-
1
-
-
51349111243
-
The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance
-
1:CAS:528:DC%2BD1cXhtF2jtLjK 10.1016/j.immuni.2008.06.015 18799149
-
T Akiyama Y Shimo H Yanai, et al. 2008 The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance Immunity 29 423 437 1:CAS:528: DC%2BD1cXhtF2jtLjK 10.1016/j.immuni.2008.06.015 18799149
-
(2008)
Immunity
, vol.29
, pp. 423-437
-
-
Akiyama, T.1
Shimo, Y.2
Yanai, H.3
-
2
-
-
17644361955
-
The NOD mouse: A model of immune dysregulation
-
DOI 10.1146/annurev.immunol.23.021704.115643
-
MS Anderson JA Bluestone 2005 The NOD mouse: a model of immune dysregulation Annu Rev Immunol 23 447 485 1:CAS:528:DC%2BD2MXktFOjurg%3D 10.1146/annurev.immunol.23.021704.115643 15771578 (Pubitemid 40563177)
-
(2005)
Annual Review of Immunology
, vol.23
, pp. 447-485
-
-
Anderson, M.S.1
Bluestone, J.A.2
-
4
-
-
0034610973
-
High frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naive mice: Mechanisms of selection of the self-reactive repertoire
-
1:CAS:528:DC%2BD3cXhslygtrY%3D 10.1084/jem.191.5.761 10704458
-
AC Anderson LB Nicholson KL Legge, et al. 2000 High frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naive mice: mechanisms of selection of the self-reactive repertoire J Exp Med 191 761 770 1:CAS:528:DC%2BD3cXhslygtrY%3D 10.1084/jem.191.5.761 10704458
-
(2000)
J Exp Med
, vol.191
, pp. 761-770
-
-
Anderson, A.C.1
Nicholson, L.B.2
Legge, K.L.3
-
5
-
-
0037112047
-
Projection of an immunological self shadow within the thymus by the aire protein
-
DOI 10.1126/science.1075958
-
MS Anderson ES Venanzi L Klein, et al. 2002 Projection of an immunological self shadow within the thymus by the aire protein Science 298 1395 1401 1:CAS:528:DC%2BD38Xos1Wnsb8%3D 10.1126/science.1075958 12376594 (Pubitemid 35346134)
-
(2002)
Science
, vol.298
, Issue.5597
, pp. 1395-1401
-
-
Anderson, M.S.1
Venanzi, E.S.2
Klein, L.3
Chen, Z.4
Berzins, S.P.5
Turley, S.J.6
Von Boehmer, H.7
Bronson, R.8
Dierich, A.9
Benoist, C.10
Mathis, D.11
-
6
-
-
23144438406
-
NOD mice and autoimmunity
-
DOI 10.1016/j.autrev.2005.02.002, PII S1568997205000236
-
CA Aoki AT Borchers WM Ridgway, et al. 2005 NOD mice and autoimmunity Autoimmun Rev 4 373 379 1:CAS:528:DC%2BD2MXhtVylu73M 10.1016/j.autrev.2005.02. 002 16081028 (Pubitemid 41080074)
-
(2005)
Autoimmunity Reviews
, vol.4
, Issue.6
, pp. 373-379
-
-
Aoki, C.A.1
Borchers, A.T.2
Ridgway, W.M.3
Keen, C.L.4
Ansari, A.A.5
Gershwin, M.E.6
-
7
-
-
70349230989
-
Crucial contribution of thymic Sirp alpha + conventional dendritic cells to central tolerance against blood-borne antigens in a CCR2-dependent manner
-
1:CAS:528:DC%2BD1MXhtVWrs7zL 10.4049/jimmunol.0900438 19675159
-
T Baba Y Nakamoto N Mukaida 2009 Crucial contribution of thymic Sirp alpha + conventional dendritic cells to central tolerance against blood-borne antigens in a CCR2-dependent manner J Immunol 183 3053 3063 1:CAS:528: DC%2BD1MXhtVWrs7zL 10.4049/jimmunol.0900438 19675159
-
(2009)
J Immunol
, vol.183
, pp. 3053-3063
-
-
Baba, T.1
Nakamoto, Y.2
Mukaida, N.3
-
8
-
-
3242713277
-
A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis
-
DOI 10.1086/422827
-
AB Begovich VE Carlton LA Honigberg, et al. 2004 A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis Am J Hum Genet 75 330 337 1:CAS:528:DC%2BD2cXlvFehs74%3D 10.1086/422827 15208781 (Pubitemid 38943877)
-
(2004)
American Journal of Human Genetics
, vol.75
, Issue.2
, pp. 330-337
-
-
Begovich, A.B.1
Carlton, V.E.H.2
Honigberg, L.A.3
Schrodi, S.J.4
Chokkalingam, A.P.5
Alexander, H.C.6
Ardlie, K.G.7
Huang, Q.8
Smith, A.M.9
Spoerke, J.M.10
Conn, M.T.11
Chang, M.12
Chang, S.-Y.P.13
Saiki, R.K.14
Catanese, J.J.15
Leong, D.U.16
Garcia, V.E.17
McAllister, L.B.18
Jeffery, D.A.19
Lee, A.T.20
Batliwalla, F.21
Remmers, E.22
Criswell, L.A.23
Seldin, M.F.24
Kastner, D.L.25
Amos, C.I.26
Sninsky, J.J.27
Gregersen, P.K.28
more..
-
9
-
-
0041884736
-
Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial cross talk via LTβR
-
DOI 10.1084/jem.20030794
-
T Boehm S Scheu K Pfeffer, et al. 2003 Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial cross talk via LTbetaR J Exp Med 198 757 769 1:CAS:528:DC%2BD3sXntFeqt7k%3D 10.1084/jem.20030794 12953095 (Pubitemid 37087775)
-
(2003)
Journal of Experimental Medicine
, vol.198
, Issue.5
, pp. 757-769
-
-
Boehm, T.1
Scheu, S.2
Pfeffer, K.3
Bleul, C.C.4
-
10
-
-
0033607506
-
Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
-
1:CAS:528:DyaK1MXnsl2nsLo%3D 10.1126/science.286.5445.1735 10576740
-
P Bouillet D Metcalf DC Huang, et al. 1999 Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity Science 286 1735 1738 1:CAS:528:DyaK1MXnsl2nsLo%3D 10.1126/science.286.5445.1735 10576740
-
(1999)
Science
, vol.286
, pp. 1735-1738
-
-
Bouillet, P.1
Metcalf, D.2
Huang, D.C.3
-
11
-
-
0037148840
-
BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes
-
DOI 10.1038/415922a
-
P Bouillet JF Purton DI Godfrey, et al. 2002 BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes Nature 415 922 926 1:CAS:528:DC%2BD38Xhs12jt7w%3D 10.1038/415922a 11859372 (Pubitemid 34174755)
-
(2002)
Nature
, vol.415
, Issue.6874
, pp. 922-926
-
-
Bouillet, P.1
Purton, J.F.2
Godfrey, D.I.3
Zhang, L.-C.4
Coultas, L.5
Puthalakath, H.6
Pellegrini, M.7
Cory, S.8
Adams, J.M.9
Strasser, A.10
-
12
-
-
43049161386
-
Recent advances in the genetics of RA susceptibility
-
1:CAS:528:DC%2BD1cXmslKhtrg%3D 10.1093/rheumatology/ken005 18263596
-
J Bowes A Barton 2008 Recent advances in the genetics of RA susceptibility Rheumatology 47 399 402 1:CAS:528:DC%2BD1cXmslKhtrg%3D 10.1093/rheumatology/ken005 18263596
-
(2008)
Rheumatology
, vol.47
, pp. 399-402
-
-
Bowes, J.1
Barton, A.2
-
13
-
-
0031058466
-
Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo
-
DOI 10.1084/jem.185.3.541
-
T Brocker M Riedinger K Karjalainen 1997 Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo J Exp Med 185 541 550 1:CAS:528:DyaK2sXhtFWlur4%3D 10.1084/jem.185.3.541 9053454 (Pubitemid 27078372)
