The CD45 tyrosine phosphatase regulates Campath-1H (CD52)-induced TCR-dependent signal transduction in human T cells

International Immunology

Volumn 12, Issue 4, 2000, Pages 505-516

  Hederer, Rosemarie A ^a   Guntermann, Christine ^a   Miller, Nigel ^a   Nagy, Peter ^b   Szollosi, Janos ^b   Damjanovich, Sandor ^b   Hale, Geoffrey ^c   Alexander, Denis R ^a  

^a BABRAHAM INSTITUTE   (United Kingdom)

^b UNIVERSITY OF DEBRECEN   (Hungary)

^c Therapeutic Antibody Centre   (United Kingdom)

Author keywords

Campath 1H; CD45; CD52; Transduction

Indexed keywords

ALEMTUZUMAB; CALCIUM; CD3 ANTIGEN; CD45 ANTIGEN; CD52 ANTIGEN; GLYCOSYLPHOSPHATIDYLINOSITOL; OKT 3; PHOSPHOLIPASE; PROTEIN P56; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE;

ANTIGEN BINDING; ARTICLE; AUTOIMMUNE DISEASE; CELL SURFACE; CLINICAL TRIAL; COMPLEX FORMATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSS LINKING; ENERGY TRANSFER; ENZYME ACTIVATION; FLUORESCENCE; HUMAN; HUMAN CELL; LEUKEMIA; LEUKEMIA CELL LINE; LYMPHOCYTE DEPLETION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TRANSPLANTATION;

EID: 0034033048     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/12.4.505     Document Type: Article

References (60)

