vol.3
, pp. 183-191
-
-
Zhang, X.K.1
Pfahl, M.2
-
11
-
-
0028415542
-
Vertebrate receptors: Molecular biology, dimerization and response elements
-
Pfahl M. Vertebrate receptors: Molecular biology, dimerization and response elements. Semin Cell Biol 1994; 5: 95-103.
-
(1994)
Semin Cell Biol
, vol.5
, pp. 95-103
-
-
Pfahl, M.1
-
12
-
-
0030800330
-
Inhibitors of both nuclear factor-kappa b and activator protein-1 activation block the neoplastic transformation response
-
Li JJ, Westergaard C, Ghosh P, Colburn NH. Inhibitors of both nuclear factor-kappa b and activator protein-1 activation block the neoplastic transformation response. Cancer Res 1997; 57: 3569-76.
-
(1997)
Cancer Res
, vol.57
, pp. 3569-3576
-
-
Li, J.J.1
Westergaard, C.2
Ghosh, P.3
Colburn, N.H.4
-
13
-
-
0029805772
-
Retinoic acid receptor-and retinoid X receptor-selective retinoids activate signaling pathways that converge on AP-1 and inhibit squamous differentiation in human bronchial epithelial cells
-
Lee HY, Dawson MI, Walsh G, Nesbitt JC, Eckert R, Fuchs E, et al. Retinoic acid receptor-and retinoid X receptor-selective retinoids activate signaling pathways that converge on AP-1 and inhibit squamous differentiation in human bronchial epithelial cells. Cell Growth Differ 1996; 7: 997-1004.
-
(1996)
Cell Growth Differ
, vol.7
, pp. 997-1004
-
-
Lee, H.Y.1
Dawson, M.I.2
Walsh, G.3
Nesbitt, J.C.4
Eckert, R.5
Fuchs, E.6
-
14
-
-
0033035635
-
Induction of apoptosis by N-(4- hydroxyphenyl)retinamide and its association with reactive oxygen species, nuclear retinoic acid receptors, and apoptosis-related genes in human prostate carcinoma cells
-
Sun SY, Yue P, Lotan R. Induction of apoptosis by N-(4- hydroxyphenyl)retinamide and its association with reactive oxygen species, nuclear retinoic acid receptors, and apoptosis-related genes in human prostate carcinoma cells. Mol Pharmacol 1999; 55: 403-10.
-
(1999)
Mol Pharmacol
, vol.55
, pp. 403-410
-
-
Sun, S.Y.1
Yue, P.2
Lotan, R.3
-
15
-
-
18844432775
-
Emerging drugs in cutaneous T-cell lymphomas
-
Dummer R. Emerging drugs in cutaneous T-cell lymphomas. Expert Opin Emerg Drugs 2005; 10: 381-92.
-
(2005)
Expert Opin Emerg Drugs
, vol.10
, pp. 381-392
-
-
Dummer, R.1
-
16
-
-
0036098460
-
Treatment of cutaneous T cell lymphoma: Current status and future directions
-
Apisarnthanarax N, Talpur R, Duvic M. Treatment of cutaneous T cell lymphoma: Current status and future directions. Am J Clin Dermatol 2002; 3: 193-215.
-
(2002)
Am J Clin Dermatol
, vol.3
, pp. 193-215
-
-
Apisarnthanarax, N.1
Talpur, R.2
Duvic, M.3
-
17
-
-
0026047459
-
The treatment of 45 patients with cutaneous T-cell lymphoma with low doses of interferon-alpha 2a and etretinate
-
Dréno B, Claudy A, Meynadier J, Verret JL, Souteyrand P, Ortonne JP, et al. The treatment of 45 patients with cutaneous T-cell lymphoma with low doses of interferon-alpha 2a and etretinate. Br J Dermatol 1991; 125: 456-9.
-
(1991)
Br J Dermatol
, vol.125
, pp. 456-459
-
-
Dréno, B.1
Claudy, A.2
Meynadier, J.3
Verret, J.L.4
Souteyrand, P.5
Ortonne, J.P.6
-
18
-
-
0023263029
-
Oral retinoids in mycosis fungoides and Sézary syndrome: A comparison of isotretinoin and etretinate. A study from the Scandinavian Mycosis Fungoides Group
-
Molin L, Thomsen K, Volden G, Aronsson A, Hammar H, Hellbe L, et al. Oral retinoids in mycosis fungoides and Sézary syndrome: A comparison of isotretinoin and etretinate. A study from the Scandinavian Mycosis Fungoides Group. Acta Derm Venereol 1987; 67: 232-6.
-
(1987)
Acta Derm Venereol
, vol.67
, pp. 232-236
-
-
Molin, L.1
Thomsen, K.2
Volden, G.3
Aronsson, A.4
Hammar, H.5
Hellbe, L.6
-
19
-
-
0028087742
-
Synthesis and structure-activity relationships of novel retinoid X receptor-selective retinoids
-
Boehm MF, Zhang L, Badea BA, White SK, Mais DE, Berger E, et al. Synthesis and structure-activity relationships of novel retinoid X receptor-selective retinoids J Med Chem 1994; 18: 2930-41.
-
(1994)
J Med Chem
, vol.18
, pp. 2930-2941
-
-
Boehm, M.F.1
Zhang, L.2
Badea, B.A.3
White, S.K.4
Mais, D.E.5
Berger, E.6
-
21
-
-
0036096774
-
Induction of apoptosis by bexarotene in cutaneous T-cell lymphoma cells
-
Zhang C, Hazarika P, Ni X, Weidner DA, Duvic M. Induction of apoptosis by bexarotene in cutaneous T-cell lymphoma cells: Relevance to mechanism of therapeutic action. Clin Cancer Res 2002; 8: 1234-40.
-
(2002)
Relevance to Mechanism of Therapeutic Action. Clin Cancer Res
, vol.8
, pp. 1234-1240
-
-
Zhang, C.1
Hazarika, P.2
Ni, X.3
Weidner, D.A.4
Duvic, M.5
-
22
-
-
13344250486
-
Effects of novel retinoid X receptor-selective ligands on myeloid leukemia differentiation and proliferation in vitro
-
Kizaki M, Dawson MI, Heyman R, Elster E, Morosetti R, Pakkala S, et al. Effects of novel retinoid X receptor-selective ligands on myeloid leukemia differentiation and proliferation in vitro. Blood 1996, 87: 1977-84.
-
(1996)
Blood
, vol.87
, pp. 1977-1984
-
-
Kizaki, M.1
Dawson, M.I.2
Heyman, R.3
Elster, E.4
Morosetti, R.5
Pakkala, S.6
-
23
-
-
33644839725
-
A selective retinoid receptor agonist bexarotene (LGD1069, targretin) inhibits angiogenesis and metastasis in solid tumours
-
Yen WC, Prudente RY, Corpuz MR, Negro-Vilar A, Lamph WW. A selective retinoid receptor agonist bexarotene (LGD1069, targretin) inhibits angiogenesis and metastasis in solid tumours. Br J Cancer 2006; 94: 654-60.
-
(2006)
Br J Cancer
, vol.94
, pp. 654-660
-
-
Yen, W.C.1
Prudente, R.Y.2
Corpuz, M.R.3
Negro-Vilar, A.4
Lamph, W.W.5
-
24
-
-
17444442152
-
Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists
-
Mukherjee R, Davies PJ, Crombie DL, Bischoff ED, Cesario RM, Jow L, et al. Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists. Nature 1997; 386: 407-10.
-
(1997)
Nature
, vol.386
, pp. 407-410
-
-
Mukherjee, R.1
Davies, P.J.2
Crombie, D.L.3
Bischoff, E.D.4
Cesario, R.M.5
Jow, L.6
-
25
-
-
0031024325
-
Initial clinical trial of a selective retinoid x receptor ligand, LGD1069
-
Miller VA, Benedetti FM, Rigas JR, Verret al., Pfister DG, Straus D, et al. Initial clinical trial of a selective retinoid x receptor ligand, LGD1069. J Clin Oncol 1997; 15: 790-5.
-
(1997)
J Clin Oncol
, vol.15
, pp. 790-795
-
-
Miller, V.A.1
Benedetti, F.M.2
Rigas, J.R.3
Verret, A.L.4
Pfister, D.G.5
Straus, D.6
-
26
-
-
0032790681
-
A Phase I study of LGD1069 in adults with advanced cancer
-
Rizvi NA, Marshall JL, Dahut W, Ness E, Truglia JA, Loewen G, et al. A Phase I study of LGD1069 in adults with advanced cancer. Clin Cancer Res 1999; 5: 1658-64.
-
(1999)
Clin Cancer Res
, vol.5
, pp. 1658-1664
-
-
Rizvi, N.A.1
Marshall, J.L.2
Dahut, W.3
Ness, E.4
Truglia, J.A.5
Loewen, G.6
-
27
-
-
0030846066
-
Oxidative metabolism of a rexinoid and rapid phase II metabolite identification by mass spectrometry
-
Shirley MA, Wheelan P, Howell SR, Murphy RC. Oxidative metabolism of a rexinoid and rapid phase II metabolite identification by mass spectrometry. Drug Metab Dispos 1997; 10: 1144-9.
-
(1997)
Drug Metab Dispos
, vol.10
, pp. 1144-1149
-
-
Shirley, M.A.1
Wheelan, P.2
Howell, S.R.3
Murphy, R.C.4
-
28
-
-
0031892908
-
Effects of retinoid treatment of rats on hepatic microsomal metabolism and cytochromes P450. Correlation between retinoic acid receptor/retinoid x receptor selectivity and effects on metabolic enzymes
-
Howell SR, Shirley MA, Ulm EH. Effects of retinoid treatment of rats on hepatic microsomal metabolism and cytochromes P450. Correlation between retinoic acid receptor/retinoid x receptor selectivity and effects on metabolic enzymes. Drug Metab Dispos 1998; 26: 234-9.
-
(1998)
Drug Metab Dispos
, vol.26
, pp. 234-239
-
-
Howell, S.R.1
Shirley, M.A.2
Ulm, E.H.3
-
29
-
-
0029904181
-
Retinoids increase human apolipoprotein A-11 expression through activation of the retinoid X receptor but not the retinoic acid receptor
-
Vu-Dac N, Schoonjans K, Kosykh V, Dallongeville J, Heyman RA, Staels B, et al. Retinoids increase human apolipoprotein A-11 expression through activation of the retinoid X receptor but not the retinoic acid receptor. Mol Cell Biol 1996; 16: 3350-60.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 3350-3360
-
-
Vu-Dac, N.1
Schoonjans, K.2
Kosykh, V.3
Dallongeville, J.4
Heyman, R.A.5
Staels, B.6
-
30
-
-
0031836567
-
RXR agonists activate PPARalpha-inducible genes, lower triglycerides, and raise HDL levels in vivo
-
Mukherjee R, Strasser J, Jow L, Hoener P, Paterniti JR Jr, Heyman RA. RXR agonists activate PPARalpha-inducible genes, lower triglycerides, and raise HDL levels in vivo. Arterioscler Thromb Vasc Biol 1998; 18: 272-6.
-
(1998)
Arterioscler Thromb Vasc Biol
, vol.18
, pp. 272-276
-
-
Mukherjee, R.1
Strasser, J.2
Jow, L.3
Hoener, P.4
Paterniti Jr., J.R.5
Heyman, R.A.6
-
31
-
-
0029098696
-
Retinoids stimulate fibrinogen production both in vitro (hepatocytes) and in vivo. Induction requires activation of the retinoid X receptor
-
Nicodeme E, Nicaud M, Issandou M. Retinoids stimulate fibrinogen production both in vitro (hepatocytes) and in vivo. Induction requires activation of the retinoid X receptor. Arterioscler Thromb Vasc Biol 1995; 15: 1660-7.
-
(1995)
Arterioscler Thromb Vasc Biol
, vol.15
, pp. 1660-1667
-
-
Nicodeme, E.1
Nicaud, M.2
Issandou, M.3
-
32
-
-
0031027183
-
Ligand-bound RXR can mediate retinoid signal transduction during embryogenesis
-
Lu HC, Eichele G, Thaller C. Ligand-bound RXR can mediate retinoid signal transduction during embryogenesis. Development 1997; 124: 195-203.
-
(1997)
Development
, vol.124
, pp. 195-203
-
-
Lu, H.C.1
Eichele, G.2
Thaller, C.3
-
33
-
-
0034999546
-
Phase 2 and 3 clinical trial of oral bexarotene (Targretin capsules) for the treatment of refractory or persistent early-stage cutaneous T-cell lymphoma
-
Duvic M, Martin AG, Kim Y, Olsen E, Wood GS, Crowley CA, et al. Phase 2 and 3 clinical trial of oral bexarotene (Targretin capsules) for the treatment of refractory or persistent early-stage cutaneous T-cell lymphoma. Arch Dermatol 2001; 137: 581-93.
-
(2001)
Arch Dermatol
, vol.137
, pp. 581-593
-
-
Duvic, M.1
Martin, A.G.2
Kim, Y.3
Olsen, E.4
Wood, G.S.5
Crowley, C.A.6
-
34
-
-
0035340844
-
Bexarotene is effective and safe for treatment of refractory advanced-stage cutaneous T-cell lymphoma: Multinational phase II-III trial results
-
Duvic M, Hymes K, Heald P, Breneman D, Martin AG, Myskowski P, et al. Bexarotene is effective and safe for treatment of refractory advanced-stage cutaneous T-cell lymphoma: Multinational phase II-III trial results. J Clin Oncol 2001; 19: 2456-71.
-
(2001)
J Clin Oncol
, vol.19
, pp. 2456-2471
-
-
Duvic, M.1
Hymes, K.2
Heald, P.3
Breneman, D.4
Martin, A.G.5
Myskowski, P.6
-
35
-
-
3042823306
-
Comparison of selective retinoic acid receptor-and retinoic X receptor-mediated efficacy, tolerance, and survival in cutaneous t-cell lymphoma
-
Querfeld C, Rosen ST, Guitart J, Rademaker A, Fung BB, Posten W, et al. Comparison of selective retinoic acid receptor-and retinoic X receptor-mediated efficacy, tolerance, and survival in cutaneous t-cell lymphoma. J Am Acad Dermatol 2004; 51: 25-32.
