-
1
-
-
0021256895
-
Alzheimer's disease: Initial report ofthe purification and characterization ofa novel cere-brovascular amyloid protein
-
Glenner GG, Wong CW (1984) Alzheimer's disease: initial report ofthe purification and characterization ofa novel cere-brovascular amyloid protein. Biochem Biophys Res Commun 120, 885-890.
-
(1984)
Biochem Biophys Res Commun
, vol.120
, pp. 885-890
-
-
Glenner, G.G.1
Wong, C.W.2
-
2
-
-
0024237246
-
Diffuse type of senile plaques in the brains of Alzheimer-type dementia
-
Yamaguchi H, Hirai S, Morimatsu M, Shoji M, Harigaya Y (1988) Diffuse type of senile plaques in the brains of Alzheimer-type dementia. Acta Neuropathol 77, 113-119.
-
(1988)
Acta Neuropathol
, vol.77
, pp. 113-119
-
-
Yamaguchi, H.1
Hirai, S.2
Morimatsu, M.3
Shoji, M.4
Harigaya, Y.5
-
3
-
-
34548036227
-
Tau-mediated neurodegeneration in Alzheimer's disease and related disorders
-
Ballatore C, Lee VM, Trojanowski JQ (2007) Tau-mediated neurodegeneration in Alzheimer's disease and related disorders. Nat Rev Neurosci 8, 663-672.
-
(2007)
Nat Rev Neurosci
, vol.8
, pp. 663-672
-
-
Ballatore, C.1
Lee, V.M.2
Trojanowski, J.Q.3
-
4
-
-
77952496309
-
Functional alterations in memory networks in early Alzheimer's disease
-
Sperling RA, Dickerson BC, Pihlajamaki M, Vannini P, LaVi-olette PS, Vitolo OV, Hedden T, Becker JA, Rentz DM, Selkoe DJ, Johnson KA (2010) Functional alterations in memory networks in early Alzheimer's disease. Neuromolecular Med 12, 27-43.
-
(2010)
Neuromolecular Med
, vol.12
, pp. 27-43
-
-
Sperling, R.A.1
Dickerson, B.C.2
Pihlajamaki, M.3
Vannini, P.4
Lavi-Olette, P.S.5
Vitolo, O.V.6
Hedden, T.7
Becker, J.A.8
Rentz, D.M.9
Selkoe, D.J.10
Johnson, K.A.11
-
6
-
-
0033864011
-
Molecular genetics of Alzheimer's disease: The role of beta-amyloid and the presenilins
-
Tandon A, Rogaeva E, Mullan M, St George-Hyslop PH (2000) Molecular genetics of Alzheimer's disease: the role of beta-amyloid and the presenilins. Curr Opin Neurol 13, 377-384.
-
(2000)
Curr Opin Neurol
, vol.13
, pp. 377-384
-
-
Tandon, A.1
Rogaeva, E.2
Mullan, M.3
St George-Hyslop, P.H.4
-
7
-
-
0034534952
-
Identifying proteases that cleave A(PP)
-
Citron M (2000) Identifying proteases that cleave A(PP). Ann NY Acad Sci 920, 192-196.
-
(2000)
Ann NY Acad Sci
, vol.920
, pp. 192-196
-
-
Citron, M.1
-
8
-
-
0035927426
-
Secretase targets for Alzheimer's disease: Identification and therapeutic potential
-
Wolfe MS (2001) Secretase targets for Alzheimer's disease: identification and therapeutic potential. J Med Chem 44, 2039-2060.
-
(2001)
J Med Chem
, vol.44
, pp. 2039-2060
-
-
Wolfe, M.S.1
-
9
-
-
76849086405
-
The secretases: Enzymes with therapeutic potential in Alzheimer disease
-
De Strooper B., Vassar R, Golde T (2010) The secretases: enzymes with therapeutic potential in Alzheimer disease. Nat Rev Neurol 6, 99-107.
-
(2010)
Nat Rev Neurol
, vol.6
, pp. 99-107
-
-
De Strooper, B.1
Vassar, R.2
Golde, T.3
-
10
-
-
18844378852
-
Presenilin function and gamma-secretase activity
-
Brunkan AL, Goate AM (2005) Presenilin function and gamma-secretase activity. J Neurochem 93, 769-792.
-
(2005)
J Neurochem
, vol.93
, pp. 769-792
-
-
Brunkan, A.L.1
Goate, A.M.2
-
11
-
-
0033518251
-
Purification and cloning ofamyloid precursor protein beta-secretase from human brain
-
Sinha S, Anderson JP, Barbour R, Basi GS, Caccavello R, Davis D, Doan M, Dovey HF, Frigon N, Hong J, Jacobson-Croak K, Jewett N, Keim P, Knops J, Lieberburg I, Power M, Tan H, Tatsuno G, Tung J, Schenk D, Seubert P, Suomensaari SM, Wang S, Walker D, Zhao J, McConlogue L, John V (1999) Purification and cloning ofamyloid precursor protein beta-secretase from human brain. Nature 402, 537-540.
-
(1999)
Nature
, vol.402
, pp. 537-540
-
-
Sinha, S.1
Anderson, J.P.2
Barbour, R.3
Basi, G.S.4
Caccavello, R.5
Davis, D.6
Doan, M.7
Dovey, H.F.8
Frigon, N.9
Hong, J.10
Jacobson-Croak, K.11
Jewett, N.12
Keim, P.13
Knops, J.14
Lieberburg, I.15
Power, M.16
Tan, H.17
Tatsuno, G.18
Tung, J.19
Schenk, D.20
Seubert, P.21
Suomensaari, S.M.22
Wang, S.23
Walker, D.24
Zhao, J.25
McConlogue, L.26
John, V.27
more..
-
12
-
-
0033595706
-
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmem-brane aspartic protease BACE
-
Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, Luo Y, Fisher S, Fuller J, Edenson S, Lile J, Jarosinski MA, Biere AL, Curran E, Burgess T, Louis JC, Collins F, Tre-anor J, Rogers G, Citron M (1999) Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmem-brane aspartic protease BACE. Science 286, 735-741.
-
(1999)
Science
, vol.286
, pp. 735-741
-
-
Vassar, R.1
Bennett, B.D.2
Babu-Khan, S.3
Kahn, S.4
Mendiaz, E.A.5
Denis, P.6
Teplow, D.B.7
Ross, S.8
Amarante, P.9
Loeloff, R.10
Luo, Y.11
Fisher, S.12
Fuller, J.13
Edenson, S.14
Lile, J.15
Jarosinski, M.A.16
Biere, A.L.17
Curran, E.18
Burgess, T.19
Louis, J.C.20
Collins, F.21
Tre-Anor, J.22
Rogers, G.23
Citron, M.24
more..
-
13
-
-
56349116391
-
Molecular genetics of Alzheimer's disease: An update
-
Brouwers N, Sleegers K, Van Broeckhoven C (2008) Molecular genetics of Alzheimer's disease: an update. Ann Med 40, 562-583.
-
(2008)
Ann Med
, vol.40
, pp. 562-583
-
-
Brouwers, N.1
Sleegers, K.2
Van Broeckhoven, C.3
-
14
-
-
0035937153
-
The Role of presenilins in gamma-secretase activity
-
Wolfe MS, Haass C (2001) The Role of presenilins in gamma-secretase activity. J Biol Chem 276, 5413-5416.
-
(2001)
J Biol Chem
, vol.276
, pp. 5413-5416
-
-
Wolfe, M.S.1
Haass, C.2
-
15
-
-
0030293676
-
Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo
-
Borchelt DR, Thinakaran G, Eckman CB, Lee MK, Davenport F, Ratovitsky T, Prada CM, Kim G, Seekins S, Yager D, Slunt HH, Wang R, Seeger M, Levey AI, Gandy SE, Copeland NG, Jenkins NA, Price DL, Younkin SG, Sisodia SS (1996) Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron 17, 1005-1013.
-
(1996)
Neuron
, vol.17
, pp. 1005-1013
-
-
Borchelt, D.R.1
Thinakaran, G.2
Eckman, C.B.3
Lee, M.K.4
Davenport, F.5
Ratovitsky, T.6
Prada, C.M.7
Kim, G.8
Seekins, S.9
Yager, D.10
Slunt, H.H.11
Wang, R.12
Seeger, M.13
Levey, A.I.14
Gandy, S.E.15
Copeland, N.G.16
Jenkins, N.A.17
Price, D.L.18
Younkin, S.G.19
Sisodia, S.S.20
more..
-
16
-
-
64549150594
-
Natural non-trasgenic animal models for research in Alzheimer's disease
-
Sarasa M, Pesini P (2009) Natural non-trasgenic animal models for research in Alzheimer's disease. Curr Alzheimer Res 6, 171-178.
-
(2009)
Curr Alzheimer Res
, vol.6
, pp. 171-178
-
-
Sarasa, M.1
Pesini, P.2
-
17
-
-
84880187096
-
Mice as models: Transgenic approaches and Alzheimer's disease
-
Games D, Buttini M, Kobayashi D, Schenk D, Seubert P (2006) Mice as models: transgenic approaches and Alzheimer's disease. J Alzheimers Dis 9, 133-149.
