Species, strain, and gender issues in the development and validation of animal models of dementia

Neuromethods

Volumn 48, Issue , 2011, Pages 53-75

  Van Dijck, Annemie ^a   Van Dam, Debby ^a   De Deyn, Peter Paul ^a  

^a NONE

Author keywords

behavior; breeding; cognition; Gene homology; housing; neuropathology

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN E; COMPLEMENTARY DNA; PRESENILIN 1; PRESENILIN 2; TAU PROTEIN;

AGGRESSION; ALZHEIMER DISEASE; ANIMAL BEHAVIOR; ANIMAL HOUSING; ARTICLE; BRAIN BLOOD VESSEL; BREEDING; CAENORHABDITIS ELEGANS; COGNITION; DISEASE MODEL; DROSOPHILA MELANOGASTER; ESTRUS CYCLE; EXPERIMENTAL ANIMAL; HUMAN; IMMUNOLOGY; MOTOR DYSFUNCTION; MOUSE STRAIN; NEUROPATHOLOGY; NONHUMAN; PERCEPTION DISORDER; PRIORITY JOURNAL; RESEARCH ETHICS; SEQUENCE HOMOLOGY; SEX DIFFERENCE; SEXUAL BEHAVIOR; SPECIES DIFFERENCE; STRAIN DIFFERENCE; TRANSGENIC ANIMAL; VALIDATION STUDY; VISUAL ACUITY; ZEBRA FISH;

ANIMALIA; CAENORHABDITIS ELEGANS; CANIS FAMILIARIS; DANIO RERIO; DROSOPHILA MELANOGASTER; MUS; MUS MUSCULUS; PRIMATES; RATTUS;

EID: 78650933535     PISSN: 08932336     EISSN: 19406045     Source Type: Book Series    
DOI: 10.1007/978-1-60761-898-0_4     Document Type: Article

References (149)

1. Braunmühl A (1956) Kongophile angiopathie und Senile Plaques bei greisen hunden. Arch Psychiatr Nervenkr 194:395-414
2. Cummings BJ, Su JH, Cotman CW, White R, Russell MJ (1993) Beta-amyloid accumulation in aged canine brain: a model of early plaque formation in Alzheimer's disease. Neurobiol Aging 14(6):547-560
3. Cummings BJ, Head E, Afagh AJ, Milgram NW, Cotman CW (1996) Beta-amyloid accumulation correlates with cognitive dysfunction in the aged canine. Neurobiol Learn Mem 66(1):11-23
4. Colle M-A, Hauw J-J, Crespeau Fet al(2000) Vascular and parenchymal Abeta deposition in the aging dog: Correlation with behavior. Neurobiol Aging 21(5):695-704
5. Pugliese M, Geloso MC, Carrasco JL, Mascort J, Michetti F, Mahy N (2006) Canine cognitive defcit correlates with diffuse plaque maturation and S100beta (-) astrocytosis but not with insulin cerebrospinal fuid level. Acta Neuropathol 111(6):519-528
6. Rofna JE, van Ederen AM, Toussaint MJ, et al. (2006) Cognitive disturbances in old dogs suffering from the canine counterpart of Alzheimer's disease. Brain Res 1069(1):216-226
7. Gunn-Moore DA, McVee J, Bradshaw JM, Pearson GR, Head E, Gunn-Moore FJ (2006) Ageing changes in cat brains demonstrated by beta-amyloid and AT8-immunoreactive phos-phorylated tau deposits. J Feline Med Surg 8(4):234-242
8. Lane MA (2000) Nonhuman primate models in biogerontology. Exp Gerontol 35(5):533-541
9. Kimura N, Tanemura K, Nakamura S, et al. (2003) Age-related changes of Alzheimer's disease-associated proteins in cynomolgus monkey brains. Biochem Biophys Res Commun 310(2):303-311
10. Sloane JA, Pietropaolo MF, Rosene DL, et al. (1997) Lack of correlation between plaque burden and cognition in the aged monkey. Acta Neuropathol 94(5):471-478
11. Gearing M, Rebeck GW, Hyman BT, Tigges J, Mirra SS (1994) Neuropathology and apo-lipoprotein E profle of aged chimpanzees: Implications for Alzheimer disease. Proc Natl Acad Sci U S A 91(20):9382-9386
12. Geula C, Nagykery N, Wu CK (2002) Amyloid-beta deposits in the cerebral cortex of the aged common marmoset (Callithrix jacchus): Incidence and chemical composition. Acta Neuropathol 103(1):48-58
