High-avidity human IgGk monoclonal antibodies from a novel strain of minilocus transgenic mice

Nature Biotechnology

Volumn 14, Issue 7, 1996, Pages 845-851

  Fishwild, Dianne M ^a   O’Donnell, Susan L ^a   Bengoechea, Tasha ^a   Hudson, Debra V ^a   Harding, Fiona ^a   Bernhard, Susan L ^a   Jones, Debbie ^a   Kay, Robert M ^a   Higgins, Kay M ^a   Schramm, Stephen R ^a   Lonberg, Nils ^a  

^a GenPharm International   (United States)

Author keywords

CD4; Human monoclonal antibody; Immunoglobulin transgenic mouse

Indexed keywords

CD4 ANTIGEN; COMPLEMENTARY DNA; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOSUPPRESSIVE AGENT; MITOMYCIN C; MONOCLONAL ANTIBODY;

ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ANTIGEN EXPRESSION; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; HYBRIDOMA; IMMUNOSUPPRESSIVE TREATMENT; MIXED LYMPHOCYTE REACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; TRANSGENIC MOUSE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY AFFINITY; ANTIGENS, CD4; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; HYBRIDOMAS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN KAPPA-CHAINS; LYMPHOCYTE CULTURE TEST, MIXED; MICE; MICE, TRANSGENIC; T-LYMPHOCYTES;

ANIMALIA; MUS MUSCULUS;

EID: 8944243547     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt0796-845     Document Type: Article

References (54)