-
(2006)
J Alzheimers Dis
, vol.9
, pp. 133-149
-
-
Games, D.1
Buttini, M.2
Kobayashi, D.3
Schenk, D.4
Seubert, P.5
-
18
-
-
0028985574
-
Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein
-
Blackwell C, Carr T, Clemens J, Donaldson T, Gillespie F, Guido T, Hagopian S, Johnson-Wood K, Khan K, Lee M, Lei-bowitz P, Lieberburg I, Little S, Masliah E, McConlogue L, Montoya-Zavala M, Mucke L, Paganini L, Penniman E, Power M, Schenk D, Seubert P, Snyder B, Soriano F, Tan H, Vitale J, Wadsworth S, Wolozin B, Zhao J
-
Games D, Adams D, Alessandrini R, Barbour R, Berthelette P, Blackwell C, Carr T, Clemens J, Donaldson T, Gillespie F, Guido T, Hagopian S, Johnson-Wood K, Khan K, Lee M, Lei-bowitz P, Lieberburg I, Little S, Masliah E, McConlogue L, Montoya-Zavala M, Mucke L, Paganini L, Penniman E, Power M, Schenk D, Seubert P, Snyder B, Soriano F, Tan H, Vitale J, Wadsworth S, Wolozin B, Zhao J (1995) Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein. Nature 373, 523-527.
-
(1995)
Nature
, vol.373
, pp. 523-527
-
-
Games, D.1
Adams, D.2
Alessandrini, R.3
Barbour, R.4
Berthelette, P.5
-
19
-
-
0033501744
-
Behavioral disturbances in transgenic mice overexpressing the V717F beta-amyloid precursor protein
-
Dodart JC, Meziane H, Mathis C, Bales KR, Paul SM, Ungerer A (1999) Behavioral disturbances in transgenic mice overexpressing the V717F beta-amyloid precursor protein. Behav Neurosci 113, 982-990.
-
(1999)
Behav Neurosci
, vol.113
, pp. 982-990
-
-
Dodart, J.C.1
Meziane, H.2
Mathis, C.3
Bales, K.R.4
Paul, S.M.5
Ungerer, A.6
-
20
-
-
0035877756
-
Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein
-
Chishti MA, Yang DS, Janus C, Phinney AL, Horne P, Pearson J, Strome R, Zuker N, Loukides J, French J, Turner S, Lozza G, Grilli M, Kunicki S, Morissette C, Paquette J, Gervais F, Bergeron C, Fraser PE, Carlson GA, George-Hyslop PS, Westaway D (2001) Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein JBiol Chem 276, 21562-21570.
-
(2001)
JBiol Chem
, vol.276
, pp. 21562-21570
-
-
Chisti, M.A.1
Yang, D.S.2
Janus, C.3
Phinney, A.L.4
Horne, P.5
Pearson, J.6
Strome, R.7
Zuker, N.8
Loukides, J.9
French, J.10
Turner, S.11
Lozza, G.12
Grilli, M.13
Kunicki, S.14
Morissette, C.15
Paquette, J.16
Gervais, F.17
Bergeron, C.18
Fraser, P.E.19
Carlson, G.A.20
George-Hyslop, P.S.21
Westaway, D.22
more..
-
21
-
-
0029742199
-
Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice
-
Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S, Yang F, Cole G (1996) Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science 274, 99-102.
-
(1996)
Science
, vol.274
, pp. 99-102
-
-
Hsiao, K.1
Chapman, P.2
Nilsen, S.3
Eckman, C.4
Harigaya, Y.5
Younkin, S.6
Yang, F.7
Cole, G.8
-
22
-
-
1642555780
-
Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: Evidence for augmentation of a 42-specific gamma secretase
-
Jankowsky JL, Fadale DJ, Anderson J, Xu GM, Gonzales V, Jenkins NA, Copeland NG, Lee MK, Younkin LH, Wagner SL, Younkin SG, Borchelt DR (2004) Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase. Hum Mol Genet 13, 159-170.
-
(2004)
Hum Mol Genet
, vol.13
, pp. 159-170
-
-
Jankowsky, J.L.1
Fadale, D.J.2
Anderson, J.3
Xu, G.M.4
Gonzales, V.5
Jenkins, N.A.6
Copeland, N.G.7
Lee, M.K.8
Younkin, L.H.9
Wagner, S.L.10
Younkin, S.G.11
Borchelt, D.R.12
-
23
-
-
0031914718
-
Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes
-
Holcomb L, Gordon MN, McGowan E, Yu X, Benkovic S, Jantzen P, Wright K, Saad I, Mueller R, Morgan D, Sanders S, Zehr C, O'Campo K, Hardy J, Prada CM, Eckman C, Younkin S, Hsiao K, Duff K (1998) Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat Med 4, 97-100.
-
(1998)
Nat Med
, vol.4
, pp. 97-100
-
-
Holcomb, L.1
Gordon, M.N.2
McGowan, E.3
Yu, X.4
Benkovic, S.5
Jantzen, P.6
Wright, K.7
Saad, I.8
Mueller, R.9
Morgan, D.10
Sanders, S.11
Zehr, C.12
O'Campo, K.13
Hardy, J.14
Prada, C.M.15
Eckman, C.16
Younkin, S.17
Hsiao, K.18
Duff, K.19
-
24
-
-
0011444914
-
Two amyloid precursor protein transgenic mouse models with Alzheimer diseaselike pathology
-
Sturchler-Pierrat C, Abramowski D, Duke M, Wiederhold KH, Mistl C, Rothacher S, Ledermann B, Burki K, Frey P, Paganetti PA, Waridel C, Calhoun ME, Jucker M, Probst A, Staufenbiel M, Sommer B (1997) Two amyloid precursor protein transgenic mouse models with Alzheimer diseaselike pathology. Proc Natl Acad Sci USA 94, 13287-13292.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 13287-13292
-
-
Sturchler-Pierrat, C.1
Abramowski, D.2
Duke, M.3
Wiederhold, K.H.4
Mistl, C.5
Rothacher, S.6
Ledermann, B.7
Burki, K.8
Frey, P.9
Paganetti, P.A.10
Waridel, C.11
Calhoun, M.E.12
Jucker, M.13
Probst, A.14
Staufenbiel, M.15
Sommer, B.16
-
25
-
-
2442594971
-
Early-onset and robust cerebral microvascular accumulation ofamyloid beta-protein in transgenic mice expressing low levels of a vas-culotropic Dutch/Iowa mutant form of amyloid beta-protein precursor
-
Davis J, Xu F, Deane R, Romanov G, Previti ML, Zeigler K, Zlokovic BV, Van Nostrand WE (2004) Early-onset and robust cerebral microvascular accumulation ofamyloid beta-protein in transgenic mice expressing low levels of a vas-culotropic Dutch/Iowa mutant form of amyloid beta-protein precursor. J Biol Chem 279, 20296-20306.
-
(2004)
J Biol Chem
, vol.279
, pp. 20296-20306
-
-
Davis, J.1
Xu, F.2
Deane, R.3
Romanov, G.4
Previti, M.L.5
Zeigler, K.6
Zlokovic, B.V.7
Van Nostrand, W.E.8
-
26
-
-
13044265226
-
Neuronal over-expression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid
-
Calhoun ME, Burgermeister P, Phinney AL, Stalder M, Tol-nay M, Wiederhold KH, Abramowski D, Sturchler-Pierrat C, Sommer B, Staufenbiel M, Jucker M (1999) Neuronal over-expression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid. Proc Natl Acad Sci USA 96, 14088-14093.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 14088-14093
-
-
Calhoun, M.E.1
Burgermeister, P.2
Phinney, A.L.3
Stalder, M.4
Tolnay, M.5
Wiederhold, K.H.6
Abramowski, D.7
Sturchler-Pierrat, C.8
Sommer, B.9
Staufenbiel, M.10
Jucker, M.11
-
27
-
-
4344648449
-
Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis
-
Herzig MC, Winkler DT, Burgermeister P, Pfeifer M, Kohler E, Schmidt SD, Danner S, Abramowski D, Sturchler-Pierrat C, Burki K, van Duinen SG, Maat-Schieman ML, Staufen-biel M, Mathews PM, Jucker M (2004) Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis. Nat Neurosci 7, 954-960.
-
(2004)
Nat Neurosci
, vol.7
, pp. 954-960
-
-
Herzig, M.C.1
Winkler, D.T.2
Burgermeister, P.3
Pfeifer, M.4
Kohler, E.5
Schmidt, S.D.6
Danner, S.7
Abramowski, D.8
Sturchler-Pierrat, C.9
Burki, K.10
Van Duinen, S.G.11
Maat-Schieman, M.L.12
Staufen-Biel, M.13
Mathews, P.M.14
Jucker, M.15
-
28
-
-
0035808361
-
Tau filament formation in transgenic mice expressing P301L tau
-
Gotz J, Chen F, Barmettler R, Nitsch RM (2001) Tau filament formation in transgenic mice expressing P301L tau. J Biol Chem 276, 529-534.
-
(2001)
J Biol Chem
, vol.276
, pp. 529-534
-
-
Gotz, J.1
Chen, F.2
Barmettler, R.3
Nitsch, R.M.4
-
29
-
-
0034426011
-
Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein
-
Lewis J, McGowan E, Rockwood J, Melrose H, Nacharaju P, Van SM, Gwinn-Hardy K, Paul MM, Baker M, Yu X, Duff K, Hardy J, Corral A, Lin WL, Yen SH, Dickson DW, Davies P, Hutton M (2000) Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein. Nat Genet 25, 402-405.
-
(2000)
Nat Genet
, vol.25
, pp. 402-405
-
-
Lewis, J.1
McGowan, E.2
Rockwood, J.3
Melrose, H.4
Nacharaju, P.5
Van, S.M.6
Gwinn-Hardy, K.7
Paul, M.M.8
Baker, M.9
Yu, X.10
Duff, K.11
Hardy, J.12
Corral, A.13
Lin, W.L.14
Yen, S.H.15
Dickson, D.W.16
Davies, P.17
Hutton, M.18
-
30
-
-
0042697305
-
Triple-transgenic model of Alzheimer's disease with plaques and tangles: Intracellular Abeta and synaptic dysfunction
-
Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, LaFerla FM (2003) Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron 39, 409-421.