13. Lemere CA, Beierschmitt A, Iglesias M, et al. (2004) Alzheimer's disease abeta vaccine reduces central nervous system abeta levels in a non-human primate, the Caribbean vervet. Am J Pathol 165(1):283-297
14. Bons N, Mestre N, Ritchie K, Petter A, Podlisny M, Selkoe D (1994) Identification of amyloid beta protein in the brain of the small, short-lived lemurian primate Microcebus murinus. Neurobiol Aging 15(2):215-220
15. Gearing M, Tigges J, Mori H, Mirra SS (1997) beta-Amyloid (A beta) deposition in the brains of aged orangutans. Neurobiol Aging 18(2):139-146
16. Lemere CA, Oh J, Stanish HA, et al. (2008) Cerebral amyloid-beta protein accumulation with aging in cotton-top tamarins: A model of early Alzheimer's disease? Rejuvenation Res 11(2):321-332
17. Rosen RF, Farberg AS, Gearing M, et al. (2008) Tauopathy with paired helical fla-ments in an aged chimpanzee. J Comp Neurol 509(3): 259-270
18. Bons N, Rieger F, Prudhomme D, Fisher A, Krause KH (2006) Microcebus murinus: A useful primate model for human cerebral aging and Alzheimer's disease? Genes Brain Behav 5(2):120-130
19. Cork LC, Powers RE, Selkoe DJ, Davies P, Geyer JJ, Price DL (1988) Neurofbrillary tangles and senile plaques in aged bears. J Neuropathol Exp Neurol 47(6):629-641
20. Tekirian TL, Cole GM, Russell MJ, et al. (1996) Carboxy terminal of beta-amyloid deposits in aged human, canine, and polar bear brains. Neurobiol Aging 17(2):249-257
21. Roertgen KE, Parisi JE, Clark HB, Barnes DL, O'Brien TD, Johnson KH (1996) A beta-associated cerebral angiopathy and senile plaques with neurofbrillary tangles and cerebral hemorrhage in an aged wolverine (Gulo gulo). Neurobiol Aging 17(2):243-247
22. Sherman KA, Friedman E (1990) Pre- and post-synaptic cholinergic dysfunction in aged rodent brain regions: New fndings and an interpretative review. Int J Dev Neurosci 8(6): 689-708
23. Takeda T, Hosokawa M, Higuchi K (1997) Senescence-accelerated mouse (SAM): A novel murine model of senescence. Exp Gerontol 32(1-2):105-109
24. Pallas M, Camins A, Smith MA, Perry G, Lee HG, Casadesus G (2008) From aging to Alzheimer's disease: Unveiling "the switch" with the senescence-accelerated mouse model (SAMP8). J Alzheimers Dis 15(4):615-624
25. Wu Y, Luo Y (2005) Transgenic C. elegans as a model in Alzheimer's research. Curr Alzheimer Res 2(1):37-45
26. The C. elegans Sequencing Consortium (1998) Genome sequence of the nematode C. elegans: a platform for investigating biology. Science 282(5396):2012-2018
27. Adams MD, Celniker SE, Holt RA, et al(2000) The genome sequence of Drosophila melano-gaster. Science 287(5461):2185-2195
28. Sang TK, Jackson GR (2005) Drosophila models of neurodegenerative disease. NeuroRx 2(3):438-446
29. Agca C, Fritz JJ, Walker LC, et al.(2008) Development of transgenic rats producing human beta-amyloid precursor protein as a model for Alzheimer's disease: Transgene and endogenous APP genes are regulated tissue-specifically. BMC Neurosci 9:28
30. Filipiak WE, Saunders TL (2006) Advances in transgenic rat production. Transgenic Res 15(6):673-686
31. Flood DG, Lin YG, Lang DM, et al. (2007) A transgenic rat model of Alzheimer's disease with extracellular Abeta deposition. Neurobiol Aging 30:1078-1090
