Perlecan binds to the β-amyloid proteins (aβ) of Alzheimer's disease, accelerates aβ fibril formation, and maintains aβ fibril stability

Journal of Neurochemistry

Volumn 69, Issue 6, 1997, Pages 2452-2465

  Castillo, Gerardo M ^a   Ngo, Catherine ^a   Cummings, Joel ^a   Wight, Thomas N ^a   Snow, Alan D ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Alzheimer's disease; Glycosaminoglycans; Heparan sulfate; Perlecan; Proteoglycans; Amyloid protein

Indexed keywords

ALPHA 1 ANTICHYMOTRYPSIN; AMYLOID BETA PROTEIN; APOLIPOPROTEIN E; COMPLEMENT COMPONENT C1Q; COMPLEMENT COMPONENT C3; PERLECAN; PROTEOHEPARAN SULFATE;

ALZHEIMER DISEASE; ARTICLE; BINDING AFFINITY; FLUOROMETRY; IMMUNOASSAY; NEUROFILAMENT; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN STABILITY;

EID: 0030725311     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1997.69062452.x     Document Type: Article

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