Effects of novel retinoid X receptor-selective ligands on myeloid leukemic differentiation and proliferation in vitro

Blood

Volumn 87, Issue 5, 1996, Pages 1977-1984

  Kizaki, Masahiro ^b   Dawson, Marcia I ^b   Heyman, Richard ^b   Elstner, Elena ^b   Morosetti, Roberta ^b   Pakkala, Seppo ^b   Chen, Dan Lin ^b   Ueno, Hironori ^b   Chao, Wan Ru ^b   Morikawa, Minoru ^b   Ikeda, Yasuo ^b   Heber, David ^b   Pfahl, Magnus ^b   Koeffler, H Phillip ^a  

^a Divisionof Hematology Oncology Blood and Marrow Transplantation   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

2 METHYL 5 [2 (5,6,7,8 TETRAHYDRO 3,5,5,8,8 PENTAMETHYL 2 NAPHTHYL) 1,3 DIOXOLAN 2 YL] 2,4 PENTADIENOIC ACID; 3,7 DIMETHYL 6 (5,6,7,8 TETRAHYDRO 5,5,8,8 TETRAMETHYL 2 NAPHTHYL) 2,4,6 OCTATRIENOIC ACID; 4 [1 (5,6,7,8 TETRAHYDRO 5,5,8,8 TETRAMETHYL 2 NAPHTHYL)CYCLOPROPYL]BENZOIC ACID; 4 [2 (3,4 DIHYDRO 4,4 DIMETHYL 2H 1 BENZOPYRAN 6 YL) 1,3 DITHIAN 2 YL]BENZOIC ACID; 4 [2 (5,6,7,8 TETRAHYDRO 5,5,8,8 TETRAMETHYL 2 NAPHTHYL) 1,3 DIOXAN 2 YL]BENZOIC ACID; ALITRETINOIN; BEXAROTENE; RETINOIC ACID; RETINOIC ACID RECEPTOR; RETINOID; RETINOID X RECEPTOR; SR 11236; SR 11238; SR 11249; SR 11269; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN HL 60; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG SCREENING; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MYELOID LEUKEMIA; PRIORITY JOURNAL;

EID: 13344250486     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v87.5.1977.bloodjournal8751977     Document Type: Article

References (44)