-
(2004)
J Am Acad Dermatol
, vol.51
, pp. 25-32
-
-
Querfeld, C.1
Rosen, S.T.2
Guitart, J.3
Rademaker, A.4
Fung, B.B.5
Posten, W.6
-
36
-
-
33646398594
-
EORTC consensus recommendations for the treatment of mycosis fungoides/Sézary syndrome
-
Trautinger F, Knobler R, Willemze R, Peris K, Stadler R, Laroche L, et al. EORTC consensus recommendations for the treatment of mycosis fungoides/Sézary syndrome. Eur J Cancer 2006; 42: 1014-30.
-
(2006)
Eur J Cancer
, vol.42
, pp. 1014-1030
-
-
Trautinger, F.1
Knobler, R.2
Willemze, R.3
Peris, K.4
Stadler, R.5
Laroche, L.6
-
37
-
-
34547911767
-
The optimal use of bexarotene in cutaneous T-cell lymphoma
-
Gniadecki R, Assaf C, Bagot M, Dummer R, Duvic M, Knobler R, et al. The optimal use of bexarotene in cutaneous T-cell lymphoma. Br J Dermatol 2007; 157: 433-40.
-
(2007)
Br J Dermatol
, vol.157
, pp. 433-440
-
-
Gniadecki, R.1
Assaf, C.2
Bagot, M.3
Dummer, R.4
Duvic, M.5
Knobler, R.6
-
38
-
-
4644340662
-
Cutaneous T-cell lymphoma treatment using bexarotene and PUVA: A case series
-
Singh F, Lebwohl MG. Cutaneous T-cell lymphoma treatment using bexarotene and PUVA: A case series. J Am Acad Dermatol 2004; 51: 570-3.
-
(2004)
J Am Acad Dermatol
, vol.51
, pp. 570-573
-
-
Singh, F.1
Lebwohl, M.G.2
-
39
-
-
0038459345
-
Psoralen plus long-wave UV-A (PUVA) and bexarotene therapy: An effective and synergistic combined adjunct to therapy for patients with advanced cutaneous T-cell lymphoma
-
McGinnis KS, Shapiro M, Vittorio CC, Rook AH, Junkins-Hopkins JM. Psoralen plus long-wave UV-A (PUVA) and bexarotene therapy: An effective and synergistic combined adjunct to therapy for patients with advanced cutaneous T-cell lymphoma. Arch Dermatol 2003; 139: 771-5.
-
(2003)
Arch Dermatol
, vol.139
, pp. 771-775
-
-
McGinnis, K.S.1
Shapiro, M.2
Vittorio, C.C.3
Rook, A.H.4
Junkins-Hopkins, J.M.5
-
40
-
-
34447109708
-
Extracorporeal photopheresis in combination with bexarotene in the treatment of mycosis fungoides and Sézary syndrome
-
Tsirigotis P, Pappa V, Papageorgiou S, Kapsimali V, Giannopoulou V, Kaitsa I, et al. Extracorporeal photopheresis in combination with bexarotene in the treatment of mycosis fungoides and Sézary syndrome. Br J Dermatol 2007; 156: 1379-81.
-
(2007)
Br J Dermatol
, vol.156
, pp. 1379-1381
-
-
Tsirigotis, P.1
Pappa, V.2
Papageorgiou, S.3
Kapsimali, V.4
Giannopoulou, V.5
Kaitsa, I.6
-
41
-
-
34247607092
-
Results of a phase II trial of oral bexarotene (Targretin) combined with interferon alfa-2b (Intron-A) for patients with cutaneous T-cell lymphoma
-
Straus DJ, Duvic M, Kuzel T, Horwitz S, Demierre MF, Myskowski P, et al. Results of a phase II trial of oral bexarotene (Targretin) combined with interferon alfa-2b (Intron-A) for patients with cutaneous T-cell lymphoma. Cancer 2007; 109: 1799-803.
-
(2007)
Cancer
, vol.109
, pp. 1799-1803
-
-
Straus, D.J.1
Duvic, M.2
Kuzel, T.3
Horwitz, S.4
Demierre, M.F.5
Myskowski, P.6
-
42
-
-
78650930920
-
-
US20070129392
-
Hong, B., Sarshar, S., Tse, B. Novel therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders. US20070129392 (2007).
-
(2007)
Novel Therapeutic Agents For the Treatment of Cancer, Metabolic Diseases and Skin Disorders
-
-
Hong, B.1
Sarshar, S.2
Tse, B.3
-
43
-
-
33644544666
-
Clinical experience with denileukin diftitox (ONTAK)
-
Foss F. Clinical experience with denileukin diftitox (ONTAK). Semin Oncol 2006; 33(1 Suppl 3): 11-6.
-
(2006)
Semin Oncol
, vol.33
, Issue.1 SUPPL 3
, pp. 11-16
-
-
Foss, F.1
-
44
-
-
0023529699
-
Diphtheria toxin receptor binding domain substitution with interleukin-2: Genetic construction and properties of a diphtheria toxin-related interleukin-2 fusion protein
-
Williams DP, Parker K, Bacha P, Bishai W, Borowski M, Genbauffe F, et al. Diphtheria toxin receptor binding domain substitution with interleukin-2: Genetic construction and properties of a diphtheria toxin-related interleukin-2 fusion protein. Protein Eng 1987; 1: 493-8.
-
(1987)
Protein Eng
, vol.1
, pp. 493-498
-
-
Williams, D.P.1
Parker, K.2
Bacha, P.3
Bishai, W.4
Borowski, M.5
Genbauffe, F.6
-
45
-
-
0026379299
-
Protein engineering of DAB-IL-2 fusion toxins to increase biological potency
-
Kiyokawa T, Williams DP, Snider CE, Waters CA, Nichols JC, Strom TB, et al. Protein engineering of DAB-IL-2 fusion toxins to increase biological potency. Ann NY Acad Sci 1991; 636: 331-9.
-
(1991)
Ann NY Acad Sci
, vol.636
, pp. 331-339
-
-
Kiyokawa, T.1
Williams, D.P.2
Snider, C.E.3
Waters, C.A.4
Nichols, J.C.5
Strom, T.B.6
-
46
-
-
0029664472
-
DAB-389 interleukin-2 receptor binding domain mutations: Cytotoxic probes for studies of ligand-receptor interactions
-
Vanderspek JC, Sutherland JA, Ratnarathorn M, Howland K, Ciardelli TL, Murphy JR. DAB-389 interleukin-2 receptor binding domain mutations: Cytotoxic probes for studies of ligand-receptor interactions. J Biol Chem 1996; 271: 12145-9.
-
(1996)
J Biol Chem
, vol.271
, pp. 12145-12149
-
-
Vanderspek, J.C.1
Sutherland, J.A.2
Ratnarathorn, M.3
Howland, K.4
Ciardelli, T.L.5
Murphy, J.R.6
-
47
-
-
0023845225
-
Interleukin 2 receptor-targeted cytotoxicity. Interleukin 2 receptor-mediated action of a diphtheria toxin-related interleukin 2 fusion protein
-
Bacha P, Williams DP, Waters C, Williams JM, Murphy JR, Strom TB. Interleukin 2 receptor-targeted cytotoxicity. Interleukin 2 receptor-mediated action of a diphtheria toxin-related interleukin 2 fusion protein. J Exp Med 1988; 167: 612-22.
-
(1988)
J Exp Med
, vol.167
, pp. 612-622
-
-
Bacha, P.1
Williams, D.P.2
Waters, C.3
Williams, J.M.4
Murphy, J.R.5
Strom, T.B.6
-
49
-
-
17744401939
-
Phase I trial of a ligand fusion-protein (DAB389IL-2) in lymphomas expressing the receptor for interleukin-2
-
LeMaistre CF, Saleh MN, Kuzel TM, Foss F, Platanias LC, Schwartz G, et al. Phase I trial of a ligand fusion-protein (DAB389IL-2) in lymphomas expressing the receptor for interleukin-2. Blood 1998; 91: 399-405.
-
(1998)
Blood
, vol.91
, pp. 399-405
-
-
Lemaistre, C.F.1
Saleh, M.N.2
Kuzel, T.M.3
Foss, F.4
Platanias, L.C.5
Schwartz, G.6
-
51
-
-
78650953811
-
-
US20090041797
-
Davis, C.G., Datta, D., Baker, M.P., Rust, A.J., Keen, S. Modified toxins. US20090041797 (2009).
-
(2009)
Modified Toxins
-
-
Davis, C.G.1
Datta, D.2
Baker, M.P.3
Rust, A.J.4
Keen, S.5
-
52
-
-
0035863468
-
Pivotal phase III trial of two dose levels of denileukin diftitox for the treatment of cutaneous T-cell lymphoma
-
Olsen E, Duvic M, Frankel A, Kim Y, Martin A, Vonderheid E, et al. Pivotal phase III trial of two dose levels of denileukin diftitox for the treatment of cutaneous T-cell lymphoma. J Clin Oncol 2001; 19: 376-88.
-
(2001)
J Clin Oncol
, vol.19
, pp. 376-388
-
-
Olsen, E.1
Duvic, M.2
Frankel, A.3
Kim, Y.4
Martin, A.5
Vonderheid, E.6
-
53
-
-
0037328760
-
A complete and durable response to denileukin diftitox in a patient with mycosis fungoides
-
Carretero-Margolis CD, Fivenson DP. A complete and durable response to denileukin diftitox in a patient with mycosis fungoides. J Am Acad Dermatol 2003; 48: 275-6.
-
(2003)
J Am Acad Dermatol
, vol.48
, pp. 275-276
-
-
Carretero-Margolis, C.D.1
Fivenson, D.P.2
-
54
-
-
38049020548
-
Durable complete remission of mycosis fungoides following erythroderma induced by denileukin diftitox
-
Kazin R, Bujanauskas P, Vonderheid EC. Durable complete remission of mycosis fungoides following erythroderma induced by denileukin diftitox. J Am Acad Dermatol 2008; 58 (2 Suppl): 31-2.
-
(2008)
J Am Acad Dermatol
, vol.58
, Issue.2 SUPPL
, pp. 31-32
-
-
Kazin, R.1
Bujanauskas, P.2
Vonderheid, E.C.3
-
55
-
-
77951650540
-
Phase III placebo-controlled trial of denileukin diftitox for patients with cutaneous T-Cell lymphoma
-
Prince HM, Duvic M, Martin A, Sterry W, Assaf C, Sun Y, et al. Phase III placebo-controlled trial of denileukin diftitox for patients with cutaneous T-Cell lymphoma. J Clin Oncol 2010;
-
(2010)
J Clin Oncol
, pp. 8
-
-
Prince, H.M.1
Duvic, M.2
Martin, A.3
Sterry, W.4
Assaf, C.5
Sun, Y.6
-
56
-
-
78650951091
-
-
American Society of Clinical Oncology- 44th Annual Meeting. Chicago, USA
-
Negro-Vilar A, Prince HM, Duvic M, Richardson S, Sun Y, Acosta M. Efficacy and safety of denileukin diftitox (Dd) in cutaneous T- cell lymphoma (CTCL) patients: Integrated analysis of three large phase III trials. American Society of Clinical Oncology- 44th Annual Meeting. Chicago, USA (2008).
-
(2008)
Efficacy and Safety of Denileukin Diftitox (Dd) In Cutaneous T- Cell Lymphoma (CTCL) Patients: Integrated Analysis of Three Large Phase III Trials
-
-
Negro-Vilar, A.1
Prince, H.M.2
Duvic, M.3
Richardson, S.4
Sun, Y.5
Acosta, M.6
-
57
-
-
0037103316
-
Immunomodulatory effects of RXR rexinoids: Modulation of high-affinity IL-2R expression enhances susceptibility to denileukin diftitox
-
Gorgun G, Foss F. Immunomodulatory effects of RXR rexinoids: modulation of high-affinity IL-2R expression enhances susceptibility to denileukin diftitox. Blood 2002; 100: 1399-403.
-
(2002)
Blood
, vol.100
, pp. 1399-1403
-
-
Gorgun, G.1
Foss, F.2
-
58
-
-
22144495793
-
A phase-1 trial of bexarotene and denileukin diftitox in patients with relapsed or refractory cutaneous T-cell lymphoma
-
Foss F, Demierre MF, DiVenuti G. A phase-1 trial of bexarotene and denileukin diftitox in patients with relapsed or refractory cutaneous T-cell lymphoma. Blood 2005; 106: 454-7.
-
(2005)
Blood
, vol.106
, pp. 454-457
-
-
Foss, F.1
Demierre, M.F.2
Divenuti, G.3
-
59
-
-
33749432146
-
Immunotoxins in the treatment of hematologic malignancies
-
Kreitman RJ, Pastan I. Immunotoxins in the treatment of hematologic malignancies. Curr Drug Targets 2006; 7: 1301-11.
-
(2006)
Curr Drug Targets
, vol.7
, pp. 1301-1311
-
-
Kreitman, R.J.1
Pastan, I.2
-
60
-
-
0034001076
-
Phase I trial of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) in patients with hematologic malignancies
-
Kreitman RJ, Wilson WH, White JD, Stetler-Stevenson M, Jaffe ES, Giardina S, et al. Phase I trial of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) in patients with hematologic malignancies. J Clin Oncol 2000; 18: 1622-36.
-
(2000)
J Clin Oncol
, vol.18
, pp. 1622-1636
-
-
Kreitman, R.J.1
Wilson, W.H.2
White, J.D.3
Stetler-Stevenson, M.4
Jaffe, E.S.5
Giardina, S.6
-
61
-
-
64349108724
-
Recombinant immunotoxins containing truncated bacterial toxins for the treatment of hematologic malignancies
-
Kreitman RJ. Recombinant immunotoxins containing truncated bacterial toxins for the treatment of hematologic malignancies. BioDrugs 2009; 23: 1-13.