-
(2003)
Neuron
, vol.39
, pp. 409-421
-
-
Oddo, S.1
Caccamo, A.2
Shepherd, J.D.3
Murphy, M.P.4
Golde, T.E.5
Kayed, R.6
Metherate, R.7
Mattson, M.P.8
Akbari, Y.9
Laferla, F.M.10
-
31
-
-
0037154117
-
AftPP transgenic mice Tg2576 accumulate Abeta peptides that are distinct from the chemically modified and insoluble peptides deposited in Alzheimer's disease senile plaques
-
Kalback W, Watson MD, Kokjohn TA, Kuo YM, Weiss N, Luehrs DC, Lopez J, Brune D, Sisodia SS, Staufenbiel M, Emmerling M, Roher AE (2002) AftPP transgenic mice Tg2576 accumulate Abeta peptides that are distinct from the chemically modified and insoluble peptides deposited in Alzheimer's disease senile plaques. Biochemistry 41, 922928.
-
(2002)
Biochemistry
, vol.41
, pp. 922928
-
-
Kalback, W.1
Watson, M.D.2
Kokjohn, T.A.3
Kuo, Y.M.4
Weiss, N.5
Luehrs, D.C.6
Lopez, J.7
Brune, D.8
Sisodia, S.S.9
Staufenbiel, M.10
Emmerling, M.11
Roher, A.E.12
-
32
-
-
0035918312
-
Comparative analysis of amyloid-beta chemical structure and amyloid plaque morphology oftransgenic mouse and Alzheimer's disease brains
-
Kuo YM, Kokjohn TA, Beach TG, Sue LI, Brune D, Lopez JC, Kalback WM, Abramowski D, Sturchler-Pierrat C, Staufenbiel M, Roher AE (2001) Comparative analysis of amyloid-beta chemical structure and amyloid plaque morphology oftransgenic mouse and Alzheimer's disease brains. JBiol Chem 276, 12991-12998.
-
(2001)
JBiol Chem
, vol.276
, pp. 12991-12998
-
-
Kuo, Y.M.1
Kokjohn, T.A.2
Beach, T.G.3
Sue, L.I.4
Brune, D.5
Lopez, J.C.6
Kalback, W.M.7
Abramowski, D.8
Sturchler-Pierrat, C.9
Staufenbiel, M.10
Roher, A.E.11
-
33
-
-
48749106996
-
Tg-SwDI transgenic mice exhibit novel alterations in AbetaPP processing, Abeta degradation, and resilient amyloid angiopathy
-
Van Vickle GD, Esh CL, Daugs ID, Kokjohn TA, Kalback WM, Patton RL, Luehrs DC, Walker DG, Lue LF, Beach TG, Davis J, Van Nostrand WE, Castano EM, Roher AE (2008) Tg-SwDI transgenic mice exhibit novel alterations in AbetaPP processing, Abeta degradation, and resilient amyloid angiopathy. Am J Pathol 173, 483-493.
-
(2008)
Am J Pathol
, vol.173
, pp. 483-493
-
-
Van Vickle, G.D.1
Esh, C.L.2
Daugs, I.D.3
Kokjohn, T.A.4
Kalback, W.M.5
Patton, R.L.6
Luehrs, D.C.7
Walker, D.G.8
Lue, L.F.9
Beach, T.G.10
Davis, J.11
Van Nostrand, W.E.12
Castano, E.M.13
Roher, A.E.14
-
34
-
-
0032558784
-
Neuron loss in AftPP transgenic mice
-
Calhoun ME, Wiederhold KH, Abramowski D, Phinney AL, Probst A, Sturchler-Pierrat C, Staufenbiel M, Sommer B, Jucker M (1998) Neuron loss in AftPP transgenic mice. Nature 395, 755-756.
-
(1998)
Nature
, vol.395
, pp. 755-756
-
-
Calhoun, M.E.1
Wiederhold, K.H.2
Abramowski, D.3
Phinney, A.L.4
Probst, A.5
Sturchler-Pierrat, C.6
Staufenbiel, M.7
Sommer, B.8
Jucker, M.9
-
35
-
-
0031791971
-
Distribution of A beta-associated proteins in cerebrovascular amyloid of Alzheimer's disease
-
Verbeek MM, Otte-Holler I, Veerhuis R, Ruiter DJ, de Waal RM (1998) Distribution of A beta-associated proteins in cerebrovascular amyloid of Alzheimer's disease. Acta Neu-ropathol (Berl) 96, 628-636.
-
(1998)
Acta Neu-ropathol (Berl)
, vol.96
, pp. 628-636
-
-
Verbeek, M.M.1
Otte-Holler, I.2
Veerhuis, R.3
Ruiter, D.J.4
De Waal, R.M.5
-
36
-
-
36248968668
-
Heat shock proteins and amateur chaperones in amyloid-Beta accumulation and clearance in Alzheimer's disease
-
Wilhelmus MM, de Waal RM, Verbeek MM (2007) Heat shock proteins and amateur chaperones in amyloid-Beta accumulation and clearance in Alzheimer's disease. Mol Neu-robiol 35, 203-216.
-
(2007)
Mol Neu-robiol
, vol.35
, pp. 203-216
-
-
Wilhelmus, M.M.1
De Waal, R.M.2
Verbeek, M.M.3
-
37
-
-
0024364438
-
The protease inhibitor, alpha 1-antichymotrypsin, is a component of the brain amyloid deposits in normal aging and Alzheimer's disease
-
Abraham CR, Potter H (1989) The protease inhibitor, alpha 1-antichymotrypsin, is a component of the brain amyloid deposits in normal aging and Alzheimer's disease. Ann Med 21,77-81.
-
(1989)
Ann Med
, vol.21
, pp. 77-81
-
-
Abraham, C.R.1
Potter, H.2
-
38
-
-
0028173205
-
Amyloid-associated proteins alpha 1-antichymotrypsin and apolipoprotein e promote assembly of Alzheimer beta-protein into filaments
-
Ma J, Yee A, Brewer HB, Jr., Das S, Potter H (1994) Amyloid-associated proteins alpha 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer beta-protein into filaments. Nature 372, 92-94.
-
(1994)
Nature
, vol.372
, pp. 92-94
-
-
Ma, J.1
Yee, A.2
Brewer, Jr.H.B.3
Das, S.4
Potter, H.5
-
39
-
-
0038376613
-
Heparan sulphate proteoglycans in Alzheimer's disease and amyloid-related disorders
-
van Horssen J, Wesseling P, van den Heuvel LP, de Waal RM, Verbeek MM (2003) Heparan sulphate proteoglycans in Alzheimer's disease and amyloid-related disorders. Lancet Neurol 2, 482-492.
-
(2003)
Lancet Neurol
, vol.2
, pp. 482-492
-
-
Van Horssen, J.1
Wesseling, P.2
Van Den Heuvel, L.P.3
De Waal, R.M.4
Verbeek, M.M.5
-
40
-
-
0027970307
-
Acceleration of Alzheimer's fibril formation by apolipoprotein e in vitro
-
Wisniewski T, Castano EM, Golabek A, Vogel T, Frangione B (1994) Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro. Am J Pathol 145, 1030-1035.
-
(1994)
Am J Pathol
, vol.145
, pp. 1030-1035
-
-
Wisniewski, T.1
Castano, E.M.2
Golabek, A.3
Vogel, T.4
Frangione, B.5
-
41
-
-
0024273721
-
The presence of heparan sulfate proteoglycans in the neuritic plaques and congophilic angiopathy in Alzheimer's disease
-
Snow AD, Mar H, Nochlin D, Kimata K, Kato M, Suzuki S, Hassell J, Wight TN (1988) The presence of heparan sulfate proteoglycans in the neuritic plaques and congophilic angiopathy in Alzheimer's disease. Am J Pathol 133, 456-463.
-
(1988)
Am J Pathol
, vol.133
, pp. 456-463
-
-
Snow, A.D.1
Mar, H.2
Nochlin, D.3
Kimata, K.4
Kato, M.5
Suzuki, S.6
Hassell, J.7
Wight, T.N.8
-
42
-
-
0035157875
-
Heparan sulfate proteoglycan expression in cere-brovascular amyloid beta deposits in Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis (Dutch) brains
-
van Horssen J, Otte-Holler I, David G, Maat-Schieman ML, van den Heuvel LP, Wesseling P, de Waal RM, Verbeek MM (2001) Heparan sulfate proteoglycan expression in cere-brovascular amyloid beta deposits in Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis (Dutch) brains. Acta Neuropathol (Berl) 102, 604-614.
-
(2001)
Acta Neuropathol (Berl)
, vol.102
, pp. 604-614
-
-
Van Horssen, J.1
Otte-Holler, I.2
David, G.3
Maat-Schieman, M.L.4
Van Den Heuvel, L.P.5
Wesseling, P.6
De Waal, R.M.7
Verbeek, M.M.8
-
43
-
-
0033953066
-
Agrin binds to beta-amyloid (Abeta), accelerates abeta fibril formation, and is localized to Abeta deposits in Alzheimer's disease brain
-
Cotman SL, Halfter W, Cole GJ (2000) Agrin binds to beta-amyloid (Abeta), accelerates abeta fibril formation, and is localized to Abeta deposits in Alzheimer's disease brain. Mol CellNeurosci 15, 183-198.
-
(2000)
Mol CellNeurosci
, vol.15
, pp. 183-198
-
-
Cotman, S.L.1
Halfter, W.2
Cole, G.J.3
-
44
-
-
0036255536
-
Accumulation of heparan sulfate proteoglycans in cerebellar senile plaques
-
van Horssen J, Kleinnijenhuis J, Maass CN, Rensink AA, Otte-Holler I, David G, van den Heuvel LP, Wesseling P, de Waal RM, Verbeek MM (2002) Accumulation of heparan sulfate proteoglycans in cerebellar senile plaques. Neurobiol Aging 23, 537-545.