1. Kohler, G. and Milstein, C. 1975. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256:495-497.
2. Goldstein, G., Schindler, J., Tsai, H., Cosimi, A.B., Russell, P.S., Norman, D., et al. 1985. A randomized clinical trial of OKT3 monoclonal antibody for acute rejection of cadaveric renal transplants. N. Engl. J. Med. 313:385-391.
3. Jaffers, G., Fuller, T.C., Cosimi, A.B., Russell, P.S., Winn, H.J., and Colvin, R.B. 1986. Monoclonal antibody therapy: Anti-idiotypic and non-anti-idiotypic anti-bodies to OKT3 arising despite intense immunosuppression. Transplantation 41:572-578.
4. Ehrlich, P.H., Moustafa, Z.A., Justice, J.C., Harfeldt, K.E., Gadi, I.K., Sciorra, L.J., et al. 1988. Human and primate monoclonal antibodies for in vivo therapy. Clinical Chemistry 34:1681-1688.
5. Jones, P.T., Dear, P.H., Foote, J., Neuberger, M.S., and Winter, G. 1986. Replacing the complementarity-determining regions in a human antibody with those from a mouse. Nature 321:522-525.
6. Newman, R., Albert, J., Anderson, D., Carner, K., Heard, C., Norton, F., et al. 1992. “Primatization” of recombinant antibodies for immunotherapy of human diseases: a macaque/human chimeric antibody against CD4. Bio/Technology 10:1455-1460.
7. Griffiths, A.D., Williams, S.C., Hartley, O., Tomlinson, I.M., Waterhouse, P., Crosby, W.L., et al. 1994. Isolation of high affinity human antibodies directly from large synthetic repertoires. EMBO J. 13:3245-3260.
8. Hale, G., Clark, M.R., Marcus, R., Winter, G., Dyer, M.J.S., Phillips, J.M., et al. 1988. Remission induction in non-Hodgkin lymphoma with reshaped human monoclonal antibody Campath-1H. Lancet i:1394-1399.
9. LoBuglio, A.F., Wheeler, R.H., Trang, J., Haynes, A., Rogers, K., Harvey, E.B., et al. 1989. Mouse/human chimeric monoclonal antibody in man: Kinetics and immune response. Proc. Natl. Acad. Sci. USA 86:4220-4224.
10. Knox, S.J., Levy, R., Hodgkinson, S., Bell, R., Brown, S., Wood, G.S., et al. 1991. Observations on the effect of chimeric anti-CD4 monoclonal antibody in patients with mycosis fungoides. Blood 77:20-30.
11. Maloney, D.G., Liles, T.M., Czerwinski, D.K., Waldichuk, C., Rosenberg, J., Grillo-Lopez, A., et al. 1994. Phase I clinical trial using escalating single-dose infusion of chimeric anti-CD20 monoclonal antibody (IDEC-C2B8) in patients with recurrent B-cell lymphoma. Blood 84:2457-2466.
12. Bruggemann, M., Caskey, H.M., Teale, C., Waldmann, H., Williams, G.T., Surani, M.A., et al. 1989. A repertoire of monoclonal antibodies with human heavy chains from transgenic mice. Proc. Natl. Acad. Sci. USA 86:6709-6713.
13. Bruggemann, M., Spicer, C., Buluwela, L., Rosewell, I., Barton, S., Surani, M.A., et al. 1991. Human antibody production in transgenic mice: expression from 100 kb of the human IgH locus. Eur. J. Immunol. 21:1323-1326.
14. Green, L.L., Hardy, M.C., Maynard-Currie, C.E., Tsuda, H., Louie, D.M., Mendez, M.J., et al. 1994. Antigen-specific human monoclonal antibodies from mice engineered with human Ig heavy and light chain YACs. Nature Genetics 7:13-21.
15. Tavlor, L.D., Carmack, C.E., Schramm, S.R., Mashayekh, R., Higgins, K.M., Kuo, C.-C., et al. 1992. A transgenic mouse that expresses a diversity of human sequence heavy and light chain immunoglobulins. Nucleic Acids Res. 20:6287-6295.
16. Davies, N.P., Rosewell, I.R., Richardson, J.C., Cook, G.P., Neuberger, M.S., Brownstein, B.H., et al. 1993. Creation of mice expressing human antibody light chains by introduction of a yeast artificial chromosome containing the core region of the human immunoglobulin κ locus. Bio/Technology 11:911-914.
17. Lonberg, N., Taylor, L.D., Harding, F.A., Trounstine, M., Higgins, K.M., Schramm, S.R., et al. 1994. Antigen-specific human antibodies from mice comprising four distinct genetic modifications. Nature 368:856-859.