-
(2009)
BioDrugs
, vol.23
, pp. 1-13
-
-
Kreitman, R.J.1
-
62
-
-
0021146614
-
Recombinant leukocyte A interferon: An active agent in advanced cutaneous T-cell lymphomas
-
Bunn PA Jr, Foon KA, Ihde DC, Longo DL, Eddy J, Winkler CF, et al. Recombinant leukocyte A interferon: An active agent in advanced cutaneous T-cell lymphomas. Ann Intern Med 1984; 101: 484-7.
-
(1984)
Ann Intern Med
, vol.101
, pp. 484-487
-
-
Bunn Jr., P.A.1
Foon, K.A.2
Ihde, D.C.3
Longo, D.L.4
Eddy, J.5
Winkler, C.F.6
-
63
-
-
78650954021
-
-
US6204022
-
Johnson, H.M., Pontzer, C.H., Subramaniam, P.S., Villarete, L.H., Campos, J. Low-toxicity human interferon-alpha analogs. US6204022 (2001).
-
(2001)
Low-toxicity Human Interferon-alpha Analogs
-
-
Johnson, H.M.1
Pontzer, C.H.2
Subramaniam, P.S.3
Villarete, L.H.4
Campos, J.5
-
64
-
-
0035086519
-
Rational design of a potent, long-lasting form of interferon: A 40kDa branched polyethylene glycol-conjugated interferon alpha-2a for the treatment of hepatitis C
-
Bailon P, Palleroni A, Schaffer CA, Spence CL, Fung WJ, Porter JE, et al. Rational design of a potent, long-lasting form of interferon: A 40kDa branched polyethylene glycol-conjugated interferon alpha-2a for the treatment of hepatitis C. Bioconjug Chem 2001; 12: 195-202.
-
(2001)
Bioconjug Chem
, vol.12
, pp. 195-202
-
-
Bailon, P.1
Palleroni, A.2
Schaffer, C.A.3
Spence, C.L.4
Fung, W.J.5
Porter, J.E.6
-
65
-
-
0642377751
-
New and modified interferon alfas: Preclinical and clinical data
-
Masci P, Bukowski RM, Patten PA, Osborn BL, Borden EC. New and modified interferon alfas: Preclinical and clinical data. Curr Oncol Rep 2003; 5: 108-13.
-
(2003)
Curr Oncol Rep
, vol.5
, pp. 108-113
-
-
Masci, P.1
Bukowski, R.M.2
Patten, P.A.3
Osborn, B.L.4
Borden, E.C.5
-
66
-
-
0035281760
-
Phase I trial of 40kd branched pegylated interferon alfa-2a for patients with advanced renal cell carcinoma
-
Motzer RJ, Rakhit A, Ginsberg M, Rittweger K, Vuky J, Yu R, et al. Phase I trial of 40kd branched pegylated interferon alfa-2a for patients with advanced renal cell carcinoma. J Clin Oncol 2001; 19: 1312-9.
-
(2001)
J Clin Oncol
, vol.19
, pp. 1312-1319
-
-
Motzer, R.J.1
Rakhit, A.2
Ginsberg, M.3
Rittweger, K.4
Vuky, J.5
Yu, R.6
-
67
-
-
0035020761
-
Improved pharmacokinetic properties of a polyethylene glycol-modified form of interferon-beta-1a with preserved in vitro bioactivity
-
Pepinsky RB, LePage DJ, Gill A, Chakraborty A, Vaidyanathan S, Green M, et al. Improved pharmacokinetic properties of a polyethylene glycol-modified form of interferon-beta-1a with preserved in vitro bioactivity. J Pharmacol Exp Ther 2001; 297: 1059-66.
-
(2001)
J Pharmacol Exp Ther
, vol.297
, pp. 1059-1066
-
-
Pepinsky, R.B.1
Lepage, D.J.2
Gill, A.3
Chakraborty, A.4
Vaidyanathan, S.5
Green, M.6
-
68
-
-
0035216905
-
Peginterferon alfa-2a (40kDa) monotherapy: A novel agent for chronic hepatitis C therapy
-
Zeuzem S, Heathcote JE, Martin N, Nieforth K, Modi M. Peginterferon alfa-2a (40kDa) monotherapy: A novel agent for chronic hepatitis C therapy. Expert Opin Investig Drugs 2001; 10: 2201-13.
-
(2001)
Expert Opin Investig Drugs
, vol.10
, pp. 2201-2213
-
-
Zeuzem, S.1
Heathcote, J.E.2
Martin, N.3
Nieforth, K.4
Modi, M.5
-
70
-
-
4344566090
-
Peginterferon alfa-2a: A review of approved and investigational uses
-
Matthews SJ, McCoy C. Peginterferon alfa-2a: A review of approved and investigational uses. Clin Ther 2004; 26: 991-1025.
-
(2004)
Clin Ther
, vol.26
, pp. 991-1025
-
-
Matthews, S.J.1
McCoy, C.2
-
71
-
-
78650950278
-
-
US20050008683
-
Mikszta, J.A., Dekker, III J.P., Pettis, R.J., Alchas, P.G. Method for delivering interferons to the intradermal compartment. US20050008683 (2005).
-
(2005)
Method For Delivering Interferons to The Intradermal Compartment
-
-
Mikszta, J.A.1
Dekker III, J.P.2
Pettis, R.J.3
Alchas, P.G.4
-
72
-
-
77349115530
-
Current and emerging treatment strategies for cutaneous T-cell lymphoma
-
Lansigan F, Foss FM. Current and emerging treatment strategies for cutaneous T-cell lymphoma. Drugs 2010; 70: 273-86.
-
(2010)
Drugs
, vol.70
, pp. 273-286
-
-
Lansigan, F.1
Foss, F.M.2
-
73
-
-
0022651327
-
The role of recombinant interferon alfa-2a in the therapy of cutaneous T-cell lymphomas
-
Bunn PA Jr, Ihde DC, Foon KA. The role of recombinant interferon alfa-2a in the therapy of cutaneous T-cell lymphomas. Cancer 1986; 57(8 Suppl): 1689-95.
-
(1986)
Cancer
, vol.57
, Issue.8 SUPPL
, pp. 1689-1695
-
-
Bunn Jr., P.A.1
Ihde, D.C.2
Foon, K.A.3
-
74
-
-
0025057402
-
Low-versus high-dose interferon alfa-2a in relapsed indolent non-Hodgkin's lymphoma
-
VanderMolen LA, Steis RG, Duffey PL, Foon KA, Smith JW 2nd, Clark JW, et al. Low-versus high-dose interferon alfa-2a in relapsed indolent non-Hodgkin's lymphoma. J Natl Cancer Inst 1990; 82: 235-8.
-
(1990)
J Natl Cancer Inst
, vol.82
, pp. 235-238
-
-
Vandermolen, L.A.1
Steis, R.G.2
Duffey, P.L.3
Foon, K.A.4
Smith 2nd, J.W.5
Clark, J.W.6
-
75
-
-
0347990623
-
Interferon in the treatment of cutaneous T-cell lymphoma
-
Olsen EA. Interferon in the treatment of cutaneous T-cell lymphoma. Dermatol Ther 2003; 16: 311-21.
-
(2003)
Dermatol Ther
, vol.16
, pp. 311-321
-
-
Olsen, E.A.1
-
76
-
-
0032533917
-
Prospective randomized multicenter clinical trial on the use of interferon -2a plus acitretin versus interferon -2a plus PUVA in patients with cutaneous T-cell lymphoma stages I and II
-
Stadler R, Otte HG, Luger T, Henz BM, Kühl P, Zwingers T, et al. Prospective randomized multicenter clinical trial on the use of interferon -2a plus acitretin versus interferon -2a plus PUVA in patients with cutaneous T-cell lymphoma stages I and II. Blood 1998; 92: 3578-81.
-
(1998)
Blood
, vol.92
, pp. 3578-3581
-
-
Stadler, R.1
Otte, H.G.2
Luger, T.3
Henz, B.M.4
Kühl, P.5
Zwingers, T.6
-
77
-
-
0028019881
-
Phase II trial of fludarabine phosphate and interferon alfa-2a in advanced mycosis fungoides/Sézary syndrome
-
Foss FM, Ihde DC, Linnoila IR, Fischmann AB, Schechter GP, Cotelingam JD, et al. Phase II trial of fludarabine phosphate and interferon alfa-2a in advanced mycosis fungoides/Sézary syndrome. J Clin Oncol 1994; 12: 2051-9.
-
(1994)
J Clin Oncol
, vol.12
, pp. 2051-2059
-
-
Foss, F.M.1
Ihde, D.C.2
Linnoila, I.R.3
Fischmann, A.B.4
Schechter, G.P.5
Cotelingam, J.D.6
-
78
-
-
25444452415
-
The addition of interferon gamma to oral bexarotene therapy with photopheresis for Sézary syndrome
-
McGinnis KS, Ubriani R, Newton S, Junkins-Hopkins JM, Vittorio CC, Kim EJ, et al. The addition of interferon gamma to oral bexarotene therapy with photopheresis for Sézary syndrome. Arch Dermatol 2005; 141: 1176-8.
-
(2005)
Arch Dermatol
, vol.141
, pp. 1176-1178
-
-
McGinnis, K.S.1
Ubriani, R.2
Newton, S.3
Junkins-Hopkins, J.M.4
Vittorio, C.C.5
Kim, E.J.6
-
79
-
-
0035863751
-
Interferon resistance of cutaneous T-cell lymphoma-derived clonal T-helper 2 cells allows selective viral replication
-
Dummer R, Döbbeling U, Geertsen R, Willers J, Burg G, Pavlovic J. Interferon resistance of cutaneous T-cell lymphoma-derived clonal T-helper 2 cells allows selective viral replication. Blood 2001; 97: 523-7.
-
(2001)
Blood
, vol.97
, pp. 523-527
-
-
Dummer, R.1
Döbbeling, U.2
Geertsen, R.3
Willers, J.4
Burg, G.5
Pavlovic, J.6
-
80
-
-
4444349308
-
Adenovirus-mediated intralesional interferon-gamma gene transfer induces tumor regressions in cutaneous lymphomas
-
Dummer R, Hassel JC, Fellenberg F, Eichmüller S, Maier T, Slos P, et al. Adenovirus-mediated intralesional interferon-gamma gene transfer induces tumor regressions in cutaneous lymphomas. Blood 2004; 104: 1631-8.
-
(2004)
Blood
, vol.104
, pp. 1631-1638
-
-
Dummer, R.1
Hassel, J.C.2
Fellenberg, F.3
Eichmüller, S.4
Maier, T.5
Slos, P.6
-
81
-
-
34249877414
-
Drug evaluation: TG-1042, an adenovirus-mediated IFNgamma gene delivery for the intratumoral therapy of primary cutaneous lymphomas
-
Urosevic M. Drug evaluation: TG-1042, an adenovirus-mediated IFNgamma gene delivery for the intratumoral therapy of primary cutaneous lymphomas. Curr Opin Investig Drugs 2007; 8: 493-8.
-
(2007)
Curr Opin Investig Drugs
, vol.8
, pp. 493-498
-
-
Urosevic, M.1
-
82
-
-
0021365826
-
Ovine trophoblast protein 1, an early secreted blastocyst protein, binds specifically to uterine endometrium and affects protein synthesis
-
Godkin JD, Bazer FW, Roberts RM. Ovine trophoblast protein 1, an early secreted blastocyst protein, binds specifically to uterine endometrium and affects protein synthesis. Endocrinology 1984; 114: 120-30.
-
(1984)
Endocrinology
, vol.114
, pp. 120-130
-
-
Godkin, J.D.1
Bazer, F.W.2
Roberts, R.M.3
-
83
-
-
0023567263
-
Interferon like sequence of ovine trophoblast protein secreted by embryonic trophectoderm
-
Imakawa K, Anthony RV, Kazemi M, Marotti KR, Polites HG, Roberts RM. Interferon like sequence of ovine trophoblast protein secreted by embryonic trophectoderm. Nature 1987; 330: 377-9.
-
(1987)
Nature
, vol.330
, pp. 377-379
-
-
Imakawa, K.1
Anthony, R.V.2
Kazemi, M.3
Marotti, K.R.4
Polites, H.G.5
Roberts, R.M.6
-
84
-
-
0023625817
-
Interferon sequence homology and receptor binding activity of ovine trophoblast antiluteolytic protein
-
Stewart HJ, McCann SH, Barker PJ, Lee KE, Lamming GE, Flint AP. Interferon sequence homology and receptor binding activity of ovine trophoblast antiluteolytic protein. J Endocrinol 1987; 115: 13-5.
-
(1987)
J Endocrinol
, vol.115
, pp. 13-15
-
-
Stewart, H.J.1
McCann, S.H.2
Barker, P.J.3
Lee, K.E.4
Lamming, G.E.5
Flint, A.P.6
-
86
-
-
0029188099
-
Interleukin-12: Potential role in cancer therapy
-
Brunda MJ, Gately MK. Interleukin-12: Potential role in cancer therapy. Important Adv Oncol 1995: 3-18.
-
(1995)
Important Adv Oncol
, pp. 3-18
-
-
Brunda, M.J.1
Gately, M.K.2
-
87
-
-
0034803597
-
The role for interleukin-12 therapy of cutaneous T cell lymphoma
-
Rook AH, Zaki MH, Wysocka M, Wood GS, Duvic M, Showe LC, et al. The role for interleukin-12 therapy of cutaneous T cell lymphoma. Ann N Y Acad Sci 2001; 941: 177-84.
-
(2001)
Ann N Y Acad Sci
, vol.941
, pp. 177-184
-
-
Rook, A.H.1
Zaki, M.H.2
Wysocka, M.3
Wood, G.S.4
Duvic, M.5
Showe, L.C.6
-
89
-
-
33749684290
-
A phase II open-label study of recombinant human interleukin-12 in patients with stage IA, IB, or IIA mycosis fungoides
-
Duvic M, Sherman ML, Wood GS, Kuzel TM, Olsen E, Foss F, et al. A phase II open-label study of recombinant human interleukin-12 in patients with stage IA, IB, or IIA mycosis fungoides. J Am Acad Dermatol 2006; 55: 807-13.
