Relative Contribution of DNA Repair, Cell Cycle Checkpoints, and Cell Death to Survival after DNA Damage in Drosophila Larvae

Current Biology

Volumn 14, Issue 1, 2004, Pages 23-32

  Jaklevic, Burnley R ^a   Su, Tin Tin ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABELMOSCHUS; ANIMALIA; DROSOPHILA; DROSOPHILA MELANOGASTER; EUKARYOTA; MELANOGASTER; PROTISTA;

EID: 0347596709     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2003.12.032     Document Type: Article

References (43)

1. Zhou, B.B., and Elledge, S.J. (2000). The DNA damage response: putting checkpoints in perspective. Nature 408, 433-439.
2. Savitsky, K., Bar-Shiva, A., Gilad, S., Rotman, G., Ziv, Y., Vanagaite, L., Tagle, D.A., Smith, S., Uziel, T., Sfez, S., et al. (1995). A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science 268, 1749-1753.
3. Jeggo, P.A., Carr, A.M., and Lehmann, A.R. (1998). Splitting the ATM: distinct repair and checkpoint defects in ataxia-telangiectasia. Trends Genet. 14, 312-316.
4. Weinert, T.A., and Hartwell, L.H. (1988). The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae. Science 247, 317-322.
5. Gatei, M., Young, D., Cerosaletti, K.M., Desai-Mehta, A., Spring, K., Kozlov, S., Lavin, M.F., Gatti, R.A., Concannon, P., Khanna, K., et al. (2000). ATM-dependent phosphorylation of nibrin in response to radiation exposure. Nat. Genet. 25, 115-119.
6. Petrini, J.H. (2000). The Mre11 complex and ATM: collaborating to navigate S phase. Curr. Opin. Cell Biol. 72, 293-296.
7. Herzog, K.H., and Chong, M.J., Kapsetaki, M., Morgan, J.I., and McKinnon, P.J. (1998). Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system. Science 280, 1089-1091.
8. Sibon, O.C., Stevenson, V.A., and Theurkauf, W.E. (1997). DNA-replication checkpoint control at the Drosophila midblastula transition. Nature 388, 93-97.
9. Sibon, O.C., Laurencon, A., Hawley, R., and Theurkauf, W.E. (1999). The Drosophila ATM homologue Mei-41 has an essential checkpoint function at the midblastula transition. Curr. Biol. 9, 302-312.
10. Brodsky, M.H., and Sekelsky, J.J., Tsang, G., Hawley, R.S., and Rubin, G.M. (2000). mus304 encodes a novel DNA damage checkpoint protein required during Drosophila development. Genes Dev. 14, 666-678.
11. Garner, M., van Kreeveld, S., and Su, T.T. (2001). mei-41 and bub1 block mitosis at two distinct steps in response to incomplete DNA replication in Drosophila embryos. Curr. Biol. 11, 1595-1599.
12. Gatti, M., Pimpinelli, S., and Baker, B.S. (1980). Relationships among chromatid interchanges, sister chromatid exchanges, and meiotic recombination in Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 77, 1575-1579.
13. Ahmad, K., and Golic, K.G. (1999). Telomere loss in somatic cells of Drosophila causes cell cycle arrest and apoptosis. Genetics 757, 1041-1051.
14. Kooistra, R., Pastink, A., Zonneveld, J.B., Lohman, P.M., and Eeken, J.C. (1999). The Drosophila melanogaster DmRAD54 gene plays a crucial role in double-strand break repair after P-element excision and acts synergistically with Ku70 in the repair of X-ray damage. Mol. Cell. Biol. 79, 6269-6275.
15. Hari, K.L., Santerre, A., Sekelsky, J.J., McKim, K.S., Boyd, J.B., Hawley, R.S. (1995). The mei-41 gene of D. melanogaster is a structural and functional homolog of the human ataxia telangiectasia gene. Cell 82, 815-821.
16. Spradling, A., and Orr-Weaver, T. (1987). Regulation of DNA replication during Drosophila development. Annu. Rev. Genet. 27, 373-403.
17. Neufeld, T.P., de la Cruz, A.F., Johnston, L.A., and Edgar, B.A. (1998). Coordination of growth and cell division in the Drosophila wing. Cell 93, 1183-1193.
18. Meinertzhagen, I.A., and Hanson, T.E. (1993). The development of the optic lobe. In The Development of Drosophila melanogaster, M. Bate and A. Martinez Arias, eds. (Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press) pp. 1363-1491.
19. Paulovich, A.G., and Hartwell, L.H. (1995). A checkpoint regulates the rate of progression through S phase in S. cerevisiae in response to DNA damage. Cell 82, 841-847.
20. Rowley, R., Phillips, E.N., and Schroeder, A.L. (1999). The effects of ionizing radiation on DNA synthesis in eukaryotic cells. Int. J. Radiat. Biol. 75, 267-283.
21. Falck, J., Mailand, N., Syljuasen, R.G., Bartek, J., and Lukas, J. (2001). The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature 470, 842-847.
