Drosophila ATM and Mre11 are essential for the G2/M checkpoint induced by low-dose irradiation

Genetics

Volumn 171, Issue 2, 2005, Pages 845-847

  Bi, Xiaolin ^a   Gong, Min ^a   Srikanta, Deepa ^a   Rong, Yikang S ^a,b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; ATR PROTEIN; DROSOPHILA PROTEIN; MRE11 PROTEIN;

ANIMAL; ANIMAL CELL; ARTICLE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CONTROLLED STUDY; DROSOPHILA; GENOTOXICITY; LOW ENERGY RADIATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RADIATION EXPOSURE; X RAY;

ANIMALS; CELL CYCLE PROTEINS; DOSE-RESPONSE RELATIONSHIP, RADIATION; DROSOPHILA; DROSOPHILA PROTEINS; ENDODEOXYRIBONUCLEASES; GENES, CDC; MITOSIS; MODELS, GENETIC; MUTAGENESIS; PROTEIN-SERINE-THREONINE KINASES;

ANIMALIA;

EID: 31544437686     PISSN: 00166731     EISSN: 00166731     Source Type: Journal    
DOI: 10.1534/genetics.105.047720     Document Type: Article

References (18)

1. ABRAHAM, R. T., 2001 Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev. 15: 2177-2196.
2. BI, X., S. D. WEI and Y. S. RONG, 2004 Telomere protection without a telomerase: the role of ATM and Mre11 in Drosophila telomere maintenance. Curr. Biol. 14: 1348-1353.
3. BRODSKY, M. H., J. J. SEKELSKY, G. TSANG, R. S. HAWLEY and G. M. RUBIN, 2000 mus304 encodes a novel DNA damage checkpoint protein required during Drosophila development. Genes Dev. 14: 666-678.
4. BUSCEMI, G., C. SAVIO, L. ZANNINI, F. MICCICHE, D. MASNADA et al., 2001 Chk2 activation dependence on Nbs1 after DNA damage. Mol. Cell. Biol. 21: 5214-5222.
5. COSTANZO, V., D. SHECHTER, P. J. LUPARDUS, K. A. CIMPRICH, M. GOTTESMAN et al., 2003 An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication. Mol. Cell 11: 203-213.
6. FERNANDEZ-CAPETILLO, O., H. T. CHEN, A. CELESTE, I. WARD, P. J. ROMANIENKO et al., 2002 DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. Nat. Cell Biol. 4: 993-997.
7. HARI, K. L., A. SANTERRE, J. J. SEKELSKY, K. S.MCKIM, J. B. BOYD et al., 1995 The mei-41 gene of D. melanogaster is a structural and functional homolog of the human ataxia telangiectasia gene. Cell 82: 815-821.
8. JORGENSEN, T. J., and Y. SHILOH, 1996 The ATM gene and the radiobiology of ataxia-telangiectasia. Int. J. Radiat. Biol. 69: 527-537.
9. LAURENÇON, A., A. PURDY, J. SEKELSKY, R. S. HAWLEY and T. T. SU, 2003 Phenotypic analysis of separation-of-function alleles of MEI-41, Drosophila ATM/ATR. Genetics 164: 589-601.
10. NAKADA, D., Y. HIRANO and K. SUGIMOTO, 2004 Requirement of the Mre11 complex and exonuclease 1 for activation of the Mec1 signaling pathway. Mol. Cell. Biol. 24: 10016-10025.
11. NEUFELD, T. P., A. F. DE LA CRUZ, L. A. JOHNSTON and B. A. EDGAR, 1998 Coordination of growth and cell division in the Drosophila wing. Cell 93: 1183-1193.
12. OIKEMUS, S. R., N. MCGINNIS, J. QUEIROZ-MACHADO, H. TUKACHINSKY, S. TAKADA et al., 2004 Drosophila atm/telomere fusion is required for telomeric localization of HP1 and telomere position effect. Genes Dev. 18: 1850-1861.
13. SILVA, E., S. TIONG, M. PEDERSEN, E. HOMOLA, A. ROYOU et al., 2004 ATM is required for telomere maintenance and chromosome stability during Drosophila development. Curr. Biol. 14: 1341-1347.
14. SOGAME, N., M. KIM and J. M. ABRAMS, 2003 Drosophila p53 preserves genomic stability by regulating cell death. Proc. Natl. Acad. Sci. USA 100: 4696-4701.
15. SONG, Y.-H., G. MIREY, M. BETSON, D. A. HABER and J. SETTLEMAN, 2004 The Drosophila ATM ortholog, dATM, mediates the response to ionizing radiation and to spontaneous DNA damage during development. Curr. Biol. 14: 1354-1359.
16. THEUNISSEN, J. W., M. I. KAPLAN, P. A. HUNT, B. R. WILLIAMS, D. O. FERGUSON et al., 2003 Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice. Mol. Cell 12: 1511-1523.
17. XU, B., S. T. KIM, D. S. LIM and M. B. KASTAN, 2002 Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation. Mol. Cell. Biol. 22: 1049-1059.
18. ZOU, L., and S. J. ELLEDGE, 2003 Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 300: 1542-1548.