-
(2006)
J Am Acad Dermatol
, vol.55
, pp. 807-813
-
-
Duvic, M.1
Sherman, M.L.2
Wood, G.S.3
Kuzel, T.M.4
Olsen, E.5
Foss, F.6
-
90
-
-
65649123377
-
Toll-like receptors and their role in hematologic malignancies
-
Wolska A, Lech-Maranda E, Robak T. Toll-like receptors and their role in hematologic malignancies. Curr Mol Med 2009; 9: 324-35.
-
(2009)
Curr Mol Med
, vol.9
, pp. 324-335
-
-
Wolska, A.1
Lech-Maranda, E.2
Robak, T.3
-
91
-
-
0034619794
-
A Toll-like receptor recognizes bacterial DNA
-
Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, Sanjo H, et al. A Toll-like receptor recognizes bacterial DNA. Nature 2000; 408: 740-5.
-
(2000)
Nature
, vol.408
, pp. 740-745
-
-
Hemmi, H.1
Takeuchi, O.2
Kawai, T.3
Kaisho, T.4
Sato, S.5
Sanjo, H.6
-
92
-
-
0035979192
-
Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition
-
Bauer S, Kirschning CJ, Häcker H, Redecke V, Hausmann S, Akira S, et al. Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. Proc Natl Acad Sci USA 2001; 98: 9237-42.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 9237-9242
-
-
Bauer, S.1
Kirschning, C.J.2
Häcker, H.3
Redecke, V.4
Hausmann, S.5
Akira, S.6
-
93
-
-
0035911644
-
Identification of hTLR10: A novel human Toll-like receptor preferentially expressed in immune cells
-
Chuang T, Ulevitch RJ. Identification of hTLR10: A novel human Toll-like receptor preferentially expressed in immune cells. Biochim Biophys Acta 2001; 1518: 157-61.
-
(2001)
Biochim Biophys Acta
, vol.1518
, pp. 157-161
-
-
Chuang, T.1
Ulevitch, R.J.2
-
99
-
-
78650937728
-
-
US20090246174
-
Rook, A.H., Benoit, B.M., Wysocka, M., Bray, S.M., Miller, R.L., Tomai, M.A. Treatment for cutaneous T cell lymphoma. US20090246174 (2009).
-
(2009)
Treatment For Cutaneous T Cell Lymphoma
-
-
Rook, A.H.1
Benoit, B.M.2
Wysocka, M.3
Bray, S.M.4
Miller, R.L.5
Tomai, M.A.6
-
100
-
-
78650947384
-
-
American Society of Haematology - 46th Annual Meeting. San Diego, USA (2004), abstract
-
[100] Kim Y, Girardi M, Duvic M, Kuzel T, Rook A, Link B, et al. TLR9 agonist immunomodulator treatment of cutaneous T-cell lymphoma (CTCL) with CPG7909. American Society of Haematology - 46th Annual Meeting. San Diego, USA (2004), abstract 743.
-
TLR9 Agonist Immunomodulator Treatment of Cutaneous T-cell Lymphoma (CTCL) With CPG7909
, pp. 743
-
-
Kim, Y.1
Girardi, M.2
Duvic, M.3
Kuzel, T.4
Rook, A.5
Link, B.6
-
101
-
-
78650950490
-
-
Available from URL: http://clinicaltrials.gov/ct2/show/ NCT00091208
-
-
-
-
102
-
-
0034610814
-
The language of covalent histone modifications
-
Strahl BD, Allis CD. The language of covalent histone modifications. Nature 2000; 403: 41-5.
-
(2000)
Nature
, vol.403
, pp. 41-45
-
-
Strahl, B.D.1
Allis, C.D.2
-
103
-
-
0035839136
-
Translating the histone code
-
Jenuwein T, Allis CD. Translating the histone code. Science 2001; 293: 1074-80.
-
(2001)
Science
, vol.293
, pp. 1074-1080
-
-
Jenuwein, T.1
Allis, C.D.2
-
104
-
-
0032142918
-
Roles of histone acetyltransferases and deacetylases in gene regulation
-
Kuo MH, Allis CD. Roles of histone acetyltransferases and deacetylases in gene regulation. Bioessays 1998; 20: 615-26.
-
(1998)
Bioessays
, vol.20
, pp. 615-626
-
-
Kuo, M.H.1
Allis, C.D.2
-
105
-
-
0035045456
-
Participation of histones and histone-modifying enzymes in cell functions through alterations in chromatin structure
-
Nakayama T, Takami Y. Participation of histones and histone-modifying enzymes in cell functions through alterations in chromatin structure. J Biochem 2001; 129: 491-9.
-
(2001)
J Biochem
, vol.129
, pp. 491-499
-
-
Nakayama, T.1
Takami, Y.2
-
106
-
-
3042785975
-
A review of depsipeptide and other histone deacetylase inhibitors in clinical trials
-
Piekarz R, Bates S. A review of depsipeptide and other histone deacetylase inhibitors in clinical trials. Curr Pharm Des 2004; 10: 2289-98.
-
(2004)
Curr Pharm Des
, vol.10
, pp. 2289-2298
-
-
Piekarz, R.1
Bates, S.2
-
107
-
-
35048856900
-
Depsipeptide (FK228) as a novel histone deacetylase mechanism of action and anticancer activity
-
Lech-Maranda E, Robak E, Korycka A, Robak T. Depsipeptide (FK228) as a novel histone deacetylase mechanism of action and anticancer activity. Mini Rev Med Chem 2007; 7: 1062-9.
-
(2007)
Mini Rev Med Chem
, vol.7
, pp. 1062-1069
-
-
Lech-Maranda, E.1
Robak, E.2
Korycka, A.3
Robak, T.4
-
108
-
-
0028299638
-
FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. II. Structure determination
-
Shigematsu N, Ueda H, Takase S, Tanaka H, Yamamoto K, Tada T. FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. II. Structure determination. J Antibiot (Tokyo) 1994; 47: 311-4.
-
(1994)
J Antibiot (Tokyo)
, vol.47
, pp. 311-314
-
-
Shigematsu, N.1
Ueda, H.2
Takase, S.3
Tanaka, H.4
Yamamoto, K.5
Tada, T.6
-
109
-
-
0028267278
-
FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. III. Antitumor activities on experimental tumors in mice
-
Ueda H, Manda T, Matsumoto S, Mukumoto S, Nishigaki F, Kawamura I, et al. FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. III. Antitumor activities on experimental tumors in mice. J Antibiot (Tokyo) 1994; 47: 315-23.
-
(1994)
J Antibiot (Tokyo)
, vol.47
, pp. 315-323
-
-
Ueda, H.1
Manda, T.2
Matsumoto, S.3
Mukumoto, S.4
Nishigaki, F.5
Kawamura, I.6
-
110
-
-
0028258610
-
FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activity
-
Ueda H, Nakajima H, Hori Y, Fujita T, Nishimura M, Goto T, Okuhara M. FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activity. J Antibiot (Tokyo) 1994; 47: 301-10.
-
(1994)
J Antibiot (Tokyo)
, vol.47
, pp. 301-310
-
-
Ueda, H.1
Nakajima, H.2
Hori, Y.3
Fujita, T.4
Nishimura, M.5
Goto, T.6
Okuhara, M.7
-
111
-
-
0032563871
-
Fungal metabolite FR901228 inhibits c-Myc and Fas ligand expression
-
Wang R, Brunner T, Zhang L, Shi Y. Fungal metabolite FR901228 inhibits c-Myc and Fas ligand expression. Oncogene 1998; 17: 1503-8.
-
(1998)
Oncogene
, vol.17
, pp. 1503-1508
-
-
Wang, R.1
Brunner, T.2
Zhang, L.3
Shi, Y.4
-
112
-
-
0028500561
-
Action of FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968, on Ha-ras transformed NIH3T3 cells
-
Ueda H, Nakajima H, Hori Y, Goto T, Okuhara M. Action of FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968, on Ha-ras transformed NIH3T3 cells. Biosci Biotechnol Biochem1994; 58: 1579-83.
-
Biosci Biotechnol Biochem1994
, vol.58
, pp. 1579-1583
-
-
Ueda, H.1
Nakajima, H.2
Hori, Y.3
Goto, T.4
Okuhara, M.5
-
113
-
-
0344431240
-
FR901228, a potent antitumor antibiotic, is a novel histone deacetylase inhibitor
-
Nakajima H, Kim YB, Terano H, Yoshida M, Horinouchi S. FR901228, a potent antitumor antibiotic, is a novel histone deacetylase inhibitor. Exp Cell Res 1998; 241: 126-33.
-
(1998)
Exp Cell Res
, vol.241
, pp. 126-133
-
-
Nakajima, H.1
Kim, Y.B.2
Terano, H.3
Yoshida, M.4
Horinouchi, S.5
-
114
-
-
0001811191
-
Histone deacetylase as a new target for cancer chemotherapy
-
Yoshida M, Furumai R, Nishiyama M, Komatsu Y, Nishino N, Horinouchi S. Histone deacetylase as a new target for cancer chemotherapy. Cancer Chemother Pharmacol 2001; 48 (Suppl 1): 20-6.
-
(2001)
Cancer Chemother Pharmacol
, vol.48
, Issue.SUPPL 1
, pp. 20-26
-
-
Yoshida, M.1
Furumai, R.2
Nishiyama, M.3
Komatsu, Y.4
Nishino, N.5
Horinouchi, S.6
-
115
-
-
0036735385
-
FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases
-
Furumai R, Matsuyama A, Kobashi N, Lee KH, Nishiyama M, Nakajima H, et al. FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases. Cancer Res 2002; 62: 4916-21.
-
(2002)
Cancer Res
, vol.62
, pp. 4916-4921
-
-
Furumai, R.1
Matsuyama, A.2
Kobashi, N.3
Lee, K.H.4
Nishiyama, M.5
Nakajima, H.6
-
116
-
-
0033822112
-
P21-dependent G(1)arrest with downregulation of cyclin D1 and upregulation of cyclin
-
Sandor V, Senderowicz A, Mertins S, Sackett D, Sausville E, Blagosklonny MV, et al. P21-dependent G(1)arrest with downregulation of cyclin D1 and upregulation of cyclin E by the histone deacetylase inhibitor FR901228. Br J Cancer 2000; 83: 817-25.
-
(2000)
E By the Histone Deacetylase Inhibitor FR901228. Br J Cancer
, vol.83
, pp. 817-825
-
-
Sandor, V.1
Senderowicz, A.2
Mertins, S.3
Sackett, D.4
Sausville, E.5
Blagosklonny, M.V.6
-
117
-
-
13444274622
-
Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway
-
Insinga A, Monestiroli S, Ronzoni S, Gelmetti V, Marchesi F, Viale A, et al. Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway. Nat Med 2005; 11: 71-6.
-
(2005)
Nat Med
, vol.11
, pp. 71-76
-
-
Insinga, A.1
Monestiroli, S.2
Ronzoni, S.3
Gelmetti, V.4
Marchesi, F.5
Viale, A.6
-
118
-
-
13444306459
-
Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells
-
Nebbioso A, Clarke N, Voltz E, Germain E, Ambrosino C, Bontempo P, et al. Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells. Nat Med 2005; 11: 77-84.
-
(2005)
Nat Med
, vol.11
, pp. 77-84
-
-
Nebbioso, A.1
Clarke, N.2
Voltz, E.3
Germain, E.4
Ambrosino, C.5
Bontempo, P.6
-
119
-
-
0042090495
-
Novel mechanisms of apoptosis induced by histone deacetylase inhibitors
-
Peart MJ, Tainton KM, Ruefli AA, Dear AE, Sedelies KA, O'Reilly LA, et al. Novel mechanisms of apoptosis induced by histone deacetylase inhibitors. Cancer Res 2003; 63: 4460-71.
-
(2003)
Cancer Res
, vol.63
, pp. 4460-4471
-
-
Peart, M.J.1
Tainton, K.M.2
Ruefli, A.A.3
Dear, A.E.4
Sedelies, K.A.5
O'Reilly, L.A.6
-
120
-
-
11144221007
-
Apoptotic and autophagic cell death induced by histone deacetylase inhibitors
-
Shao Y, Gao Z, Marks PA, Jiang X. Apoptotic and autophagic cell death induced by histone deacetylase inhibitors. Proc Natl Acad Sci USA 2004; 101: 18030-5.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 18030-18035
-
-
Shao, Y.1
Gao, Z.2
Marks, P.A.3
Jiang, X.4
-
121
-
-
0037137896
-
Histone deacetylase inhibitor FK228 inhibits tumor angiogenesis
-
Kwon HJ, Kim MS, Kim MJ, Nakajima H, Kim KW. Histone deacetylase inhibitor FK228 inhibits tumor angiogenesis. Int J Cancer 2002; 97: 290-6.
-
(2002)
Int J Cancer
, vol.97
, pp. 290-296
-
-
Kwon, H.J.1
Kim, M.S.2
Kim, M.J.3
Nakajima, H.4
Kim, K.W.5
-
122
-
-
0042261694
-
Antitumor efficacy of FK228, a novel histone deacetylase inhibitor, depends on the effect on expression of angiogenesis factors
-
Sasakawa Y, Naoe Y, Noto T, Inoue T, Sasakawa T, Matsuo M, et al. Antitumor efficacy of FK228, a novel histone deacetylase inhibitor, depends on the effect on expression of angiogenesis factors. Biochem Pharmacol 2003; 66: 897-906.
