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Volumn 25, Issue 5, 2004, Pages 641-650

ApoE genotype accounts for the vast majority of AD risk and AD pathology

Author keywords

AD pathology; AD risk; ApoE genotype

Indexed keywords

AMYLOID BETA PROTEIN; APOLIPOPROTEIN E; APOLIPOPROTEIN E2; APOLIPOPROTEIN E3; APOLIPOPROTEIN E4; LIPID; SYNAPTOPHYSIN; TAU PROTEIN; THROMBIN;

EID: 2542502430     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2003.12.023     Document Type: Article
Times cited : (488)

References (64)
  • 1
    • 0035857449 scopus 로고    scopus 로고
    • Alzheimer's disease as a disorder of mechanisms underlying structural brain self-organization
    • Arendt T. Alzheimer's disease as a disorder of mechanisms underlying structural brain self-organization. Neuroscience. 102:2001;723-765
    • (2001) Neuroscience , vol.102 , pp. 723-765
    • Arendt, T.1
  • 3
    • 0036592518 scopus 로고    scopus 로고
    • Non-familial Alzheimer's disease is mainly due to genetic factors
    • Ashford J.W., Mortimer J.A. Non-familial Alzheimer's disease is mainly due to genetic factors. J. Alzheimer's Dis. 4:2002;169-177
    • (2002) J. Alzheimer's Dis. , vol.4 , pp. 169-177
    • Ashford, J.W.1    Mortimer, J.A.2
  • 4
    • 0031278270 scopus 로고    scopus 로고
    • Lack of apolipoprotein e dramatically reduces amyloid beta-peptide deposition
    • Bales K.R., Verina T., Dodel R.C., Du Y., Altstiel L., Bender M., et al. Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition. Nat. Genet. 17:1997;263-264
    • (1997) Nat. Genet. , vol.17 , pp. 263-264
    • Bales, K.R.1    Verina, T.2    Dodel, R.C.3    Du, Y.4    Altstiel, L.5    Bender, M.6
  • 6
    • 0037115049 scopus 로고    scopus 로고
    • Modulation of Alzheimer-like synaptic and choninergic deficits in transgenic mice by human apolipoprotein e depends on isoform, aging, and overexpression of amyloid β peptides but not on plaque formation
    • Buttini M., Shockley K., Huang Y., Jones B., Masliah E., Mallory M., et al. Modulation of Alzheimer-like synaptic and choninergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid β peptides but not on plaque formation. J. Neurosci. 22:2002;10539-10548
    • (2002) J. Neurosci. , vol.22 , pp. 10539-10548
    • Buttini, M.1    Shockley, K.2    Huang, Y.3    Jones, B.4    Masliah, E.5    Mallory, M.6
  • 7
    • 0035061891 scopus 로고    scopus 로고
    • Quantitation of apoE domains in Alzheimer disease brain suggests a role for apoE in Ab aggregation
    • Cho H.S., Hyman B.T., Greenberg S.M., Rebeck G.W. Quantitation of apoE domains in Alzheimer disease brain suggests a role for apoE in Ab aggregation. J. Neuropathol. Exp. Neurol. 60:2001;342-349
    • (2001) J. Neuropathol. Exp. Neurol. , vol.60 , pp. 342-349
    • Cho, H.S.1    Hyman, B.T.2    Greenberg, S.M.3    Rebeck, G.W.4
  • 8
    • 0027194791 scopus 로고
    • Gene dose of apolipoprotein e type 4 allele and the risk of Alzheimer's disease in late onset families
    • Corder E.H., Saunders A.M., Strittmatter W.J., Schmechel D.E., Gaskell P.C., Small G.W., et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science. 261:1993;921-923
    • (1993) Science , vol.261 , pp. 921-923
    • Corder, E.H.1    Saunders, A.M.2    Strittmatter, W.J.3    Schmechel, D.E.4    Gaskell, P.C.5    Small, G.W.6
  • 9
    • 0028831614 scopus 로고
    • The apolipoprotein e E4 allele and sex-specific risk of Alzheimer's disease [letter comment]