-
(2002)
Neurobiol Aging
, vol.23
, pp. 537-545
-
-
Van Horssen, J.1
Kleinnijenhuis, J.2
Maass, C.N.3
Rensink, A.A.4
Otte-Holler, I.5
David, G.6
Van Den Heuvel, L.P.7
Wesseling, P.8
De Waal, R.M.9
Verbeek, M.M.10
-
45
-
-
0029047722
-
Differential binding of vascular cell-derived proteoglycans (perlecan, biglycan, decorin, and versican) to the beta-amyloid protein of Alzheimer's disease
-
Snow AD, Kinsella MG, Parks E, Sekiguchi RT, Miller JD, Kimata K, Wight TN (1995) Differential binding of vascular cell-derived proteoglycans (perlecan, biglycan, decorin, and versican) to the beta-amyloid protein of Alzheimer's disease. Arch Biochem Biophys 320, 84-95.
-
(1995)
Arch Biochem Biophys
, vol.320
, pp. 84-95
-
-
Snow, A.D.1
Kinsella, M.G.2
Parks, E.3
Sekiguchi, R.T.4
Miller, J.D.5
Kimata, K.6
Wight, T.N.7
-
46
-
-
0030725311
-
Perlecan binds to the beta-amyloid proteins (A beta) of Alzheimer's disease, accelerates A beta fibril formation, and maintains A beta fibril stability
-
Castillo GM, Ngo C, Cummings J, Wight TN, Snow AD (1997) Perlecan binds to the beta-amyloid proteins (A beta) of Alzheimer's disease, accelerates A beta fibril formation, and maintains A beta fibril stability. J Neurochem 69, 24522465.
-
(1997)
J Neurochem
, vol.69
, pp. 24522465
-
-
Castillo, G.M.1
Ngo, C.2
Cummings, J.3
Wight, T.N.4
Snow, A.D.5
-
47
-
-
0033026552
-
The sulfate moieties of glycosaminoglycans are critical for the enhancement of beta-amyloid protein fibril formation
-
Castillo GM, Lukito W, Wight TN, Snow AD (1999) The sulfate moieties of glycosaminoglycans are critical for the enhancement of beta-amyloid protein fibril formation. J Neurochem 72, 1681-1687.
-
(1999)
J Neurochem
, vol.72
, pp. 1681-1687
-
-
Castillo, G.M.1
Lukito, W.2
Wight, T.N.3
Snow, A.D.4
-
48
-
-
0033943119
-
Transgenic mouse models of Alzheimer's disease
-
Bornemann KD, Staufenbiel M (2000) Transgenic mouse models of Alzheimer's disease. Ann N Y Acad Sci 908, 260266.
-
(2000)
Ann N y Acad Sci
, vol.908
, pp. 260266
-
-
Bornemann, K.D.1
Staufenbiel, M.2
-
49
-
-
51249091645
-
Heparan sulfate accumulation with Abeta deposits in Alzheimer's disease and Tg2576 mice is contributed by glial cells
-
O'Callaghan P, Sandwall E, Li JP, Yu H, Ravid R, Guan ZZ, van Kuppevelt TH, Nilsson LN, Ingelsson M, Hyman BT, Kalimo H, Lindahl U, Lannfelt L, Zhang X (2008) Heparan sulfate accumulation with Abeta deposits in Alzheimer's disease and Tg2576 mice is contributed by glial cells. Brain Pathol 18, 548-561.
-
(2008)
Brain Pathol
, vol.18
, pp. 548-561
-
-
O'Callaghan, P.1
Sandwall, E.2
Li, J.P.3
Yu, H.4
Ravid, R.5
Guan, Z.Z.6
Van Kuppevelt, T.H.7
Nilsson, L.N.8
Ingelsson, M.9
Hyman, B.T.10
Kalimo, H.11
Lindahl, U.12
Lannfelt, L.13
Zhang, X.14
-
50
-
-
77956512204
-
Limited expression of hep-aran sulfate proteoglycans associated with Abeta deposits in the AftPPswe/PS 1dE9 mouse model for Alzheimer's disease
-
Timmer NM, Herbert MK, Kleinovink JW, Kiliaan AJ, de Waal RM, Verbeek MM (2010) Limited expression of hep-aran sulfate proteoglycans associated with Abeta deposits in the AftPPswe/PS 1dE9 mouse model for Alzheimer's disease. Neuropathol Appl Neurobiol 36, 478-486.
-
(2010)
Neuropathol Appl Neurobiol
, vol.36
, pp. 478-486
-
-
Timmer, N.M.1
Herbert, M.K.2
Kleinovink, J.W.3
Kiliaan, A.J.4
De Waal, R.M.5
Verbeek, M.M.6
-
51
-
-
67649805281
-
Amyloid precursor protein transgenic mouse models and Alzheimer's disease: Understanding the paradigms, limitations, and contributions
-
Kokjohn TA, Roher AE (2009) Amyloid precursor protein transgenic mouse models and Alzheimer's disease: understanding the paradigms, limitations, and contributions. Alzheimers Dement 5, 340-347.
-
(2009)
Alzheimers Dement
, vol.5
, pp. 340-347
-
-
Kokjohn, T.A.1
Roher, A.E.2
-
52
-
-
0024387388
-
Proteoglycans in the pathogenesis of Alzheimer's disease and other amyloidoses
-
Snow AD, Wight TN (1989) Proteoglycans in the pathogenesis of Alzheimer's disease and other amyloidoses. Neurobiol Aging 10, 481-497.
-
(1989)
Neurobiol Aging
, vol.10
, pp. 481-497
-
-
Snow, A.D.1
Wight, T.N.2
-
53
-
-
0022350033
-
Apolipoprotein e associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system
-
Boyles JK, Pitas RE, Wilson E, Mahley RW, Taylor JM (1985) Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system. J Clin Invest 76, 1501-1513.
-
(1985)
J Clin Invest
, vol.76
, pp. 1501-1513
-
-
Boyles, J.K.1
Pitas, R.E.2
Wilson, E.3
Mahley, R.W.4
Taylor, J.M.5
-
54
-
-
75549089646
-
Apolipoprotein e protects cultured pericytes and astrocytes from D-Abeta(1-40)-mediated cell death
-
Bruinsma IB, Wilhelmus MM, Kox M, Veerhuis R, de Waal RM, Verbeek MM (2010) Apolipoprotein E protects cultured pericytes and astrocytes from D-Abeta(1-40)-mediated cell death. Brain Res 1315, 169-180.
-
(2010)
Brain Res
, vol.1315
, pp. 169-180
-
-
Bruinsma, I.B.1
Wilhelmus, M.M.2
Kox, M.3
Veerhuis, R.4
De Waal, R.M.5
Verbeek, M.M.6
-
55
-
-
17044433857
-
Apolipoprotein e genotype regulates amyloid-beta cytotoxicity
-
Wilhelmus MM, Otte-Holler I, Davis J, Van Nostrand WE, de Waal RM, Verbeek MM (2005) Apolipoprotein E genotype regulates amyloid-beta cytotoxicity. J Neurosci 25, 36213627.
-
(2005)
J Neurosci
, vol.25
, pp. 36213627
-
-
Wilhelmus, M.M.1
Otte-Holler, I.2
Davis, J.3
Van Nostrand, W.E.4
De Waal, R.M.5
Verbeek, M.M.6
-
56
-
-
0023280054
-
Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain
-
Pitas RE, Boyles JK, Lee SH, Hui D, Weisgraber KH (1987) Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain. JBiol Chem 262, 14352-14360.
-
(1987)
JBiol Chem
, vol.262
, pp. 14352-14360
-
-
Pitas, R.E.1
Boyles, J.K.2
Lee, S.H.3
Hui, D.4
Weisgraber, K.H.5
-
57
-
-
0027407565
-
Apolipopro-tein E: High-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease
-
Strittmatter WJ, Saunders AM, Schmechel D, Pericak-Vance M, Enghild J, Salvesen GS, Roses AD (1993) Apolipopro-tein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci USA 90, 1977-1981.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 1977-1981
-
-
Strittmatter, W.J.1
Saunders, A.M.2
Schmechel, D.3
Pericak-Vance, M.4
Enghild, J.5
Salvesen, G.S.6
Roses, A.D.7
-
58
-
-
68249134074
-
The role of apolipoprotein e in Alzheimer's disease
-
Kim J, Basak JM, Holtzman DM (2009) The role of apolipoprotein E in Alzheimer's disease. Neuron 63, 287-303.
-
(2009)
Neuron
, vol.63
, pp. 287-303
-
-
Kim, J.1
Basak, J.M.2
Holtzman, D.M.3
-
59
-
-
0025971426
-
Apolipoprotein e immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease
-
Namba Y, Tomonaga M, Kawasaki H, Otomo E, Ikeda K (1991) Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease. Brain Res 541, 163-166.
-
(1991)
Brain Res
, vol.541
, pp. 163-166
-
-
Namba, Y.1
Tomonaga, M.2
Kawasaki, H.3
Otomo, E.4
Ikeda, K.5
-
60
-
-
0842342533
-
Immunohistochemical study of distribution of apolipoproteins e and D in human cerebral beta amyloid deposits
-
Navarro A, Del VE, Astudillo A, Gonzalez del RC, Tolivia J (2003) Immunohistochemical study of distribution of apolipoproteins E and D in human cerebral beta amyloid deposits. Exp Neurol 184, 697-704.
