메뉴 건너뛰기




Volumn 12, Issue 8, 2010, Pages 882-889

mTOR signaling in glioblastoma: Lessons learned from bench to bedside

Author keywords

Glioblastoma; mTOR; PI3K

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; TEMSIROLIMUS; PROTEIN SERINE THREONINE KINASE; SIGNAL PEPTIDE;

EID: 78149479091     PISSN: 15228517     EISSN: 15235866     Source Type: Journal    
DOI: 10.1093/neuonc/noq052     Document Type: Review
Times cited : (150)

References (80)
  • 1
    • 35949002429 scopus 로고    scopus 로고
    • Malignant astrocytic glioma: Genetics, biology, and paths to treatment
    • Furnari FB, Fenton T, Bachoo RM, et al. Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes Dev. 2007;21:2683-2710.
    • (2007) Genes Dev. , vol.21 , pp. 2683-2710
    • Furnari, F.B.1    Fenton, T.2    Bachoo, R.M.3
  • 2
    • 20044366163 scopus 로고    scopus 로고
    • Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
    • Stupp R, Mason WP, van den Bent MJ, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 2005;352:987-996.
    • (2005) N Engl J Med. , vol.352 , pp. 987-996
    • Stupp, R.1    Mason, W.P.2    Van Den Bent, M.J.3
  • 3
    • 33746257209 scopus 로고    scopus 로고
    • The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
    • Engelman JA, Luo J, Cantley LC. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet. 2006;7:606-619.
    • (2006) Nat Rev Genet. , vol.7 , pp. 606-619
    • Engelman, J.A.1    Luo, J.2    Cantley, L.C.3
  • 4
    • 67650601691 scopus 로고    scopus 로고
    • Cell type specificity of PI3K signaling in Pdk1- and Pten-deficient brains
    • Chalhoub N, Zhu G, Zhu X, Baker SJ. Cell type specificity of PI3K signaling in Pdk1- and Pten-deficient brains. Genes Dev. 2009;23:1619-1624.
    • (2009) Genes Dev. , vol.23 , pp. 1619-1624
    • Chalhoub, N.1    Zhu, G.2    Zhu, X.3    Baker, S.J.4
  • 5
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase AKT pathway in human cancer
    • Vivanco I, Sawyers CL. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer. 2002;2:489-501.
    • (2002) Nat Rev Cancer. , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 6
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • The Cancer Genome Atlas Research Network
    • The Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature. 2008;455:1061-1068.
    • (2008) Nature. , vol.455 , pp. 1061-1068
  • 7
    • 52949127312 scopus 로고    scopus 로고
    • An integrated genomic analysis of human glioblastoma multiforme
    • Parsons DW, Jones S, Zhang X, et al. An integrated genomic analysis of human glioblastoma multiforme. Science. 2008;321:1807-1812.
    • (2008) Science. , vol.321 , pp. 1807-1812
    • Parsons, D.W.1    Jones, S.2    Zhang, X.3
  • 8
    • 0038615946 scopus 로고    scopus 로고
    • Analysis of the phosphatidylinositol 3'-kinase signaling pathway in glioblastoma patients in vivo
    • Choe G, Horvath S, Cloughesy TF, et al. Analysis of the phosphatidylinositol 3'-kinase signaling pathway in glioblastoma patients in vivo. Cancer Res. 2003;63:2742-2746.
    • (2003) Cancer Res. , vol.63 , pp. 2742-2746
    • Choe, G.1    Horvath, S.2    Cloughesy, T.F.3
  • 9
    • 14444288522 scopus 로고    scopus 로고
    • The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling
    • Huang HS, Nagane M, Klingbeil CK, et al. The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling. J Biol Chem. 1997;272:2927-2935.
    • (1997) J Biol Chem. , vol.272 , pp. 2927-2935
    • Huang, H.S.1    Nagane, M.2    Klingbeil, C.K.3
  • 10
    • 0029591402 scopus 로고
    • Differential modulation of mitogen-activated protein (MAP) kinase/extracellular signal-related kinase kinase and MAP kinase activities by a mutant epidermal growth factor receptor
    • Montgomery RB, Moscatello DK, Wong AJ, Cooper JA, Stahl WL. Differential modulation of mitogen-activated protein (MAP) kinase/extracellular signal-related kinase kinase and MAP kinase activities by a mutant epidermal growth factor receptor. J Biol Chem. 1995;270:30562-30566.
    • (1995) J Biol Chem. , vol.270 , pp. 30562-30566
    • Montgomery, R.B.1    Moscatello, D.K.2    Wong, A.J.3    Cooper, J.A.4    Stahl, W.L.5
  • 11
    • 0030832167 scopus 로고    scopus 로고