-
(1997)
Journal of Experimental Medicine
, vol.185
, Issue.3
, pp. 541-550
-
-
Brocker, T.1
Riedinger, M.2
Karjalainen, K.3
-
14
-
-
0028807837
-
A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection
-
1:CAS:528:DyaK2MXosVygu70%3D 10.1016/1074-7613(95)90113-2 7552993
-
BJ Calnan S Szychowski FK Chan 1995 A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection Immunity 3 273 282 1:CAS:528:DyaK2MXosVygu70%3D 10.1016/1074-7613(95)90113-2 7552993
-
(1995)
Immunity
, vol.3
, pp. 273-282
-
-
Calnan, B.J.1
Szychowski, S.2
Chan, F.K.3
-
15
-
-
22244483747
-
Regulatory T cells in the control of autoimmune diabetes: The case of the NOD Mouse
-
DOI 10.1080/08830180590934994
-
L Chatenoud JF Bach 2005 Regulatory T cells in the control of autoimmune diabetes: the case of the NOD mouse Int Rev Immunol 24 247 267 1:CAS:528:DC%2BD2MXls1Slt74%3D 10.1080/08830180590934994 16036377 (Pubitemid 40991004)
-
(2005)
International Reviews of Immunology
, vol.24
, Issue.3-4
, pp. 247-267
-
-
Chatenoud, L.1
Bach, J.-F.2
-
16
-
-
0242624626
-
Lymphotoxin pathway directs thymic Aire expression
-
DOI 10.1038/ni982
-
RK Chin JC Lo O Kim, et al. 2003 Lymphotoxin pathway directs thymic Aire expression Nat Immunol 4 1121 1127 1:CAS:528:DC%2BD3sXosVyktLk%3D 10.1038/ni982 14517552 (Pubitemid 37428040)
-
(2003)
Nature Immunology
, vol.4
, Issue.11
, pp. 1121-1127
-
-
Chin, R.K.1
Lo, J.C.2
Kim, O.3
Blink, S.E.4
Christiansen, P.A.5
Peterson, P.6
Wang, Y.7
Ware, C.8
Fu, Y.-X.9
-
17
-
-
0033559313
-
Cloning and characterization of a lymphoid-specific, inducible human protein tyrosine phosphatase, Lyp
-
1:CAS:528:DyaK1MXhvFSmurw%3D 10068674
-
S Cohen H Dadi E Shaoul, et al. 1999 Cloning and characterization of a lymphoid-specific, inducible human protein tyrosine phosphatase, Lyp Blood 93 2013 2024 1:CAS:528:DyaK1MXhvFSmurw%3D 10068674
-
(1999)
Blood
, vol.93
, pp. 2013-2024
-
-
Cohen, S.1
Dadi, H.2
Shaoul, E.3
-
18
-
-
56649117451
-
Multiple sclerosis and regulatory T cells
-
10.1007/s10875-008-9236-x 18763026
-
CM Costantino C Baecher-Allan DA Hafler 2008 Multiple sclerosis and regulatory T cells J Clin Immunol 28 697 706 10.1007/s10875-008-9236-x 18763026
-
(2008)
J Clin Immunol
, vol.28
, pp. 697-706
-
-
Costantino, C.M.1
Baecher-Allan, C.2
Hafler, D.A.3
-
19
-
-
20444396226
-
Thymic commitment of regulatory T cells is a pathway of TCR-dependent selection that isolates repertoires undergoing positive or negative selection
-
1:CAS:528:DC%2BD2MXhtVWgu77F 10.1007/3-540-27702-1-3 15981475
-
A Coutinho I Caramalho E Seixas, et al. 2005 Thymic commitment of regulatory T cells is a pathway of TCR-dependent selection that isolates repertoires undergoing positive or negative selection Curr Top Microbiol Immunol 293 43 71 1:CAS:528:DC%2BD2MXhtVWgu77F 10.1007/3-540-27702-1-3 15981475
-
(2005)
Curr Top Microbiol Immunol
, vol.293
, pp. 43-71
-
-
Coutinho, A.1
Caramalho, I.2
Seixas, E.3
-
20
-
-
20144387851
-
Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: The PTPN22 620W allele associates with multiple autoimmune phenotypes
-
DOI 10.1086/429096
-
LA Criswell KA Pfeiffer RF Lum, et al. 2005 Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes Am J Hum Genet 76 561 571 1:CAS:528:DC%2BD2MXisleis7Y%3D 10.1086/429096 15719322 (Pubitemid 40432164)
-
(2005)
American Journal of Human Genetics
, vol.76
, Issue.4
, pp. 561-571
-
-
Criswell, L.A.1
Pfeiffer, K.A.2
Lum, R.F.3
Gonzales, B.4
Novitzke, J.5
Kern, M.6
Moser, K.L.7
Begovich, A.B.8
Carlton, V.E.H.9
Li, W.10
Lee, A.T.11
Ortmann, W.12
Behrens, T.W.13
Gregersen, P.K.14
-
21
-
-
58149386381
-
The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors
-
10.1073/pnas.0810713105 19073938
-
AM D'Alise V Auyeung M Feuerer, et al. 2008 The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors Proc Natl Acad Sci USA 105 19857 19862 10.1073/pnas.0810713105 19073938
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 19857-19862
-
-
D'Alise, A.M.1
Auyeung, V.2
Feuerer, M.3
-
22
-
-
34147184187
-
Generalized multi-organ autoimmunity in CCR7-deficient mice
-
DOI 10.1002/eji.200636656
-
AC Davalos-Misslitz J Rieckenberg S Willenzon, et al. 2007 Generalized multi-organ autoimmunity in CCR7-deficient mice Eur J Immunol 37 613 622 1:CAS:528:DC%2BD2sXjs1SjsLc%3D 10.1002/eji.200636656 17304629 (Pubitemid 46916929)
-
(2007)
European Journal of Immunology
, vol.37
, Issue.3
, pp. 613-622
-
-
Davalos-Misslitz, A.C.M.1
Rieckenberg, J.2
Willenzon, S.3
Worbs, T.4
Kremmer, E.5
Bernhardt, G.6
Forster, R.7
-
23
-
-
0038062649
-
Defect in activation-induced cell death in non-obese diabetic (NOD) T lymphocytes
-
DOI 10.1016/S0896-8411(03)00025-8
-
B Decallonne E van Etten A Giulietti, et al. 2003 Defect in activation-induced cell death in non-obese diabetic (NOD) T lymphocytes J Autoimmun 20 219 226 1:CAS:528:DC%2BD3sXktlKqsr0%3D 10.1016/S0896-8411(03)00025- 8 12753807 (Pubitemid 36561487)
-
(2003)
Journal of Autoimmunity
, vol.20
, Issue.3
, pp. 219-226
-
-
Decallonne, B.1
Van Etten, E.2
Giulietti, A.3
Casteels, K.4
Overbergh, L.5
Bouillon, R.6
Mathieu, C.7
-
24
-
-
20144369107
-
3 restores thymocyte apoptosis sensitivity in non-obese diabetic (NOD) mice through dendritic cells
-
DOI 10.1016/j.jaut.2005.03.007, PII S0896841105000454
-
B Decallonne E van Etten L Overbergh, et al. 2005 1Alpha, 25-dihydroxyvitamin D3 restores thymocyte apoptosis sensitivity in non-obese diabetic (NOD) mice through dendritic cells J Autoimmun 24 281 289 1:CAS:528:DC%2BD2MXltFWksbs%3D 10.1016/j.jaut.2005.03.007 15913954 (Pubitemid 40775852)
-
(2005)
Journal of Autoimmunity
, vol.24
, Issue.4
, pp. 281-289
-
-
Decallonne, B.1
Van Etten, E.2
Overbergh, L.3
Valckx, D.4
Bouillon, R.5
Mathieu, C.6
-
25
-
-
24744448656
-
Linking signalling pathways, thymic stroma integrity and autoimmunity
-
DOI 10.1016/j.it.2005.07.006, PII S1471490605001857
-