-
(2003)
Exp Neurol
, vol.184
, pp. 697-704
-
-
Navarro, A.1
Del, V.E.2
Astudillo, A.3
Gonzalez Del, R.C.4
Tolivia, J.5
-
61
-
-
0026542786
-
Apolipoprotein E: Apatho-logical chaperone protein in patients with cerebral and systemic amyloid
-
Wisniewski T, Frangione B (1992) Apolipoprotein E: apatho-logical chaperone protein in patients with cerebral and systemic amyloid. Neurosci Lett 135, 235-238.
-
(1992)
Neurosci Lett
, vol.135
, pp. 235-238
-
-
Wisniewski, T.1
Frangione, B.2
-
62
-
-
0029757510
-
Apolipoprotein e distribution among different plaque types in Alzheimer's disease: Implications for its role in plaque progression
-
Sheng JG, Mrak RE, Griffin WS (1996) Apolipoprotein E distribution among different plaque types in Alzheimer's disease: implications for its role in plaque progression. Neu-ropathol Appl Neurobiol 22, 334-341.
-
(1996)
Neu-ropathol Appl Neurobiol
, vol.22
, pp. 334-341
-
-
Sheng, J.G.1
Mrak, R.E.2
Griffin, W.S.3
-
63
-
-
0034183020
-
Elevated A beta and apolipoprotein e in A betaPP transgenic mice and its relationship to amyloid accumulation in Alzheimer's disease
-
Kuo YM, Crawford F, Mullan M, Kokjohn TA, Emmer-ling MR, Weller RO, Roher AE (2000) Elevated A beta and apolipoprotein E in A betaPP transgenic mice and its relationship to amyloid accumulation in Alzheimer's disease. MolMed 6, 430-439.
-
(2000)
MolMed
, vol.6
, pp. 430-439
-
-
Kuo, Y.M.1
Crawford, F.2
Mullan, M.3
Kokjohn, T.A.4
Emmerling, M.R.5
Weller, R.O.6
Roher, A.E.7
-
64
-
-
0035805091
-
Apolipoprotein e deposition and astroglio-sis are associated with maturation ofbeta-amyloid plaques in betaAftPPswe transgenic mouse: Implications for the patho-genesis of Alzheimer's disease
-
Terai K, Iwai A, Kawabata S, Sasamata M, Miyata K, Yamaguchi T (2001) Apolipoprotein E deposition and astroglio-sis are associated with maturation ofbeta-amyloid plaques in betaAftPPswe transgenic mouse: Implications for the patho-genesis of Alzheimer's disease. Brain Res 900, 48-56.
-
(2001)
Brain Res
, vol.900
, pp. 48-56
-
-
Terai, K.1
Iwai, A.2
Kawabata, S.3
Sasamata, M.4
Miyata, K.5
Yamaguchi, T.6
-
65
-
-
2942611429
-
Transgenic mice overexpressing amyloid beta protein are an incomplete model of Alzheimer disease
-
Schwab C, Hosokawa M, McGeer PL (2004) Transgenic mice overexpressing amyloid beta protein are an incomplete model of Alzheimer disease. Exp Neurol 188, 52-64.
-
(2004)
Exp Neurol
, vol.188
, pp. 52-64
-
-
Schwab, C.1
Hosokawa, M.2
McGeer, P.L.3
-
66
-
-
0037474140
-
Co-localization of cholesterol, apolipoprotein e and fibrillar Abeta in amyloid plaques
-
Burns MP, Noble WJ, Olm V, Gaynor K, Casey E, LaFran-cois J, Wang L, Duff K (2003) Co-localization of cholesterol, apolipoprotein E and fibrillar Abeta in amyloid plaques. Brain Res Mol Brain Res 110, 119-125.
-
(2003)
Brain Res Mol Brain Res
, vol.110
, pp. 119-125
-
-
Burns, M.P.1
Noble, W.J.2
Olm, V.3
Gaynor, K.4
Casey, E.5
Lafran-Cois, J.6
Wang, L.7
Duff, K.8
-
67
-
-
0035664046
-
Neuropathological characterization of mutant amyloid precursor protein yeast artificial chromosome transgenic mice
-
Kulnane LS, Lamb BT (2001) Neuropathological characterization of mutant amyloid precursor protein yeast artificial chromosome transgenic mice. Neurobiol Dis 8, 982-992.
-
(2001)
Neurobiol Dis
, vol.8
, pp. 982-992
-
-
Kulnane, L.S.1
Lamb, B.T.2
-
68
-
-
0030007964
-
Sequence of deposition ofheteroge-neous amyloid beta-peptides and APO e in Down syndrome: Implications for initial events in amyloid plaque formation
-
Lemere CA, Blusztajn JK, Yamaguchi H, Wisniewski T, Sai-do TC, Selkoe DJ(1996) Sequence of deposition ofheteroge-neous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation. NeurobiolDis 3, 16-32.
-
(1996)
NeurobiolDis
, vol.3
, pp. 16-32
-
-
Lemere, C.A.1
Blusztajn, J.K.2
Yamaguchi, H.3
Wisniewski, T.4
Sai-Do, T.C.5
Selkoe, D.J.6
-
69
-
-
0033593027
-
Apolipoprotein e is essential for amyloid deposition in the AftPP(V717F) transgenic mouse model of Alzheimer's disease
-
Bales KR, Verina T, Cummins DJ, Du Y, Dodel RC, Saura J, Fishman CE, DeLong CA, Piccardo P, Petegnief V, Ghetti B, Paul SM (1999) Apolipoprotein E is essential for amyloid deposition in the AftPP(V717F) transgenic mouse model of Alzheimer's disease. Proc Natl Acad Sci U SA 96, 1523315238.
-
(1999)
Proc Natl Acad Sci U SA
, vol.96
, pp. 15233-15238
-
-
Bales, K.R.1
Verina, T.2
Cummins, D.J.3
Du, Y.4
Dodel, R.C.5
Saura, J.6
Fishman, C.E.7
Delong, C.A.8
Piccardo, P.9
Petegnief, V.10
Ghetti, B.11
Paul, S.M.12
-
70
-
-
0034123538
-
Apolipoprotein e facilitates neuritic and cerebrovas-cular plaque formation in an Alzheimer's disease model
-
Holtzman DM, Fagan AM, Mackey B, Tenkova T, Sartorius L, Paul SM, Bales K, Ashe KH, Irizarry MC, Hyman BT (2000) Apolipoprotein E facilitates neuritic and cerebrovas-cular plaque formation in an Alzheimer's disease model. Ann Neurol 47, 739-747.
-
(2000)
Ann Neurol
, vol.47
, pp. 739-747
-
-
Holtzman, D.M.1
Fagan, A.M.2
MacKey, B.3
Tenkova, T.4
Sartorius, L.5
Paul, S.M.6
Bales, K.7
Ashe, K.H.8
Irizarry, M.C.9
Hyman, B.T.10
-
71
-
-
70349558522
-
Genome-wide association study identifies variants at CLU and PI-CALM associated with Alzheimer's disease
-
Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Williams A, Jones N, Thomas C, Stretton A, Morgan AR, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Morgan K, Brown KS, Passmore PA, Craig D, McGuinness B, Todd S, Holmes C, Mann D, Smith AD, Love S, Kehoe PG, Hardy J, Mead S, Fox N, Rossor M, Collinge J, Maier W, Jessen F, Schur-mann B, van den Bussche H, Heuser I, Kornhuber J, Wiltfang J, Dichgans M, Frolich L, Hampel H, Hull M, Rujescu D, Goate AM, Kauwe JS, Cruchaga C, Nowotny P, Morris JC, Mayo K, Sleegers K, Bettens K, Engelborghs S, De Deyn PP, Van Broeckhoven C, Livingston G, Bass NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Al-Chalabi A, Shaw CE, Tsolaki M, Singleton AB, Guerreiro R, Muhleisen TW, Nothen MM, Moebus S, Jockel KH, Klopp N, Wichmann HE, Carrasquillo MM, Pankratz VS, Younkin SG, Holmans PA, O'Donovan M, Owen MJ, Williams J (2009) Genome-wide association study identifies variants at CLU and PI-CALM associated with Alzheimer's disease. Nat Genet 41, 1088-1093.
-
(2009)
Nat Genet
, vol.41
, pp. 1088-1093
-
-
Harold, D.1
Abraham, R.2
Hollingworth, P.3
Sims, R.4
Gerrish, A.5
Hamshere, M.L.6
Pahwa, J.S.7
Moskvina, V.8
Dowzell, K.9
Williams, A.10
Jones, N.11
Thomas, C.12
Stretton, A.13
Morgan, A.R.14
Lovestone, S.15
Powell, J.16
Proitsi, P.17
Lupton, M.K.18
Brayne, C.19
Rubinsztein, D.C.20
Gill, M.21
Lawlor, B.22
Lynch, A.23
Morgan, K.24
Brown, K.S.25
Passmore, P.A.26
Craig, D.27
McGuinness, B.28
Todd, S.29
Holmes, C.30
Mann, D.31
Smith, A.D.32
Love, S.33
Kehoe, P.G.34
Hardy, J.35
Mead, S.36
Fox, N.37
Rossor, M.38
Collinge, J.39
Maier, W.40
Jessen, F.41
Schur-Mann, B.42
Van Den Bussche, H.43
Heuser, I.44
Kornhuber, J.45
Wiltfang, J.46
Dichgans, M.47
Frolich, L.48
Hampel, H.49
Hull, M.50
Rujescu, D.51
Goate, A.M.52
Kauwe, J.S.53
Cruchaga, C.54
Nowotny, P.55
Morris, J.C.56
Mayo, K.57
Sleegers, K.58
Bettens, K.59
Engelborghs, S.60
De Deyn, P.P.61
Van Broeckhoven, C.62
Livingston, G.63
Bass, N.J.64
Gurling, H.65
McQuillin, A.66
Gwilliam, R.67
Deloukas, P.68
Al-Chalabi, A.69
Shaw, C.E.70
Tsolaki, M.71
Singleton, A.B.72
Guerreiro, R.73
Muhleisen, T.W.74
Nothen, M.M.75
Moebus, S.76
Jockel, K.H.77
Klopp, N.78
Wichmann, H.E.79
Carrasquillo, M.M.80
Pankratz, V.S.81
Younkin, S.G.82
Holmans, P.A.83
O'Donovan, M.84
Owen, M.J.85
Williams, J.86
more..