-
(2003)
Biochem Pharmacol
, vol.66
, pp. 897-906
-
-
Sasakawa, Y.1
Naoe, Y.2
Noto, T.3
Inoue, T.4
Sasakawa, T.5
Matsuo, M.6
-
124
-
-
0036301281
-
Phase I trial of the histone deacetylase inhibitor, depsipeptide (FR901228, NSC 630176), in patients with refractory neoplasms
-
Sandor V, Bakke S, Robey RW, Kang MH, Blagosklonny MV, Bender J, et al. Phase I trial of the histone deacetylase inhibitor, depsipeptide (FR901228, NSC 630176), in patients with refractory neoplasms. Clin Cancer Res 2002; 8: 718-28.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 718-728
-
-
Sandor, V.1
Bakke, S.2
Robey, R.W.3
Kang, M.H.4
Blagosklonny, M.V.5
Bender, J.6
-
125
-
-
33747065289
-
Phase I study of depsipeptide in pediatric patients with refractory solid tumors: A Children's Oncology Group report
-
Fouladi M, Furman WL, Chin T, Freeman BB 3rd, Dudkin L, Stewart CF, et al. Phase I study of depsipeptide in pediatric patients with refractory solid tumors: A Children's Oncology Group report. J Clin Oncol 2006; 24: 3678-85.
-
(2006)
J Clin Oncol
, vol.24
, pp. 3678-3685
-
-
Fouladi, M.1
Furman, W.L.2
Chin, T.3
Freeman 3rd, B.B.4
Dudkin, L.5
Stewart, C.F.6
-
126
-
-
19944432566
-
A phase 1 and pharmacodynamic study of depsipeptide (FK228) in chronic lymphocytic leukemia and acute myeloid leukemia
-
Byrd JC, Marcucci G, Parthun MR, Xiao JJ, Klisovic RB, Moran M, et al. A phase 1 and pharmacodynamic study of depsipeptide (FK228) in chronic lymphocytic leukemia and acute myeloid leukemia. Blood 2005; 105: 959-67.
-
(2005)
Blood
, vol.105
, pp. 959-967
-
-
Byrd, J.C.1
Marcucci, G.2
Parthun, M.R.3
Xiao, J.J.4
Klisovic, R.B.5
Moran, M.6
-
127
-
-
0035525781
-
Inhibitor of histone deacetylation, depsipeptide (FR901228), in the treatment of peripheral and cutaneous T-cell lymphoma: A case report
-
Piekarz RL, Robey R, Sandor V, Bakke S, Wilson WH, Dahmoush L, et al. Inhibitor of histone deacetylation, depsipeptide (FR901228), in the treatment of peripheral and cutaneous T-cell lymphoma: a case report. Blood 2001; 98: 2865-8.
-
(2001)
Blood
, vol.98
, pp. 2865-2868
-
-
Piekarz, R.L.1
Robey, R.2
Sandor, V.3
Bakke, S.4
Wilson, W.H.5
Dahmoush, L.6
-
128
-
-
78650961657
-
-
Atlanta, USA
-
Whittaker S, McCulloch W, Robak T, Baran E, Prentice A. American Society of Clinical Oncology-42th Annual Meeting. Atlanta, USA (2006).
-
(2006)
American Society of Clinical Oncology-42th Annual Meeting
-
-
Whittaker, S.1
McCulloch, W.2
Robak, T.3
Baran, E.4
Prentice, A.5
-
129
-
-
73949149251
-
Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma
-
Piekarz RL, Frye R, Turner M, Wright JJ, Allen SL, Kirschbaum MH, et al. Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma. J Clin Oncol 2009; 27: 5410-7.
-
(2009)
J Clin Oncol
, vol.27
, pp. 5410-5417
-
-
Piekarz, R.L.1
Frye, R.2
Turner, M.3
Wright, J.J.4
Allen, S.L.5
Kirschbaum, M.H.6
-
130
-
-
33745683507
-
Cardiac studies in patients treated with depsipeptide, FK228, in a phase II trial for T-cell lymphoma
-
Piekarz RL, Frye AR, Wright JJ, Steinberg SM, Liewehr DJ, Rosing DR, et al. Cardiac studies in patients treated with depsipeptide, FK228, in a phase II trial for T-cell lymphoma. Clin Cancer Res 2006; 12: 3762-73.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 3762-3773
-
-
Piekarz, R.L.1
Frye, A.R.2
Wright, J.J.3
Steinberg, S.M.4
Liewehr, D.J.5
Rosing, D.R.6
-
131
-
-
0026446246
-
Hexamethylene bisacetamide in myelodysplastic syndrome and acute myelogenous leukemia: A phase II clinical trial with a differentiation-inducing agent
-
Andreef M, Stone R, Michaeli J, Young CW, Tong WP, Sogoloff H, et al. Hexamethylene bisacetamide in myelodysplastic syndrome and acute myelogenous leukemia: A phase II clinical trial with a differentiation-inducing agent. Blood 1992; 80: 2604-9.
-
(1992)
Blood
, vol.80
, pp. 2604-2609
-
-
Andreef, M.1
Stone, R.2
Michaeli, J.3
Young, C.W.4
Tong, W.P.5
Sogoloff, H.6
-
132
-
-
1542588471
-
Second generation hybrid polar compounds are potent inducers of transformed cell differentiation
-
Richon VM, Webb Y, Merger R, Sheppard T, Jursic B, Ngo L, et al. Second generation hybrid polar compounds are potent inducers of transformed cell differentiation. Proc Natl Acad Sci USA 1996; 93: 5705-8.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 5705-5708
-
-
Richon, V.M.1
Webb, Y.2
Merger, R.3
Sheppard, T.4
Jursic, B.5
Ngo, L.6
-
133
-
-
0033539092
-
Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors
-
Finnin MS, Donigan JR, Cohen A, Richon VM, Rifkind RA, Marks PA, et al. Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors. Nature 1999; 401: 188-93.
-
(1999)
Nature
, vol.401
, pp. 188-193
-
-
Finnin, M.S.1
Donigan, J.R.2
Cohen, A.3
Richon, V.M.4
Rifkind, R.A.5
Marks, P.A.6
-
134
-
-
0037075081
-
Inhibitors of human histone deacetylase: Synthesis and enzyme and cellular activity of straight chain hydroxamates
-
Remiszewski SW, Sambucetti LC, Atadja P, Bair KW, Cornell WD, Green MA, et al. Inhibitors of human histone deacetylase: Synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem 2002; 45: 753-7.
-
(2002)
J Med Chem
, vol.45
, pp. 753-757
-
-
Remiszewski, S.W.1
Sambucetti, L.C.2
Atadja, P.3
Bair, K.W.4
Cornell, W.D.5
Green, M.A.6
-
135
-
-
0034596309
-
Histone deacetylase inhibitors: Inducers of differentiation or apoptosis of transformed cells
-
Marks PA, Richon VM, Rifkind RA. Histone deacetylase inhibitors: Inducers of differentiation or apoptosis of transformed cells. J Natl Cancer Inst 2000; 92: 1210-16.
-
(2000)
J Natl Cancer Inst
, vol.92
, pp. 1210-1216
-
-
Marks, P.A.1
Richon, V.M.2
Rifkind, R.A.3
-
137
-
-
0032539890
-
A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases
-
Richon VM, Emiliani S, Verdin E, Webb Y, Breslow R, Rifkind RA, et al. A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. Proc Natl Acad Sci USA 1998; 95: 3003-7.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 3003-3007
-
-
Richon, V.M.1
Emiliani, S.2
Verdin, E.3
Webb, Y.4
Breslow, R.5
Rifkind, R.A.6
-
138
-
-
0034297220
-
Suberoylanilide hydroxamic acid as a potential therapeutic agent for human breast cancer treatment
-
Huang L, Pardee AB. Suberoylanilide hydroxamic acid as a potential therapeutic agent for human breast cancer treatment. Mol Med 2000; 6: 6: 849-66.
-
(2000)
Mol Med
, vol.6
, Issue.6
, pp. 849-866
-
-
Huang, L.1
Pardee, A.B.2
-
139
-
-
0033604457
-
Induction of apoptosis in U937 human leukemia cells by suberoylanilide hydroxamic acid (SAHA) proceeds through pathways that are regulated by Bcl-2/Bcl-XL, c-Jun, and p21CIP1, but independent of p53
-
Vrana JA, Decker RH, Johnson CR, Wang Z, Jarvis WD, Richon VM, et al. Induction of apoptosis in U937 human leukemia cells by suberoylanilide hydroxamic acid (SAHA) proceeds through pathways that are regulated by Bcl-2/Bcl-XL, c-Jun, and p21CIP1, but independent of p53. Oncogene 1999; 18: 7016-25.
-
(1999)
Oncogene
, vol.18
, pp. 7016-7025
-
-
Vrana, J.A.1
Decker, R.H.2
Johnson, C.R.3
Wang, Z.4
Jarvis, W.D.5
Richon, V.M.6
-
140
-
-
0035845541
-
The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species
-
Ruefli AA, Ausserlechner MJ, Bernhard D, Sutton VR, Tainton KM, Kofler R, et al. The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species. Proc Natl Acad Sci USA 2001; 98: 10833-8.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 10833-10838
-
-
Ruefli, A.A.1
Ausserlechner, M.J.2
Bernhard, D.3
Sutton, V.R.4
Tainton, K.M.5
Kofler, R.6
-
141
-
-
0037589018
-
Molecular sequelae of histone deacetylase inhibition in human malignant B cells
-
Mitsiades N, Mitsiades CS, Richardson PG, McMullan C, Poulaki V, Fanourakis G, et al. Molecular sequelae of histone deacetylase inhibition in human malignant B cells. Blood 2003; 101: 4055-62.
-
(2003)
Blood
, vol.101
, pp. 4055-4062
-
-
Mitsiades, N.1
Mitsiades, C.S.2
Richardson, P.G.3
McMullan, C.4
Poulaki, V.5
Fanourakis, G.6
-
142
-
-
0038485588
-
Role of caspases, Bid, and p53 in the apoptotic response triggered by histone deacetylase inhibitors trichostatin-A (TSA) and suberoylanilide hydroxamic acid (SAHA)
-
Henderson C, Mizzau M, Paroni G, Maestro R, Schneider C, Brancolini C. Role of caspases, Bid, and p53 in the apoptotic response triggered by histone deacetylase inhibitors trichostatin-A (TSA) and suberoylanilide hydroxamic acid (SAHA). J Biol Chem 2003, 278: 12579-89.
-
(2003)
J Biol Chem
, vol.278
, pp. 12579-89
-
-
Henderson, C.1
Mizzau, M.2
Paroni, G.3
Maestro, R.4
Schneider, C.5
Brancolini, C.6
-
143
-
-
85047699941
-
Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling
-
Deroanne CF, Bonjean K, Servotte S, Devy L, Colige A, Clausse N, et al. Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling. Oncogene 2002; 21: 427-36.
-
(2002)
Oncogene
, vol.21
, pp. 427-436
-
-
Deroanne, C.F.1
Bonjean, K.2
Servotte, S.3
Devy, L.4
Colige, A.5
Clausse, N.6
-
144
-
-
12444321545
-
Phase I clinical trial of histone deacetylase inhibitor: Suberoylanilide hydroxamic acid administered intravenously
-
Kelly WK, Richon VM, O'Connor O, Curley T, MacGregor Curtelli B, Tong W, et al. Phase I clinical trial of histone deacetylase inhibitor: Suberoylanilide hydroxamic acid administered intravenously. Clin Cancer Res 2003; 9: 3578-88.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 3578-3588
-
-
Kelly, W.K.1
Richon, V.M.2
O'Connor, O.3
Curley, T.4
Curtelli, M.B.5
Tong, W.6
-
145
-
-
36148950997
-
FDA approval summary: Vorinostat for treatment of advanced primary cutaneous T-cell lymphoma
-
Mann BS, Johnson JR, Cohen MH, Justice R, Pazdur R. FDA approval summary: Vorinostat for treatment of advanced primary cutaneous T-cell lymphoma. Oncologist 2007; 12: 1247-52.
-
(2007)
Oncologist
, vol.12
, pp. 1247-1252
-
-
Mann, B.S.1
Johnson, J.R.2
Cohen, M.H.3
Justice, R.4
Pazdur, R.5
-
146
-
-
34247860871
-
Vorinostat for treatment of cutaneous manifestations of advanced primary cutaneous T-cell lymphoma
-
Mann BS, Johnson JR, He K, Sridhara R, Abraham S, Booth BP, et al. Vorinostat for treatment of cutaneous manifestations of advanced primary cutaneous T-cell lymphoma. Clin Cancer Res 2007; 13: 2318-22.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 2318-2322
-
-
Mann, B.S.1
Johnson, J.R.2
He, K.3
Sridhara, R.4
Abraham, S.5
Booth, B.P.6
-
147
-
-
33845996135
-
Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL)
-
Duvic M, Talpur R, Ni X, Zhang C, Hazarika P, Kelly C, et al. Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL). Blood 2007; 109: 31-9.
-
(2007)
Blood
, vol.109
, pp. 31-39
-
-
Duvic, M.1
Talpur, R.2
Ni, X.3
Zhang, C.4
Hazarika, P.5
Kelly, C.6
-
148
-
-
34547683194
-
Phase IIb multicenter trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous T-cell lymphoma
-
Olsen EA, Kim YH, Kuzel TM, Pacheco TR, Foss FM, Parker S, et al. Phase IIb multicenter trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous T-cell lymphoma. J Clin Oncol 2007; 25: 3109-15.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3109-3115
-
-
Olsen, E.A.1
Kim, Y.H.2
Kuzel, T.M.3
Pacheco, T.R.4
Foss, F.M.5
Parker, S.6
-
149
-
-
72549108624
-
Evaluation of the long-term tolerability and clinical benefit of vorinostat in patients with advanced cutaneous T- cell lymphoma
-
Duvic M, Olsen EA, Breneman D, Pacheco TR, Parker S, Vonderheid EC, et al. Evaluation of the long-term tolerability and clinical benefit of vorinostat in patients with advanced cutaneous T- cell lymphoma. Clin Lymphoma Myeloma 2009; 9: 412-6.
-
(2009)
Clin Lymphoma Myeloma
, vol.9
, pp. 412-416
-
-
Duvic, M.1
Olsen, E.A.2
Breneman, D.3
Pacheco, T.R.4
Parker, S.5
Vonderheid, E.C.6
-
151
-
-
78650942803
-
-
US20090247549
-
Frankel, S.R., Deutsch, P.J., Randolph, S., Fine, B. Methods of using saha and bortezomib for treating cancer. US20090247549 (2009).