J Derbinski B Kyewski 2005 Linking signalling pathways, thymic stroma integrity and autoimmunity Trends Immunol 26 503 506 1:CAS:528: DC%2BD2MXhtVWgsLbO 10.1016/j.it.2005.07.006 16039157 (Pubitemid 41297677)
-
(2005)
Trends in Immunology
, vol.26
, Issue.10
, pp. 503-506
-
-
Derbinski, J.1
Kyewski, B.2
-
26
-
-
0035171545
-
Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self
-
DOI 10.1038/ni723
-
J Derbinski A Schulte B Kyewski, et al. 2001 Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self Nat Immunol 2 1032 1039 1:CAS:528:DC%2BD3MXotF2gtrc%3D 10.1038/ni723 11600886 (Pubitemid 33069498)
-
(2001)
Nature Immunology
, vol.2
, Issue.11
, pp. 1032-1039
-
-
Derbinski, J.1
Schulte, A.2
Kyewski, B.3
Klein, L.4
-
27
-
-
22344449972
-
Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels
-
DOI 10.1084/jem.20050471
-
J Derbinski J Gabler B Brors, et al. 2005 Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels J Exp Med 202 33 45 1:CAS:528:DC%2BD2MXmtVaqsb8%3D 10.1084/jem.20050471 15983066 (Pubitemid 41002908)
-
(2005)
Journal of Experimental Medicine
, vol.202
, Issue.1
, pp. 33-45
-
-
Derbinski, J.1
Gabler, J.2
Brors, B.3
Tierling, S.4
Jonnakuty, S.5
Hergenhahn, M.6
Peltonen, L.7
Walter, J.8
Kyewski, B.9
-
29
-
-
0037378671
-
Two developmentally distinct populations of dendritic cells inhabit the adult mouse thymus: Demonstration by differential importation of hematogenous precursors under steady state conditions
-
1:CAS:528:DC%2BD3sXitFKltr8%3D 12646612
-
E Donskoy I Goldschneider 2003 Two developmentally distinct populations of dendritic cells inhabit the adult mouse thymus: demonstration by differential importation of hematogenous precursors under steady state conditions J Immunol 170 3514 3521 1:CAS:528:DC%2BD3sXitFKltr8%3D 12646612
-
(2003)
J Immunol
, vol.170
, pp. 3514-3521
-
-
Donskoy, E.1
Goldschneider, I.2
-
30
-
-
15844366743
-
A full genome search in multiple sclerosis
-
DOI 10.1038/ng0896-472
-
GC Ebers K Kukay DE Bulman, et al. 1996 A full genome search in multiple sclerosis Nat Genet 13 472 476 1:CAS:528:DyaK28XkslOnu7Y%3D 10.1038/ng0896-472 8696345 (Pubitemid 26256624)
-
(1996)
Nature Genetics
, vol.13
, Issue.4
, pp. 472-476
-
-
Ebers, G.C.1
Kukay, K.2
Bulman, D.E.3
Sadovnick, A.D.4
Rice, G.5
Anderson, C.6
Armstrong, H.7
Cousin, K.8
Bell, R.B.9
Hader, W.10
Paty, D.W.11
Hashimoto, S.12
Oger, J.13
Duquette, P.14
Warren, S.15
Gray, T.16
O'Connor, P.17
Nath, A.18
Auty, A.19
-
31
-
-
70349194383
-
Thymus-specific deletion of insulin induces autoimmune diabetes
-
1:CAS:528:DC%2BD1MXpsFKgtLo%3D 10.1038/emboj.2009.212 19680229
-
Y Fan WA Rudert M Grupillo, et al. 2009 Thymus-specific deletion of insulin induces autoimmune diabetes EMBO J 28 2812 2824 1:CAS:528: DC%2BD1MXpsFKgtLo%3D 10.1038/emboj.2009.212 19680229
-
(2009)
EMBO J
, vol.28
, pp. 2812-2824
-
-
Fan, Y.1
Rudert, W.A.2
Grupillo, M.3
-
32
-
-
37549071821
-
Promiscuous gene expression and the developmental dynamics of medullary thymic epithelial cells
-
10.1002/eji.200737131 18000951
-
J Gabler J Arnold B Kyewski 2007 Promiscuous gene expression and the developmental dynamics of medullary thymic epithelial cells Eur J Immunol 37 3363 3372 10.1002/eji.200737131 18000951
-
(2007)
Eur J Immunol
, vol.37
, pp. 3363-3372
-
-
Gabler, J.1
Arnold, J.2
Kyewski, B.3
-
33
-
-
7244227645
-
Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation
-
DOI 10.1084/jem.20041457
-
AM Gallegos MJ Bevan 2004 Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation J Exp Med 200 1039 1049 1:CAS:528:DC%2BD2cXovVensb4%3D 10.1084/jem.20041457 15492126 (Pubitemid 39431128)
-
(2004)
Journal of Experimental Medicine
, vol.200
, Issue.8
, pp. 1039-1049
-
-
Gallegos, A.M.1
Bevan, M.J.2
-
34
-
-
23444442192
-
Dendritic cells in human thymus and periphery display a proinsulin epitope in a transcription-dependent, capture-independent fashion
-
1:CAS:528:DC%2BD2MXntVSrtL0%3D 16081777
-
CA Garcia KR Prabakar J Diez, et al. 2005 Dendritic cells in human thymus and periphery display a proinsulin epitope in a transcription-dependent, capture-independent fashion J Immunol 175 2111 2122 1:CAS:528: DC%2BD2MXntVSrtL0%3D 16081777
-
(2005)
J Immunol
, vol.175
, pp. 2111-2122
-
-
Garcia, C.A.1
Prabakar, K.R.2
Diez, J.3
-
35
-
-
0036582215
-
T-cell development and the CD4-CD8 lineage decision
-
1:CAS:528:DC%2BD38Xjsl2rsrc%3D 10.1038/nri798 12033737
-
RN Germain 2002 T-cell development and the CD4-CD8 lineage decision Nat Rev Immunol 2 309 322 1:CAS:528:DC%2BD38Xjsl2rsrc%3D 10.1038/nri798 12033737
-
(2002)
Nat Rev Immunol
, vol.2
, pp. 309-322
-
-
Germain, R.N.1
-
36
-
-
33646477813
-
Features of medullary thymic epithelium implicate postnatal development in maintaining epithelial heterogeneity and tissue-restricted antigen expression
-
1:CAS:528:DC%2BD28XktVWgt70%3D 16670287
-
GO Gillard AG Farr 2006 Features of medullary thymic epithelium implicate postnatal development in maintaining epithelial heterogeneity and tissue-restricted antigen expression J Immunol 176 5815 5824 1:CAS:528:DC%2BD28XktVWgt70%3D 16670287
-
(2006)
J Immunol
, vol.176
, pp. 5815-5824
-
-
Gillard, G.O.1
Farr, A.G.2
-
37
-
-
34548151158
-
An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus
-
DOI 10.1038/nature06066, PII NATURE06066
-
M Giraud R Taubert C Vandiedonck, et al. 2007 An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus Nature 448 934 937 1:CAS:528:DC%2BD2sXptlWjs7Y%3D 10.1038/nature06066 17687331 (Pubitemid 47312776)
-
(2007)
Nature
, vol.448
, Issue.7156
, pp. 934-937
-
-
Giraud, M.1
Taubert, R.2
Vandiedonck, C.3
Ke, X.4
Levi-Strauss, M.5
Pagani, F.6
Baralle, F.E.7
Eymard, B.8
Tranchant, C.9
Gajdos, P.10
Vincent, A.11
Willcox, N.12
Beeson, D.13
Kyewski, B.14
Garchon, H.-J.15
-
38
-
-
33845239216
-
Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells
-
DOI 10.1182/blood-2006-02-004531
-