18. Choi, T., Hollenbach, P.W., Pearson, B.E., Ueada, R.M., Weddell, G.N., Kurahara, C.G., et al. 1993. Transgenic mice containing a human heavy chain immuno-globulin gene fragment cloned in a yeast artificial chromosome. Nature Genetics 4:117-123.
19. Taylor, L.D., Carmack, C.E., Huszar, D., Higgins, K.M., Mashayekh, R., Sequar, G., et al. 1994. Human immunoglobulin transgenes undergo rearrangement, somatic mutation and class switching in mice that lack endogenous IgM. Internatl. Immunol. 6:579-591.
20. Wagner, S.D., Williams, G.T., Larson, T., Neuberger, M.S., Kitamura, D., Rajewsky, K., et al. 1994. Antibodies generated from human miniloci in transgenic mice. Nucleic Acids Res. 22:1389-1393.
21. Wagner, S.D., Popov, A.V., Davies, S.L., Xian, J., Neuberger, M.S., and Bruggemann, M. 1994. The diversity of antigen-specific monoclonal antibodies from transgenic mice bearing human immunoglobulin gene miniloci. Eur. J. Immunol. 24:2672-2681.
22. Lonberg, N. and Huszar, D. 1995. Human antibodies from transgenic mice. Intern. Rev. Immunol. 13:65-93.
23. Collins, T.L., Hahn, W.C., Bierer, B.E., and Burakoff, S.J. 1993. CD4, CD8 and CD2 in T cell adhesion and signalling. Curr. Top. Microbiol. Immunol. 184:223-233.
24. Miceli, M.C. and Parnes, J.R. 1993. Role of CD4 and CD8 in T cell activation and differentiation. Adv. Immunol. 53:59-122.
25. Doyle, C. and Strominger, J.L. 1987. Interaction between CD4 and class II MHC molecules mediates cell adhesion. Nature 330:256-258.
26. Saito, T., Weiss, A., Miller, J., Norcross, M.A., and Germain, R.N. 1987. Specific antigen-la activation of transfected human T cells expressing murine Ti αβ-human T3 receptor complexes. Nature 325:125-127.
27. Wofsy, D. and Seaman, W.E. 1985. Successful treatment of autoimmunity in NZB/NZW F1 mice with monoclonal antibody to L3T4. J. Exp. Med. 161:378-391.
28. Wofsy, D. and Seaman, W.E. 1987. Reversal of advanced murine lupus in NZB/NZW F1 mice by treatment with monoclonal antibody to L3T4. J. Immunol. 138:3247-3253.
29. Waldor, M.K., Sriram, S., Hardy, R., Herzenberg, L.A., Herzenberg, L.A., Lanier, L., et al. 1985. Reversal of experimental allergic encephalomyelitis with monoclonal antibody to a T-cell subset marker. Science 227:415-417.
30. Goldberg, D., Morel, P., Chatenoud, L., Boitard, C., Menkes, C.J., Bertoye, P.-H., et al. 1991. Immunological effects of high dose administration of anti-CD4 antibody in rheumatoid arthrits patients. J. Autoimmunity 4:617-630.
31. Herzog, C., Walker, C., Pichler, W., Aeschlimann, A., Wassmer, P., Stockinger, H., et al. 1987. Monoclonal anti-CD4 in arthritis. Lancet ii:1461-1462.
32. Horneff, G., Burmester, G.R., Emmrich, F., and Kalden, J.R. 1991. Treatment of rheumatoid arthritis with an anti-CD4 monoclonal antibody. Arthritis Rheum. 34:129-140.
33. Reiter, C., Kakavand, B., Rieber, E.P., Schattenkirchner, M., Riethmuller, G., and Kruger, K. 1991. Treatment of rheumatoid arthritis with monoclonal CD4 antibody M-T151: Clinical results and immunopharmacologic effects in an open study, including repeated administration. Arthritis Rheum. 34:525-536.
34. Wendling, D., Wijdenes, J., Racadot, E., and Morel-Fourrier, B. 1991. Therapeutic use of monoclonal anti-CD4 antibody in rheumatoid arthritis. J. Rheum. 18:325-327.
35. Van der Lubbe, P.A., Dijkmans, B.A.C., Markusse, H.M., Nassander, U., and Breedveld, F.C. 1995. A randomized, double-blind, placebo-controlled study of CD4 monoclonal antibody therapy in early rheumatoid arthritis. Arthritis Rheum. 38:1097-1106.
36. Van der Lubbe, P.A., Reiter, C., Breedveld, F.C., Kruger, K., Schattenkirchner, M., Sanders, M.E., et al. 1993. Chimeric CD4 monoclonal antibody CM-T412 as a therapeutic approach to rheumatoid arthritis. Arthritis Rheum. 36:1375-1379.