-
(2009)
Methods of Using Saha and Bortezomib For Treating Cancer
-
-
Frankel, S.R.1
Deutsch, P.J.2
Randolph, S.3
Fine, B.4
-
154
-
-
78650940823
-
-
US20100105721
-
Lee, K. C., Sun, E. T., Wang, H. Imidazo [1,2-a]pyridine derivatives: Preparation and pharmaceutical applications. US20100105721 (2010).
-
(2010)
Imidazo [1,2-a]pyridine Deriva- Tives: Preparation and Pharmaceutical Applications
-
-
Lee, K.C.1
Sun, E.T.2
Wang, H.3
-
155
-
-
78650965249
-
-
US20100130523
-
Dickens, J. W.J., Houpis, I. N., Lang, Y. L., Leys, C., Stokbroekx, S. C. M., Weerts, J. E. E. Mono-hydrochloric salts of an inhibitor of histone deacetylase. US20100130523 (2010).
-
(2010)
Mono-hydrochloric Salts of An Inhibitor of Histone Deacetylase
-
-
Dickens, J.W.J.1
Houpis, I.N.2
Lang, Y.L.3
Leys, C.4
Stokbroekx, S.C.M.5
Weerts, J.E.E.6
-
156
-
-
78650950277
-
-
US20100160321
-
Ten Holte, P., Van Emelen, K., Angibaud, P. R., Marconnet-Decrane, L. F. B., Meerpoel, L. Imidazolinone and hydantoine derivatives as novel inhibitors of histone deacetylase. US20100160321 (2010).
-
(2010)
Imidazolinone and Hydantoine Derivatives As Novel Inhibitors of Histone Deacetylase
-
-
Holte, T.P.1
van Emelen, K.2
Angibaud, P.R.3
Marconnet-Decrane, L.F.B.4
Meerpoel, L.5
-
157
-
-
78650956698
-
-
EP1485099
-
Van Emelen, K., Verdonck, M. G. C., Van Brandt, S. F. A., Angibaud, P. R. J.-C., Meerpoel, L., Dyatkin, A. B. Inhibitors of histone deacetylase. EP1485099 (2010).
-
(2010)
Inhibitors of Histone Deacetylase
-
-
van Emelen, K.1
Verdonck, M.G.C.2
van Brandt, S.F.A.3
Angibaud, P.R.J.-C.4
Meerpoel, L.5
Dyatkin, A.B.6
-
158
-
-
78650952362
-
-
US7732490
-
Richon, V. M., Chiao, J. H., Kelly, W. K., Miller, T. A. Methods of treating cancer. US7732490 (2010).
-
(2010)
Methods of Treating Cancer
-
-
Richon, V.M.1
Chiao, J.H.2
Kelly, W.K.3
Miller, T.A.4
-
160
-
-
0027194472
-
Structure of the CAMPATH-1 antigen, a glycosyl-phosphatidylinositol-anchored glycoprotein which is an exceptionally good target for complement lysis
-
Xia MQ, Hale G, Lifely MR, Ferguson MA, Campbell D, Packman L, et al. Structure of the CAMPATH-1 antigen, a glycosyl-phosphatidylinositol-anchored glycoprotein which is an exceptionally good target for complement lysis. Biochem J 1993; 293: 633-40.
-
(1993)
Biochem J
, vol.293
, pp. 633-640
-
-
Xia, M.Q.1
Hale, G.2
Lifely, M.R.3
Ferguson, M.A.4
Campbell, D.5
Packman, L.6
-
161
-
-
0034033048
-
The CD45 tyrosine phosphatase regulates Campath-1H (CD52) - induced TCR-dependent signal transduction in human T cells
-
Hederer RA, Guntermann C, Miller N, Nagy P, Szollosi J, Damjanovich S, et al. The CD45 tyrosine phosphatase regulates Campath-1H (CD52) - induced TCR-dependent signal transduction in human T cells. Int Immunol 2000; 12: 505-16.
-
(2000)
Int Immunol
, vol.12
, pp. 505-516
-
-
Hederer, R.A.1
Guntermann, C.2
Miller, N.3
Nagy, P.4
Szollosi, J.5
Damjanovich, S.6
-
162
-
-
0032005642
-
Levels of expression of CD52 in normal and leukemic B and T cells: Correlation with in vivo therapeutic responses to Campath-1H
-
Ginaldi L, De Martinis M, Matutes E, Farahat N, Morilla R, Dyer MJ, et al. Levels of expression of CD52 in normal and leukemic B and T cells: correlation with in vivo therapeutic responses to Campath-1H. Leuk Res 1998; 22: 185-91.
-
(1998)
Leuk Res
, vol.22
, pp. 185-191
-
-
Ginaldi, L.1
de Martinis, M.2
Matutes, E.3
Farahat, N.4
Morilla, R.5
Dyer, M.J.6
-
163
-
-
33746836125
-
CD52 is a novel costimulatory molecule for induction of CD4+ regulatory T cells
-
Watanabe T, Masuyama J, Sohma Y, Inazawa H, Horie K, Kojima K, et al. CD52 is a novel costimulatory molecule for induction of CD4+ regulatory T cells. Clin Immunol 2006; 120: 247-59.
-
(2006)
Clin Immunol
, vol.120
, pp. 247-259
-
-
Watanabe, T.1
Masuyama, J.2
Sohma, Y.3
Inazawa, H.4
Horie, K.5
Kojima, K.6
-
164
-
-
0032490341
-
Prope tolerance, perioperative campath 1H, and low-dose cyclosporin monotherapy in renal allograft recipients
-
Calne R, Friend P, Moffatt S, Bradley A, Hale G, Firth J, et al. Prope tolerance, perioperative campath 1H, and low-dose cyclosporin monotherapy in renal allograft recipients. Lancet 1998; 351: 1701-2.
-
(1998)
Lancet
, vol.351
, pp. 1701-1702
-
-
Calne, R.1
Friend, P.2
Moffatt, S.3
Bradley, A.4
Hale, G.5
Firth, J.6
-
165
-
-
0026783632
-
Humanised monoclonal antibody therapy for rheumatoid arthritis
-
Isaacs JD, Watts RA, Hazleman BL, Hale G, Keogan MT, Cobbold SP, et al. Humanised monoclonal antibody therapy for rheumatoid arthritis. Lancet 1992; 340: 748-52.
-
(1992)
Lancet
, vol.340
, pp. 748-752
-
-
Isaacs, J.D.1
Watts, R.A.2
Hazleman, B.L.3
Hale, G.4
Keogan, M.T.5
Cobbold, S.P.6
-
166
-
-
0030177999
-
CAMPATH-IH in multiple sclerosis
-
Moreau T, Coles A, Wing M, Thorpe J, Miller D, Moseley I,et al. CAMPATH-IH in multiple sclerosis. Mult Scler 1996; 1: 357-65.
-
(1996)
Mult Scler
, vol.1
, pp. 357-365
-
-
Moreau, T.1
Coles, A.2
Wing, M.3
Thorpe, J.4
Miller, D.5
Moseley, I.6
-
167
-
-
0027156307
-
Long term remission of intractable systemic vasculitis with monoclonal antibody therapy
-
Lockwood CM, Thiru S, Isaacs JD, Hale G, Waldmann H. Long term remission of intractable systemic vasculitis with monoclonal antibody therapy. Lancet 1993; 2: 1620-22.
-
(1993)
Lancet
, vol.2
, pp. 1620-1622
-
-
Lockwood, C.M.1
Thiru, S.2
Isaacs, J.D.3
Hale, G.4
Waldmann, H.5
-
168
-
-
0027991085
-
CAMPATH-1 monoclonal antibodies in bone marrow transplantation
-
Hale G, Waldmann H. CAMPATH-1 monoclonal antibodies in bone marrow transplantation. J Hematother 1994, 3: 15-31.
-
(1994)
J Hematother
, vol.3
, pp. 15-31
-
-
Hale, G.1
Waldmann, H.2
-
169
-
-
0032589668
-
The role of CAMPATH-1 antibodies in the treatment of lymphoid malignancies
-
Dyer MJ. The role of CAMPATH-1 antibodies in the treatment of lymphoid malignancies. Semin Oncol 1999; 26 (Suppl 14): 52-7.
-
(1999)
Semin Oncol
, vol.26
, Issue.SUPPL 14
, pp. 52-57
-
-
Dyer, M.J.1
-
170
-
-
34249655671
-
Alemtuzumab (Campath-1H) in the treatment of chronic lymphocytic leukemia
-
Alinari L, Lapalombella R, Andritsos L, Baiocchi RA, Lin TS, Byrd JC. Alemtuzumab (Campath-1H) in the treatment of chronic lymphocytic leukemia. Oncogene 2007; 26: 3644-53.
-
(2007)
Oncogene
, vol.26
, pp. 3644-3653
-
-
Alinari, L.1
Lapalombella, R.2
Andritsos, L.3
Baiocchi, R.A.4
Lin, T.S.5
Byrd, J.C.6
-
171
-
-
48849109653
-
Alemtuzumab for B-cell chronic lymphocytic leukemia
-
Robak T. Alemtuzumab for B-cell chronic lymphocytic leukemia. Expert Rev Anticancer Ther 2008; 8: 1033-51.
-
(2008)
Expert Rev Anticancer Ther
, vol.8
, pp. 1033-1051
-
-
Robak, T.1
-
172
-
-
37649004407
-
Alemtuzumab compared with chlorambucil as first-line therapy for chronic lymphocytic leukemia
-
Hillmen P, Skotnicki AB, Robak T, Jaksic B, Dmoszynska A, Wu J, et al. Alemtuzumab compared with chlorambucil as first-line therapy for chronic lymphocytic leukemia. J Clin Oncol 2007; 25: 5616-23.
-
(2007)
J Clin Oncol
, vol.25
, pp. 5616-5623
-
-
Hillmen, P.1
Skotnicki, A.B.2
Robak, T.3
Jaksic, B.4
Dmoszynska, A.5
Wu, J.6
-
173
-
-
40349114506
-
FDA drug approval summary: Alemtuzumab as single-agent treatment for B-cell chronic lymphocytic leukemia
-
Demko S, Summers J, Keegan P, Pazdur R. FDA drug approval summary: Alemtuzumab as single-agent treatment for B-cell chronic lymphocytic leukemia. Oncologist 2008; 13: 167-74.
-
(2008)
Oncologist
, vol.13
, pp. 167-174
-
-
Demko, S.1
Summers, J.2
Keegan, P.3
Pazdur, R.4
-
174
-
-
0036139106
-
Campath-1H treatment of T-cell prolymphocytic leukemia in patients for whom at least one prior chemotherapy regimen has failed
-
Keating MJ, Cazin B, Coutré S, Birhiray R, Kovacsovics T, Langer W, et al. Campath-1H treatment of T-cell prolymphocytic leukemia in patients for whom at least one prior chemotherapy regimen has failed. J Clin Oncol 2002; 20: 205-13.
-
(2002)
J Clin Oncol
, vol.20
, pp. 205-213
-
-
Keating, M.J.1
Cazin, B.2
Coutré, S.3
Birhiray, R.4
Kovacsovics, T.5
Langer, W.6
-
175
-
-
1442331659
-
Efficacy of alemtuzumab treatment for refractory T-cell large granular lymphocytic leukemia
-
Rosenblum MD, LaBelle JL, Chang CC, Margolis DA, Schauer DW, Vesole DH. Efficacy of alemtuzumab treatment for refractory T-cell large granular lymphocytic leukemia. Blood 2004; 103: 1969-71.
-
(2004)
Blood
, vol.103
, pp. 1969-1971
-
-
Rosenblum, M.D.1
Labelle, J.L.2
Chang, C.C.3
Margolis, D.A.4
Schauer, D.W.5
Vesole, D.H.6
-
177
-
-
0033522647
-
A structure of the therapeutic antibody CAMPATH-1H lab in complex with a synthetic peptide antigen
-
Page MJ, Sydenham MA. A structure of the therapeutic antibody CAMPATH-1H lab in complex with a synthetic peptide antigen. J Mol Biol 1999; 289: 293-301.
-
(1999)
J Mol Biol
, vol.289
, pp. 293-301
-
-
Page, M.J.1
Sydenham, M.A.2
-
178
-
-
14744277083
-
High level expression of the humanized monoclonal antibody Campath-1H in Chinese hamster ovary cells
-
Page MJ, Sydenham MA. High level expression of the humanized monoclonal antibody Campath-1H in Chinese hamster ovary cells. Biotechnology 1991; 9: 64-8.
-
(1991)
Biotechnology
, vol.9
, pp. 64-68
-
-
Page, M.J.1
Sydenham, M.A.2
-
179
-
-
0031553988
-
Characterization of monoclonal antibody glycosylation: Comparison of terminal alpha-linked galactose
-
Sheeley DM, Merrill BM, Taylor LC. Characterization of monoclonal antibody glycosylation: Comparison of terminal alpha-linked galactose. Anal Biochem 1997; 247: 102-10.
-
(1997)
Anal Biochem
, vol.247
, pp. 102-110
-
-
Sheeley, D.M.1
Merrill, B.M.2
Taylor, L.C.3
-
180
-
-
0027283918
-
Efficient complement mediated lysis of cells contaning the CAMPATH-1 (CDw52) antigen
-
Xia MQ, Hale G, Waldmann H. Efficient complement mediated lysis of cells contaning the CAMPATH-1 (CDw52) antigen. Mol Immunol 1993; 30: 1089-96.
-
(1993)
Mol Immunol
, vol.30
, pp. 1089-1096
-
-
Xia, M.Q.1
Hale, G.2
Waldmann, H.3
-
181
-
-
0034076307
-
Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets
-
Clynes RA, Towers TL, Presta LG, Ravetch JV. Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets. Nat Med 2000; 6: 443-6.
-
(2000)
Nat Med
, vol.6
, pp. 443-446
-
-
Clynes, R.A.1
Towers, T.L.2
Presta, L.G.3
Ravetch, J.V.4
-
182
-
-
0034765991
-
The CD52 antigen and development of the CAMPATH antibodies
-
Hale G. The CD52 antigen and development of the CAMPATH antibodies. Cytotherapy 2002; 3: 137-43.