    • Corder E.H., Saunders A.M., Strittmatter W.J., Schmechel D.E., Gaskell P.J., Roses A.D., et al. The apolipoprotein E E4 allele and sex-specific risk of Alzheimer's disease [letter comment]. JAMA. 273:1995;373-374
    • (1995) JAMA , vol.273 , pp. 373-374
    • Corder, E.H.1    Saunders, A.M.2    Strittmatter, W.J.3    Schmechel, D.E.4    Gaskell, P.J.5    Roses, A.D.6
  • 11
    • 0030614816 scopus 로고    scopus 로고
    • Apolipoprotein e epsilon4 and incidence of Alzheimer disease in a community population of older persons
    • Evans D.A., Beckett L.A., Field T.S., Feng L., Albert M.S., Bennett D.A., et al. Apolipoprotein E epsilon4 and incidence of Alzheimer disease in a community population of older persons. JAMA. 12(277):1997;822-824
    • (1997) JAMA , vol.12 , Issue.277 , pp. 822-824
    • Evans, D.A.1    Beckett, L.A.2    Field, T.S.3    Feng, L.4    Albert, M.S.5    Bennett, D.A.6
  • 12
    • 0036233168 scopus 로고    scopus 로고
    • Human and murine apoE markedly alters a beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease
    • Fagan A.M., Watson M., Parsadanian M., Bales K.R., Paul S.M., Holtzman D.M. Human and murine apoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease. Neurobiol. Dis. 9:2002;305-318
    • (2002) Neurobiol. Dis. , vol.9 , pp. 305-318
    • Fagan, A.M.1    Watson, M.2    Parsadanian, M.3    Bales, K.R.4    Paul, S.M.5    Holtzman, D.M.6
  • 13
    • 0030823158 scopus 로고    scopus 로고
    • Effects of age, sex, and ethnicity on the association between apolipoprotein e genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium
    • Farrer L.A., Cupples L.A., Haines J.L., Hyman B., Kukull W.A., Mayeux R., et al. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. JAMA. 278:1997;1349-1356
    • (1997) JAMA , vol.278 , pp. 1349-1356
    • Farrer, L.A.1    Cupples, L.A.2    Haines, J.L.3    Hyman, B.4    Kukull, W.A.5    Mayeux, R.6
  • 15
    • 0033799573 scopus 로고    scopus 로고
    • Apolipoprotein e variation at the sequence haplotype level: Implications for the origin and maintenance of a major human polymorphism
    • Fullerton S.M., Clark A.G., Weiss K.M., Nickerson D.A., Taylor S.L., Stengard J.H., et al. Apolipoprotein E variation at the sequence haplotype level: implications for the origin and maintenance of a major human polymorphism. Am J. Hum. Genet. 67:2000;881-900
    • (2000) Am J. Hum. Genet. , vol.67 , pp. 881-900
    • Fullerton, S.M.1    Clark, A.G.2    Weiss, K.M.3    Nickerson, D.A.4    Taylor, S.L.5    Stengard, J.H.6
  • 16
    • 0035930837 scopus 로고    scopus 로고
    • The reliability theory of aging and longevity
    • Gavrilov L.A., Gavrilova N.S. The reliability theory of aging and longevity. J. Theor. Biol. 213:2001;527-545
    • (2001) J. Theor. Biol. , vol.213 , pp. 527-545
    • Gavrilov, L.A.1    Gavrilova, N.S.2
  • 17
    • 0031664361 scopus 로고    scopus 로고
    • High frequency of apolipoprotein e epsilon4 allele in young individuals with very mild Alzheimer's disease-related neurofibrillary changes
    • Ghebremedhin E., Schultz C., Braak E., Braak H. High frequency of apolipoprotein E epsilon4 allele in young individuals with very mild Alzheimer's disease-related neurofibrillary changes. Exp. Neurol. 153:1998;152-155
    • (1998) Exp. Neurol. , vol.153 , pp. 152-155
    • Ghebremedhin, E.1    Schultz, C.2    Braak, E.3    Braak, H.4
  • 18
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • Hardy J., Selkoe D.J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science. 297:2002;353-356
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 19