1. Croft, M. and Dubey, C. 1997. Accessory molecule and costimulation requirements for CD4 T cell response. Crit. Rev. Immunol. 17:89.
2. Gunter, K. C., Malek, T. R. and Shevach, E. M. 1984. T cell-activating properties of an anti-Thy-1 monoclonal antibody. J. Exp. Med. 159:716.
3. Cook, R. G., Leone, B., Leone, J. W., Widacki, S. M. and Zavell, P. J. 1992. Characterization of T cell proliferative responses induced by anti-Qa-2 monoclonal antibodies. Cell. Immunol. 144:367.
4. Shevach, E. M. and Korty, P. E. 1989. Ly-6-a multigene family in search of a function. Immunol. Today 10:195.
5. Shenoyscaria, A. M., Kwong, J., Fujita, T., Olszowy, M. W., Shaw, A. S. and Lublin, D. M. 1992. Signal transduction through decay-accelerating factor - interaction of glycosyl-phophatidylinositol anchor and protein tyrosine kinases p56(Lck) and p59(Fyn-1). J. Immunol. 149:3535.
6. 2+-signaling competent. J. Cell. Biol. 131:669.
7. Thompson, L. F., Ruedi, J. M., Glass, A., Lew, M. G. and Lucas, A. H. 1989. Antibodies to 5′ nucleotidase (CD73) a glycosyl-phosphatidylinositol-anchored protein, cause human peripheral blood T cells to proliferate. J. Immunol. 143:1815.
8. Riechmann, L., Clark, M., Waldmann, H. and Winter, G. 1988. Reshaping human-antibodies for therapy. Nature 332:323.
9. Greenwood, J., Clark, M. and Waldmann, H. 1993. Structural motifs involved in human-IgG antibody effector functions. Eur. J. Immunol. 23:1098.
10. Hale, G., Bright, S., Chumbley, G., Hoang, T., Metcalf, D., Munro, A. J. and Waldmann, H. 1983. Removal of T-cells from bone-marrow for transplantation - a monoclonal anti-lymphocyte antibody that fixes human-complement. Blood 62:873.
11. Hale, G., Xia, M. Q., Tighe, H. P., Dyer, M. J. S. and Waldmann, H. 1990. The Campath-1 Antigen (CDw52). Tissue Antigens 35:118.
12. Xia, M. Q., Hale, G. and Waldmann, H. 1993. Efficient complement-mediated lysis of cells containing the Campath-1 (CDw52) antigen. Mol. Immunol. 30:1089
13. Lockwood, C. M., Thiru, S., Isaacs, J. D., Hale, G. and Waldmann, H. 1993. Long-term remission of intractable systemic vasculitis with monoclonal-antibody therapy. Lancet 341:1620.
14. Moreau, T., Thorpe, J., Miller, D., Moseley, I., Hale, G., Waldmann, H., Clayton, D., Wing, M., Scolding, N. and Compston, A. 1994. Preliminary evidence from magnetic-resonance-imaging for reduction in disease-activity after lymphocyte depletion in multiple-sclerosis. Lancet 344:298.
15. Osterborg, A., Fassas, A. S., Anagnostopoulos, A., Dyer, M. J. S., Catovsky, D. and Mellstedt, H. 1996. Humanized CD52 monoclonal-antibody Campath-1H as first-line treatment in chronic lymphocytic-leukemia. Br. J. Haematol. 93:151.
16. Isaacs, J. D., Manna, V. K., Rapson, N., Bulpitt, K. J., Hazleman, B. L., Matteson, E. L., Stclair, E. W., Schnitzer, T. J. and Johnston, J. M. 1996. Campath-1H in rheumatoid-arthritis - an intravenous dose-ranging study. Br J. Rheumatol. 35:231.
17. Friend, P. J., Rebello, P., Oliveira, D., Manna, V., Cobbold, S. P., Hale, G., Jamieson, N. V., Calne, R. Y., Harris, D. T. and Waldmann, H. 1995. Successful treatment of renal-allograft rejection with a humanized antilymphocyte monoclonal-antibody. Transplant. Proc. 27:869.
18. Xia, M. Q., Tone, M., Packman, L., Hale, G. and Waldmann, H. 1991. Characterization Of the Campath-1 (CDw52) antigen-biochemical analysis and cDNA cloning reveal an unusually small peptide backbone. Eur. J. Immunol. 21:1677.
19. Xia, M. Q., Hale, G., Lifely, M. R., Ferguson, M. A. J., Campbell, D., Packman, L. and Waldmann, H. 1993. Structure of the Campath-1 antigen, a glycosylphosphatidylinositol-anchored glycoprotein which is an exceptionally good target for complement lysis. Biochem. J. 293.633.
20. Treumann, A., Lifely, M. R., Schneider, P. and Ferguson, M. A. J. 1995. Primary structure of CD52. J. Biol. Chem. 270:6088.
21. Rowan, W. C., Hale, G., Tite, J. P. and Brett, S. J. 1995. Cross-linking of the Campath-1 antigen (CD52) triggers activation of normal human T lymphocytes. Int. Immunol. 7:69.