32. Ruiz-Opazo N, Kosik KS, Lopez LV, Bagamasbad P, Ponce LR, Herrera VL (2004) Attenuated hippocampus-dependent learning and memory decline in transgenic TgAPPswe Fischer-344 rats. Mol Med 10(1-6):36-44
33. Herrera VL, Ponce LR, Ruiz-Opazo N (2007) Genome-wide scan for interacting loci affecting human cholesteryl ester transfer protein-induced hypercholesterolemia in transgenic human cho-lesteryl ester transfer protein F2-intercross rats. J Hypertens 25(8):1608-1612
34. Hendrickx AG, Dukelow WR (1995) Reproductive biology. In: Bennett BT, Christian RA, Roy H (eds) Nonhuman primates in biomedical research. Academic, San Diego, CA, pp 147-191
35. Havenaar R, Ritskes-Hoitinga J, Meijer J, Zwart P (1991) Biologie en zootechniek. In: Van Zutphen L, Baumans V, Beyen A (eds) Proefdieren en dierproeven. Wetenschappelijke Uitgeverij Bunge, Utrecht, The Netherlands, pp 20-74
36. Whitten WK, Bronson FH, Greenstein JA (1968) Estrus-inducing pheromone of male mice: Transport by movement of air. Science 161(841):584-585
37. Bruce HM (1959) An exteroceptive block to pregnancy in the mouse. Nature 184:105
38. Crawley J (2000) What's wrong with my mouse? Behavioral phenotyping of transgenic and knockout mice, 1st edn. Wiley-Liss, Wilmington, DE
39. Lohmiller JJ, Swing SP (2006) Reproduction and breeding. In: Mark AS, Steven HW, Craig LF (eds) The laboratory rat, 2nd edn. Academic, Burlington, MA, pp 147-164
40. Hau J, Van Hoosier GL (2003) Handbook of laboratory animal science, essential principles and practices, 2nd edn. CRC Press, Boca Raton, FL
41. Corsi AK (2006) A biochemist's guide to Caenorhabditis elegans. Anal Biochem 359(1):1-17
42. Ashburner M, Thompson JJ (1978) The laboratory culture of Drosophila. In: Ashburner M, Wright T (eds) The genetics and biology of Drosophila. Academic, London, pp 1-81
43. Ashburner M, Golic K, Hawley R (2005). Drosophila: A laboratory Hhndbook, 2nd edn. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
44. Goldgaber D, Lerman MI, McBride OW, Saffotti U, Gajdusek DC (1987) Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease. Science 235(4791):877-880
45. Kang J, Lemaire HG, Unterbeck A, et al. (1987) The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 325(6106):733-736
46. Robakis NK, Ramakrishna N, Wolfe G, Wisniewski HM (1987) Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides. Proc Natl Acad Sci U S A 84(12):4190-4194
47. Rosen DR, Martin-Morris L, Luo LQ, White K (1989) A Drosophila gene encoding a protein resembling the human beta-amyloid protein precursor. Proc Natl Acad Sci U S A 86(7): 2478-2482
48. Daigle I, Li C (1993) apl-1, a Caenorhabditis elegans gene encoding a protein related to the human beta-amyloid protein precursor. Proc Natl Acad Sci U S A 90(24):12045-12049
49. Johnstone EM, Chaney MO, Norris FH, Pascual R, Little SP (1991) Conservation of the sequence of the Alzheimer's disease amyloid peptide in dog, polar bear and fve other mammals by cross-species polymerase chain reaction analysis. Brain Res Mol Brain Res 10(4):299-305
50. Coulson EJ, Paliga K, Beyreuther K, Masters CL (2000) What the evolution of the amyloid protein precursor supergene family tells us about its function. Neurochem Int 36(3):175-184
51. Luo L, Tully T, White K (1992) Human amyloid precursor protein ameliorates behavioral defcit of fies deleted for Appl gene. Neuron 9(4): 595-605