37. Moreland, L.W., Bucy, R.P., Tilden, A., Pratt, P.W., LoBuglio, A.F., Khazaeli, M., et al. 1993. Use of a chimeric monoclonal anti-CD4 antibody in patients with refractory rheumatoid arthritis. Arthritis Rheum. 36:307-318.
38. Chen, J., Trounstine, M., Alt, F.W., Young, F., Kurahara, C., Loring, J.F., et al. 1993. Immunoglobulin gene rearrangement in B cell deficient mice generated by targeted deletion of the Jh locus. Internatl. Immunol. 5:647-656.
39. Chen, J., Trounstine, M., Kurahara, C., Young, F., Kuo, C.-C., Xu, Y., et al. 1993. B cell development in mice that lack one or both immunoglobulin κ light chain genes. EMBO J. 12:821-830.
40. Lautner-Rieske, A., Huber, C., Meindl, A., Pargent, W., Schable, K.F., Thiebe, R., et al. 1992. The human immunoglobulin κ locus. Characterization of the duplicated A regions. Eur. J. Immunol. 22:1023-1029.
41. Huber, C., Huber, E., Lautner-Reiske, A., Schable, K.F., and Zachau, H.G. 1993. The human immunoglobulin κ locus. Characterization of the partially duplicated L regions. Eur. J. Immunol. 23:2860-2867.
42. Karlson, R., Michaelsson, A., and Mattsson, L. 1991. Kinetic analysis of mono-clonal antibody-antigen interactions with a new biosensor based analytical system. J. Immunol. Meth. 145:229-240.
43. Engleman, E.G., Benike, C., Glickman, E., and Evans, R.L. 1981. Antibodies to membrane structures that distinguish suppressor/cytotoxic and helper T lymphocyte subpopulations block the mixed leukocyte reaction in man. J. Exp. Med. 153:193-198.
44. Merkenschlager, M., Buck, D., Beverley, P.C.L., and Sattentau, Q.J. 1990. Functional epitope analysis of the human CD4 molecule: The MHC Class II-dependent activation of resting T cells is inhibited by monoclonal anti-bodies to CD4 regardless whether or not they recognize epitopes involved in the binding of MHC Class II or HIV gp120. J. Immunol. 145:2839-2845.
45. Pargent, W., Meindl, A., Thiebe, R., Mitzel, S., and Zachau, H.G. 1991. The human κ locus. Characterization of the duplicated O regions. Eur. J. Immunol. 21:1821-1827.
46. Weichhoid, G.M., Ohnheiser, R., and Zachau, H.G. 1993. The human immuno-globulin κ locus consists of two copies that are organized in opposite polarity. Genomics 16:503-511.
47. Rath, S., Nisonoff, A., Selsing, E., and Durdick, J.M. 1991. B cell abnormalities induced by a µ Ig transgene extend to L chain isotype usage. J. Immunol. 146:2841-2847.
48. Stall, A.M., Kroese, F.G.M., Gadus, F.T., Sieckmann, D.G., Herzenberg, L.A., and Herzenberg, L.A. 1988. Rearrangement and expression of endogenous immunoglobulin genes occur in many murine B cells expressing transgenic membrane IgM. Proc. Natl. Acad. Sci. USA 85:3546-3550.
49. Morel, P., Nicolas, J.F., Wijdenes, J., and Revillard, J.P. 1992. Down-regulation of lymphocyte CD4 antigen expression by administration of anti-CD4 monoclonal antibody. Clin. Immunol. Immunopath. 64:248-253.
50. Dalesandro, M.R., Pak, K.-Y., Tam, S., Wilson, E., Looney, J.E., Riethmuller, G., et al. 1993. Effects of isotype and Fc region on in vitro function of a mouse/human chimeric CD4 antibody. Internatl. Immunol. 5:283-291.
51. Larin, Z., Monaco, A.R, and Lehrach, H. 1991. Yeast artificial chromosome libraries containing large inserts from mouse and human DNA. Proc. Natl. Acad. Sci. USA 88:4123-4127.
52. Marks, J., Tristem, M., Karpas, A., and Winter, G. 1991. Oligonucleotide primers for polymerase chain reaction amplification of human immunoglobulin variable genes and design of family-specific oligonucleotide probes. Eur. J. Immunol. 21:985-991.
53. Boyum, A. 1968. Isolation of mononuclear cells and granulocytes from human blood. Scand. J. Clin. Lab. Invest. 21:(suppl. 97)51-76.
54. Fishwild, D.M. and Saria, E.A. 1991. Investigation and prevention of artifactual staining in flow cytometric analyses of whole blood samples from patients treated with H65-RTA, an anti-CD5 monoclonal antibody conjugated to ricin A chain. J. Immunol. Meth. 144:27-34.