    • 0141814636 scopus 로고    scopus 로고
    • Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer disease-like neurodegeneration and behavioral deficits in transgenic mice
    • Harris F.M., Brecht W.J., Xu Q., Tesseur I., Kekonius L., Wyss-Coray T., et al. Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer disease-like neurodegeneration and behavioral deficits in transgenic mice. Proc Natl Acad Sci USA. 100:2003;10966-10971
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 10966-10971
    • Harris, F.M.1    Brecht, W.J.2    Xu, Q.3    Tesseur, I.4    Kekonius, L.5    Wyss-Coray, T.6
  • 20
    • 0035857377 scopus 로고    scopus 로고
    • Incidence of dementia and Alzheimer's disease in 2 communities: Yoruba residing in Ibadan, Nigeria, and African Americans residing in Indianapolis, Indiana
    • Hendrie H.C., Ogunniyi A., Hall K.S., Bayewu O., Unverzagt F.W., Gurejo O., et al. Incidence of dementia and Alzheimer's disease in 2 communities: Yoruba residing in Ibadan, Nigeria, and African Americans residing in Indianapolis, Indiana. JAMA. 285:2001;739-747
    • (2001) JAMA , vol.285 , pp. 739-747
    • Hendrie, H.C.1    Ogunniyi, A.2    Hall, K.S.3    Bayewu, O.4    Unverzagt, F.W.5    Gurejo, O.6
  • 21
    • 0028274607 scopus 로고
    • Can an improved environment cause maximum lifespan to decrease? Comments on lifespan criteria and longitudinal Gompertzian analysis
    • Hirsch H.R. Can an improved environment cause maximum lifespan to decrease? Comments on lifespan criteria and longitudinal Gompertzian analysis. Exp. Gerontol. 29:1994;119-137
    • (1994) Exp. Gerontol. , vol.29 , pp. 119-137
    • Hirsch, H.R.1
  • 22
    • 0028935409 scopus 로고
    • Do intersections of mortality-rate and survival functions have significance?
    • Hirsch H.R. Do intersections of mortality-rate and survival functions have significance? Exp. Gerontol. 30:1995;147-167
    • (1995) Exp. Gerontol. , vol.30 , pp. 147-167
    • Hirsch, H.R.1
  • 23
    • 0031006081 scopus 로고    scopus 로고
    • Intersections of mortality-rate and survival functions: Model-independent considerations
    • Hirsch H.R. Intersections of mortality-rate and survival functions: model-independent considerations. Exp Gerontol. 32:1997;287-296
    • (1997) Exp Gerontol. , vol.32 , pp. 287-296
    • Hirsch, H.R.1
  • 24
    • 4243215848 scopus 로고    scopus 로고
    • Apolipoprotein e isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease
    • Holtzman D.M., Bales K.R., Tenkova T., Fagan A.M., Parsadanian M., Sartorius L.J., et al. Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. USA. 97:2000;2892-2897
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 2892-2897
    • Holtzman, D.M.1    Bales, K.R.2    Tenkova, T.3    Fagan, A.M.4    Parsadanian, M.5    Sartorius, L.J.6
  • 25
    • 0035902514 scopus 로고    scopus 로고
    • Apolipoprotein e fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons
    • Huang Y., Liu X.Q., Wyss-Coray T., Brecht W.J., Sanan D.A., Mahley R.W. Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons. Proc. Natl. Acad. Sci. USA. 98:2001;8838-8843
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 8838-8843
    • Huang, Y.1    Liu, X.Q.2    Wyss-Coray, T.3    Brecht, W.J.4    Sanan, D.A.5    Mahley, R.W.6
  • 26
    • 4143091289 scopus 로고    scopus 로고
    • Apolipoprotein E: Diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease
    • Huang Y, Weisgraber KH, Mucke L, Mahley RW. Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease. J Mol Neurosci 2004;32:187-202.
