Genetic modification of the phenotypes produced by amyloid precursor protein overexpression in transgenic mice

Human Molecular Genetics

Volumn 6, Issue 11, 1997, Pages 1951-1959

  Carlson, George A ^a   Borchelt, David R ^b   Dake, Angela ^a,e   Turner, Sherry ^a   Danielson, Valerie ^a,f   Coffin, J Douglas ^a   Eckman, Chris ^c   Meiners, James ^d   Nilsen, Steven P ^d   Younkin, Steven G ^c   Hsiao, Karen K ^d  

^a MCLAUGHLIN RESEARCH INSTITUTE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MAYO CLINIC   (United States)

^d UNIVERSITY OF MINNESOTA   (United States)

^e UNIVERSITY OF MONTANA   (United States)

^f BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; FIBROBLAST GROWTH FACTOR 2; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GENETICS; LETHAL GENE; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENE; TRANSGENIC MOUSE;

ALLELES; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; APOLIPOPROTEINS E; FIBROBLAST GROWTH FACTOR 2; GENE DELETION; GENE EXPRESSION; GENES, LETHAL; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, TRANSGENIC; PHENOTYPE; PROTEIN PROCESSING, POST-TRANSLATIONAL; SUPEROXIDE DISMUTASE;

EID: 9844255568     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/6.11.1951     Document Type: Article

References (43)