52. Musa A, Lehrach H, Russo VA (2001) Distinct expression patterns of two zebrafish homo-logues of the human APP gene during embryonic development. Dev Genes Evol 211(11): 563-567
53. Levitan D, Greenwald I (1995) Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene. Nature 377(6547):351-354
54. Li X, Greenwald I (1997) HOP-1, a Caenorhab-ditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling. Proc Natl Acad Sci U S A 94(22):12204-12209
55. Arduengo PM, Appleberry OK, Chuang P, L'Hernault SW (1998) The presenilin protein family member SPE-4 localizes to an ER/Golgi derived organelle and is required for proper cytoplasmic partitioning during Caenorhabditis elegans spermatogenesis. J Cell Sci 111 (Pt 24):3645-3654
56. Baumeister R, Leimer U, Zweckbronner I, Jakubek C, Grunberg J, Haass C (1997) Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing. Genes Funct 1(2):149-159
57. Levitan D, Doyle TG, Brousseau D, et al.(1996) Assessment of normal and mutant human pre-senilin function in Caenorhabditis elegans. Proc Natl Acad Sci U S A 93(25): 14940-14944
58. L'Hernault SW, Arduengo PM (1992) Mutation of a putative sperm membrane protein in Caenorhabditis elegans prevents sperm differentiation but not its associated meiotic divisions. J Cell Biol 119(1):55-68
59. Gosney R, Liau WS, Lamunyon CW (2008) A novel function for the presenilin family member spe-4: Inhibition of spermatid activation in Caenorhabditis elegans. BMC Dev Bio 18:44
60. Leimer U, Lun K, Romig H, et al. (1999) Zebrafish (Danio rerio) presenilin promotes aberrant amyloid beta-peptide production and requires a critical aspartate residue for its function in amyloidogenesis. Biochemistry 38(41):13602-13609
61. Groth C, Nornes S, McCarty R, Tamme R, Lardelli M (2002) Identification of a second presenilin gene in zebrafish with similarity to the human Alzheimer's disease gene preseni-lin2. Dev Genes Evol 212(10):486-490
62. Rall SC, Jr., Weisgraber KH, Mahley RW (1982) Human apolipoprotein E. The complete amino acid sequence. J Biol Chem 257(8):4171-4178
63. Hixson JE, Cox LA, Borenstein S (1988) The baboon apolipoprotein E gene: Structure, expression, and linkage with the gene for apo-lipoprotein C-1. Genomics 2(4):315-323
64. Marotti KR, Whitted BE, Castle CK, Polites HG, Melchior GW (1989) Nucleotide sequence of the cynomolgus monkey apolipoprotein E cDNA. Nucleic Acids Res 17(4):1778
65. McLean JW, Fukazawa C, Taylor JM (1983) Rat apolipoprotein E mRNA. Cloning and sequencing of double-stranded cDNA. J Biol Chem 258(14):8993-9000
66. Rajavashisth TB, Kaptein JS, Reue KL, Lusis AJ (1985) Evolution of apolipoprotein E: Mouse sequence and evidence for an 11-nucle-otide ancestral unit. Proc Natl Acad Sci U S A 82(23):8085-8089
67. Matsushima T, Getz GS, Meredith SC (1990) Primary structure of guinea pig apolipopro-tein E. Nucleic Acids Res 18(1):202
68. Lee BR, Miller JM, Yang CY, et al. (1991) Amino acid sequence of rabbit apolipoprotein E. J Lipid Res 32(1):165-171
69. Yang YW, Chan L, Li WH (1991) Cloning and sequencing of bovine apolipoprotein E complementary DNA and molecular evolution of apolipoproteins E, C-I, and C-II. J Mol Evol 32(6):469-475