22. Alexander, D. R. 1997. The role of the CD45 phosphatase in lymphocyte signalling. In Harnett, M. M. and Rigley, K. P., eds, Lymphocyte Signalling: Mechanisms, Subversion and Manipulation, p. 107. Wiley, Chichester.
23. Gunter, K. C., Germain, R. N., Kroczek, R. A., Saito, T., Yokoyama, W. M., Chan, C., Weiss, A. and Shevach, E. M. 1987. Thy-1-mediated T-cell activation requires co-expression Of CD3/Ti complex. Nature 326:505.
24. Sussman, J. J., Saito, T., Shevach, E. M., Germain, R. N. and Ashwell, J. D. 1988. Thy-1 -mediated and Ly-6-mediated lymphokine production and growth-inhibition of a T-cell hybridoma require co-expression of the T-cell antigen receptor complex. J. Immunol. 140:2520.
25. Pingel, J. T., McFarland, E. D. C. and Thomas, M. L. 1994. Activation of CD45-deficient T cell clones by lectin mitogens but not anti-Thy-1. Int. Immunol. 6:169.
26. Volarevic, S., Burns, C. M., Sussman, J. J. and Ashwell, J. D. 1990. Intimate association of Thy-1 and the T-cell antigen receptor with the CD45 tyrosine phosphatase. Proc. Natl Acad. Sci. USA 87:7085.
27. Szollosi, J., Horejsi, V., Bene, L., Angelisova, P. and Damjanovich, S. 1996. Supramolecular Complexes of MHC class-I, MHC class-II, CD20, and tetraspan molecules (CD53, CD81, and CD82) at the surface of a B-cell line Jy. J. Immunol. 157:2939.
28. Stone, J. D., Conroy, L. A., Byth, K. F., Hederer, R. A., Howlett, S., Takemoto, Y., Holmes, N. and Alexander, D. R. 1997. Aberrant TCR-mediated signalling in CD45-null thymocytes involves dysfunctional regulation of Lck, Fyn, TCR-ζ and ZAP-70. J. Immunol. 158:5773.
29. Berridge, M. J., Dawson, R. M. C., Downes, C. P., Heslop, J. P. and Irvine, R. F. 1983. Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides. Biochem. J. 212:473.
30. Szollosi, J., Damjanovich, S., Balazs, M., Nagy, P., Tron, L., Fulwyler, M. J. and Brodsky, F. M. 1989. Physical association between MHC class-I and class-II molecules detected on the cell-surface by flow cytometric energy-transfer. J. Immunol. 143:208.
31. Szollosi, J., Tron, L., Damjanovich, S., Helliwell, S. H., Arndtjovin, D. and Jovin, T. M. 1984. Fluorescence energy-transfer measurements on cell-surfaces - a critical comparison of steady-state fluorimetric and flow cytometric methods. Cytometry 5:210.
32. Tron, L., Szollosi, J., Damjanovich, S., Helliwell, S. H., Arndtjovin, D. J. and Jovin, T. M. 1984. Flow cytometric measurement of fluorescence resonance energy-transfer on cell-surfaces-quantitative-evaluation of the transfer efficiency on a cell-by-cell basis. Biophys. J. 45:939.
33. Dale, R. E., Eisinger, J. and Blumberg, W. E. 1979. The orientational freedom of molecular probes. The orientation factor in intramolecular energy transfer. Biophys. J. 26:161.
34. Peterson, E. J., Clements, J. L., Fang, N. and Koretzky, G. A. 1998. Adaptor proteins in lymphocyte antigen-receptor signaling, Curr. Opin. Immunol. 10:337.
35. Rudd, C. E. 1999. Adaptors and molecular scaffolds in immune cell signaling. Cell 96:5.
36. Van Oers, N. S. C., Killeen, N. and Weiss, A. 1996. Lck regulates the tyrosine phosphorylation of the T-cell receptor subunits and ZAP-70 in murine thymocytes. J. Exp. Med. 183:1053.
37. Zhang, W. G., SloanLancaster, J., Kitchen, J., Trible, R. P. and Samelson, L. E. 1998. LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell 92:83.
38. Koretzky, G. A., Picus, J., Schultz, T. and Weiss, A. 1991. Tyrosine phosphatase CD45 is required for T-cell antigen receptor and CD2-mediated activation of a protein tyrosine kinase and interleukin-2 production. Proc. Natl Acad. Sci. USA 88:2037.
39. Wegener, A. M. K., Letourneur, F., Hoeveler, A., Brocker, T., Luton, F. and Malissen, B. 1992. The T-cell receptor/CD3 complex is composed of at least 2 autonomous transduction modules. Cell 68:83.
40. Codias, E. K., Fleming, T. J., Zacharchuk, C. M., Ashwell, J. D. and Malek, T. R. 1992. Role of Ly-6a/E and T-cell receptor-zeta for IL-2 production phosphatidylinositol-anchored Ly-6a/E antagonizes T-cell receptor-mediated IL-2 production by a zeta-independent pathway. J. Immunol. 149:1825.