1. Jarrelt, J.T., Berger, E.P. and Lansbury, P.T., Jr (1993) The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease. Biochemistry, 32, 4693-4697.
2. Gravina, S.A., Ho, L., Eckman, C.B., Long, K.E., Otvos, L., Younkin, L.H., Suzuki, N. and Younkin, S.G. (1995) Amyloid beta protein (Aβ) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at Aβ40 or Aβ42(43). J.Biol. Chem., 270, 7013-7016.
3. Roher, A. et al. (1993) Structural alterations in the peptide backbone of β-amyloid core protein may account for its deposition and stability in Alzheimer's disease. J. Biol. Chem., 268, 3072-3083.
4. Vigo-Pelfrey, C., Lee, D., Keim, P., Lieberburg, I. and Schenk, D.B (1993) Characterization of β amyloid peptide from human cerebrospinal fluid. J. Neurochem., 61, 19965-19968.
5. Masters, C.L., Simms, G., Weinman, N.A., Multhaup, G., McDonald, B.L. and Beyreuther, K. (1985) Amyloid plaque core protein in Alzheimer disease and Down syndrome, Proc. Natl Acad. Sci. USA, 82, 4245-4249.
6. Goate, A., Chartier-Harlin, M.C., Mullan, M., Brown, J., Crawford, F., Fidani, L., Giuffra, L., Mant, R., Newton, P., Rooke, K., Roques, P., Talbot, C., Pericak-Vance, M., Roses, A., Williamson, R., Rossor, M., Owen, M. and Hardy, J. (1991) Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature, 349, 704-706.
7. Mullan, M., Crawford, F., Axelman, K., Houlden, H., Lilius, L., Winblad, B. and Lannfelt, L. (1992) A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of β-amyloid, Nature Genet., 1, 345-347.
8. Murrell, J., Farlow, M., Ghetti, B. and Benson, M.D. (1991) A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease. Science, 254, 97-99.
9. Chartier-Harlin, M.-C., Crawford, F., Houlden, H., Warren, A., Hughes, D., Fidani, L., Goate, A., Rossor, M., Roques, P., Hardy, J. and Mullan, M. (1991) Early-onset Alzheimer's disease caused by mutation at codon 717 of the β-amyloid precursor protein gene. Nature, 353, 844-846.
10. Hendriks, L., Van Duijn, C.M., Cras, P., Cruts, M., Hul, W.V., van Harskamp, F., Warren, A., McGinnis, M.G., Antonarakis, S.E., Martin, J.-J. et al. (1992) Presenile dementia and cerebral hemorrhage linked to a mutation in at codon 692 of the β-amyloid precursor protein gene. Nature Genet., 1, 218-221.
11. Citron, M., Oltersdorf, T., Haass, C., McConlogue, L., Hung, A.Y., Seubert, P., Vigo-Pelfrey, C., Lieberburg, I. and Selkoe, D.J. (1992) Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production. Nature, 360, 672-674.
12. Cai, X.D., Golde, T.E. and Younkin, S.G. (1993) Release of excess amyloid β protein from a mutant amyloid β protein precursor. Science, 250, 514-516.
13. 717) mutants. Science, 264, 1336-1340.
14. St.George-Hyslop, P., Haines, J., Rogaev, E., Mortilla, M., Vaula, G., Pericak-Vance, M., Foncin, J.-F., Montesi, M., Bruni, A., Sorbi, S., Rainero, I., Pinessi, L., Pollen, D., Polinsky, R., Nee, L., Kennedy, J., Macciardi, F., Rogaeva, E., Liang, Y., Alexandrova, N., Lukiw, W., Schlumpf, K., Tanzi, R., Tsuda, T., Farrer, L., Cantu, J.-M., Duara, R., Amaducci, L., Bergamini, L., Gusella, J., Roses, A. and Crapper McLachlan, D. (1992) Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14. Nature Genet., 2, 330-334.
15. Sherrington, R., Rogaev, E.I., Liang, Y., Rogaeva, E.A., Levesque, G., Ikeda, M., Chi, H., Lin, C., Li, G., Holman, K., Tsuda, T., Mar, L., Foncin, J.F., Bruni, A.C., Montesi, M.P., Sorbi, S., Rainero, I., Pinessi, L., Nee, L., Chumakov, I., Pollen, D., Brookes, A., Sanseau, P., Polinsky, R. J., Wasco, W., Da Silva, H.A.R., Haines, J.L., Pericak-Vance, M.A., Tanzi, R.E., Roses, A.D., Fraser, P.E., Rommens, J.M. and St.George-Hyslop, P.H. (1995) Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature, 375, 754-760.
16. Levy-Lahad, E., Wijsman, E.M., Nemens, E., Anderson, L., Goddard, K.A.B, Weber, J.L., Bird, T.D. and Schellenberg, G.D. (1995) A familial Alzheimer's disease locus on chromosome 1. Science, 269, 970-973.
17. Mullan, M. and Crawford, F. (1993) Genetic and molecular advances in Alzheimer's disease. Trends Neurosci., 16, 398-403.
18. Scheuner, D., Eckman, C., Jensen, M., Song, X., Citron, M., Suzuki, N., Bird, T.D., Hardy, J., Hutton, M., Kukull, W., Larson, E., Levy-Lahad, E., Viitanen, M., Peskind, E., Poorkaj, P., Schellenberg, G., Tanzi, R., Wasco, W., Lannfelt, L., Selkoe, D. and Younkin, S, (1996) Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nature Med., 2, 864-870.
19. Duff, K., Eckman, C., Zehr, C., Yu, X., Prada, C.-M., Perez-tur, J., Hutton, M., Buee, L., Harigaya, Y., Yager, D., Morgan, D., Gordon, M.N., Holcomb, L., Refolo, L., Zenk, B., Hardy, J. and Younkin, S. (1996) Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1. Nature, 383, 710-713.
20. Borchelt, D.R., Thinakaran, G., Eckman, C.B., Lee, M.K., Davenport, F., Ratovitsky, T., Prada, C.-M., Kim, G., Seekins, S., Yager, D., Slunt, H.H., Wang, R., Seeger, M., Levey, A.I., Gandy, S.E., Copeland, N.G., Jenkins, N.A., Price, S.L., Younkin, S.G. and Sisodia, S.S. (1996) Familial Alzheimer's disease-linked presenilin 1 variants elevate Aβ1-42/1-40 ratio in vitro and in vivo. Neuron, 17, 1005-1013.