    • (2004) J Mol Neurosci , vol.32 , pp. 187-202
    • Huang, Y.1    Weisgraber, K.H.2    Mucke, L.3    Mahley, R.W.4
  • 28
    • 0031720801 scopus 로고    scopus 로고
    • The incidence of dementia: A meta-analysis
    • Jorm A.F., Jolley D. The incidence of dementia: a meta-analysis. Neurology. 51:1998;728-733
    • (1998) Neurology , vol.51 , pp. 728-733
    • Jorm, A.F.1    Jolley, D.2
  • 31
    • 0043095312 scopus 로고    scopus 로고
    • Dendritic spine loss in the hippocampus of young PDAPP and Tg2576 mice and its prevention by the ApoE2 genotype
    • Lanz T.A., Carter D.B., Merchant K.M. Dendritic spine loss in the hippocampus of young PDAPP and Tg2576 mice and its prevention by the ApoE2 genotype. Neurobiol Dis. Aug. 13:2003;246-253
    • (2003) Neurobiol Dis. Aug , vol.13 , pp. 246-253
    • Lanz, T.A.1    Carter, D.B.2    Merchant, K.M.3
  • 32
    • 0042093508 scopus 로고    scopus 로고
    • ApoE4 impairs hippocampal plasticity isoform-specifically and blocks the environmental stimulation of synaptogenesis and memory
    • Levi O., Jongen-Relo A.L., Feldon J., Roses A.D., Michaelson D.M. ApoE4 impairs hippocampal plasticity isoform-specifically and blocks the environmental stimulation of synaptogenesis and memory. Neurobiol. Dis. 13:2003;273-282
    • (2003) Neurobiol. Dis. , vol.13 , pp. 273-282
    • Levi, O.1    Jongen-Relo, A.L.2    Feldon, J.3    Roses, A.D.4    Michaelson, D.M.5
  • 33
    • 0028173205 scopus 로고
    • 1-antichymotrypsin and apolipoprotein e promote assembly of Alzheimer b-protein into filaments
    • 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer b-protein into filaments. Nature. 372:1994;92-94
    • (1994) Nature , vol.372 , pp. 92-94
    • Ma, J.1    Yee, A.2    Brewer Jr., H.B.3    Das, S.4    Potter, H.5
  • 34
    • 2542430827 scopus 로고    scopus 로고
    • Apolipoprotein E. Structure and function in lipid metabolism and neurobiology
    • Rosenberg RN, Prusiner SB, DiMauro S, Barchi RL, Nestler EJ, editors. Philadelphia: Butterworth Heinemann;
    • Mahley R, Huang Y, Apolipoprotein E. Structure and function in lipid metabolism and neurobiology. In: Rosenberg RN, Prusiner SB, DiMauro S, Barchi RL, Nestler EJ, editors. The molecular and genetic basis of neurologic and psychiatric disease, third ed. Philadelphia: Butterworth Heinemann; 2003. p. 565-73.