    • Cell surface localization and density of the tumor-associated variant of the epidermal growth factor receptor EGFRvIII
    • Wikstrand CJ, McLendon RE, Friedman AH, Bigner DD. Cell surface localization and density of the tumor-associated variant of the epidermal growth factor receptor, EGFRvIII. Cancer Res. 1997;57:4130-4140.
    • (1997) Cancer Res. , vol.57 , pp. 4130-4140
    • Wikstrand, C.J.1    McLendon, R.E.2    Friedman, A.H.3    Bigner, D.D.4
  • 12
    • 51349164790 scopus 로고    scopus 로고
    • Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer
    • Carracedo A, Ma L, Teruya-Feldstein J, et al. Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer. J Clin Invest. 2008;118:3065-3074.
    • (2008) J Clin Invest. , vol.118 , pp. 3065-3074
    • Carracedo, A.1    Ma, L.2    Teruya-Feldstein, J.3
  • 13
    • 38949117993 scopus 로고    scopus 로고
    • Development of a real-time RT-PCR assay for detecting EGFRvIII in glioblastoma samples
    • Yoshimoto K, Dang J, Zhu S, et al. Development of a real-time RT-PCR assay for detecting EGFRvIII in glioblastoma samples. Clin Cancer Res. 2008;14:488-493.
    • (2008) Clin Cancer Res. , vol.14 , pp. 488-493
    • Yoshimoto, K.1    Dang, J.2    Zhu, S.3
  • 14
    • 34547881522 scopus 로고    scopus 로고
    • Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma
    • Huang PH, Mukasa A, Bonavia R, et al. Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma. Proc Natl Acad Sci USA. 2007;104:12867-12872.
    • (2007) Proc Natl Acad Sci USA. , vol.104 , pp. 12867-12872
    • Huang, P.H.1    Mukasa, A.2    Bonavia, R.3
  • 15
    • 35348822482 scopus 로고    scopus 로고
    • Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies
    • Stommel JM, Kimmelman AC, Ying H, et al. Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies. Science. 2007;318:287-290.
    • (2007) Science. , vol.318 , pp. 287-290
    • Stommel, J.M.1    Kimmelman, A.C.2    Ying, H.3
  • 16
    • 0036094711 scopus 로고    scopus 로고
    • Dysregulation of PTEN and protein kinase B is associated with glioma histology and patient survival
    • Ermoian RP, Furniss CS, Lamborn KR, et al. Dysregulation of PTEN and protein kinase B is associated with glioma histology and patient survival. Clin Cancer Res. 2002;8:1100-1106.
    • (2002) Clin Cancer Res. , vol.8 , pp. 1100-1106
    • Ermoian, R.P.1    Furniss, C.S.2    Lamborn, K.R.3
  • 17
    • 67649321430 scopus 로고    scopus 로고
    • Proteasomal and genetic inactivation of the NF1 tumor suppressor in gliomagenesis
    • McGillicuddy LT, Fromm JA, Hollstein PE, et al. Proteasomal and genetic inactivation of the NF1 tumor suppressor in gliomagenesis. Cancer Cell. 2009;16:44-54.
    • (2009) Cancer Cell. , vol.16 , pp. 44-54
    • McGillicuddy, L.T.1    Fromm, J.A.2    Hollstein, P.E.3
  • 18
    • 0037264633 scopus 로고    scopus 로고
    • Targeting RAS signalling pathways in cancer therapy
    • Downward J. Targeting RAS signalling pathways in cancer therapy. Nat Rev Cancer. 2003;3:11-22.
    • (2003) Nat Rev Cancer. , vol.3 , pp. 11-22
    • Downward, J.1
  • 19
    • 57449104947 scopus 로고    scopus 로고
    • PI3K signaling in glioma-animal models and therapeutic challenges
    • Cheng CK, Fan QW, Weiss WA. PI3K signaling in glioma-animal models and therapeutic challenges. Brain Pathol. 2009;19:112-120.
    • (2009) Brain Pathol. , vol.19 , pp. 112-120
    • Cheng, C.K.1    Fan, Q.W.2    Weiss, W.A.3
  • 20
    • 0035256772 scopus 로고    scopus 로고
    • Gliomagenesis: Genetic alterations and mouse models
    • Holland EC. Gliomagenesis: genetic alterations and mouse models. Nat Rev Genet. 2001;2:120-129.
    • (2001) Nat Rev Genet. , vol.2 , pp. 120-129
    • Holland, E.C.1
  • 21
    • 0035884505 scopus 로고    scopus 로고
    • Akt pathway activation converts anaplastic astrocytoma to glioblastoma multiforme in a human astrocyte model of glioma
    • Sonoda Y, Ozawa T, Aldape KD, Deen DF, Berger MS, Pieper RO. Akt pathway activation converts anaplastic astrocytoma to glioblastoma multiforme in a human astrocyte model of glioma. Cancer Res. 2001;61:6674-6678.
    • (2001) Cancer Res. , vol.61 , pp. 6674-6678