70. Luo CC, Li WH, Chan L (1989) Structure and expression of dog apolipoprotein A-I, E, and C-I mRNAs: Implications for the evolution and functional constraints of apo-lipoprotein structure. J Lipid Res 30(11): 1735-1746
71. Davis RW, Pierotti VR, Lauer SJ, et al. (1991) Lipoproteins in pinnipeds: Analysis of a high molecular weight form of apolipoprotein E. J Lipid Res 32(6):1013-1023
72. Weisgraber KH (1994) Apolipoprotein E: Structure-function relationships. Adv Protein Chem 45:249-302
73. Mahley RW, Rall SC, Jr (1999) Is epsilon4 the ancestral human apoE allele? Neurobiol Aging 20(4):429-430
74. Finch CE, Sapolsky RM (1999) The evolution of Alzheimer disease, the reproductive schedule, and apoE isoforms. Neurobiol Aging 20(4):407-428
75. Raber J, Huang Y, Ashford JW (2004) ApoE genotype accounts for the vast majority of AD risk and AD pathology. Neurobiol Aging 25(5):641-650
76. Eichner JE, Dunn ST, Perveen G, Thompson DM, Stewart KE, Stroehla BC (2002) Apolipoprotein E polymorphism and cardiovascular disease: A HuGE review. Am J Epidemiol 155(6):487-495
77. Link CD (2005). Invertebrate models of Alzheimer's disease. Genes Brain Behav 4(3): 147-156
78. Iqbal K, Alonso AC, Chen S, et al. (2005) Tau pathology in Alzheimer disease and other tauopathies. Biochim Biophys Acta 1739(2-3): 198-210
79. Heidary G, Fortini ME (2001) Identification and characterization of the Drosophila tau homolog. Mech Dev 108(1-2):171-178
80. Doerfinger H, Benton R, Shulman JM, St JD (2003) The role of PAR-1 in regulating the polarised microtubule cytoskeleton in the Drosophila follicular epithelium. Development 130(17):3965-3975
81. Goedert M, Baur CP, Ahringer J, et al. (1996) PTL-1, a microtubule-associated protein with tau-like repeats from the nematode Caenor-habditis elegans. J Cell Sci 109 (Pt 11): 2661-2672
82. Olesen OF, Kawabata-Fukui H, Yoshizato K, Noro N (2002) Molecular cloning of XTP, a tau-like microtubule-associated protein from Xenopus laevis tadpoles. Gene 283(1-2): 299-309
83. Lee G, Cowan N, Kirschner M (1988) The primary structure and heterogeneity of tau protein from mouse brain. Science 239(4837): 285-288
84. Lehman EJ, Kulnane LS, Gao Y, et al. (2003) Genetic background regulates beta-amyloid precursor protein processing and beta-amyloid deposition in the mouse. Hum Mol Genet 12(22):2949-2956
85. Ryman D, Gao Y, Lamb BT (2008) Genetic loci modulating amyloid-beta levels in a mouse model of Alzheimer's disease. Neurobiol Aging 29(8):1190-1198
86. Carlson GA, Borchelt DR, Dake A, et al. (1997) Genetic modification of the pheno-types produced by amyloid precursor protein overexpression in transgenic mice. Hum Mol Genet 6(11):1951-1959
87. Chishti MA, Yang DS, Janus C, et al. (2001) Early-onset amyloid deposition and cognitive defcits in transgenic mice expressing a double mutant form of amyloid precursor protein 695. J Biol Chem 276(24):21562-21570
88. Ali SM, Siedlak SL, Gonzalez-DeWhitt PA, et al. (1996) Artifactual strain-specific signs of incipient brain amyloidosis in APP transgenic mice. Neurobiol Aging 17(2):223-234
89. Brich J, Shie FS, Howell BW, et al. (2003) Genetic modulation of tau phosphorylation in the mouse. J Neurosci 23(1):187-192
90. Crawley JN, Belknap JK, Collins A, et al. (1997) Behavioral phenotypes of inbred mouse strains: Implications and recommendations for molecular studies. Psychopharma cology (Berl) 132(2):107-124