DH Gray N Seach T Ueno, et al. 2006 Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells Blood 108 3777 3785 1:CAS:528:DC%2BD28Xht1Kgs7zJ 10.1182/blood-2006-02-004531 16896157 (Pubitemid 44864559)
-
(2006)
Blood
, vol.108
, Issue.12
, pp. 3777-3785
-
-
Gray, D.H.D.1
Seach, N.2
Ueno, T.3
Milton, M.K.4
Liston, A.5
Lew, A.M.6
Goodnow, C.C.7
Boyd, R.L.8
-
39
-
-
35748941369
-
Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire
-
DOI 10.1084/jem.20070795
-
D Gray J Abramson C Benoist, et al. 2007 Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire J Exp Med 204 2521 2528 1:CAS:528:DC%2BD2sXht1KnurvP 10.1084/jem.20070795 17908938 (Pubitemid 350044777)
-
(2007)
Journal of Experimental Medicine
, vol.204
, Issue.11
, pp. 2521-2528
-
-
Gray, D.1
Abramson, J.2
Benoist, C.3
Mathis, D.4
-
40
-
-
67549104034
-
Neonatal tolerance revisited: A perinatal window for Aire control of autoimmunity
-
1:CAS:528:DC%2BD1MXntFGmu78%3D 10.1084/jem.20090300 19487417
-
M Guerau-de-Arellano M Martinic C Benoist, et al. 2009 Neonatal tolerance revisited: a perinatal window for Aire control of autoimmunity J Exp Med 206 1245 1252 1:CAS:528:DC%2BD1MXntFGmu78%3D 10.1084/jem.20090300 19487417
-
(2009)
J Exp Med
, vol.206
, pp. 1245-1252
-
-
Guerau-De-Arellano, M.1
Martinic, M.2
Benoist, C.3
-
41
-
-
18244392426
-
Unconventional topology of self peptide-major histocompatibility complex binding by a human autoimmune T cell receptor
-
DOI 10.1038/ni1187
-
M Hahn MJ Nicholson J Pyrdol, et al. 2005 Unconventional topology of self peptide-major histocompatibility complex binding by a human autoimmune T cell receptor Nat Immunol 6 490 496 1:CAS:528:DC%2BD2MXjtlymt7g%3D 10.1038/ni1187 15821740 (Pubitemid 41716762)
-
(2005)
Nature Immunology
, vol.6
, Issue.5
, pp. 490-496
-
-
Hahn, M.1
Nicholson, M.J.2
Pyrdol, J.3
Wucherpfennig, K.W.4
-
42
-
-
0009573338
-
A complete genomic screen for multiple sclerosis underscores a role for the major histocompatibility complex
-
DOI 10.1038/ng0896-469
-
JL Haines M Ter-Minassian A Bazyk, et al. 1996 A complete genomic screen for multiple sclerosis underscores a role for the major histocompatability complex. The Multiple Sclerosis Genetics Group Nat Genet 13 469 471 1:CAS:528:DyaK28XkslOnu7k%3D 10.1038/ng0896-469 8696344 (Pubitemid 26256623)
-
(1996)
Nature Genetics
, vol.13
, Issue.4
, pp. 469-471
-
-
Haines, J.L.1
Ter-Minassian, M.2
Bazyk, A.3
Gusella, J.F.4
Kim, D.J.5
Terwedow, H.6
Pericak-Vance, M.A.7
Rimmler, J.B.8
Haynes, C.S.9
Roses, A.D.10
Lee, A.11
Shaner, B.12
Menold, M.13
Seboun, E.14
Fitoussi, R.-P.15
Gartioux, C.16
Reyes, C.17
Ribierre, F.18
Gyapay, G.19
-
43
-
-
0034469448
-
Association of MHC and rheumatoid arthritis why is rheumatoid arthritis associated with the MHC genetic region? An introduction
-
DOI 10.1186/ar87
-
R Holmdahl 2000 Association of MHC and rheumatoid arthritis. Why is rheumatoid arthritis associated with the MHC genetic region? An introduction Arthritis Res 2 203 204 1:CAS:528:DC%2BD3cXlslyis7c%3D 10.1186/ar87 11094429 (Pubitemid 32223727)
-
(2000)
Arthritis Research
, vol.2
, Issue.3
, pp. 203-204
-
-
Holmdahl, R.1
-
44
-
-
0028590184
-
Presentation and intercellular transfer of self antigen within the thymic microenvironment: Expression of the e alpha peptide-I-Ab complex by isolated thymic stromal cells
-
1:CAS:528:DyaK2MXjsF2qurk%3D 10.1093/intimm/6.12.1949 7696212
-
C Humblet Rudensky AYu B Kyewski 1994 Presentation and intercellular transfer of self antigen within the thymic microenvironment: expression of the E alpha peptide-I-Ab complex by isolated thymic stromal cells Int Immunol 6 1949 1958 1:CAS:528:DyaK2MXjsF2qurk%3D 10.1093/intimm/6.12.1949 7696212
-
(1994)
Int Immunol
, vol.6
, pp. 1949-1958
-
-
Humblet, C.1
Rudensky, A.2
Kyewski, B.3
-
46
-
-
0023663430
-
T cell tolerance by clonal elimination in the thymus
-
1:CAS:528:DyaL1cXlsVantw%3D%3D 10.1016/0092-8674(87)90568-X 3494522
-
JW Kappler N Roehm P Marrack 1987 T cell tolerance by clonal elimination in the thymus Cell 49 273 280 1:CAS:528:DyaL1cXlsVantw%3D%3D 10.1016/0092-8674(87)90568-X 3494522
-
(1987)
Cell
, vol.49
, pp. 273-280
-
-
Kappler, J.W.1
Roehm, N.2
Marrack, P.3
-
47
-
-
27844447147
-
Immunogenetics of type 1 diabetes
-
DOI 10.1159/000089190
-
MS Kim C Polychronakos 2005 Immunogenetics of type 1 diabetes Horm Res 64 180 188 1:CAS:528:DC%2BD2MXht1aiurjO 10.1159/000089190 16254432 (Pubitemid 41642762)
-
(2005)
Hormone Research
, vol.64
, Issue.4
, pp. 180-188
-
-
Kim, M.S.1
Polychronakos, C.2
-
48
-
-
0035175577
-
A defect in central tolerance in NOD mice
-
DOI 10.1038/ni726
-
H Kishimoto J Sprent 2001 A defect in central tolerance in NOD mice Nat Immunol 2 1025 1031 1:CAS:528:DC%2BD3MXotF2gtrk%3D 10.1038/ni726 11668341 (Pubitemid 33069497)
-
(2001)
Nature Immunology
, vol.2
, Issue.11
, pp. 1025-1031
-
-
Kishimoto, H.1
Sprent, J.2
-
49
-
-
0023900635
-
Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+ 8+ thymocytes
-
1:STN:280:DyaL1c3mtFCquw%3D%3D 10.1038/333742a0 3260350
-
P Kisielow H Bluthmann UD Staerz, et al. 1988 Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+ 8+ thymocytes Nature 333 742 746 1:STN:280:DyaL1c3mtFCquw%3D%3D 10.1038/333742a0 3260350
-
(1988)
Nature
, vol.333
, pp. 742-746
-
-
Kisielow, P.1
Bluthmann, H.2
Staerz, U.D.3
-
50
-
-
0033984067
-
Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells
-
DOI 10.1038/71540
-
L Klein M Klugmann KA Nave, et al. 2000 Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells Nat Med 6 56 61 1:CAS:528:DC%2BD3cXks1WlsQ%3D%3D 10.1038/71540 10613824 (Pubitemid 30048526)
-
(2000)
Nature Medicine
, vol.6
, Issue.1
, pp. 56-61
-
-
Klein, L.1
Klugmann, M.2
Nave, K.-A.3
Tuohy, V.K.4
Kyewski, B.5
-
51
-
-
72949104779
-
Antigen presentation in the thymus for positive selection and central tolerance induction
-
1:CAS:528:DC%2BD1MXhsVOhurrM 10.1038/nri2669 19935803
-