-
(2002)
Cytotherapy
, vol.3
, pp. 137-143
-
-
Hale, G.1
-
183
-
-
4844229401
-
Rituximab and alemtuzumab induce a nonclasic, caspase-independent apoptotic pathway in B- lymphoid cell lines and in chronic lymphocytic leukemia cells
-
Stanglmaier M, Reis S, Hallek M. Rituximab and alemtuzumab induce a nonclasic, caspase-independent apoptotic pathway in B- lymphoid cell lines and in chronic lymphocytic leukemia cells. Ann Hematol 2004; 83: 634-45.
-
(2004)
Ann Hematol
, vol.83
, pp. 634-645
-
-
Stanglmaier, M.1
Reis, S.2
Hallek, M.3
-
184
-
-
1842507429
-
Alemtuzumab (CAMPATH 1H) does not kill chronic lymphocytic leukemia cells in serum free medium
-
Zent CS, Chen JB, Kurten RC, Kaushal GP, Lacy HM, Schichman SA. Alemtuzumab (CAMPATH 1H) does not kill chronic lymphocytic leukemia cells in serum free medium. Leuk Res 2004; 28: 495-507.
-
(2004)
Leuk Res
, vol.28
, pp. 495-507
-
-
Zent, C.S.1
Chen, J.B.2
Kurten, R.C.3
Kaushal, G.P.4
Lacy, H.M.5
Schichman, S.A.6
-
185
-
-
12744279711
-
Proapoptotic activity of alemtuzumab alone and in combination with rituximab or purine nucleoside analogues in chronic lymphocytic leukemia cells
-
Smolewski P, Szmigielska-Kaplon A, Cebula B, Jamroziak K, Rogalinska M, Kilianska Z, et al. Proapoptotic activity of alemtuzumab alone and in combination with rituximab or purine nucleoside analogues in chronic lymphocytic leukemia cells. Leuk Lymphoma 2005; 46: 87-100.
-
(2005)
Leuk Lymphoma
, vol.46
, pp. 87-100
-
-
Smolewski, P.1
Szmigielska-Kaplon, A.2
Cebula, B.3
Jamroziak, K.4
Rogalinska, M.5
Kilianska, Z.6
-
186
-
-
31444453579
-
Alemtuzumab induces caspase-independent cell death in human chronic lymphocytic leukemia cells through a lipid raft-dependent mechanism
-
Mone AP, Cheney C, Banks AL, Tridandapani S, Mehter N, Guster S, et al. Alemtuzumab induces caspase-independent cell death in human chronic lymphocytic leukemia cells through a lipid raft-dependent mechanism. Leukemia 2006; 20: 272-9.
-
(2006)
Leukemia
, vol.20
, pp. 272-279
-
-
Mone, A.P.1
Cheney, C.2
Banks, A.L.3
Tridandapani, S.4
Mehter, N.5
Guster, S.6
-
187
-
-
3843129540
-
Blood concentrations of alemtuzumab and antiglobulin responses in patients with chronic lymphocytic leukemia following intravenous or subcutaneous routes of administration
-
Hale G, Rebello P, Brettman LR, Fegan C, Kennedy B, Kimby E, et al. Blood concentrations of alemtuzumab and antiglobulin responses in patients with chronic lymphocytic leukemia following intravenous or subcutaneous routes of administration. Blood 2004; 104: 948-55.
-
(2004)
Blood
, vol.104
, pp. 948-955
-
-
Hale, G.1
Rebello, P.2
Brettman, L.R.3
Fegan, C.4
Kennedy, B.5
Kimby, E.6
-
188
-
-
0030300084
-
Immunosuppressive toxicity of CAMPATH1H monoclonal antibody in the treatment of patients with recurrent low grade lymphoma
-
Tang SC, Hewitt K, Reis MD, Berinstein NL. Immunosuppressive toxicity of CAMPATH1H monoclonal antibody in the treatment of patients with recurrent low grade lymphoma. Leuk Lymphoma 1996; 24: 93-101.
-
(1996)
Leuk Lymphoma
, vol.24
, pp. 93-101
-
-
Tang, S.C.1
Hewitt, K.2
Reis, M.D.3
Berinstein, N.L.4
-
189
-
-
0036470439
-
Pharmacokinetics of CAMPATH-1H: Assay development and validation
-
Rebello P, Hale G. Pharmacokinetics of CAMPATH-1H: Assay development and validation. J Immunol Methods 2002; 260: 285-302.
-
(2002)
J Immunol Methods
, vol.260
, pp. 285-302
-
-
Rebello, P.1
Hale, G.2
-
190
-
-
34548028700
-
Population pharmacokinetics-pharmacodynamics of alemtuzumab (Campath) in patients with chronic lymphocytic leukaemia and its link to treatment response
-
Mould DR, Baumann A, Kuhlmann J, Keating MJ, Weitman S, Hillmen P, et al. Population pharmacokinetics-pharmacodynamics of alemtuzumab (Campath) in patients with chronic lymphocytic leukaemia and its link to treatment response. Br J Clin Pharmacol 2007; 64: 278-91.
-
(2007)
Br J Clin Pharmacol
, vol.64
, pp. 278-291
-
-
Mould, D.R.1
Baumann, A.2
Kuhlmann, J.3
Keating, M.J.4
Weitman, S.5
Hillmen, P.6
-
191
-
-
0036076178
-
Safety and efficacy of subcutaneous Campath-1H for treating residual disease in patients with chronic lymphocytic leukemia responding to fludarabine
-
Montillo M, Cafro AM, Tedeschi A, Brando B, Oreste P, Veronese S, et al. Safety and efficacy of subcutaneous Campath-1H for treating residual disease in patients with chronic lymphocytic leukemia responding to fludarabine. Haematologica 2002; 87: 695-700.
-
(2002)
Haematologica
, vol.87
, pp. 695-700
-
-
Montillo, M.1
Cafro, A.M.2
Tedeschi, A.3
Brando, B.4
Oreste, P.5
Veronese, S.6
-
192
-
-
15944377427
-
Alemtuzumab in the treatment of chronic lymphocytic leukemia
-
Robak T. Alemtuzumab in the treatment of chronic lymphocytic leukemia. BioDrugs 2005; 19: 9-22.
-
(2005)
BioDrugs
, vol.19
, pp. 9-22
-
-
Robak, T.1
-
193
-
-
11144357712
-
Management guidelines for use of alemtuzumab in B-cell chronic lymphocytic leukemia
-
Keating M, Coutré S, Rai K, Osterborg A, Faderl S, Kennedy B, et al. Management guidelines for use of alemtuzumab in B-cell chronic lymphocytic leukemia. Clin Lymphoma 2004; 4: 220-7.
-
(2004)
Clin Lymphoma
, vol.4
, pp. 220-227
-
-
Keating, M.1
Coutré, S.2
Rai, K.3
Osterborg, A.4
Faderl, S.5
Kennedy, B.6
-
194
-
-
1542503801
-
Cellular immune reconstitution after subcutaneous alemtuzumab (anti-CD52 monoclonal antibody, CAMPATH-1H) treatment as first-line therapy for B-cell chronic lymphocytic leukaemia
-
Lundin J, Porwit-MacDonald A, Rossmann ED, Karlsson C, Edman P, Rezvany MR, et al. Cellular immune reconstitution after subcutaneous alemtuzumab (anti-CD52 monoclonal antibody, CAMPATH-1H) treatment as first-line therapy for B-cell chronic lymphocytic leukaemia. Leukemia 2004; 18: 484-90.
-
(2004)
Leukemia
, vol.18
, pp. 484-490
-
-
Lundin, J.1
Porwit-Macdonald, A.2
Rossmann, E.D.3
Karlsson, C.4
Edman, P.5
Rezvany, M.R.6
-
195
-
-
33644790476
-
Spectrum of infection risk and recomendations for prophylaxis and screening among patients lymphoproliferative disorders treated with alemtuzumab
-
Thursky KA, Worth LJ, Seymour JF, Prince H, Slavin MA. Spectrum of infection risk and recomendations for prophylaxis and screening among patients lymphoproliferative disorders treated with alemtuzumab. Br J Haematol 2006; 132: 3-12.
-
(2006)
Br J Haematol
, vol.132
, pp. 3-12
-
-
Thursky, K.A.1
Worth, L.J.2
Seymour, J.F.3
Prince, H.4
Slavin, M.A.5
-
196
-
-
0042071567
-
Phase II study of alemtuzumab in chroniclymphoproli-ferative disorders
-
Ferrajoli A, O'Brien SM, Cortes JE, Giles FJ, Thomas DA, Faderl S, et al. Phase II study of alemtuzumab in chroniclymphoproli-ferative disorders. Cancer 2003; 98:773-8.
-
(2003)
Cancer
, vol.98
, pp. 773-778
-
-
Ferrajoli, A.1
O'Brien, S.M.2
Cortes, J.E.3
Giles, F.J.4
Thomas, D.A.5
Faderl, S.6
-
197
-
-
3242816208
-
Cardiac toxicity of alemtuzumab in patients with mycosis fungoides/Sézary syndrome
-
Lenihan DJ, Alencar AJ, Yang D, Kurzrock R, Keating MJ, Duvic M. Cardiac toxicity of alemtuzumab in patients with mycosis fungoides/Sézary syndrome. Blood 2004; 104: 655-8.
-
(2004)
Blood
, vol.104
, pp. 655-658
-
-
Lenihan, D.J.1
Alencar, A.J.2
Yang, D.3
Kurzrock, R.4
Keating, M.J.5
Duvic, M.6
-
198
-
-
0031757274
-
CAMPATH-1H monoclonal antibody in therapy for previously treated low-grade non-Hodgkin's lymphomas: A phase II multicenter study. European Study Group of CAMPATH- 1H Treatment in Low-Grade Non-Hodgkin's Lymphoma
-
Lundin J, Osterborg A, Brittinger G, Crowther D, Dombret H, Engert A, et al. CAMPATH-1H monoclonal antibody in therapy for previously treated low-grade non-Hodgkin's lymphomas: A phase II multicenter study. European Study Group of CAMPATH- 1H Treatment in Low-Grade Non-Hodgkin's Lymphoma. J Clin Oncol 1998; 16: 3257-63.
-
(1998)
J Clin Oncol
, vol.16
, pp. 3257-3263
-
-
Lundin, J.1
Osterborg, A.2
Brittinger, G.3
Crowther, D.4
Dombret, H.5
Engert, A.6
-
199
-
-
0141540362
-
Treatment of patients with advanced mycosis fungoides and Sézary syndrome with alemtuzumab
-
Kennedy GA, Seymour JF, Wolf M, Januszewicz H, Davison J, McCormack C, et al. Treatment of patients with advanced mycosis fungoides and Sézary syndrome with alemtuzumab. Eur J Haematol 2003; 71: 250-6.
-
(2003)
Eur J Haematol
, vol.71
, pp. 250-256
-
-
Kennedy, G.A.1
Seymour, J.F.2
Wolf, M.3
Januszewicz, H.4
Davison, J.5
McCormack, C.6
-
200
-
-
34347206835
-
Low-dose intermittent alemtuzumab in the treatment of Sézary syndrome: Clinical and immunologic findings in 14 patients
-
Bernengo MG, Quaglino P, Comessatti A, Ortoncelli M, Novelli M, Lisa F, et al. Low-dose intermittent alemtuzumab in the treatment of Sézary syndrome: Clinical and immunologic findings in 14 patients. Haematologica 2007; 92: 784-94.
-
(2007)
Haematologica
, vol.92
, pp. 784-794
-
-
Bernengo, M.G.1
Quaglino, P.2
Comessatti, A.3
Ortoncelli, M.4
Novelli, M.5
Lisa, F.6
-
201
-
-
42749087486
-
Subcutaneous alemtuzumab for Sézary Syndrome in the very elderly
-
Alinari L, Geskin L, Grady T, Baiocchi RA, Bechtel MA, Porcu P. Subcutaneous alemtuzumab for Sézary Syndrome in the very elderly. Leuk Res 2008; 32: 1299-303.
-
(2008)
Leuk Res
, vol.32
, pp. 1299-1303
-
-
Alinari, L.1
Geskin, L.2
Grady, T.3
Baiocchi, R.A.4
Bechtel, M.A.5
Porcu, P.6
-
202
-
-
72949118893
-
Alemtuzumab for relapsed and refractory erythrodermic cutaneous T-cell lymphoma: A single institution experience from the Robert H. Lurie Comprehensive Cancer Center
-
Querfeld C, Mehta N, Rosen ST, Guitart J, Rademaker A, Gerami P, et al. Alemtuzumab for relapsed and refractory erythrodermic cutaneous T-cell lymphoma: A single institution experience from the Robert H. Lurie Comprehensive Cancer Center. Leuk Lymphoma 2009; 50: 1969-76.
-
(2009)
Leuk Lymphoma
, vol.50
, pp. 1969-1976
-
-
Querfeld, C.1
Mehta, N.2
Rosen, S.T.3
Guitart, J.4
Rademaker, A.5
Gerami, P.6
-
203
-
-
8944243547
-
High-avidity human IgGk monoclonal antibodies from a novel strain of minilocus transgenic mice
-
Fishwild DM, O'Donnell SL, Bengoechea T, Hudson DV, Harding F, Bernhard SL, et al. High-avidity human IgGk monoclonal antibodies from a novel strain of minilocus transgenic mice. Nat Biotechnol 1996; 14: 845-51.
-
(1996)
Nat Biotechnol
, vol.14
, pp. 845-851
-
-
Fishwild, D.M.1
O'Donnell, S.L.2
Bengoechea, T.3
Hudson, D.V.4
Harding, F.5
Bernhard, S.L.6
-
204
-
-
0032814976
-
Differential effects of administration of a human anti-CD4 monoclonal antibody, HM6G, in nonhuman primates
-
Fishwild DM, Hudson DV, Deshpande U, Kung AH. Differential effects of administration of a human anti-CD4 monoclonal antibody, HM6G, in nonhuman primates. Clin Immunol 1999; 92: 138-52.