21. Citron, M., Westaway, D., Xia, W., Carlson, G., Diehl, T., Levesque, G., Johnson-Wood, K., Lee, M., Seubert, P., Davis, A., Kholodenko, D., Motter, R., Perry, B., Yao, H., Strome, R., Lieberburg, I., Rommens, J., Kim, S., Schenk, D., Fraser, P., St George-Hyslop, P. and Selkoe, D.J. (1997) Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice. Nature Med., 3, 67-72.
22. Games, D., Adams, D., Alessandrini, R., Barbour, R., Berthelette, P., Blackwell, C., Carr, T., Clemens, J., Donaldson, T., Gillespie, F., Guido, T., Hagopian, S., Johnson-Wood, K., Khan, K., Lee, M., Leibowitz, P., Lieberburg, I., Little, S., Masliah, E., McConlogue, L., Montoya-Zavala, M., Mucke, L., Paganini, L., Penniman, E., Power, M., Schenk, D., Seubert, P., Snyder, B., Soriano, F., Tan, H., Vitale, J., Wadsworth, S., Wolozin, B. and Zhao, J. (1995) Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein. Nature, 373, 523-527.
23. Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F. and Cole, G. (1996) Correlative memory deficits, Ab elevation, and amyloid plaques in transgenic mice. Science, 274, 99-102.
24. Scott, M.R., Kohler, R., Foster, D. and Prusiner, S.B. (1992) Chimeric prion protein expression in cultured cells and transgenic mice. Protein Sci., 1, 986-997.
25. Hsiao, K.K., Borchelt, D.R., Olson, K., Johannsdottir, R., Kitt, C., Yunis, W., Xu, S., Eckman, C., Younkin, S., Price, D., Iadecola, C., Clark, H.B. and Carlson, G. (1995) Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins. Neuron, 15, 1203-1218.
26. Corder, E.H., Saunders, A.M., Strittmatter, W.J., Schmechel, D.E., Gaskell, P.C., Small, G.W., Roses, A.D., Haines, J.L. and Pericak-Vance, M.A. (1993) Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science, 261, 921-923.
27. Corder, E.H., Saunders, A.M., Risch, N.J., Strittmatter, W.J., Schmechel, D.E., Gaskell, P.C., Rimmler, J.B., Locke, P.A., Conneally, P.M., Schmader, K.E., Small, G.W., Roses, A.D., Haines, J.L. and Pericak-Vance, M.A. (1994) Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease. Nature Genet., 7, 180-184.
28. Roses, A.D. (1994) Apolipoprotein E affects the rate of Alzheimer disease expression: β-amyloid burden is a secondary consequence dependent on APOE genotype and duration of disease. J. Neuropathol. Exp. Neurol., 53, 429-437.
29. Wisniewski, T., Lalowski, M., Golabek, A., Vogel, T. and Frangione, B. (1995) Is Alzheimer's disease an apolipoprotein E amyloidosis? Lancet, 345, 956-958.
30. Ma, J., Yee, A., Brewer, H.B., Das, S. and Potter, H. (1994) Amyloid-assoicated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments. Nature, 372, 92-94.
31. Piedrahita, J.A., Zhang, S.H., Hagaman, J.R., Oliver, P.M. and Maeda, N. (1992) Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells. Proc. Natl Acad. Sci. USA, 89, 4471-4475.
32. Wong, P.C., Pardo, CA., Borchelt, D.R., Lee, M.K., Copeland, N.G., Jenkins, N.A., Sisodia, S.S., Cleveland, D.W. and Price, D.L. (1995) An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron, 14, 1105-1116.
33. Macmillan, V., Judge, D., Wiseman, A., Settles, D., Swain, J. and Davis, J. (1993) Mice expressing a bovine basic fibroblast growth factor transgene in the brain show increased resistance to hypoxemic-ischemic cerebral damage. Stroke, 24, 1735-1739.
34. Coffin, J.D., Florkiewicz, R.Z., Neumann, J., Mort-Hopkins, T., Dorn, G.W., Lightfoot, P., German, R., Howles, P.N., Kier, A., O'Toole, B.A., Sasse, J., Gonzalez, A.M., Baird, A. and Doetschman, T.C. (1995) Abnormal bone growth and selective translational regulation in basic fibroblast growth factor transgenic mice. Mol. Biol. Cell, 6, 1861-1873.
35. LaFerla, F.M., Tinkle, B.T., Bieberich, C.J., Haudenschild, C.C. and Jay, G. (1995) The Alzheimer's Aβ peptide induces neurodegeneration and apoptotic cell death in transgenic mice. Nature Genet., 9, 21-30.
36. Nalbantoglu, J., Tirade-Santiago, G., Lahsaïni, A., Poirer, J., Goncalves, O., Verge, G., Momoli, F., Weiner, S. A., Massicotte, G., Julien, J.-P. and Shapiro, M.L. (1997) Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein. Nature, 387, 500-505.
37. Hensley, K., Carney, J.M., Mattson, M.P., Aksenova, M., Harris, M., Wu, J.F., Floyd, R.A. and Butterfield, D.A. (1994) A model for β-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease. Proc. Natl Acad. Sci. USA, 91, 3270-3274.
38. Behl, C., Davis, J., Lesley, R. and Schubert, D. (1994) Hydrogen peroxide mediates amyloid β protein toxicity. Cell, 77, 817-827.
39. Miyata, M. and Smith, J.D. (1996) Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and β-amyloid peptides. Nature Genet., 14, 55-61.
40. Thomas, T., Thomas, G., McLendon, C., Sutton, T. and Mullan, M. (1996) β-Amyloid-mediated vasoactivity and vascular endothelial damage. Nature, 380, 168-171.
41. Snowdon, D.A., Greiner, L.H., Mortimer, J.A., Riley, K.P., Greiner, P.A. and Markesbery, W.R. (1997) Brain infarction and the clinical expression of Alzheimer disease. J. Am. Med. Assoc., 277, 813-817.
42. Rajavashisth, T.B., Kaptein, J.S., Reue, K.L. and Lusis, A.J. (1985) Evolution of apolipoprotein E: mouse sequence and evidence for an 11-nucleotide ancestral unit. Proc. Natl Acad. Sci. USA, 82, 8085-8089.
43. Dietrich, W., Katz, H., Lincoln, S.E., Shin, H.-S., Friedman, J., Dracopoli, N.C. and Lander, E.S. (1992) A genetic map of the mouse suitable for typing intraspecific crosses. Genetics, 131, 423-447.