-
72
-
-
78549264026
-
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
-
Lambert JC, Heath S, Even G, Campion D, Sleegers K, Hiltunen M, Combarros O, Zelenika D, Bullido MJ, Tavernier B, Letenneur L, Bettens K, Berr C, Pasquier F, Fievet N, Barberger-Gateau P, Engelborghs S, De DP, Mateo I, Franck A, Helisalmi S, Porcellini E, Hanon O, de Pancorbo MM, Lendon C, Dufouil C, Jaillard C, Leveillard T, Alvarez V, Bosco P, Mancuso M, Panza F, Nacmias B, Bossu P, Piccardi P, Annoni G, Seripa D, Galimberti D, Hannequin D, Licastro F, Soininen H, Ritchie K, Blanche H, Dartigues JF, Tzou-rio C, Gut I, Van BC, Alperovitch A, Lathrop M, Amouyel P (2009) Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nat Genet 41, 1094-1099.
-
(2009)
Nat Genet
, vol.41
, pp. 1094-1099
-
-
Lambert, J.C.1
Heath, S.2
Even, G.3
Campion, D.4
Sleegers, K.5
Hiltunen, M.6
Combarros, O.7
Zelenika, D.8
Bullido, M.J.9
Tavernier, B.10
Letenneur, L.11
Bettens, K.12
Berr, C.13
Pasquier, F.14
Fievet, N.15
Barberger-Gateau, P.16
Engelborghs, S.17
De Dp Mateo, I.18
Franck, A.19
Helisalmi, S.20
Porcellini, E.21
Hanon, O.22
De Pancorbo, M.M.23
Lendon, C.24
Dufouil, C.25
Jaillard, C.26
Leveillard, T.27
Alvarez, V.28
Bosco, P.29
Mancuso, M.30
Panza, F.31
Nacmias, B.32
Bossu, P.33
Piccardi, P.34
Annoni, G.35
Seripa, D.36
Galimberti, D.37
Hannequin, D.38
Licastro, F.39
Soininen, H.40
Ritchie, K.41
Blanche, H.42
Dartigues, J.F.43
Tzou-Rio, C.44
Gut, I.45
Van, B.C.46
Alperovitch, A.47
Lathrop, M.48
Amouyel, P.49
more..
-
73
-
-
0026567452
-
SP-40,40 is a constituent of Alzheimer's amyloid
-
Choi-Miura NH, Ihara Y, Fukuchi K, Takeda M, Nakano Y, Tobe T, Tomita M (1992) SP-40,40 is a constituent of Alzheimer's amyloid. Acta Neuropathol 83, 260-264.
-
(1992)
Acta Neuropathol
, vol.83
, pp. 260-264
-
-
Choi-Miura, N.H.1
Ihara, Y.2
Fukuchi, K.3
Takeda, M.4
Nakano, Y.5
Tobe, T.6
Tomita, M.7
-
74
-
-
0030014990
-
Apolipoprotein J and Alzheimer's amyloid beta solubility
-
Matsubara E, Soto C, Governale S, Frangione B, Ghiso J (1996) Apolipoprotein J and Alzheimer's amyloid beta solubility. Biochem J 316 (Pt 2), 671-679.
-
(1996)
Biochem J
, vol.316
, Issue.PART 2
, pp. 671-679
-
-
Matsubara, E.1
Soto, C.2
Governale, S.3
Frangione, B.4
Ghiso, J.5
-
75
-
-
0036678856
-
Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model ofAlzheimer's disease
-
DeMattos RB, O'dell MA, Parsadanian M, Taylor JW, Harmony JA, Bales KR, Paul SM, Aronow BJ, Holtzman DM (2002) Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model ofAlzheimer's disease. Proc Natl Acad Sci USA 99, 10843-10848.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 10843-10848
-
-
Demattos, R.B.1
O'Dell, M.A.2
Parsadanian, M.3
Taylor, J.W.4
Harmony, J.A.5
Bales, K.R.6
Paul, S.M.7
Aronow, B.J.8
Holtzman, D.M.9
-
76
-
-
0030271257
-
Expression of complement in the brain: Role in health and disease
-
Morgan BP, Gasque P (1996) Expression of complement in the brain: role in health and disease. Immunol Today 17, 461-466.
-
(1996)
Immunol Today
, vol.17
, pp. 461-466
-
-
Morgan, B.P.1
Gasque, P.2
-
77
-
-
0032479929
-
Complement-dependent proinflammatory properties of the Alzheimer's disease beta-peptide
-
Bradt BM, Kolb WP, Cooper NR (1998) Complement-dependent proinflammatory properties of the Alzheimer's disease beta-peptide. J Exp Med 188, 431-438.
-
(1998)
J Exp Med
, vol.188
, pp. 431-438
-
-
Bradt, B.M.1
Kolb, W.P.2
Cooper, N.R.3
-
78
-
-
0028178458
-
Beta-Amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain
-
Jiang H, Burdick D, Glabe CG, Cotman CW, Tenner AJ (1994) beta-Amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain. J Immunol 152, 5050-5059.
-
(1994)
J Immunol
, vol.152
, pp. 5050-5059
-
-
Jiang, H.1
Burdick, D.2
Glabe, C.G.3
Cotman, C.W.4
Tenner, A.J.5
-
79
-
-
0033061855
-
Up-regulated production and activation of the complement system in Alzheimer's disease brain
-
Yasojima K, Schwab C, McGeer EG, McGeer PL (1999) Up-regulated production and activation of the complement system in Alzheimer's disease brain. Am J Pathol 154, 927936.
-
(1999)
Am J Pathol
, vol.154
, pp. 927936
-
-
Yasojima, K.1
Schwab, C.2
McGeer, E.G.3
McGeer, P.L.4
-
81
-
-
18144373149
-
Using animal models to determine the significance of complement activation in Alzheimer's disease
-
Loeffler DA (2004) Using animal models to determine the significance of complement activation in Alzheimer's disease. J Neuroinflammation 1, 18.
-
(2004)
J Neuroinflammation
, vol.1
, pp. 18
-
-
Loeffler, D.A.1
-
82
-
-
0028135459
-
Enhanced aggregation and beta structure of amyloid beta peptide after coincubation with C1q
-
Webster S, O'Barr S, Rogers J (1994) Enhanced aggregation and beta structure of amyloid beta peptide after coincubation with C1q. J Neurosci Res 39, 448-456.
-
(1994)
J Neurosci Res
, vol.39
, pp. 448-456
-
-
Webster, S.1
O'Barr, S.2
Rogers, J.3
-
83
-
-
0028836519
-
Complement-mediated neurotoxicity is regulated by homologous restriction
-
Shen Y, Halperin JA, Lee CM (1995) Complement-mediated neurotoxicity is regulated by homologous restriction. Brain Res 671, 282-292.
-
(1995)
Brain Res
, vol.671
, pp. 282-292
-
-
Shen, Y.1
Halperin, J.A.2
Lee, C.M.3
-
84
-
-
0036679142
-
Prominent neurodegenera-tion and increased plaque formation in complement-inhibited Alzheimer's mice
-
Wyss-Coray T, Yan F, Lin AH, Lambris JD, Alexander JJ, Quigg RJ, Masliah E (2002) Prominent neurodegenera-tion and increased plaque formation in complement-inhibited Alzheimer's mice. Proc Natl Acad Sci USA 99, 1083710842.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 1083710842
-
-
Wyss-Coray, T.1
Yan, F.2
Lin, A.H.3
Lambris, J.D.4
Alexander, J.J.5
Quigg, R.J.6
Masliah, E.7
-
85
-
-
3242766671
-
Absence of C1q leads to less neuropathology in transgenic mouse models of Alzheimer's disease
-
Fonseca MI, Zhou J, Botto M, Tenner AJ (2004) Absence of C1q leads to less neuropathology in transgenic mouse models of Alzheimer's disease. J Neurosci 24, 6457-6465.
-
(2004)
J Neurosci
, vol.24
, pp. 6457-6465
-
-
Fonseca, M.I.1
Zhou, J.2
Botto, M.3
Tenner, A.J.4
-
86
-
-
49549095792
-
Complement C3 and C4 expression in C1q sufficient and deficient mouse models of Alzheimer's disease
-
Zhou J, Fonseca MI, Pisalyaput K, Tenner AJ (2008) Complement C3 and C4 expression in C1q sufficient and deficient mouse models of Alzheimer's disease. J Neurochem 106, 2080-2092.
-
(2008)
J Neurochem
, vol.106
, pp. 2080-2092
-
-
Zhou, J.1
Fonseca, M.I.2
Pisalyaput, K.3
Tenner, A.J.4
-
87
-
-
0035067311
-
Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer's disease
-
Matsuoka Y, Picciano M, Malester B, LaFrancois J, Zehr H, Daeschner JM, Olschowka JA, Fonseca MI, O'Banion MK, Tenner AJ, Lemere CA, Duff K (2001) Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer's disease. Am J Pathol 158, 1345-1354.