41. Tosello, A., Mary, F., Amiot, M., Bernard, A. and Mary, D. 1998. Activation of T cells via CD55: recruitment of early components of the CD3-TCR pathway is required for IL-2 secretion. J. Inflamm. 48:13.
42. Korty, P. E., Brando, C. and Shevach, E. M. 1991. CD59 functions as a signal-transducing molecule for human T-cell activation. J. Immunol. 146:4092.
43. Pingel, J. T. and Thomas, M. L. 1989. Evidence that the leukocyte-common antigen is required for antigen-induced lymphocyte-T proliferation. Cell 58:1055.
44. Koretzky, G. A., Picus, J., Thomas, M. L. and Weiss, A. 1990. Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway. Nature 346:66.
45. Shiroo, M., Goff, L., Biffen, M., Shivnan, E. and Alexander, D. 1992. CD45-tyrosine phosphatase-activated p59fyn couples the T-cell antigen receptor to pathways of diacylglycerol production, protein-kinase-C activation and calcium influx. EMBO J. 11:4887.
46. Byth, K. F., Conroy, L. A., Howlett, S., Smith, A. J. H., May, J., Alexander, D. R. and Holmes, N. 1996. CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4(+)CD8(+) thymocytes, and in B-cell maturation. J. Exp. Med. 183:1707.
47. Ostergaard, H. L., Shackelford, D. A., Hurley, T. R., Johnson, P., Hyman, R., Setton, B. M. and Trowbridge, I. S. 1989. Expression of CD45 alters phosphorylation of the Lck-encoded tyrosine protein-kinase in murine lymphoma T-cell lines. Proc. Natl Acad. Sci. USA 86:8959.
48. McFarland, E. D. C., Hurley, T. R., Pingel, J. T., Sefton, B. M., Shaw, A. and Thomas, M. L. 1993. Correlation between Src family member regulation by the protein-tyrosine-phosphatase CD45 and transmembrane signaling through the T-cell receptor. Proc. Natl Acad Sci. USA 90:1402.
49. Vanoers, N. S. C., Killeen, N. and Weiss, A. 1996. Lck regulates the tyrosine phosphorylation of the T-cell subunits and Zap-70 in murine thymocytes. J. Exp. Med. 183:1053.
50. Sieh, M., Bolen, J. B. and Weiss, A. 1993. CD45 specifically modulates binding of Lck to a phosphopeptide encompassing the negative regulatory tyrosine of Lck. EMBO J. 12:315.
51. Morgan, B. P., Vandenberg, C. W., Davies, E. V., Hallett, M. B. and Horejsi, V. 1993. Cross-linking of CD59 and of other glycosyl phosphatidylinositol-anchored molecules on neutrophils triggers cell activation via tyrosine kinase Eur. J. Immunol. 23:2841.
52. Berridge, M. J. 1993. Inositol trisphosphate and calcium signaling. Nature 361:315.
53. Finco, T. S., Kadlecek, T., Zhang, W., Samelson, L. E. and Weiss, A. 1998. LAT is required for TCR-mediated activation of PLCγ1 and the ras pathway. Immunity 9: 617.
54. Xavier, R., Brennan, T., Li, Q., McCormack, C. and Seed, B. 1998. Membrane compartmentation is required for efficient T cell activation. Immunity 8:723.
55. Hooper, N. M. 1998. Do glycolipid microdomains really exist? Curr Biol. 8:R114.
56. Ami, S., Ilangumaran, S., Vanechtendeckert, G., Sandhoff, K., Poincelet, M., Briol, A., Runggerbrandle, E. and Hoessli, D. C. 1996. Differential regulation of Src-family protein-tyrosine kinases in GPI domains of T-lymphocyte plasma-membranes. Biochem. Biophys. Res. Commun. 225:801.
57. Parolini, I., Sargiacomo, M., Lisanti, M. P. and Peschle, C. 1996. Signal-transduction and glycophosphatidylinositol-linked proteins (Lyn, Lck, CD4, CD45, G-Proteins, and CD55) selectively localize in Triton-insoluble plasma-membrane domains of human leukemic-cell lines and normal granulocytes. Blood 87:3783.
58. Rodgers, W. and Rose, J. K. 1996. Exclusion of CD45 inhibits activity of p56(lck) associated with glycolipid-enriched membrane domains. J. Cell. Biol. 135:1515.
59. Robinson, P. J., Millrain, M., Antoniou, J., Simpson, E. and Mellor, A. L. 1989. A glycophospholipid anchor is required for Qa-2-mediated T cell activation. Nature 342:85.
60. Sloan-Lancaster, J., Steinberg, T. H. and Allen, P. M. 1996. Selective activation of the calcium signaling pathway by altered peptide ligands. J. Exp. Med. 184:1525.