L Klein M Hinterberger G Wirnsberger, et al. 2009 Antigen presentation in the thymus for positive selection and central tolerance induction Nat Rev Immunol 9 833 844 1:CAS:528:DC%2BD1MXhsVOhurrM 10.1038/nri2669 19935803
-
(2009)
Nat Rev Immunol
, vol.9
, pp. 833-844
-
-
Klein, L.1
Hinterberger, M.2
Wirnsberger, G.3
-
52
-
-
67650507153
-
The thymic medulla: A unique microenvironment for intercellular self-antigen transfer
-
1:CAS:528:DC%2BD1MXos1eisLw%3D 10.1084/jem.20082449 19564355
-
C Koble B Kyewski 2009 The thymic medulla: a unique microenvironment for intercellular self-antigen transfer J Exp Med 206 1505 1513 1:CAS:528: DC%2BD1MXos1eisLw%3D 10.1084/jem.20082449 19564355
-
(2009)
J Exp Med
, vol.206
, pp. 1505-1513
-
-
Koble, C.1
Kyewski, B.2
-
53
-
-
33646165128
-
A central role for central tolerance
-
1:CAS:528:DC%2BD28XkvFSqtLk%3D 10.1146/annurev.immunol.23.021704.115601 16551260
-
B Kyewski L Klein 2006 A central role for central tolerance Annu Rev Immunol 24 571 606 1:CAS:528:DC%2BD28XkvFSqtLk%3D 10.1146/annurev.immunol.23. 021704.115601 16551260
-
(2006)
Annu Rev Immunol
, vol.24
, pp. 571-606
-
-
Kyewski, B.1
Klein, L.2
-
54
-
-
73149112590
-
Aire, master of many trades
-
1:CAS:528:DC%2BC3cXkvVWitbk%3D 10.1016/j.cell.2009.12.036 20085700
-
B Kyewski P Peterson 2010 Aire, master of many trades Cell 140 24 26 1:CAS:528:DC%2BC3cXkvVWitbk%3D 10.1016/j.cell.2009.12.036 20085700
-
(2010)
Cell
, vol.140
, pp. 24-26
-
-
Kyewski, B.1
Peterson, P.2
-
55
-
-
63449133991
-
Thymus-homing peripheral dendritic cells constitute two of the three major subsets of dendritic cells in the steady-state thymus
-
1:CAS:528:DC%2BD1MXjsVaisbs%3D 10.1084/jem.20082232 19273629
-
J Li J Park D Foss, et al. 2009 Thymus-homing peripheral dendritic cells constitute two of the three major subsets of dendritic cells in the steady-state thymus J Exp Med 206 607 622 1:CAS:528:DC%2BD1MXjsVaisbs%3D 10.1084/jem.20082232 19273629
-
(2009)
J Exp Med
, vol.206
, pp. 607-622
-
-
Li, J.1
Park, J.2
Foss, D.3
-
56
-
-
10344231974
-
Generalized resistance to thymic deletion in the NOD mouse; A polygenic trait characterized by defective induction of Bim
-
1:CAS:528:DC%2BD2MXjvFGjtg%3D%3D 15589170
-
A Liston S Lesage DH Gray, et al. 2004 Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim Immunity 21 817 830 1:CAS:528:DC%2BD2MXjvFGjtg%3D%3D 15589170
-
(2004)
Immunity
, vol.21
, pp. 817-830
-
-
Liston, A.1
Lesage, S.2
Gray, D.H.3
-
57
-
-
34547151992
-
A decade of AIRE
-
DOI 10.1038/nri2136, PII NRI2136
-
D Mathis C Benoist 2007 A decade of AIRE Nat Rev Immunol 7 645 650 1:CAS:528:DC%2BD2sXotFahtLc%3D 10.1038/nri2136 17641664 (Pubitemid 47123552)
-
(2007)
Nature Reviews Immunology
, vol.7
, Issue.8
, pp. 645-650
-
-
Mathis, D.1
Benoist, C.2
-
58
-
-
67549118180
-
Aire
-
1:CAS:528:DC%2BD1MXlsFSltr8%3D 10.1146/annurev.immunol.25.022106.141532 19302042
-
D Mathis C Benoist 2009 Aire Annu Rev Immunol 27 287 312 1:CAS:528:DC%2BD1MXlsFSltr8%3D 10.1146/annurev.immunol.25.022106.141532 19302042
-
(2009)
Annu Rev Immunol
, vol.27
, pp. 287-312
-
-
Mathis, D.1
Benoist, C.2
-
59
-
-
58149154739
-
Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla
-
1:CAS:528:DC%2BD1cXhtlWntL7I 10.1084/jem.20080866 18936237
-
TM McCaughtry TA Baldwin MS Wilken, et al. 2008 Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla J Exp Med 205 2575 2584 1:CAS:528:DC%2BD1cXhtlWntL7I 10.1084/jem.20080866 18936237
-
(2008)
J Exp Med
, vol.205
, pp. 2575-2584
-
-
McCaughtry, T.M.1
Baldwin, T.A.2
Wilken, M.S.3
-
60
-
-
27144541459
-
A defect in deletion of nucleosome-specific autoimmune T cells in lupus-prone thymus: Role of thymic dendritic cells
-
1:CAS:528:DC%2BD2MXhtFahurjL 16237078
-
MA Michaels HK Kang A Kaliyaperumal, et al. 2005 A defect in deletion of nucleosome-specific autoimmune T cells in lupus-prone thymus: role of thymic dendritic cells J Immunol 175 5857 5865 1:CAS:528:DC%2BD2MXhtFahurjL 16237078
-
(2005)
J Immunol
, vol.175
, pp. 5857-5865
-
-
Michaels, M.A.1
Kang, H.K.2
Kaliyaperumal, A.3
-
61
-
-
47049085776
-
Intercellular MHC transfer between thymic epithelial and dendritic cells
-
1:CAS:528:DC%2BD1cXmsVGrs78%3D 10.1002/eji.200737982 18412162
-
V Millet P Naquet RR Guinamard 2008 Intercellular MHC transfer between thymic epithelial and dendritic cells Eur J Immunol 38 1257 1263 1:CAS:528:DC%2BD1cXmsVGrs78%3D 10.1002/eji.200737982 18412162
-
(2008)
Eur J Immunol
, vol.38
, pp. 1257-1263
-
-
Millet, V.1
Naquet, P.2
Guinamard, R.R.3
-
62
-
-
4344574151
-
Thymic T cell development and progenitor localization depend on CCR7
-
DOI 10.1084/jem.20040383
-
A Misslitz O Pabst G Hintzen, et al. 2004 Thymic T cell development and progenitor localization depend on CCR7 J Exp Med 200 481 491 1:CAS:528:DC%2BD2cXmvFehtrk%3D 10.1084/jem.20040383 15302903 (Pubitemid 39121905)
-
(2004)
Journal of Experimental Medicine
, vol.200
, Issue.4
, pp. 481-491
-
-
Misslitz, A.1
Pabst, O.2
Hintzen, G.3
Ohl, L.4
Kremmer, E.5
Petrie, H.T.6
Forster, R.7
-
63
-
-
70350131707
-
CCR7-mediated migration of developing thymocytes to the medulla is essential for negative selection to tissue-restricted antigens
-
1:CAS:528:DC%2BD1MXhtlaksLzP 10.1073/pnas.0906956106 19805112
-
T Nitta S Nitta Y Lei, et al. 2009 CCR7-mediated migration of developing thymocytes to the medulla is essential for negative selection to tissue-restricted antigens Proc Natl Acad Sci USA 106 17129 17133 1:CAS:528:DC%2BD1MXhtlaksLzP 10.1073/pnas.0906956106 19805112
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 17129-17133
-
-
Nitta, T.1
Nitta, S.2
Lei, Y.3
-
64
-
-
73249135168
-
CD4+ CD25+ regulatory T cells in autoimmune arthritis
-
1:CAS:528:DC%2BC3cXjslarurk%3D 10.1111/j.0105-2896.2009.00848.x 20192995
-
S Oh AL Rankin AJ Caton 2010 CD4+ CD25+ regulatory T cells in autoimmune arthritis Immunol Rev 233 97 111 1:CAS:528:DC%2BC3cXjslarurk%3D 10.1111/j.0105-2896.2009.00848.x 20192995
-
(2010)
Immunol Rev
, vol.233
, pp. 97-111
-
-
Oh, S.1
Rankin, A.L.2
Caton, A.J.3
-
65
-
-
63449108301