91. Brown RE, Wong AA (2007) The infuence of visual ability on learning and memory performance in 13 strains of mice. Learn Mem 14(3):134-144
92. Johnson KR, Zheng QY, Noben-Trauth K (2006) Strain background effects and genetic modifers of hearing in mice. Brain Res 1091(1):79-88
93. Johnson KR, Zheng QY, Erway LC (2000) A major gene affecting age-related hearing loss is common to at least ten inbred strains of mice. Genomics 70(2):171-180
94. Zheng QY, Johnson KR (2001) Hearing loss associated with the modifer of deaf waddler (mdfw) locus corresponds with age-related hearing loss in 12 inbred strains of mice. Hear Res 154(1-2):45-53
95. D'Hooge R, De Deyn PP (2001) Applications of the Morris water maze in the study of learning and memory. Brain Res Brain Res Rev 36(1):60-90
96. Owen EH, Logue SF, Rasmussen DL, Wehner JM (1997) Assessment of learning by the Morris water task and fear conditioning in inbred mouse strains and F1 hybrids: Implications of genetic background for single gene mutations and quantitative trait loci analyses. Neuroscience 80(4):1087-1099
97. Upchurch M, Wehner JM (1989) Inheritance of spatial learning ability in inbred mice: A classical genetic analysis. Behav Neurosci 103(6):1251-1258
98. Holmes A, Wrenn CC, Harris AP, Thayer KE, Crawley JN (2002) Behavioral profles of inbred strains on novel olfactory, spatial and emotional tests for reference memory in mice. Genes Brain Behav 1(1):55-69
99. Ammassari-Teule M, Hoffmann HJ, Rossi-Arnaud C (1993) Learning in inbred mice: Strain-specific abilities across three radial maze problems. Behav Genet 23(4):405-412
100. Chapillon P, Roullet P, Lassalle JM (1995) Ontogeny of orientation and spatial learning on the radial maze in mice. Dev Psychobiol 28(8):429-442
101. Brooks SP, Pask T, Jones L, Dunnett SB (2005) Behavioural profles of inbred mouse strains used as transgenic backgrounds. II: Cognitive tests. Genes Brain Behav 4(5):307-317
102. Balogh SA, Wehner JM (2003) Inbred mouse strain differences in the establishment of long-term fear memory. Behav Brain Res 140(1-2):97-106
103. Baron SP, Meltzer LT (2001) Mouse strains differ under a simple schedule of operant learning. Behav Brain Res 118(2):143-152
104. Brennan FX (2004) Genetic differences in leverpress escape/avoidance conditioning in seven mouse strains. Genes Brain Behav 3(2):110-114
105. Sik A, van NP, Prickaerts J, Blokland A (2003) Performance of different mouse strains in an object recognition task. Behav Brain Res 147(1-2):49-54
106. Hall CS (1934) Emotional behavior in the rat. I. Defecation and urination as measures of individual differences in emotionality. J Comp Psychol 18:385-403
107. Hall CS (1936) Emotional behavior in the rat. III. The relationship between emotionality and ambulatory activity. J Comp Psychol 22:345-352
108. Walsh RN, Cummins RA (1976) The open-feld test: A critical review. Psychol Bull 83(3):482-504
109. Guillot PV, Chapouthier G (1996) Intermale aggression and dark/light preference in ten inbred mouse strains. Behav Brain Res 77(1-2):211-213
110. Jones SE, Brain PF (1987) Performances of inbred and outbred laboratory mice in putative tests of aggression. Behav Genet 17(1):87-96
111. Kulikov AV, Osipova DV, Naumenko VS, Popova NK (2005) Association between Tph2 gene polymorphism, brain tryptophan hydrox-ylase activity and aggressiveness in mouse strains. Genes Brain Behav 4(8):482-485
