MCM2-7 proteins are essential components of prereplicative complexes that accumulate cooperatively in the nucleus during G1-phase and are required to establish, but not maintain, the S-phase checkpoint

Molecular Biology of the Cell

Volumn 12, Issue 11, 2001, Pages 3658-3667

  Labib, K ^a   Kearsey, S E ^a   Diffley, J F X ^a  

^a CHRISTIE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FUNGAL PROTEIN; PROTEIN MCM2 7; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CHROMATIN; CHROMOSOME REPLICATION; COMPLEX FORMATION; CONTROLLED STUDY; MITOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN DEGRADATION;

SACCHAROMYCETALES;

EID: 0035201229     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.12.11.3658     Document Type: Article

References (56)

1. Differential assembly of Cdc45p and DNA polymerases at early and late origins of DNA replication
2. Components and dynamics of DNA replication complexes in S. cerevisiae: Redistribution of MCM complexes and Cdc45p during S phase
3. Dpb11, which interacts with DNApolymerase II(epsilon) in Saccharomyces cerevisiae, has a dual role in S-phase progression and at a cell-cycle checkpoint
4. ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex
5. Chromosomal ARS1 has a single leading strand start site
6. Purification of an MCM-containing complex as a component of the DNA replication licensing system
7. An essential role for the Cdc6 protein in forming the prereplicative complexes of budding yeast
8. S-phase-promoting cyclin-dependent kinases prevent rereplication by inhibiting the transition of origins to a prereplicative state
9. Cell-cycle-regulated nuclear import and export of Cdc47, a protein essential for initiation of DNA-replication in budding yeast
10. RAD9 and RAD24 define two additive, interacting branches of the DNA damage checkpoint pathway in budding yeast normally required for Rad53 modification and activation
11. Cdc6p establishes and maintains a state of replication competence during G1 phase
12. Ectopic induction of Clb2 in early G1 phase is sufficient to block prereplicative complex formation in Saccharomyces cerevisiae
13. Protein-DNA interactions at a yeast replication origin
14. Two steps in the assembly of complexes at yeast replication origins in vivo
15. Heat-inducible degron: A method for constructing temperature-sensitive mutants
16. Cdc6-dependent loading of Mcm proteins onto prereplicative chromatin in budding yeast
17. The Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeast
18. Subcellular localization of yeast CDC46 varies with the cell cycle
19. Sld3, which interacts with Cdc45 (Sld4), functions for chromosomal DNA replication in Saccharomyces cerevisiae
20. + gene product couples S-phase to START and mitosis
21. Licensing of DNA replication by a multiprotein complex of MCM/P1 proteins in Xenopus extracts
22. G1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleus
23. Uninterrupted MCM2-M7 function required for DNA replication fork progression
24. Physical interactions among MCM proteins and effects of MCM dosage on DNA-replication in Saccharomyces cerevisiae
25. Exercising self-restraint: Discouraging illicit acts of S and M in eukaryotes
26. Persistent initiation of DNA replication and chromatin-bound MCM proteins during the cell cycle in cdc6 mutants
27. The nuclear envelope prevents reinitiation of replication by regulating the binding of MCM3 to chromatin in Xenopus egg extracts
28. Fission yeast cdc21, a member of the mcm protein family, is required for onset of s-phase and is located in the nucleus throughout the cell-cycle
29. Characterization of the Schizosaccharomyces pombe rad4/cut5 mutant phenotypes: Dissection of DNA replication and G2 checkpoint control function
30. Activation of the DNA replication checkpoint through RNA synthesis by primase
31. Clb/Cdc28 kinases promote nuclear export of the replication initiator proteins Mcm2-m7
32. The RFC2 gene, encoding the third-largest subunit of the replication factor C complex, is required for an S-phase checkpoint in Saccharomyces cerevisiae
33. CDK inactivation is the only essential function of the APC/C and the mitotic exit network proteins for origin resetting during mitosis
34. CDC45 is required in conjunction with CDC7/DBF4 to trigger the initiation of DNA replication
35. Nuclear localization of Schizosaccharomyces pombe Mcm2/Cdc19p requires MCM complex assembly
36. Nucleotide dependent prereplicative complex assembly by Cdc6p, a homologue of eukaryotic and prokaryotic clamp-loaders
37. Cdc6 is an unstable protein whose de novo synthesis in G1 is important for the onset of S phase and for preventing a reductional anaphase in the budding yeast Saccharomyces cerevisiae
38. A key role for replication factor C in DNA replication checkpoint function in fission yeast
39. Fission yeast cut5 links nuclear chromatin and M phase regulator in the replication checkpoint control
40. +
41. ORC- and Cdc6-dependent complexes at active and inactive chromosomal replication origins in Saccharomyces cerevisiae
42. A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication
43. Activation of dormant origins of DNA replication in budding yeast
44. Replication factor C3 of Schizosaccharomyces pombe, a small subunit of replication factor C complex, plays a role in both replication and damage checkpoints
45. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae
46. Mitosis in living budding yeast: Anaphase A but no metaphase plate
47. Rfc5, a replication factor C component, is required for regulation of Rad53 protein kinase in the yeast checkpoint pathway
48. Loading of an Mcm protein onto DNA-replication origins is regulated by Cdc6p and CDKs
49. DNA synthesis at individual replication forks requires the essential initiation factor Cdc45p
50. The RLF-M component of the replication licensing system forms complexes containing all six MCM/P1 polypeptides
51. Segregation of unreplicated chromosomes in Saccharomyces cerevisiae reveals a novel G1/M-phase checkpoint
52. An origin-deficient yeast artificial chromosome triggers a cell cycle checkpoint
53. DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae
54. Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA-replication and repair
55. The Cdc6p nucleotide-binding motif is required for loading Mcm proteins onto chromatin
56. Cell cycle-regulated nuclear localization of MCM2 and MCM3, which are required for the initiation of DNA synthesis at chromosomal replication origins in yeast