-
Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity
-
1:CAS:528:DC%2BD1MXjsVaisb8%3D 10.1084/jem.20082394 19237601
-
C Ohnmacht A Pullner SB King, et al. 2009 Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity J Exp Med 206 549 559 1:CAS:528:DC%2BD1MXjsVaisb8%3D 10.1084/jem.20082394 19237601
-
(2009)
J Exp Med
, vol.206
, pp. 549-559
-
-
Ohnmacht, C.1
Pullner, A.2
King, S.B.3
-
66
-
-
58149376454
-
Dendritic cells in the thymus contribute to T-regulatory cell induction
-
1:CAS:528:DC%2BD1cXhsFCltrjI 10.1073/pnas.0810268105 19073916
-
AI Proietto S van Dommelen P Zhou, et al. 2008 Dendritic cells in the thymus contribute to T-regulatory cell induction Proc Natl Acad Sci USA 105 19869 19874 1:CAS:528:DC%2BD1cXhsFCltrjI 10.1073/pnas.0810268105 19073916
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 19869-19874
-
-
Proietto, A.I.1
Van Dommelen, S.2
Zhou, P.3
-
67
-
-
18244421874
-
The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes
-
DOI 10.1038/ng0397-293
-
A Pugliese M Zeller A Fernandez Jr, et al. 1997 The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes Nat Genet 15 293 297 1:CAS:528:DyaK2sXhsVGrtbg%3D 10.1038/ng0397-293 9054945 (Pubitemid 27098726)
-
(1997)
Nature Genetics
, vol.15
, Issue.3
, pp. 293-297
-
-
Pugliese, A.1
Zeller, M.2
Fernandez Jr., A.3
Zalcberg, L.J.4
Bartlett, R.J.5
Ricordi, C.6
Pietropaolo, M.7
Eisenbarth, G.S.8
Bennett, S.T.9
Patel, D.D.10
-
68
-
-
40349109578
-
Genetic variation in PTPN22 corresponds to altered function of T and B lymphocytes
-
1:CAS:528:DC%2BD2sXhtVCrurrP 17878369
-
M Rieck A Arechiga S Onengut-Gumuscu, et al. 2007 Genetic variation in PTPN22 corresponds to altered function of T and B lymphocytes J Immunol 179 4704 4710 1:CAS:528:DC%2BD2sXhtVCrurrP 17878369
-
(2007)
J Immunol
, vol.179
, pp. 4704-4710
-
-
Rieck, M.1
Arechiga, A.2
Onengut-Gumuscu, S.3
-
69
-
-
0030849637
-
Targeted complementation of MHC class II deficiency by intrathymic delivery of recombinant adenoviruses
-
DOI 10.1016/S1074-7613(00)80515-4
-
R Rooke C Waltzinger C Benoist, et al. 1997 Targeted complementation of MHC class II deficiency by intrathymic delivery of recombinant adenoviruses Immunity 7 123 134 1:CAS:528:DyaK2sXltFWhtb0%3D 10.1016/S1074-7613(00)80515-4 9252125 (Pubitemid 27357270)
-
(1997)
Immunity
, vol.7
, Issue.1
, pp. 123-134
-
-
Rooke, R.1
Waltzinger, C.2
Benoist, C.3
Mathis, D.4
-
70
-
-
34250336454
-
- inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla
-
DOI 10.1084/jem.20062497
-
SW Rossi MY Kim A Leibbrandt, et al. 2007 RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla J Exp Med 204 1267 1272 1:CAS:528:DC%2BD2sXms1aktrg%3D 10.1084/jem.20062497 17502664 (Pubitemid 46919863)
-
(2007)
Journal of Experimental Medicine
, vol.204
, Issue.6
, pp. 1267-1272
-
-
Rossi, S.W.1
Kim, M.-Y.2
Leibbrandt, A.3
Parnell, S.M.4
Jenkinson, W.E.5
Glanville, S.H.6
McConnell, F.M.7
Scott, H.S.8
Penninger, J.M.9
Jenkinson, E.J.10
Lane, P.J.L.11
Anderson, G.12
-
71
-
-
0345414139
-
Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice
-
DOI 10.1038/nature02119
-
N Sakaguchi T Takahashi H Hata, et al. 2003 Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice Nature 426 454 560 1:CAS:528:DC%2BD3sXpt1Gls7k%3D 10.1038/nature02119 14647385 (Pubitemid 37490133)
-
(2003)
Nature
, vol.426
, Issue.6965
, pp. 454-460
-
-
Sakaguchi, N.1
Takahashi, T.2
Hata, H.3
Nomura, T.4
Tagami, T.5
Yamazaki, S.6
Sakihama, T.7
Matsutani, T.8
Negishi, I.9
Nakatsuru, S.10
Sakaguchi, S.11
-
72
-
-
0028988659
-
Thymic emigration: Conveyor belts or lucky dips?
-
(discussion 273-274)
-
Scollay R, Godfrey DI (1995) Thymic emigration: conveyor belts or lucky dips? Immunol Today 16:268-273 (discussion 273-274)
-
(1995)
Immunol Today
, vol.16
, pp. 268-273
-
-
Scollay, R.1
Godfrey, D.I.2
-
73
-
-
33846193992
-
Apoptotic cells induce Mer tyrosine kinase-dependent blockade of NF-κB activation in dendritic cells
-
DOI 10.1182/blood-2006-04-017368
-
P Sen MA Wallet Z Yi, et al. 2007 Apoptotic cells induce Mer tyrosine kinase-dependent blockade of NF-kappaB activation in dendritic cells Blood 109 653 660 1:CAS:528:DC%2BD2sXivVyrs78%3D 10.1182/blood-2006-04-017368 17008547 (Pubitemid 46105966)
-
(2007)
Blood
, vol.109
, Issue.2
, pp. 653-660
-
-
Sen, P.1
Wallet, M.A.2
Yi, Z.3
Huang, Y.4
Henderson, M.5
Mathews, C.E.6
Earp, H.S.7
Matsushima, G.8
Baldwin Jr., A.S.9
Tisch, R.M.10
-
74
-
-
33644636553
-
The why and how of thymocyte negative selection
-
DOI 10.1016/j.coi.2006.01.001, PII S0952791506000033, Lymphocyte Development / Tumor Immunology
-
OM Siggs LE Makaroff A Liston 2006 The why and how of thymocyte negative selection Curr Opin Immunol 18 175 183 1:CAS:528:DC%2BD28XitVaksLg%3D 10.1016/j.coi.2006.01.001 16459069 (Pubitemid 43327299)
-
(2006)
Current Opinion in Immunology
, vol.18
, Issue.2
, pp. 175-183
-
-
Siggs, O.M.1
Makaroff, L.E.2
Liston, A.3
-
75
-
-
33645337913
-
Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases
-
10.1186/1471-2350-7-20 16519819
-
DJ Smyth JM Howson F Payne, et al. 2006 Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases BMC Med Genet 7 20 10.1186/1471-2350-7-20 16519819
-
(2006)
BMC Med Genet
, vol.7
, pp. 20
-
-
Smyth, D.J.1
Howson, J.M.2
Payne, F.3
-
76
-
-
0032402315
-
Transcription of a broad range of self-antigens in human thymus suggests a role for central mechanisms in tolerance toward peripheral antigens
-
1:CAS:528:DyaK1cXnslCrsLc%3D 9834072
-
M Sospedra X Ferrer-Francesch O Dominguez, et al. 1998 Transcription of a broad range of self-antigens in human thymus suggests a role for central mechanisms in tolerance toward peripheral antigens J Immunol 161 5918 5929 1:CAS:528:DyaK1cXnslCrsLc%3D 9834072
-
(1998)
J Immunol
, vol.161
, pp. 5918-5929
-
-
Sospedra, M.1
Ferrer-Francesch, X.2
Dominguez, O.3
-
77
-
-
39149118342
-
Do the peptide-binding properties of diabetogenic class II molecules explain autoreactivity?
