Alzheimer's peptide Aβ1-42 binds to two β-sheets of α1- antichymotrypsin and transforms it from inhibitor to substrate

Journal of Biological Chemistry

Volumn 273, Issue 43, 1998, Pages 28360-28364

  Janciauskiene, Sabina ^a   Rubin, Harvey ^b   Lukacs, Christine M ^b,d   Wright, H Tonie ^c  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^d MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ANTICHYMOTRYPSIN; AMYLOID A PROTEIN;

ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; ARTICLE; AUTORADIOGRAPHY; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME SUBSTRATE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN BINDING;

ALPHA 1-ANTICHYMOTRYPSIN; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; HUMANS; MODELS, CHEMICAL; MODELS, MOLECULAR; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; SUBSTRATE SPECIFICITY;

EID: 0032561313     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.43.28360     Document Type: Article

References (31)

1. Rubin. H. (1992) Biol. Chem. Hoppe-Seyler 373, 497-502
2. Bruch, M., Weiss, V., and Engel, J. (1988) J. Biol. Chem. 263, 16626-16630
3. Cooperman, B. S., Stavridi, E., Nickbarg, E., Rescorla, E., Schechter, N. M., and Rubin, H H. (1993) J. Biol. Chem. 268, 23616-23625
4. Baumann, U., Huber, R., Bode, W., Grosse, D., Lesjak, M., and Laurell, C. B. (1991) J. Mol. Biol. 218, 595-606
5. Wei, A., Rubin, H., Cooperman, B. S., and Christianson, D. W. (1994) Nat. Struct. Biol. 1, 251-258
6. Travis, J., and Salvesen, G. (1983) Annu. Rev. Biochem. 52, 655-709
7. Huber, R., and Carrell, R. (1989) Biochemistry 28, 8951-8966
8. Gettins, P., Patston, P. A., and Schapira, M. (1993) Bioessays 15, 461-467
9. Schulze, A. J., Huber, R., Bode, W., and Engh, R. A. (1994) FEBS Lett. 344, 117-124
10. Wright, H. T., and Scarsdale, J. N. (1994) Proteins Struct. Fund. Genet. 22, 210-225
11. Wright, H. T. (1996) Bioessays 18, 453-464
12. Carrell, R. W., and Stein, P. E. (1996) Biol. Chem. Hoppe-Seyler 377, 1-17
13. Stratikos, E., and Gettins, P. G. W. (1997) Proc. Natl. Acad. Sci. U.S. A. 94, 453-458
14. Wilczynska, M., Fa, M., Karolin, J., Ohlsson, P. I., Johansson, L. B.-A., and Ny, T. (1997) Nat. Struct. Biol. 4, 354-356
15. Schulze, A. J., Baumann, U., Knof, S., Jaeger, E., Huber, R., and Laurell, C.-B. (1990) Eur. J. Biochem. 194, 51-56
16. Björk I., Ylinenjarvi, K., Olson, S. T., and Bock, P. E. (1992) J. Biol. Chem. 267, 1976-1982
17. Eitzman, D. T., Fay, W. P., Lawrence, D. A., Francis-Chmura, A. M., Shore, J. D., Olson, S. T., and Ginsburg, D. J. (1995) J. Clin. Invest. 95, 2416-2420
18. Abraham, C. R., Selkoe, D. J., and Potter, H. (1988) Cell 52, 487-501
19. Ma, J., Yee, A., Brewer, B., Jr., Das, S., and Potter, H. (1994) Nature 372, 92-94
20. Janciauskiene, S., Eriksson, S., and Wright, H. T. (1996) Natl. Struct. Biol. 3, 668-671
21. Fraser, P. E., Nguyen, J. T., McLachlan, D. R., Abraham, C. R., and Kirschner, D. A. (1993) J. Neurochem. 61, 298-305
22. Eriksson, S., Janciauskiene, S., and Lannfelt, L. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 2313-2317
23. Lukacs, C., and Christianson, D. W. (1996) Proteins. Struct. Funct. Genet. 25, 420-424
24. Thorell, J. I., and Johansson, B. G. (1971) Biochim. Biophys. Acta 251, 363-369
25. McLarney, S., Rubin, H., Wang, Z. M., Nickbarg, E. B., Naidoo, N., Schoenberger, O. L., Johnson, J. L., and Cooperman, B. S. (1990) J. Biol. Chem. 265, 1199-1207
26. LeVine, H. III (1993) Protein Science 2, 404-410
27. Ma, J., Brewer, B., Jr., and Potter, H. (1996) Neurobiol. of Aging 17, 773-780
28. Soto, C., Castaño, E. M., Frangione, B., and Inestrosa, N. C. (1995) J. Biol. Chem. 270, 3063-3067
29. Wisniewski, T., Ghiso, J., and Frangione, B. (1994) Neurobiol. Aging 15, 420-424
30. Harper, J. D., and Lansbury, P. T. Jr. (1997) Annu. Rev. Biochem. 66, 385-407
31. Hardy, J. (1997) Trends Neurosci. 20, 154-159