    • (2003) The Molecular and Genetic Basis of Neurologic and Psychiatric Disease, Third Ed. , pp. 565-573
    • Mahley, R.1    Huang, Y.2
  • 35
    • 0032545939 scopus 로고    scopus 로고
    • Utility of the apolipoprotein e genotype in the diagnosis of Alzheimer's disease. Alzheimer's Disease Centers Consortium on Apolipoprotein e and Alzheimer's Disease
    • Mayeux R., Saunders A.M., Shea S., Mirra S., Evans D., Roses A.D., et al. Utility of the apolipoprotein E genotype in the diagnosis of Alzheimer's disease. Alzheimer's Disease Centers Consortium on Apolipoprotein E and Alzheimer's Disease. N. Engl. J. Med. 338:1998;506-511
    • (1998) N. Engl. J. Med. , vol.338 , pp. 506-511
    • Mayeux, R.1    Saunders, A.M.2    Shea, S.3    Mirra, S.4    Evans, D.5    Roses, A.D.6
  • 36
    • 0029877490 scopus 로고    scopus 로고
    • Apolipoprotein e polymorphism is associated with both senile plaque load and Alzheimer-type neurofibrillary tangle formation
    • Marz W., Scharnagl H., Kirca M., Bohl J., Gross W., Ohm T.G. Apolipoprotein E polymorphism is associated with both senile plaque load and Alzheimer-type neurofibrillary tangle formation. Ann N Y Acad. Sci. 777:1996;276-280
    • (1996) Ann N Y Acad. Sci. , vol.777 , pp. 276-280
    • Marz, W.1    Scharnagl, H.2    Kirca, M.3    Bohl, J.4    Gross, W.5    Ohm, T.G.6
  • 37
    • 0034509333 scopus 로고    scopus 로고
    • A plasticity-based theory of the pathogenenesis of Alzeimer's disease
    • Mesulam M.M. A plasticity-based theory of the pathogenenesis of Alzeimer's disease. Ann. N. Y. Acad. Sci. 924:2000;42-52
    • (2000) Ann. N. Y. Acad. Sci. , vol.924 , pp. 42-52
    • Mesulam, M.M.1
  • 38
    • 0037154236 scopus 로고    scopus 로고
    • Incidence of AD may decline in the early 90s for men, later for women: The Cache County study
    • Miech R.A., Breitner J.C., Zandi P.P., Khachaturian A.S., Anthony J.C., Mayer L. Incidence of AD may decline in the early 90s for men, later for women: the Cache County study. Neurology. 58:2002;209-218
    • (2002) Neurology , vol.58 , pp. 209-218
    • Miech, R.A.1    Breitner, J.C.2    Zandi, P.P.3    Khachaturian, A.S.4    Anthony, J.C.5    Mayer, L.6
  • 39
    • 0033528666 scopus 로고    scopus 로고
    • Differential effects of apolipoprotein e isoforms on metal-induced aggregation of Ab using physiological concentrations
    • Moir R.D., Atwood C.S., Romano D.M., Laurans M.H., Huang X., Bush A.I., et al. Differential effects of apolipoprotein E isoforms on metal-induced aggregation of Ab using physiological concentrations. Biochemistry. 38:1999;4595-4603
    • (1999) Biochemistry , vol.38 , pp. 4595-4603
    • Moir, R.D.1    Atwood, C.S.2    Romano, D.M.3    Laurans, M.H.4    Huang, X.5    Bush, A.I.6
  • 40
    • 0028787064 scopus 로고
    • Influence of the apolipoprotein e genotype on amyloid deposition and neurofibrillary tangle formation in Alzheimer's disease
    • Nagy Z.S., Esiri M.M., Jobst K.A., Johnston C., Lichtfiel S., Sim E., et al. Influence of the apolipoprotein E genotype on amyloid deposition and neurofibrillary tangle formation in Alzheimer's disease. Neuroscience. 69:1995;757-761
    • (1995) Neuroscience , vol.69 , pp. 757-761
    • Nagy, Z.S.1    Esiri, M.M.2    Jobst, K.A.3    Johnston, C.4    Lichtfiel, S.5    Sim, E.6
  • 41
    • 0025971426 scopus 로고
    • Apolipoprotein e immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease
    • Namba Y., Tomonoga M., Kawasaki E., Ikeda K. Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease. Brain Res. 541:1991;163-166