112. Guillot PV, Roubertoux PL, Crusio WE (1994) Hippocampal mossy fber distributions and intermale aggression in seven inbred mouse strains. Brain Res 660(1): 167-169
113. Miczek KA, Maxson SC, Fish EW, Faccidomo S (2001) Aggressive behavioral phenotypes in mice. Behav Brain Res 125(1-2):167-181
114. Vitiello MV, Bliwise DL, Prinz PN (1992) Sleep in Alzheimer's disease and the sundown syndrome. Neurology 42(7 Suppl 6): 83-93
115. Vloeberghs E, Van Dam D, Engelborghs S, Nagels G, Staufenbiel M, De Deyn PP (2004) Altered circadian locomotor activity in APP23 mice: A model for BPSD disturbances. Eur J Neurosci 20(10):2757-2766
116. Tankersley CG, Irizarry R, Flanders S, Rabold R (2002) Circadian rhythm variation in activity, body temperature, and heart rate between C3H/HeJ and C57BL/6J inbred strains. J Appl Physiol 92(2):870-877
117. Lewy AJ (2007) Melatonin and human chro-nobiology. Cold Spring Harb Symp Quant Biol 72:623-636
118. Vivien-Roels B, Malan A, Rettori MC, Delagrange P, Jeanniot JP, Pevet P (1998) Daily variations in pineal melatonin concentrations in inbred and outbred mice. J Biol Rhythms 13(5):403-409
119. Carlier M, Roubertoux P, Cohen-Salmon C (1982) Differences in patterns of pup care in Mus musculus domesticus l-Comparisons between eleven inbred strains. Behav Neural Biol 35(2):205-210
120. Spooner ET, Desai RV, Mori C, Leverone JF, Lemere CA (2002) The generation and characterization of potentially therapeutic Abeta antibodies in mice: differences according to strain and immunization protocol. Vaccine 21(3-4):290-297
121. Seabrook TJ, Iglesias M, Bloom JK, Spooner ET, Lemere CA (2004) Differences in the immune response to long term Abeta vaccination in C57BL/6 and B6D2F1 mice. Vaccine 22(29-30):4075-4083
122. Beckmann N (2000) High resolution magnetic resonance angiography non-invasively reveals mouse strain differences in the cere-brovascular anatomy in vivo. Magn Reson Med 44(2):252-258
123. Yang G, Kitagawa K, Matsushita K, et al. (1997) C57BL/6 strain is most susceptible to cerebral ischemia following bilateral common carotid occlusion among seven mouse strains: Selective neuronal death in the murine transient forebrain ischemia. Brain Res 752(1-2): 209-218
124. Majid A, He YY, Gidday JM, et al. (2000) Differences in vulnerability to permanent focal cerebral ischemia among 3 common mouse strains. Stroke 31(11):2707-2714
125. Wellons JC, III, Sheng H, Laskowitz DT, Burkhard MG, Pearlstein RD, Warner DS (2000) A comparison of strain-related susceptibility in two murine recovery models of global cerebral ischemia. Brain Res 868(1): 14-21
126. Barone FC, Knudsen DJ, Nelson AH, Feuerstein GZ, Willette RN (1993) Mouse strain differences in susceptibility to cerebral ischemia are related to cerebral vascular anatomy. J Cereb Blood Flow Metab 13(4): 683-692
127. Grubb SC, Churchill GA, Bogue MA (2004) A collaborative database of inbred mouse strain characteristics. Bioinformatics 20(16): 2857-2859
128. Godfroid IO (1999) Sex differences relating to psychiatric treatment. Can J Psychiatry 44(4):362-367
129. Brookmeyer R, Gray S, Kawas C (1998) Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset. Am J Public Health 88(9):1337-1342