1. Lotan R: Effect of vitamin A and its analogs (retinoids) on normal and neoplastic cells. Biochem Biophys Acta 605:33, 1980
2. Strickland S, Mahdavi V: The induction of differentiation in teratocarcinoma stem cells by retinoic acid. Cell 15:393, 1978
3. Koeffler HP: Induction of differentiation of human acute myelogeneous leukemia cells: Therapeutic implications. Blood 62:709, 1983
4. Breitman TR, Selonick SE, Collins SJ: Induction of differentiation of the human promyelocytic cell lines (HL-60) by retinoic acid. Proc Natl Acad Sci USA 77:2936, 1980
5. Douer D, Koeffler HP: Retinoic acid. Inhibition of the clonal growth of human myeloid leukemia cells. J Clin Invest 69:277, 1982
6. Huang ME, Ye YC, Chen SR, Chai JR, Lu JX, Zhoa L, Gu HT, Wang ZY: Use of all-trans-retinoic acid in the treatment of acute promyelocytic leukemia. Blood 72:567, 1988
7. Castaigne S, Chomienne C, Daniel MT, Bollarini P, Berger R, Fenaux P, Degos L: All-frans-retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results. Blood 76:1704, 1990
8. Warrell RP Jr, Frankel SR, Miller WH Jr, Sheinberg DA, Itri LM, Hittelman WN, Vyas R, Andreeff MS, Tafuri A, Jakubowski A, Gabrilove J, Gordon MS, Dimitrovsky E: Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans-retinoic acid). N Engl J Med 324:1385, 1991
9. Chen ZX, Xue YQ, Zhang R, Tao RF, Xia XM, Li C, Wang W, Zu WY, Yao XZ, Ling BJ: A clinical and experimental study on all-trans-retinoic acid-treated acute promyelocytic patients. Blood 78:1413, 1991
10. Giguere V, Ong ES, Segui P, Evans RM: Identification of a receptor for the morphogen retinoic acid. Nature 330:624, 1987
11. Petkovick M, Brand NJ, Krust A, Chambon P: A human retinoic acid receptor which belongs to the family of nuclear receptors. Nature 330:444, 1987
12. Mangelsdorf DJ, Ong ES, Dyck JA, Evans RM: A nuclear receptor that identifies a novel retinoic acid response pathway. Nature 345:224, 1990
13. Evans RM: The steroid and thyroid receptor superfamily. Science 240:889, 1988
14. Lotan R, Clifford JL: Nuclear receptors for retinoids: Mediators of retinoid effects on normal and malignant cells. Biomed Pharmacother 45:145, 1991
15. Gaub MP, Lutz Y, Ruberte E, Petkovich M, Brand N, Chambon P: Antibodies specific to the retinoic acid human nuclear receptors alpha and beta. Proc Natl Acad Sci USA 86:3089, 1989
16. Hashimoto Y, Petkovic M, Gaub MP, Kagechika H, Shudo K, Chambon P: The retinoic acid receptors alpha and beta are expressed in the human promyelocytic leukemia cell line HL-60. Mol Endocrinol 3:1046, 1989
17. Kizaki M, Ikeda Y, Tanosaki R, Nakajima H, Morikawa M, Sakashita A, Koeffler HP: Effects of novel retinoic acid compound, 9-cis retinoic acid, on proliferation, differentiation, and expression of retinoic acid receptor (RAR)-α and retinoid X receptor (RXR)-α RNA by HL-60 cells. Blood 82:3592, 1993
18. Boehm MF, Xhang L, Badea BA, White SK, Mais DE, Berger E, Suto CM, Goldman ME, Heyman RA: Synthesis and structure - activity relationships of novel retinoid X receptor-selective retinoids. J Med Chem 37:2930, 1994
19. Hashimoto Y, Petkovich M, Gaub MP, Kagechika H, Shuko K, Chambon P: The retinoic acid receptors α and β are expressed in the human promyelocytic leukemia cell line HL-60. Mol Endocrinol 3:1046, 1989
20. Ishikawa T, Umesono K, Mangelsdorf DJ, Aburatani H, Stanger BZ, Shibasaki Y, Imawan M, Evans RM, Takaku F: A functional retinoic acid receptor encoded by the gene on human chromosome 12. Mol Endocrinol 4:837, 1990
21. Levin AA, Sturzenbecker LJ, Kazmer S, Bosakowski M, Lovey A, Grippo JF: 9-cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα. Nature 355:359, 1992
22. Heyman RA, Mangelsdorf DJ, Dyck JA, Stein RB, Eichele G, Evans RM, Thaller C: 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor. Cell 68:397, 1992
23. Leid M, Kastner P, Lyons R, Nakshatri H, Saunders M, Zacharewski, Chen JY, Staub A, Garnier JM, Mader S, Chambon P: Purification, cloning, and RXR identity of the HeLa cell factor with which RAR and TR heterodimerizes to bind target sequences efficiently. Cell 68:377, 1992