-
(2001)
Am J Pathol
, vol.158
, pp. 1345-1354
-
-
Matsuoka, Y.1
Picciano, M.2
Malester, B.3
Lafrancois, J.4
Zehr, H.5
Daeschner, J.M.6
Olschowka, J.A.7
Fonseca, M.I.8
O'Banion, M.K.9
Tenner, A.J.10
Lemere, C.A.11
Duff, K.12
-
88
-
-
36849063880
-
Induction of complement proteins in a mouse model for cerebral mi-crovascular A beta deposition
-
Fan R, DeFilippis K, Van Nostrand WE (2007) Induction of complement proteins in a mouse model for cerebral mi-crovascular A beta deposition. J Neuroinflammation 4, 22.
-
(2007)
J Neuroinflammation
, vol.4
, pp. 22
-
-
Fan, R.1
Defilippis, K.2
Van Nostrand, W.E.3
-
89
-
-
71049194870
-
Expression of complement system components during aging and amyloid deposition in AftPP transgenic mice
-
Reichwald J, Danner S, Wiederhold KH, Staufenbiel M (2009) Expression of complement system components during aging and amyloid deposition in AftPP transgenic mice. J Neuroinflammation 6, 35.
-
(2009)
J Neuroinflammation
, vol.6
, pp. 35
-
-
Reichwald, J.1
Danner, S.2
Wiederhold, K.H.3
Staufenbiel, M.4
-
90
-
-
0033133360
-
The mouse C1q A-chain sequence alters beta-amyloid-induced complement activation
-
Webster SD, Tenner AJ, Poulos TL, Cribbs DH (1999) The mouse C1q A-chain sequence alters beta-amyloid-induced complement activation. Neurobiol Aging 20, 297-304.
-
(1999)
Neurobiol Aging
, vol.20
, pp. 297-304
-
-
Webster, S.D.1
Tenner, A.J.2
Poulos, T.L.3
Cribbs, D.H.4
-
91
-
-
0029971956
-
Mouse complement component C4 is devoid ofclassical pathway C5 convertase subunit activity
-
Ebanks RO, Isenman DE (1996) Mouse complement component C4 is devoid ofclassical pathway C5 convertase subunit activity. Mol Immunol 33, 297-309.
-
(1996)
Mol Immunol
, vol.33
, pp. 297-309
-
-
Ebanks, R.O.1
Isenman, D.E.2
-
92
-
-
10744230547
-
Subacute menin-goencephalitis in a subset of patients with AD after Abeta42 immunization
-
Orgogozo JM, Gilman S, Dartigues JF, Laurent B, Puel M, Kirby LC, Jouanny P, Dubois B, Eisner L, Flitman S, Michel BF, Boada M, Frank A, Hock C (2003) Subacute menin-goencephalitis in a subset of patients with AD after Abeta42 immunization. Neurology 61, 46-54.
-
(2003)
Neurology
, vol.61
, pp. 46-54
-
-
Orgogozo, J.M.1
Gilman, S.2
Dartigues, J.F.3
Laurent, B.4
Puel, M.5
Kirby, L.C.6
Jouanny, P.7
Dubois, B.8
Eisner, L.9
Flitman, S.10
Michel, B.F.11
Boada, M.12
Frank, A.13
Hock, C.14
-
93
-
-
0033536163
-
Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAftPP mouse
-
Lee M, Liao Z, Lieberburg I, Motter R, Mutter L, Soriano F, Shopp G, Vasquez N, Vandevert C, Walker S, Wogulis M, Yednock T, Games D, Seubert P (1999) Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAftPP mouse. Nature 400, 173-177.
-
(1999)
Nature
, vol.400
, pp. 173-177
-
-
Lee, M.1
Liao, Z.2
Lieberburg, I.3
Motter, R.4
Mutter, L.5
Soriano, F.6
Shopp, G.7
Vasquez, N.8
Vandevert, C.9
Walker, S.10
Wogulis, M.11
Yednock, T.12
Games, D.13
Seubert, P.14
-
94
-
-
0023838532
-
Immunochem-ical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease
-
Abraham CR, Selkoe DJ, Potter H (1988) Immunochem-ical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease. Cell 52, 487-501.
-
(1988)
Cell
, vol.52
, pp. 487-501
-
-
Abraham, C.R.1
Selkoe, D.J.2
Potter, H.3
-
95
-
-
0025309009
-
Serum amyloid P immunore-activity in hippocampal tangles, plaques and vessels: Implications for leakage across the blood-brain barrier in Alzheimer's disease
-
Kalaria RN, Grahovac I (1990) Serum amyloid P immunore-activity in hippocampal tangles, plaques and vessels: implications for leakage across the blood-brain barrier in Alzheimer's disease. Brain Res 516, 349-353.
-
(1990)
Brain Res
, vol.516
, pp. 349-353
-
-
Kalaria, R.N.1
Grahovac, I.2
-
96
-
-
0035696284
-
The pentraxins: Possible role in Alzheimer's disease and other innate inflammatory diseases
-
McGeer EG, Yasojima K, Schwab C, McGeer PL (2001) The pentraxins: possible role in Alzheimer's disease and other innate inflammatory diseases. Neurobiol Aging 22, 843-848.
-
(2001)
Neurobiol Aging
, vol.22
, pp. 843-848
-
-
McGeer, E.G.1
Yasojima, K.2
Schwab, C.3
McGeer, P.L.4
-
97
-
-
0027394985
-
Human serum amyloid P component oligomers bind and activate the classical complement pathway via residues 14-26 and 76-92 of the A chain collagen-like region of C1q
-
Ying SC, Gewurz AT, Jiang H, Gewurz H (1993) Human serum amyloid P component oligomers bind and activate the classical complement pathway via residues 14-26 and 76-92 of the A chain collagen-like region of C1q. J Immunol 150, 169-176.
-
(1993)
J Immunol
, vol.150
, pp. 169-176
-
-
Ying, S.C.1
Gewurz, A.T.2
Jiang, H.3
Gewurz, H.4
-
98
-
-
0032732637
-
Serum amyloid P is not present in amyloid beta deposits ofa transgenic animal model
-
Shi J, Perry G, Aliev G, Smith MA, Ashe KH, Friedland RP (1999) Serum amyloid P is not present in amyloid beta deposits ofa transgenic animal model. Neuroreport 10, 32293232.
-
(1999)
Neuroreport
, vol.10
, pp. 3229-3232
-
-
Shi, J.1
Perry, G.2
Aliev, G.3
Smith, M.A.4
Ashe, K.H.5
Friedland, R.P.6
-
99
-
-
0036330242
-
Labeling ofcerebralamyloid beta deposits in vivo using intranasal basic fibroblast growth factor and serum amyloid P component in mice
-
Shi J, Perry G, Berridge MS, Aliev G, Siedlak SL, Smith MA, LaManna JC, Friedland RP (2002) Labeling ofcerebralamyloid beta deposits in vivo using intranasal basic fibroblast growth factor and serum amyloid P component in mice. J Nucl Med 43, 1044-1051.
-
(2002)
J Nucl Med
, vol.43
, pp. 1044-1051
-
-
Shi, J.1
Perry, G.2
Berridge, M.S.3
Aliev, G.4
Siedlak, S.L.5
Smith, M.A.6
Lamanna, J.C.7
Friedland, R.P.8
-
100
-
-
0035282982
-
Spontaneous hemorrhagic stroke in a mouse model of cerebral amyloid angiopathy
-
Winkler DT, Bondolfi L, Herzig MC, Jann L, Calhoun ME, Wiederhold KH, Tolnay M, Staufenbiel M, Jucker M (2001) Spontaneous hemorrhagic stroke in a mouse model of cerebral amyloid angiopathy. J Neurosci 21, 1619-1627.
-
(2001)
J Neurosci
, vol.21
, pp. 1619-1627
-
-
Winkler, D.T.1
Bondolfi, L.2
Herzig, M.C.3
Jann, L.4
Calhoun, M.E.5
Wiederhold, K.H.6
Tolnay, M.7
Staufenbiel, M.8
Jucker, M.9
-
101
-
-
0027160249
-
Alpha 2-Macroglobulin expression in neuritic-type plaques in patients with Alzheimer's disease
-
Van Gool D., De Strooper B., Van Leuven F., Triau E, Dom R (1993) alpha 2-Macroglobulin expression in neuritic-type plaques in patients with Alzheimer's disease. Neurobiol Aging 14, 233-237.
-
(1993)
Neurobiol Aging
, vol.14
, pp. 233-237
-
-
Van Gool, D.1
De Strooper, B.2
Van Leuven, F.3
Triau, E.4
Dom, R.5
-
102
-
-
0032539723
-
Alpha2-macroglobulin associates with beta-amyloid peptide and prevents fibril formation
-
Hughes SR, Khorkova O, Goyal S, Knaeblein J, Heroux J, Riedel NG, Sahasrabudhe S (1998) Alpha2-macroglobulin associates with beta-amyloid peptide and prevents fibril formation. Proc Natl Acad Sci USA 95, 3275-3280.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 3275-3280
-
-
Hughes, S.R.1
Khorkova, O.2
Goyal, S.3
Knaeblein, J.4
Heroux, J.5
Riedel, N.G.6
Sahasrabudhe, S.7
-
103
-
-
0041939975
-
Deposition of Alpha2-Macroglobulin in Fibrillar Type of Senile Plaques in the Brain of PS/A(PP-Transgenic Mice
-
Kondo T, Tooyama I (2003) Deposition of Alpha2-Macroglobulin in Fibrillar Type of Senile Plaques in the Brain of PS/A(PP-Transgenic Mice. ActaHistochem Cytochem 36, 215-220.