130. Hy LX, Keller DM (2000) Prevalence of AD among whites: A summary by levels of severity. Neurology 55(2):198-204
131. Kopp C, Ressel V, Wigger E, Tobler I (2006) Infuence of estrus cycle and ageing on activity patterns in two inbred mouse strains. Behav Brain Res 167(1):165-174
132. Palanza P, Gioiosa L, Parmigiani S (2001) Social stress in mice: Gender differences and effects of estrous cycle and social dominance. Physiol Behav 73(3):411-420
133. Voikar V, Koks S, Vasar E, Rauvala H (2001) Strain and gender differences in the behavior of mouse lines commonly used in transgenic studies. Physiol Behav 72(1-2):271-281
134. Tarantino LM, Gould TJ, Druhan JP, Bucan M (2000) Behavior and mutagenesis screens: The importance of baseline analysis of inbred strains. Mamm Genome 11(7):555-564
135. Ogawa S, Makino J (1984) Aggressive behavior in inbred strains of mice during pregnancy. Behav Neural Biol 40(2):195-204
136. Jonasson Z (2005) Meta-analysis of sex differences in rodent models of learning and memory: a review of behavioral and biological data. Neurosci Biobehav Rev 28(8): 811-825
137. Benice TS, Rizk A, Kohama S, Pfankuch T, Raber J (2006) Sex-differences in age-related cognitive decline in C57BL/6J mice associated with increased brain microtubule-associated protein 2 and synaptophysin immunoreactivity. Neuroscience 137(2):413-423
138. Gresack JE, Frick KM (2003) Male mice exhibit better spatial working and reference memory than females in a water-escape radial arm maze task. Brain Res 982(1):98-107
139. LaBuda CJ, Mellgren RL, Hale RL (2002) Sex differences in the acquisition of a radial maze task in the CD-1 mouse. Physiol Behav 76(2):213-217
140. Mihalick SM, Langlois JC, Krienke JD (2000) Strain and sex differences on olfactory discrimination learning in C57BL/6J and DBA/2J inbred mice (Mus musculus). J Comp Psychol 114(4):365-370
141. Callahan MJ, Lipinski WJ, Bian F, Durham RA, Pack A, Walker LC (2001) Augmented senile plaque load in aged female beta-amyloid precursor protein-transgenic mice. Am J Pathol 158(3):1173-1177
142. Sturchler-Pierrat C, Staufenbiel M (2000) Pathogenic mechanisms of Alzheimer's disease analyzed in the APP23 transgenic mouse model. Ann N Y Acad Sci 920:134-139
143. Lewis J, Dickson DW, Lin WL et al. (2001) Enhanced neurofbrillary degeneration in transgenic mice expressing mutant tau and APP. Science 293(5534):1487-1491
144. Wang J, Tanila H, Puolivali J, Kadish I, van GT (2003) Gender differences in the amount and deposition of amyloidbeta in APPswe and PS1 double transgenic mice. Neurobiol Dis 14(3):318-327
145. Hirata-Fukae C, Li HF, Hoe HS et al. (2008) Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer trans-genic model. Brain Res 1216:92-103
146. Gandy S, Duff K(2000) Post-menopausal estrogen deprivation and Alzheimer's disease. Exp Gerontol 35(4):503-511
147. Zheng H, Xu H, Uljon SN et al. (2002) Modulation of A(beta) peptides by estrogen in mouse models. J Neurochem 80(1): 191-196
148. Carroll JC, Rosario ER, Chang L et al. (2007) Progesterone and estrogen regulate Alzheimer-like neuropathology in female 3xTg-AD mice. J Neurosci 27(48): 13357-13365
149. Green PS, Bales K, Paul S, Bu G (2005) Estrogen therapy fails to alter amyloid deposition in the PDAPP model of Alzheimer's disease. Endocrinology 146(6): 2774-2781