Cell Cycle: A genome-wide RNAi screen identifies core components of the G2-M DNA damage checkpoint

Science Signaling

Volumn 4, Issue 154, 2011, Pages

  Kondo, Shu ^a   Perrimon, Norbert ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; NUCLEASE; CELL CYCLE PROTEIN; SMALL INTERFERING RNA;

ANIMAL CELL; ARTICLE; CELL CYCLE; CELL CYCLE G2 PHASE; CELL CYCLE REGULATION; CHROMATIN; CONTROLLED STUDY; CROSSOVER PROCEDURE; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DNA STRAND BREAKAGE; DROSOPHILA; GENE; GENE MUTATION; GENETIC ASSOCIATION; GENETIC SCREENING; IN VIVO STUDY; MUS101 GENE; MUS312 GENE; NONHUMAN; PRIORITY JOURNAL; RNA INTERFERENCE; RNA PROCESSING; SIGNAL TRANSDUCTION; ANIMAL; CELL CYCLE G1 PHASE; CELL DIVISION; CYTOLOGY; GENETICS; GENOME;

ATAXIA TELANGIECTASIA;

ANIMALS; CELL CYCLE PROTEINS; CELL DIVISION; DNA DAMAGE; DROSOPHILA; G1 PHASE; GENOME; RNA, SMALL INTERFERING;

EID: 78650920825     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2001350     Document Type: Article

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64. Acknowledgments: We thank the Drosophila RNAi Screening Center and the Institute of Chemistry and Cell Biology-Longwood for assistance with the RNAi screen and automated microscopy, respectively; K. McKim for antibody against phosphoH2Av; and J. Sekelsky, T.-S. Hsieh, P. Gallant, D. Glover, K. Moses, H.-M. Bourbon, the Bloomington Drosophila Stock Center, the National Institute of Genetics Fly Stock Center, and the Transgenic RNAi Project for fly stocks. We thank S. Elledge for helpful discussions and M. Markstein for critical reading of the manuscript. Funding: S.K. is supported by a Research Fellowship from the Uehara Memorial Foundation. N.P. is an investigator of the Howard Hughes Medical Institute. Author contributions: S.K. and N.P. designed the experiments. S.K. conducted the experiments. S.K. and N.P. interpreted the results and wrote the manuscript. Competing interests: The authors declare that they have no competing financial interests.