-
1:CAS:528:DC%2BD1cXisVWhu70%3D 10.1016/j.coi.2007.10.007 18082388
-
A Suri MG Levisetti ER Unanue 2008 Do the peptide-binding properties of diabetogenic class II molecules explain autoreactivity? Curr Opin Immunol 20 105 110 1:CAS:528:DC%2BD1cXisVWhu70%3D 10.1016/j.coi.2007.10.007 18082388
-
(2008)
Curr Opin Immunol
, vol.20
, pp. 105-110
-
-
Suri, A.1
Levisetti, M.G.2
Unanue, E.R.3
-
78
-
-
34250184506
-
Gene expression studies in multiple sclerosis
-
DOI 10.2174/138920207780833829
-
L Tajouri F Fernandez LR Griffiths 2007 Gene expression studies in multiple sclerosis Curr Genomics 8 181 189 1:CAS:528:DC%2BD2sXmvFahu7k%3D 10.2174/138920207780833829 18645602 (Pubitemid 46902208)
-
(2007)
Current Genomics
, vol.8
, Issue.3
, pp. 181-189
-
-
Tajouri, L.1
Fernandez, F.2
Griffiths, L.R.3
-
79
-
-
33644845679
-
Journey through the thymus: Stromal guides for T-cell development and selection
-
DOI 10.1038/nri1781, PII N1781
-
Y Takahama 2006 Journey through the thymus: stromal guides for T-cell development and selection Nat Rev Immunol 6 127 135 1:CAS:528: DC%2BD28XhsFeqtbo%3D 10.1038/nri1781 16491137 (Pubitemid 43361588)
-
(2006)
Nature Reviews Immunology
, vol.6
, Issue.2
, pp. 127-135
-
-
Takahama, Y.1
-
80
-
-
73249123243
-
Role of HLA class II genes in susceptibility/resistance to inflammatory arthritis: Studies with humanized mice
-
1:CAS:528:DC%2BC3cXjslaruro%3D 10.1111/j.0105-2896.2009.00858.x 20192993
-
V Taneja CS David 2010 Role of HLA class II genes in susceptibility/ resistance to inflammatory arthritis: studies with humanized mice Immunol Rev 233 62 78 1:CAS:528:DC%2BC3cXjslaruro%3D 10.1111/j.0105-2896.2009.00858.x 20192993
-
(2010)
Immunol Rev
, vol.233
, pp. 62-78
-
-
Taneja, V.1
David, C.S.2
-
81
-
-
43549097825
-
During negative selection, Nur77 family proteins translocate to mitochondria where they associate with Bcl-2 and expose its proapoptotic BH3 domain
-
DOI 10.1084/jem.20080101
-
J Thompson A Winoto 2008 During negative selection, Nur77 family proteins translocate to mitochondria where they associate with Bcl-2 and expose its proapoptotic BH3 domain J Exp Med 205 1029 1036 1:CAS:528:DC%2BD1cXlvFWrsrg%3D 10.1084/jem.20080101 18443228 (Pubitemid 351679679)
-
(2008)
Journal of Experimental Medicine
, vol.205
, Issue.5
, pp. 1029-1036
-
-
Thompson, J.1
Winoto, A.2
-
82
-
-
77951926420
-
Etiology of type 1 diabetes
-
1:CAS:528:DC%2BC3cXlslSju74%3D 10.1016/j.immuni.2010.04.001 20412756
-
JA Todd 2010 Etiology of type 1 diabetes Immunity 32 457 467 1:CAS:528:DC%2BC3cXlslSju74%3D 10.1016/j.immuni.2010.04.001 20412756
-
(2010)
Immunity
, vol.32
, pp. 457-467
-
-
Todd, J.A.1
-
83
-
-
56549085984
-
The thymus medulla slowly yields its secrets
-
1:CAS:528:DC%2BD1MXpvFKruw%3D%3D 10.1196/annals.1443.018 19076347
-
LO Tykocinski A Sinemus B Kyewski 2008 The thymus medulla slowly yields its secrets Ann NY Acad Sci 1143 105 122 1:CAS:528:DC%2BD1MXpvFKruw%3D%3D 10.1196/annals.1443.018 19076347
-
(2008)
Ann NY Acad Sci
, vol.1143
, pp. 105-122
-
-
Tykocinski, L.O.1
Sinemus, A.2
Kyewski, B.3
-
84
-
-
4344668118
-
CCR7 signals are essential for cortex-medulla migration of developing thymocytes
-
DOI 10.1084/jem.20040643
-
T Ueno F Saito DH Gray, et al. 2004 CCR7 signals are essential for cortex-medulla migration of developing thymocytes J Exp Med 200 493 505 1:CAS:528:DC%2BD2cXmvFehtrY%3D 10.1084/jem.20040643 15302902 (Pubitemid 39121906)
-
(2004)
Journal of Experimental Medicine
, vol.200
, Issue.4
, pp. 493-505
-
-
Ueno, T.1
Saito, F.2
Gray, D.H.D.3
Kuse, S.4
Hieshima, K.5
Nakano, H.6
Kakiuchi, T.7
Lipp, M.8
Boyd, R.L.9
Takahama, Y.10
-
85
-
-
0031018819
-
Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus
-
DOI 10.1038/ng0397-289
-
P Vafiadis ST Bennett JA Todd, et al. 1997 Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus Nat Genet 15 289 292 1:CAS:528:DyaK2sXhsVGrtL0%3D 10.1038/ng0397-289 9054944 (Pubitemid 27098725)
-
(1997)
Nature Genetics
, vol.15
, Issue.3
, pp. 289-292
-
-
Vafiadis, P.1
Bennett, S.T.2
Todd, J.A.3
Nadeau, J.4
Grabs, R.5
Goodyer, C.G.6
Wickramasinghe, S.7
Colle, E.8
Polychronakos, C.9
-
86
-
-
32044456473
-
Association of the PTPN22*R620W polymorphism with autoimmune myasthenia gravis
-
DOI 10.1002/ana.20751
-
C Vandiedonck C Capdevielle M Giraud, et al. 2006 Association of the PTPN22*R620W polymorphism with autoimmune myasthenia gravis Ann Neurol 59 404 407 1:CAS:528:DC%2BD28XhvVSksb0%3D 10.1002/ana.20751 16437561 (Pubitemid 43202499)
-
(2006)
Annals of Neurology
, vol.59
, Issue.2
, pp. 404-407
-
-
Vandiedonck, C.1
Capdevielle, C.2
Giraud, M.3
Krumeich, S.4
Jais, J.-P.5
Eymard, B.6
Tranchant, C.7
Gajdos, P.8
Garchon, H.-J.9
-
87
-
-
28444469783
-
Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant
-
DOI 10.1038/ng1673, PII N1673
-
T Vang M Congia MD Macis, et al. 2005 Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant Nat Genet 37 1317 1319 1:CAS:528:DC%2BD2MXht1Ggsr%2FN 10.1038/ng1673 16273109 (Pubitemid 41722185)
-
(2005)
Nature Genetics
, vol.37
, Issue.12
, pp. 1317-1319
-
-
Vang, T.1
Congia, M.2
Macis, M.D.3
Musumeci, L.4
Orru, V.5
Zavattari, P.6
Nika, K.7
Tautz, L.8
Tasken, K.9
Cucca, F.10
Mustelin, T.11
Bottini, N.12
-
88
-
-
76249094369
-
Disturbed regulatory T cell homeostasis in multiple sclerosis
-
1:CAS:528:DC%2BC3cXitVKgsbk%3D 10.1016/j.molmed.2009.12.003 20159585
-
K Venken N Hellings R Liblau, et al. 2010 Disturbed regulatory T cell homeostasis in multiple sclerosis Trends Mol Med 16 58 68 1:CAS:528: DC%2BC3cXitVKgsbk%3D 10.1016/j.molmed.2009.12.003 20159585
-
(2010)
Trends Mol Med
, vol.16
, pp. 58-68
-
-
Venken, K.1
Hellings, N.2
Liblau, R.3
-
89
-
-
16244367143
-
AIRE and APECED: Molecular insights into an autoimmune disease
-
DOI 10.1111/j.0105-2896.2005.00246.x
-
J Villasenor C Benoist D Mathis 2005 AIRE and APECED: molecular insights into an autoimmune disease Immunol Rev 204 156 164 1:CAS:528: DC%2BD2MXkslGns7s%3D 10.1111/j.0105-2896.2005.00246.x 15790357 (Pubitemid 40460500)
-
(2005)
Immunological Reviews
, vol.204
, pp. 156-164
-
-
Villasenor, J.1
Benoist, C.2
Mathis, D.3
-
90
-
-
56749184864
-
Ectopic expression of peripheral-tissue antigens in the thymic epithelium: Probabilistic, monoallelic, misinitiated
-
1:CAS:528:DC%2BD1cXht1yitrnJ 10.1073/pnas.0808069105 18836079
-
J Villasenor W Besse C Benoist, et al. 2008 Ectopic expression of peripheral-tissue antigens in the thymic epithelium: probabilistic, monoallelic, misinitiated Proc Natl Acad Sci USA 105 15854 15859 1:CAS:528: DC%2BD1cXht1yitrnJ 10.1073/pnas.0808069105 18836079
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 15854-15859
-
-
Villasenor, J.1
Besse, W.2
Benoist, C.3
-
91
-
-
70349242192
-
Central tolerance: Essential for preventing autoimmune disease?