-
(2003)
ActaHistochem Cytochem
, vol.36
, pp. 215-220
-
-
Kondo, T.1
Tooyama, I.2
-
104
-
-
0028986858
-
Alpha 1-antichymotrypsin regulates Alzheimer beta-amyloid peptide fibril formation
-
Eriksson S, Janciauskiene S, Lannfelt L (1995) Alpha 1-antichymotrypsin regulates Alzheimer beta-amyloid peptide fibril formation. Proc Natl Acad Sci USA 92, 2313-2317.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 2313-2317
-
-
Eriksson, S.1
Janciauskiene, S.2
Lannfelt, L.3
-
105
-
-
0032561313
-
Alzheimer's peptide Abeta1-42 binds to two beta-sheets of alpha1-antichymotrypsin and transforms it from inhibitor to substrate
-
Janciauskiene S, Rubin H, Lukacs CM, Wright HT (1998) Alzheimer's peptide Abeta1-42 binds to two beta-sheets of alpha1-antichymotrypsin and transforms it from inhibitor to substrate. J Biol Chem 273, 28360-28364.
-
(1998)
J Biol Chem
, vol.273
, pp. 28360-28364
-
-
Janciauskiene, S.1
Rubin, H.2
Lukacs, C.M.3
Wright, H.T.4
-
106
-
-
0035282790
-
Alpha-1-antichymotrypsin promotes beta-sheet amyloid plaque deposition in a transgenic mouse model of Alzheimer's disease
-
Nilsson LN, Bales KR, DiCarlo G, Gordon MN, Morgan D, Paul SM, Potter H (2001) Alpha-1-antichymotrypsin promotes beta-sheet amyloid plaque deposition in a transgenic mouse model of Alzheimer's disease. J Neurosci 21, 14441451.
-
(2001)
J Neurosci
, vol.21
, pp. 1444-1451
-
-
Nilsson, L.N.1
Bales, K.R.2
Dicarlo, G.3
Gordon, M.N.4
Morgan, D.5
Paul, S.M.6
Potter, H.7
-
107
-
-
0028239387
-
Accumulation of intercellular adhesion molecule-1 in senile plaques in brain tissue of patients with Alzheimer's disease
-
Verbeek MM, Otte-Holler I, Westphal JR, Wesseling P, Ruiter DJ, de Waal RM (1994) Accumulation of intercellular adhesion molecule-1 in senile plaques in brain tissue of patients with Alzheimer's disease. Am J Pathol 144, 104-116.
-
(1994)
Am J Pathol
, vol.144
, pp. 104-116
-
-
Verbeek, M.M.1
Otte-Holler, I.2
Westphal, J.R.3
Wesseling, P.4
Ruiter, D.J.5
De Waal, R.M.6
-
108
-
-
15844373497
-
Differential expression of intercellular adhesion molecule-1 (ICAM-1) in the A beta-containing lesions in brains of patients with dementia of the Alzheimer type
-
Verbeek MM, Otte-Holler I, Wesseling P, Ruiter DJ, de Waal RM (1996) Differential expression of intercellular adhesion molecule-1 (ICAM-1) in the A beta-containing lesions in brains of patients with dementia of the Alzheimer type. Acta Neuropathol 91, 608-615.
-
(1996)
Acta Neuropathol
, vol.91
, pp. 608-615
-
-
Verbeek, M.M.1
Otte-Holler, I.2
Wesseling, P.3
Ruiter, D.J.4
De Waal, R.M.5
-
109
-
-
0037162769
-
Beta-amyloid-associated expression of intercellular adhesion molecule-1 in brain cortical tissue of transgenic Tg2576 mice
-
Apelt J, Lessig J, Schliebs R (2002) Beta-amyloid-associated expression of intercellular adhesion molecule-1 in brain cortical tissue of transgenic Tg2576 mice. Neurosci Lett 329, 111-115.
-
(2002)
Neurosci Lett
, vol.329
, pp. 111-115
-
-
Apelt, J.1
Lessig, J.2
Schliebs, R.3
-
110
-
-
0035140013
-
Codeposition of cystatin C with amyloid-beta protein in the brain of Alzheimer disease patients
-
Levy E, Sastre M, Kumar A, Gallo G, Piccardo P, Ghetti B, Tagliavini F (2001) Codeposition of cystatin C with amyloid-beta protein in the brain of Alzheimer disease patients. J Neuropathol Exp Neurol 60, 94-104.
-
(2001)
J Neuropathol Exp Neurol
, vol.60
, pp. 94-104
-
-
Levy, E.1
Sastre, M.2
Kumar, A.3
Gallo, G.4
Piccardo, P.5
Ghetti, B.6
Tagliavini, F.7
-
111
-
-
0029999658
-
The molecular pathology of hereditary cystatin C amyloid angiopathy causing brain hemorrhage
-
Olafsson I, Thorsteinsson L, Jensson O (1996) The molecular pathology of hereditary cystatin C amyloid angiopathy causing brain hemorrhage. Brain Pathol 6, 121-126.
-
(1996)
Brain Pathol
, vol.6
, pp. 121-126
-
-
Olafsson, I.1
Thorsteinsson, L.2
Jensson, O.3
-
112
-
-
36549085086
-
Cystatin C modulates cerebral beta-amyloidosis
-
Kaeser SA, HerzigMC, Coomaraswamy J, KilgerE, Selenica ML, Winkler DT, Staufenbiel M, Levy E, Grubb A, Jucker M (2007) Cystatin C modulates cerebral beta-amyloidosis. Nat Genet 39, 1437-1439.
-
(2007)
Nat Genet
, vol.39
, pp. 1437-1439
-
-
Kaeser, S.A.1
Herzig, M.C.2
Coomaraswamy, J.3
Kilger, E.4
Selenica, M.L.5
Winkler, D.T.6
Staufenbiel, M.7
Levy, E.8
Grubb, A.9
Jucker, M.10
-
113
-
-
36549043900
-
Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models
-
Mi W, Pawlik M, Sastre M, Jung SS, Radvinsky DS, Klein AM, Sommer J, Schmidt SD, Nixon RA, Mathews PM, Levy E (2007) Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models. Nat Genet 39, 14401442.
-
(2007)
Nat Genet
, vol.39
, pp. 1440-1442
-
-
Mi, W.1
Pawlik, M.2
Sastre, M.3
Jung, S.S.4
Radvinsky, D.S.5
Klein, A.M.6
Sommer, J.7
Schmidt, S.D.8
Nixon, R.A.9
Mathews, P.M.10
Levy, E.11
-
114
-
-
53849106834
-
Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease
-
Sun B, Zhou Y, Halabisky B, Lo I, Cho SH, Mueller-Steiner S, Devidze N, Wang X, Grubb A, Gan L (2008) Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease. Neuron 60, 247-257.
-
(2008)
Neuron
, vol.60
, pp. 247-257
-
-
Sun, B.1
Zhou, Y.2
Halabisky, B.3
Lo, I.4
Cho, S.H.5
Mueller-Steiner, S.6
Devidze, N.7
Wang, X.8
Grubb, A.9
Gan, L.10
-
115
-
-
18444418272
-
CLAC: A novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV
-
Hashimoto T, Wakabayashi T, Watanabe A, Kowa H, Hosoda R, Nakamura A, Kanazawa I, Arai T, Takio K, Mann DM, Iwatsubo T (2002) CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV. EMBOJ 21, 1524-1534.
-
(2002)
EMBOJ
, vol.21
, pp. 1524-1534
-
-
Hashimoto, T.1
Wakabayashi, T.2
Watanabe, A.3
Kowa, H.4
Hosoda, R.5
Nakamura, A.6
Kanazawa, I.7
Arai, T.8
Takio, K.9
Mann, D.M.10
Iwatsubo, T.11
-
116
-
-
3042643601
-
Mostly separate distributions of CLAC-versus A(rfsti 40-or Thioflavin S-reactivities in senile plaques reveal two distinct subpopu-lations of (-amyloid deposits
-
Kowa H, Sakakura T, Matsuura Y, Wakabayashi T, Mann DM, Duff K, Tsuji S, Hashimoto T, Iwatsubo T (2004) Mostly separate distributions of CLAC-versus A(40-or Thioflavin S-reactivities in senile plaques reveal two distinct subpopu-lations of (-amyloid deposits. Am J Pathol 165, 273-281.
-
(2004)
Am J Pathol
, vol.165
, pp. 273-281
-
-
Kowa, H.1
Sakakura, T.2
Matsuura, Y.3
Wakabayashi, T.4
Mann, D.M.5
Duff, K.6
Tsuji, S.7
Hashimoto, T.8
Iwatsubo, T.9
-
117
-
-
69449102408
-
Characterizing the appearance and growth of amyloid plaques in A(PP/PS1 mice
-
Yan P, Bero AW, Cirrito JR, Xiao Q, Hu X, Wang Y, Gonzales E, Holtzman DM, Lee JM (2009) Characterizing the appearance and growth of amyloid plaques in A(PP/PS1 mice. J Neurosci 29, 10706-10714
-
(2009)
J Neurosci
, vol.29
, pp. 10706-10714
-
-
Yan, P.1
Bero, A.W.2
Cirrito, J.R.3
Xiao, Q.4
Hu, X.5
Wang, Y.6
Gonzales, E.7
Holtzman, D.M.8
Lee, J.M.9
-
118
-
-
38949123792
-
Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease
-
Meyer-Luehmann M, Spires-Jones TL, Prada C, Garcia-Alloza M, de CA Rozkalne A, Koenigsknecht-Talboo J, Holtzman DM, Bacskai BJ, Hyman BT, 2008 Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease, Nature, 451, 720-724
-
(2008)
Nature
, vol.451
, pp. 720-724
-
-
Meyer-Luehmann, M.1
Spires-Jones, T.L.2
Prada, C.3
Garcia-Alloza, M.4
De Ca Rozkalne, A.5
Koenigsknecht-Talboo, J.6
Holtzman, D.M.7
Bacskai, B.J.8
Hyman, B.T.9
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