    • (1991) Brain Res. , vol.541 , pp. 163-166
    • Namba, Y.1    Tomonoga, M.2    Kawasaki, E.3    Ikeda, K.4
  • 42
    • 0032168460 scopus 로고    scopus 로고
    • Isoform-specific effects of human apolipoprotein e on brain function revealed in ApoE knockout mice: Increased susceptibility of females
    • Raber J., Wong D., Buttini M., Orth M., Bellosta S., Pitas R.E., et al. Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females. Proc. Natl. Acad. Sci. USA. 95:1998;10914-10919
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 10914-10919
    • Raber, J.1    Wong, D.2    Buttini, M.3    Orth, M.4    Bellosta, S.5    Pitas, R.E.6
  • 44
    • 0037096337 scopus 로고    scopus 로고
    • Androgens protect against apolipoprotein E4-indiced cognitive deficits
    • Raber J., Bonger G., LeFevour A., Buttini M., Mucke L. Androgens protect against apolipoprotein E4-indiced cognitive deficits. J. Neurosci. 22:2002;5204-5209
    • (2002) J. Neurosci. , vol.22 , pp. 5204-5209
    • Raber, J.1    Bonger, G.2    Lefevour, A.3    Buttini, M.4    Mucke, L.5
  • 45
    • 0027973579 scopus 로고
    • Lower cognitive performance in normal older adult male twins carrying the apolipoprotein e epsilon 4 allele
    • Reed T., Carmelli D., Swan G.E., Breitner J.C., Welsh K.A., Jarvik G.P., et al. Lower cognitive performance in normal older adult male twins carrying the apolipoprotein E epsilon 4 allele. Arch. Neurol. 51:1994;1189-1192
    • (1994) Arch. Neurol. , vol.51 , pp. 1189-1192
    • Reed, T.1    Carmelli, D.2    Swan, G.E.3    Breitner, J.C.4    Welsh, K.A.5    Jarvik, G.P.6
  • 46
    • 0028997817 scopus 로고
    • Apolipoprotein e genotyping in the differential diagnosis, not prediction, of Alzheimer's disease
    • Roses A.D. Apolipoprotein E genotyping in the differential diagnosis, not prediction, of Alzheimer's disease. Ann Neurol. 38:1995;6-14
    • (1995) Ann Neurol. , vol.38 , pp. 6-14
    • Roses, A.D.1
  • 47
    • 0030481305 scopus 로고    scopus 로고
    • Apolipoprotein e and Alzheimer's disease. A rapidly expanding field with medical and epidemiological consequences
    • Roses A.D. Apolipoprotein E and Alzheimer's disease. A rapidly expanding field with medical and epidemiological consequences. Ann. N Y Acad. Sci. 802:1996;50-57
    • (1996) Ann. N Y Acad. Sci. , vol.802 , pp. 50-57
    • Roses, A.D.1
  • 48
    • 0028026587 scopus 로고
    • Apolipoprotein e associates with b amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3
    • Sanan D.A., Weisgraber K.H., Russell S.J., Mahley R.W., Huang D., Saunders A., et al. Apolipoprotein E associates with b amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3. J. Clin. Invest. 94:1994;860-869
    • (1994) J. Clin. Invest. , vol.94 , pp. 860-869
    • Sanan, D.A.1    Weisgraber, K.H.2    Russell, S.J.3    Mahley, R.W.4    Huang, D.5    Saunders, A.6
  • 50
    • 0027365822 scopus 로고
    • Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein-E genotype in late-onset Alzheimer disease
    • Schmechel D.E., Saunders A.M., Strittmatter W.J., Crain B.J., Hulette C.M., Joo S.H., et al. Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein-E genotype in late-onset Alzheimer disease. Proc. Natl. Acad. Sci. USA. 90:1993;9649-9653
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 9649-9653
    • Schmechel, D.E.1    Saunders, A.M.2    Strittmatter, W.J.3    Crain, B.J.4    Hulette, C.M.5    Joo, S.H.6
  • 51
    • 0035950225 scopus 로고    scopus 로고
    • Clearing the brain's amyloid cobwebs
    • Selkoe D.J. Clearing the brain's amyloid cobwebs. Neuron. 32:2001;177-180