-
(1999)
Clin Immunol
, vol.92
, pp. 138-152
-
-
Fishwild, D.M.1
Hudson, D.V.2
Deshpande, U.3
Kung, A.H.4
-
205
-
-
57649223210
-
Depletion of human CD4+ T cells in peripheral blood and skin by HuMax-CD4
-
Villadsen LS, Havenith CEG, Skov L, Dam TN, Dagncs-Hansen F, Rygaard J, et al. Depletion of human CD4+ T cells in peripheral blood and skin by HuMax-CD4. J Investig Dermatol 2004; 123: 2 (A56).
-
(2004)
J Investig Dermatol
, vol.2
, Issue.56
, pp. 123
-
-
Villadsen, L.S.1
Havenith, C.E.G.2
Skov, L.3
Dam, T.N.4
Dagncs-Hansen, F.5
Rygaard, J.6
-
206
-
-
5444237610
-
HuMax-CD4, a fully human monoclonal antibody: Early results of an ongoing phase II trial in Cutaneous T Cell Lymphoma (CTCL)
-
Obitz E, Kim YH, Iversen L, Osterborg A, Jensen P, Baadsgaard O, et al. HuMax-CD4, a fully human monoclonal antibody: Early results of an ongoing phase II trial in Cutaneous T Cell Lymphoma (CTCL). Blood 2003; 102: 11 (Abs 2383).
-
(2003)
Blood
, vol.11
, Issue.2383
, pp. 102
-
-
Obitz, E.1
Kim, Y.H.2
Iversen, L.3
Osterborg, A.4
Jensen, P.5
Baadsgaard, O.6
-
207
-
-
33646564246
-
HuMax-CD4, fully human monoclonal antibody: Phase II trial in cutaneous T cell lymphoma
-
Kim YH, Obitz E, Iversen L, Oesterborg A, Whittaker S, Illidge TM, et al. HuMax-CD4, fully human monoclonal antibody: Phase II trial in cutaneous T cell lymphoma. J Investig Dermatol 2004; 122: 3 (A57).
-
(2004)
J Investig Dermatol
, vol.3
, Issue.57
, pp. 122
-
-
Kim, Y.H.1
Obitz, E.2
Iversen, L.3
Oesterborg, A.4
Whittaker, S.5
Illidge, T.M.6
-
208
-
-
34249742116
-
Clinical efficacy of zanolimumab (HuMax-CD4): Two phase 2 studies in refractory cutaneous T-cell lymphoma
-
Kim YH, Duvic M, Obitz E, Gniadecki R, Iversen L, Osterborg A, et al. Clinical efficacy of zanolimumab (HuMax-CD4): Two phase 2 studies in refractory cutaneous T-cell lymphoma. Blood 2007; 109: 4655-62.
-
(2007)
Blood
, vol.109
, pp. 4655-4662
-
-
Kim, Y.H.1
Duvic, M.2
Obitz, E.3
Gniadecki, R.4
Iversen, L.5
Osterborg, A.6
-
209
-
-
78650926434
-
-
Available from URL: http://clinicaltrials.gov/ct2/show/ NCT00127881
-
-
-
-
210
-
-
0242691662
-
Synthesis of second-generation transition state analogues of human purine nucleoside phosphorylase
-
Evans GB, Furneaux RH, Lewandowicz A, Schramm VL, Tyler PC. Synthesis of second-generation transition state analogues of human purine nucleoside phosphorylase. J Med Chem 2003; 46: 5271-6.
-
(2003)
J Med Chem
, vol.46
, pp. 5271-5276
-
-
Evans, G.B.1
Furneaux, R.H.2
Lewandowicz, A.3
Schramm, V.L.4
Tyler, P.C.5
-
211
-
-
33644884485
-
Synthesis and bio-activities of L-enantiomers of two potent transition state analogue inhibitor of purine nucleoside phosphorylases
-
Clinch K, Evans GB, Fleet GW, Furneaux RH, Johnson SW, Lenz DH, et al. Synthesis and bio-activities of L-enantiomers of two potent transition state analogue inhibitor of purine nucleoside phosphorylases. Org Biomol Chem 2006; 4: 1131-9.
-
(2006)
Org Biomol Chem
, vol.4
, pp. 1131-1139
-
-
Clinch, K.1
Evans, G.B.2
Fleet, G.W.3
Furneaux, R.H.4
Johnson, S.W.5
Lenz, D.H.6
-
212
-
-
63449116519
-
Current status of older and new purine nucleoside analogues in the treatment of lymphoproliferative diseases
-
Robak T, Korycka A, Lech-Maranda E, Robak P. Current status of older and new purine nucleoside analogues in the treatment of lymphoproliferative diseases. Molecules 2009; 14: 1183-226.
-
(2009)
Molecules
, vol.14
, pp. 1183-1226
-
-
Robak, T.1
Korycka, A.2
Lech-Maranda, E.3
Robak, P.4
-
213
-
-
33749365341
-
Forodesine, an inhibitor of purine nucleoside phosphorylase, induces apoptosis in chronic lymphocytic leukemia cells
-
Balakrishnan K, Nimmanapalli R, Ravandi F, Keating MJ, Gandhi V. Forodesine, an inhibitor of purine nucleoside phosphorylase, induces apoptosis in chronic lymphocytic leukemia cells. Blood 2006; 108: 2392-8.
-
(2006)
Blood
, vol.108
, pp. 2392-2398
-
-
Balakrishnan, K.1
Nimmanapalli, R.2
Ravandi, F.3
Keating, M.J.4
Gandhi, V.5
-
214
-
-
62349113957
-
Update on treatment of cutaneous T-cell lymphoma
-
Gardner JM, Evans KG, Musiek A, Rook AH, Kim EJ. Update on treatment of cutaneous T-cell lymphoma. Curr Opin Oncol 2009; 21: 131-7.
-
(2009)
Curr Opin Oncol
, vol.21
, pp. 131-137
-
-
Gardner, J.M.1
Evans, K.G.2
Musiek, A.3
Rook, A.H.4
Kim, E.J.5
-
217
-
-
78650955758
-
-
US20060160765
-
Evans, G.B., Hubert, R., Lrnz, D.H., Schramm, V.L., Tyler, P.C, Zubkova, O.V. Inhibitors of nucleoside phosphorylases and nucleosidases. US20060160765 (2006).
-
(2006)
Inhibitors of Nucleoside Phosphorylases and Nucleosidases
-
-
Evans, G.B.1
Hubert, R.2
Lrnz, D.H.3
Schramm, V.L.4
Tyler, P.C.5
Zubkova, O.V.6
-
219
-
-
78650947605
-
-
Orlando USA
-
Duvic M, Forero-Torres A, Foss F, Olsen E, Pinter-Brown L, Kim Y. Long-term treatment of CTCL wih the oral PNP inhibitor, forodesine. American Society of Oncology - 45th Annual Meeting, Orlando USA (2009).
-
(2009)
Long-term Treatment of CTCL Wih the Oral PNP Inhibitor, Forodesine. American Society of Oncology - 45th Annual Meeting
-
-
Duvic, M.1
Forero-Torres, A.2
Foss, F.3
Olsen, E.4
Pinter-Brown, L.5
Kim, Y.6
-
220
-
-
78650934693
-
-
Available from URL: http://clinicaltrials.gov/ct2/show/ NCT00501735
-
-
-
-
221
-
-
58949099540
-
Novel therapies for cutaneous T-cell lymphomas
-
Horwitz SM. Novel therapies for cutaneous T-cell lymphomas. Clin Lymphoma Myeloma 2008;8 (Suppl 5):S187-92.
-
(2008)
Clin Lymphoma Myeloma
, vol.8
, Issue.SUPPL 5
, pp. 187-192
-
-
Horwitz, S.M.1
-
222
-
-
77955176402
-
Targeted treatment and new agents in peripheral T-cell lymphoma
-
Zain JM, O'Connor O. Targeted treatment and new agents in peripheral T-cell lymphoma. Int J Hematol 2010; 92: 33-44.
-
(2010)
Int J Hematol
, vol.92
, pp. 33-44
-
-
Zain, J.M.1
O'Connor, O.2
-
223
-
-
0037409795
-
Activity of a novel anti-folate (PDX, 10-propargyl 10- deazaaminopterin) against human lymphoma is superior to methotrexate and correlates with tumor RFC-1 gene expression
-
Wang ES, O'Connor O, She Y, Zelenetz AD, Sirotnak FM, Moore MA. Activity of a novel anti-folate (PDX, 10-propargyl 10- deazaaminopterin) against human lymphoma is superior to methotrexate and correlates with tumor RFC-1 gene expression. Leuk Lymphoma 2003; 44:1027-35.
-
(2003)
Leuk Lymphoma
, vol.44
, pp. 1027-1035
-
-
Wang, E.S.1
O'Connor, O.2
She, Y.3
Zelenetz, A.D.4
Sirotnak, F.M.5
Moore, M.A.6
-
224
-
-
34848829782
-
Pralatrexate, a novel class of antifol with high affinity for the reduced folate carrier-type 1, produces marked complete and durable remissions in a diversity of chemotherapy refractory cases of T-cell lymphoma
-
O'Connor OA, Hamlin PA, Portlock C, Moskowitz CH, Noy A, Straus DJ, et al. Pralatrexate, a novel class of antifol with high affinity for the reduced folate carrier-type 1, produces marked complete and durable remissions in a diversity of chemotherapy refractory cases of T-cell lymphoma. Br J Haematol 2007; 139: 425-8.
-
(2007)
Br J Haematol
, vol.139
, pp. 425-428
-
-
O'Connor, O.A.1
Hamlin, P.A.2
Portlock, C.3
Moskowitz, C.H.4
Noy, A.5
Straus, D.J.6
-
225
-
-
78650960182
-
-
American Society of Haematology - 48th Annual Meeting, Orlando, USA
-
O'Connor OA, Hamlin PA, Gerecitano J, Portlock CS, Noy A, Moskowitz C, et al. Pralatrexate (PDX) Produces Durable Complete Remissions in Patients with Chemotherapy Resistant Precursor and Peripheral T-Cell Lymphomas: Results of the MSKCC Phase I/II Experience. American Society of Haematology - 48th Annual Meeting, Orlando, USA (2006).
-
(2006)
Pralatrexate (PDX) Produces Durable Complete Remissions In Patients With Chemotherapy Resistant Precursor and Peripheral T-Cell Lymphomas: Results of the MSKCC Phase I/II Experience
-
-
O'Connor, O.A.1
Hamlin, P.A.2
Gerecitano, J.3
Portlock, C.S.4
Noy, A.5
Moskowitz, C.6
-
226
-
-
78650936593
-
-
10th International Conference on Malignant Lymphoma, Lugano, Switzerland
-
Horwitz SM, Duvc M, Kim Y, et al. Low-dose pralatrexate (PDX) is active in cutaneous T-cell lymphoma: preliminary results of a multi-center dose finding trial. 10th International Conference on Malignant Lymphoma, Lugano, Switzerland (2008).
-
(2008)
Low-dose Pralatrexate (PDX) is Active In Cutaneous T-cell Lymphoma: Preliminary Results of a Multi-center Dose Finding Trial
-
-
Horwitz, S.M.1
Duvc, M.2
Kim, Y.3
-
227
-
-
62749162681
-
Proteasome inhibitors therapeutic strategies for cancer
-
D'Alessandro A, Pieroni L, Ronci M, D'Aguanno S, Federici G, Urbani A. Proteasome inhibitors therapeutic strategies for cancer. Recent Pat Anticancer Drug Discov 2009; 4: 73-82.
-
(2009)
Recent Pat Anticancer Drug Discov
, vol.4
, pp. 73-82
-
-
D'Alessandro, A.1
Pieroni, L.2
Ronci, M.3
D'Aguanno, S.4
Federici, G.5
Urbani, A.6
-
228
-
-
0038649638
-
The proteasome-an emerging therapeutic target in cancer
-
Mitchell BS. The proteasome-an emerging therapeutic target in cancer. N Engl J Med 2003; 348: 2597-8.
-
(2003)
N Engl J Med
, vol.348
, pp. 2597-2598
-
-
Mitchell, B.S.1
-
229
-
-
2642551603
-
Development of the proteasome inhibitor Velcade (Bortezomib)
-
Adams J, Kauffman M. Development of the proteasome inhibitor Velcade (Bortezomib). Cancer Invest 2004; 22: 304-11.
-
(2004)
Cancer Invest
, vol.22
, pp. 304-311
-
-
Adams, J.1
Kauffman, M.2
-
230
-
-
77952310929
-
Bortezomib plus melphalan and prednisone compared with melphalan and prednisone in previously untreated multiple myeloma: Updated follow-up and impact of subsequent therapy in the phase III VISTA trial
-
Mateos MV, Richardson PG, Schlag R, Khuageva NK, Dimopoulos MA, Shpilberg O, et al. Bortezomib plus melphalan and prednisone compared with melphalan and prednisone in previously untreated multiple myeloma: Updated follow-up and impact of subsequent therapy in the phase III VISTA trial. J Clin Oncol 2010; 28: 2259-66.
-
(2010)
J Clin Oncol
, vol.28
, pp. 2259-2266
-
-
Mateos, M.V.1
Richardson, P.G.2
Schlag, R.3
Khuageva, N.K.4
Dimopoulos, M.A.5
Shpilberg, O.6
-
231
-
-
34948833649
-
Phase II trial of proteasome inhibitor bortezomib in patients with relapsed or refractory cutaneous T-cell lymphoma
-
Zinzani PL, Musuraca G, Tani M, Stefoni V, Marchi E, Fina M, et al. Phase II trial of proteasome inhibitor bortezomib in patients with relapsed or refractory cutaneous T-cell lymphoma. J Clin Oncol 2007; 25: 4293-7.
-
(2007)
J Clin Oncol
, vol.25
, pp. 4293-4297
-
-
Zinzani, P.L.1
Musuraca, G.2
Tani, M.3
Stefoni, V.4
Marchi, E.5
Fina, M.6
|