22. Zhao, H., and Watkins, J.L., and Piwnica-Worms, H. (2002). Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints. Proc. Natl. Acad. Sci. USA 99, 14795-14800.
23. Boyd, J.B., Golino, M.D., Nguyen, T.D., and Green, M.M. (1976). Isolation and characterization of X-linked mutants of Drosophila melanogaster which are sensitive to mutagens. Genetics 84, 485-506.
24. Hay, B.A., Wolff, T., and Rubin, G.M. (1994). Expression of baculovirus P35 prevents cell death in Drosophila. Development 120, 2121-2129.
25. Brodsky, M.H., Nordstrom, W., Tsang, G., Kwan, E., Rubin, G.M., and Abrams, J.M. (2000). Drosophila p53 binds a damage response element at the reaper locus. Cell 101, 103-113.
26. Haynie, J.L., and Bryant, P.J. (1977). The Effects of X-rays on the proliferation dynamics of cells in the imaginai wing disc of Drosophila melanogaster. Wilhelm Roux's Archives 183, 85-100.
27. Sogame, N., Kim, M., and Abrams, J.M. (2003). Drosophila p53 preserves genomic stability by regulating cell death. Proc. Natl. Acad. Sci. USA 700, 4696-4701.
28. Wolff, T., and Ready, D.F. (1993). Pattern formation in the Drosophila retina. In The Development of Drosophila melanogaster, M. Bate and A. Martinez Arias, eds. (Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press) pp. 1277-1326.
29. Ashburner, M. (1989). Drosophila: A Laboratory Handbook (Cold Spring Harbor, N.Y.: Cold Spring Harbor Laboratory Press).
30. Feger, G., Vaessin, H., Su, T.T., Wolff, E., Jan, L.Y., and Jan, Y.N. (1995). dpa, a member of the MCM family, is required for mitotic DNA replication but not endoreplication in Drosophila. EMBO J. 14, 5387-5398.
31. Treisman, J.E., Follette, P.J., O'Farrell, P.M., and Rubin, G.M. (1995). Cell proliferation and DNA replication defects in a Drosophila MCM2 mutant. Genes Dev. 9, 1709-1715.
32. Abbott, L.A., and Natzle, J.E. (1992). Epithelial polarity and cell separation in the neoplastic l(1)dlg-1 mutant of Drosophila. Mech. Dev. 37, 43-56.
33. James, A.A., and Bryant, P.J. (1981). A quantitative study of cell death and mitotic inhibition in gamma-irradiated imaginai wing discs of Drosophila melanogaster. Radiat. Res. 87, 552-564.
34. Baker, N.E., and Yu, S.Y. (2001). The EGF receptor defines domains of cell cycle progression and survival to regulate cell number in the developing Drosophila eye. Cell 704, 699-708.
35. Sanchez, Y., Bachant, J., Wang, H., Hu, F., Liu, D., Tetzlaff, M., and Elledge, S.J. (1999). Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms. Science 286, 1166-1171.
36. Michalopoulos, G.K., and DeFrances, M.C. (1997). Liver regeneration. Science 276, 60-66.
37. Kooistra, R., Vreeken, K., and Zonneveld, J.B., de Jong, A., Eeken, J.C., Osgood, C.J., Buerstedde, J.M., Lohman, P.M., and Pastink, A. (1997). The Drosophila melanogaster RAD54 homolog, DmRAD54, is involved in the repair of radiation damage and recombination. Mol. Cell. Biol. 17, 6097-6104.
38. Laurençon, A., Purdy, A., Sekelsky, J., Hawley, R.S., and Su, T.T. (2003). Phenotypic analysis of separation-of-function alleles of MEI-41, a Drosophila ATR. Genetics 764, 589-601.
39. Fogarty, P., and Campbell, S.D., Abu-Shumays, R., Phalle, B.S., Yu, K.R., Uy, G.L., Goldberg, M.L., and Sullivan, W. (1997). The Drosophila grapes gene is related to checkpoint gene chk1/ rad27 and is required for late syncytial division fidelity. Curr. Biol. 7, 418-426.
40. Rong, Y.S., Titen, S.W., Xie, H.B., Golic, N.M., Bastiani, M., Bandyopadhyay, P., Olivera, B.M., Brodsky, M., Rubin, G.M., and Golic, K.G., et al. (2002). Targeted mutagenesis by homologous recombination in D. melanogaster. Genes Dev. 76, 1568-1581.
41. Pimpinelli, S., Bonaccorsi, S., Fanti, L., and Gatti, M. (2000). Preparation and analysis of Drosophila mitotic Chromosomes. In Drosophila Protocols, W. Sullivan, M. Ashburner, and R.S. Hawley, eds. (Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press) pp. 3-23
42. Su, T.T., Sprenger, F., DiGregorio, P.J., Campbell, S.D., and O'Farrell, P.H. (1998). Exit from mitosis in Drosophila syncytial embryos requires proteolysis and cyclin degradation, and is associated with localized dephosphorylation. Genes Dev. 12, 1495-1503.
43. Tercero, J.A., Longhese, M.P., and Diffley, J.F. (2003). A central role for DNA replication forks in checkpoint activation and response. Mol. Cell 11, 1323-1336.