    • (2001) Neuron , vol.32 , pp. 177-180
    • Selkoe, D.J.1
  • 54
    • 12044254746 scopus 로고
    • Binding of human apolipoprotein e to synthetic amyloid (peptide: Isoform-specific effects and implications for late-onset Alzheimer disease
    • Strittmatter W.J., Weisgraber K.H., Huang D.Y., Dong L-M., Salvesen G.S., Pericak-Vance M. Binding of human apolipoprotein E to synthetic amyloid (peptide: isoform-specific effects and implications for late-onset Alzheimer disease. Proc. Natl. Acad. Sci. USA. 90:1993;8098-8102
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 8098-8102
    • Strittmatter, W.J.1    Weisgraber, K.H.2    Huang, D.Y.3    Dong, L.-M.4    Salvesen, G.S.5    Pericak-Vance, M.6
  • 55
    • 0033889344 scopus 로고    scopus 로고
    • Expression of human apolipoprotein E4 in neurons causes hyperphosphorylation of protein tau in the brains of transgenic mice
    • Tesseur I., Van Dorpe J., Spittaels K., Van den Haute C., Moechars D., Van Leuven F. Expression of human apolipoprotein E4 in neurons causes hyperphosphorylation of protein tau in the brains of transgenic mice. Am J. Pathol. 156:2000;951-964
    • (2000) Am J. Pathol. , vol.156 , pp. 951-964
    • Tesseur, I.1    Van Dorpe, J.2    Spittaels, K.3    Van Den Haute, C.4    Moechars, D.5    Van Leuven, F.6
  • 56
    • 0037010297 scopus 로고    scopus 로고
    • Neuroplasticity in Alzheimer's disease
    • Teter B., Ashford J.W. Neuroplasticity in Alzheimer's disease. J. Neurosci. Res. 70:2002;402-437
    • (2002) J. Neurosci. Res. , vol.70 , pp. 402-437
    • Teter, B.1    Ashford, J.W.2
  • 57
    • 0030804828 scopus 로고    scopus 로고
    • Neurotoxicity of the 22 kDa thrombin-cleavage fragment of apolipoprotein e and related synthetic peptides is receptor-mediated
    • Tolar M., Marques M.A., Harmony J.A.K., Crutcher K.A. Neurotoxicity of the 22 kDa thrombin-cleavage fragment of apolipoprotein E and related synthetic peptides is receptor-mediated. J. Neurosci. 17:1997;5678-5686
    • (1997) J. Neurosci. , vol.17 , pp. 5678-5686
    • Tolar, M.1    Marques, M.A.2    Harmony, J.A.K.3    Crutcher, K.A.4
  • 58
    • 0033567074 scopus 로고    scopus 로고
    • Truncated apolipoprotein e (apoE) causes increased intracellular calcium and may mediate apoE neurotoxicity
    • Tolar M., Keller J.N., Chan S., Mattson M.P., Marques M.A., Crutcher K.A. Truncated apolipoprotein E (apoE) causes increased intracellular calcium and may mediate apoE neurotoxicity. J. Neurosci. 19:1999;7100-7110
    • (1999) J. Neurosci. , vol.19 , pp. 7100-7110
    • Tolar, M.1    Keller, J.N.2    Chan, S.3    Mattson, M.P.4    Marques, M.A.5    Crutcher, K.A.6
  • 59
    • 0037469193 scopus 로고    scopus 로고
    • APOE E4 is a determininant for Alzheimer type pathology in progressive supranuclear palsy
    • Tsuboi Y., Josephs K.A., Cookson N., Dickson D.W. APOE E4 is a determininant for Alzheimer type pathology in progressive supranuclear palsy. Neurology. 60:2003;240-245
    • (2003) Neurology , vol.60 , pp. 240-245
    • Tsuboi, Y.1    Josephs, K.A.2    Cookson, N.3    Dickson, D.W.4
  • 64
    • 0030870127 scopus 로고    scopus 로고
    • Apolipoprotein e phenotype and cognitive decline in a prospective study of elderly community women
    • Yaffe K., Cauley J., Sands L., Browner W. Apolipoprotein E phenotype and cognitive decline in a prospective study of elderly community women. Arch. Neurol. 54:1997;1110-1114
    • (1997) Arch. Neurol , vol.54 , pp. 1110-1114
    • Yaffe, K.1    Cauley, J.2    Sands, L.3    Browner, W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.