-
10.1002/eji.200939575
-
H von Boehmer 2009 Central tolerance: essential for preventing autoimmune disease? Eur J Immunol 39 2313 2316 10.1002/eji.200939575
-
(2009)
Eur J Immunol
, vol.39
, pp. 2313-2316
-
-
Von Boehmer, H.1
-
92
-
-
38749108510
-
MerTK is required for apoptotic cell-induced T cell tolerance
-
DOI 10.1084/jem.20062293
-
MA Wallet P Sen RR Flores, et al. 2008 MerTK is required for apoptotic cell-induced T cell tolerance J Exp Med 205 219 232 1:CAS:528: DC%2BD1cXht1yktLY%3D 10.1084/jem.20062293 18195070 (Pubitemid 351185728)
-
(2008)
Journal of Experimental Medicine
, vol.205
, Issue.1
, pp. 219-232
-
-
Wallet, M.A.1
Sen, P.2
Flores, R.R.3
Wang, Y.4
Yi, Z.5
Huang, Y.6
Mathews, C.E.7
Earp, H.S.8
Matsushima, G.9
Wang, B.10
Tisch, R.11
-
93
-
-
63849156298
-
MerTK regulates thymic selection of autoreactive T cells
-
1:CAS:528:DC%2BD1MXktFGqsL4%3D 10.1073/pnas.0900683106 19251650
-
MA Wallet RR Flores Y Wang, et al. 2009 MerTK regulates thymic selection of autoreactive T cells Proc Natl Acad Sci USA 106 4810 4815 1:CAS:528:DC%2BD1MXktFGqsL4%3D 10.1073/pnas.0900683106 19251650
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 4810-4815
-
-
Wallet, M.A.1
Flores, R.R.2
Wang, Y.3
-
94
-
-
22144444873
-
Heterogeneity of thymic dendritic cells
-
DOI 10.1016/j.smim.2005.05.001, PII S1044532305000394, Dendritic Cell Heterogenity
-
L Wu K Shortman 2005 Heterogeneity of thymic dendritic cells Semin Immunol 17 304 312 1:CAS:528:DC%2BD2MXmsVWktLk%3D 10.1016/j.smim.2005.05.001 15946853 (Pubitemid 40981935)
-
(2005)
Seminars in Immunology
, vol.17
, Issue.4
, pp. 304-312
-
-
Wu, L.1
Shortman, K.2
-
95
-
-
0030961031
-
Recognition of the immunodominant myelin basic protein peptide by autoantibodies and HLA-DR2-restricted T cell clones from multiple sclerosis patients. Identity of key contact residues in the B-cell and T-cell epitopes
-
1:CAS:528:DyaK2sXlvFOgsL0%3D 10.1172/JCI119622 9276728
-
KW Wucherpfennig I Catz S Hausmann, et al. 1997 Recognition of the immunodominant myelin basic protein peptide by autoantibodies and HLA-DR2-restricted T cell clones from multiple sclerosis patients. Identity of key contact residues in the B-cell and T-cell epitopes J Clin Invest 100 1114 1122 1:CAS:528:DyaK2sXlvFOgsL0%3D 10.1172/JCI119622 9276728
-
(1997)
J Clin Invest
, vol.100
, pp. 1114-1122
-
-
Wucherpfennig, K.W.1
Catz, I.2
Hausmann, S.3
-
96
-
-
57749170446
-
Immunoregulatory pathways controlling progression of autoimmunity in NOD mice
-
1:CAS:528:DC%2BD1MXhsFGqtrw%3D 10.1196/annals.1447.046 19120317
-
S You MA Alyanakian B Segovia, et al. 2008 Immunoregulatory pathways controlling progression of autoimmunity in NOD mice Ann NY Acad Sci 1150 300 310 1:CAS:528:DC%2BD1MXhsFGqtrw%3D 10.1196/annals.1447.046 19120317
-
(2008)
Ann NY Acad Sci
, vol.1150
, pp. 300-310
-
-
You, S.1
Alyanakian, M.A.2
Segovia, B.3
-
97
-
-
0034485826
-
HLA class II association with rheumatoid arthritis: Facts and interpretations
-
DOI 10.1016/S0198-8859(00)00185-3, PII S0198885900001853
-
E Zanelli FC Breedveld RR de Vries 2000 HLA class II association with rheumatoid arthritis: facts and interpretations Hum Immunol 61 1254 1261 1:CAS:528:DC%2BD3MXksVWhsQ%3D%3D 10.1016/S0198-8859(00)00185-3 11163080 (Pubitemid 32102413)
-
(2000)
Human Immunology
, vol.61
, Issue.12
, pp. 1254-1261
-
-
Zanelli, E.1
Breedveld, F.C.2
De Vries, R.R.P.3
-
98
-
-
0035871631
-
Impaired Fas signaling pathway is involved in defective T cell apoptosis in autoimmune murine arthritis
-
1:CAS:528:DC%2BD3MXivVKmsrs%3D 11290777
-
J Zhang T Bardos K Mikecz, et al. 2001 Impaired Fas signaling pathway is involved in defective T cell apoptosis in autoimmune murine arthritis J Immunol 166 4981 4986 1:CAS:528:DC%2BD3MXivVKmsrs%3D 11290777
-
(2001)
J Immunol
, vol.166
, pp. 4981-4986
-
-
Zhang, J.1
Bardos, T.2
Mikecz, K.3
-
99
-
-
0037446749
-
T cell tolerance to a neo-self antigen expressed by thymic epithelial cells: The soluble form is more effective than the membrane-bound form
-
1:CAS:528:DC%2BD3sXislektbc%3D 12682222
-
M Zhang MS Vacchio BP Vistica, et al. 2003 T cell tolerance to a neo-self antigen expressed by thymic epithelial cells: the soluble form is more effective than the membrane-bound form J Immunol 170 3954 3962 1:CAS:528:DC%2BD3sXislektbc%3D 12682222
-
(2003)
J Immunol
, vol.170
, pp. 3954-3962
-
-
Zhang, M.1
Vacchio, M.S.2
Vistica, B.P.3
-
100
-
-
77951891703
-
Prediction and pathogenesis in type 1 diabetes
-
1:CAS:528:DC%2BC3cXlslSju78%3D 10.1016/j.immuni.2010.03.018 20412757
-
AG Ziegler GT Nepom 2010 Prediction and pathogenesis in type 1 diabetes Immunity 32 468 478 1:CAS:528:DC%2BC3cXlslSju78%3D 10.1016/j.immuni.2010.03.018 20412757
-
(2010)
Immunity
, vol.32
, pp. 468-478
-
-
Ziegler, A.G.1
Nepom, G.T.2
|