24. 3 signalling. Nature 355:446, 1992
25. Marks MS, Hallenbeck PL, Nagata T, Segars JM, Appella E, Nikodem VM, Ozato K: H-2RUBP (RXR β) heterodimerization provides a mechanism for combinational diversity in the regulation of retinoic acid and thyroid hormone responsive genes. EMBO J 11:1419, 1992
26. Yu VC, Delsert C, Anderson B, Holloway JM, Devary OV, Naar AM, Kim SY, Boutin J-M, Glass CK, Rosenfeld MG: RXRβ: A coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements. Cell 67:1251, 1991
27. Zhang XK, Hoffmann B, Tran PB, Graupner G, Pfahl M: Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors. Nature 355:441, 1992
28. Zhang XK, Lehmann B, Hoffmann B, Dawson MI, Cameron J, Graupner G, Hertmann T, Tran P, Pfhal M: Homodimer formation of retinoid X receptor induced by 9-cis retinoic acid. Nature 358:587, 1992
29. Sakashita A, Kizaki M, Pakkala S, Schiller G, Tsuruoka N, Tanosaki R, Cameron JF, Dawson MI, Koeffler HP: 9-cis retinoic acid: Effects on normal and leukemic hematopoiesis in vitro. Blood 81:1009, 1993
30. Kizaki M, Nakajima H, Mori S, Koike T, Morikawa M, Ohta M, Saito M, Koeffler HP, Ikeda Y: Novel retinoic acid, 9-cis retinoic acid, in combination with all-trans retinoic acid is an effective inducer of differentiation of retinoic acid-resistant HL-60 cells. Blood 83:3289, 1994
31. Lehmann JM, Jong L, Fanjul A, Cameron JF, Lu XP, Haefner P, Dawson MI, Pfahl M: Retinoids selective for retinoid X receptor response pathways. Science 258:1944, 1992
32. Bennett JM, Catavsky D, Daniel MT, Flandrin O, Gallon DAG, Gralnick HR, Sultan C: Proposed revised criteria for the classification of acute myeloid leukemia. Ann Intern Med 103:620, 1985
33. Dawson MI, Jong L, Hobbs PD, Cameron JF, Chao W, Pfahl M, Lee M-O, Shroot B, Pfahl M: Conformational effects on retinoid receptor selectivity. 2. Effect of retinoid bridging group on retinoid X receptor activity and selectivity. J Med Chem 38:3368, 1995
34. Lehmann JM, Zhang X-K, Pfahl M: RARγ2 expression is regulated through a retinoic acid response element embedded in Sp1 sites. Mol Cell Biol 12:2976, 1992
35. Munker R, Norman AW, Koeffler HP: Vitamin D compounds: Effects on clonal proliferation and differentiation of human myeloid cells. J Clin Invest 78:424, 1986
36. Bugge TH, Pohl J, Lonnoy O, Stunnenberg HG: RXR alpha, a promiscuous partner of retinoic acid and thyroid hormone receptors. EMBO J 11:1409, 1992
37. Dawson MI, Elstner E, Kizaki M, Chen DL, Pakkala S, Kerner B, Koeffler HP: Myeloid differentiation mediated through RAR/RXR not RXR/RXR pathway. Blood 84:446, 1994
38. Kizaki M, Nakajima H, Mori S, Koike T, Morikawa, Ohta M, Saito M, Koeffler HP, Ikeda Y: Novel retinoic acid, 9-cis-retinoic acid, in combination with all-trans retinoic acid is effective inducer of differentiation of retinoic acid-resistant HL-60 cells. Blood 83:3289, 1994
39. Takahashi N, Breitman TR: Induction of differentiation and covalent binding to proteins by the synthetic retinoids Ch55 and Am80. Arch Biochem Biophys 314:82, 1994
40. Fanjul A, Dawson MI, Hobbs PD, Jong L, Cameron JF, Harlev E, Graupner G, Lu XP, Pfahl M: A new class of retinoids with selective inhibition of AP-1 inhibits proliferation. Nature 372:107, 1994
41. Apfel C, Bauer F, Crettaz M, Forni L, Kamber M, Kaufmann F, LeMotte P, Pirson W, Klaus M: A retinoic acid receptor antagonist selectively counteracts retinoic acid effects. Proc Natl Acad Sci USA 89:7129, 1992
42. Li YP, Said F, Gallagher RE: Retinoic acid-resistant HL-60 cells exclusively contain mutant reinoic acid receptor-alpha. Blood 83:3298, 1994
43. Robertson KA, Emami B, Collins SJ: Retinoic acid-resistant HL-60R cells harbor a point mutation in the retinoic acid recepor ligand-binding domain that confers dominant negative acitivity Blood 80:1885, 1992
44. Collins SJ, Roberlson KA, Mueller L: Retinoic acid-induced granulocytic differentiation of HL-60 myeloid leuekmia cells is mediated directly through the retinoic acid receptor (RARα). Mol Cell Biol 10:2154, 1990