    • Sonoda, Y.1    Ozawa, T.2    Aldape, K.D.3    Deen, D.F.4    Berger, M.S.5    Pieper, R.O.6
  • 22
    • 58149330085 scopus 로고    scopus 로고
    • Development of a novel mouse glioma model using lentiviral vectors
    • Marumoto T, Tashiro A, Friedmann-Morvinski D, et al. Development of a novel mouse glioma model using lentiviral vectors. Nat Med. 2009;15:110-116.
    • (2009) Nat Med. , vol.15 , pp. 110-116
    • Marumoto, T.1    Tashiro, A.2    Friedmann-Morvinski, D.3
  • 23
    • 19044397160 scopus 로고    scopus 로고
    • Epidermal growth factor receptor and Ink4a/Arf: Convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis
    • Bachoo RM, Maher EA, Ligon KL, et al. Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell. 2002;1:269-277.
    • (2002) Cancer Cell. , vol.1 , pp. 269-277
    • Bachoo, R.M.1    Maher, E.A.2    Ligon, K.L.3
  • 24
    • 0036490954 scopus 로고    scopus 로고
    • Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation
    • Xiao A,Wu H, Pandolfi PP, Louis DN, Van Dyke T. Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation. Cancer Cell. 2002;1:157-168.
    • (2002) Cancer Cell. , vol.1 , pp. 157-168
    • Xiao Awu, H.1    Pandolfi, P.P.2    Louis, D.N.3    Van Dyke, T.4
  • 25
    • 20444484560 scopus 로고    scopus 로고
    • Somatic induction of Pten loss in a preclinical astrocytoma model reveals major roles in disease progression and avenues for target discovery and validation
    • Xiao A, Yin C, Yang C, Di Cristofano A, Pandolfi PP, Van Dyke T. Somatic induction of Pten loss in a preclinical astrocytoma model reveals major roles in disease progression and avenues for target discovery and validation. Cancer Res. 2005;65:5172-5180.
    • (2005) Cancer Res. , vol.65 , pp. 5172-5180
    • Xiao, A.1    Yin, C.2    Yang, C.3    Di Cristofano, A.4    Pandolfi, P.P.5    Van Dyke, T.6
  • 27
    • 67349241955 scopus 로고    scopus 로고
    • DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival
    • Peterson TR, Laplante M, Thoreen CC, et al. DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. Cell. 2009;137:873-886.
    • (2009) Cell. , vol.137 , pp. 873-886
    • Peterson, T.R.1    Laplante, M.2    Thoreen, C.C.3
  • 28
    • 0031127305 scopus 로고    scopus 로고
    • Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha
    • Alessi DR, James SR, Downes CP, et al. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Curr Biol. 1997;7:261-269.
    • (1997) Curr Biol. , vol.7 , pp. 261-269
    • Alessi, D.R.1    James, S.R.2    Downes, C.P.3
  • 29
    • 58849120491 scopus 로고    scopus 로고
    • Role of a novel PH-kinase domain interface in PKB/Akt regulation: Structural mechanism for allosteric inhibition
    • Calleja V, Laguerre M, Parker PJ, Larijani B. Role of a novel PH-kinase domain interface in PKB/Akt regulation: structural mechanism for allosteric inhibition. PLoS Biol. 2009;7:e17.
    • (2009) PLoS Biol. , vol.7
    • Calleja, V.1    Laguerre, M.2    Parker, P.J.3    Larijani, B.4
  • 30
    • 34247391898 scopus 로고    scopus 로고
    • Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo
    • Calleja V, Alcor D, Laguerre M, et al. Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo. PLoS Biol. 2007;5:e95.
    • (2007) PLoS Biol. , vol.5
    • Calleja, V.1    Alcor, D.2    Laguerre, M.3
  • 31
    • 33750072949 scopus 로고    scopus 로고
    • MTOR and cancer therapy
    • Easton JB, Houghton PJ. mTOR and cancer therapy. Oncogene. 2006;25:6436-6446.
    • (2006) Oncogene. , vol.25 , pp. 6436-6446
    • Easton, J.B.1    Houghton, P.J.2
  • 32
    • 62349110027 scopus 로고    scopus 로고
    • EGFR signals to mTOR through PKC and independently of Akt in glioma
    • Fan QW, Cheng C, Knight ZA, et al. EGFR signals to mTOR through PKC and independently of Akt in glioma. Sci Signal. 2009;2:ra4.
    • (2009) Sci Signal. , vol.2
    • Fan, Q.W.1    Cheng, C.2    Knight, Z.A.3
  • 33
    • 53049084191 scopus 로고    scopus 로고
    • S6K1 plays a key role in glial transformation
    • Nakamura JL, Garcia E, Pieper RO. S6K1 plays a key role in glial transformation. Cancer Res. 2008;68:6516-6523.
    • (2008) Cancer Res. , vol.68 , pp. 6516-6523
    • Nakamura, J.L.1    Garcia, E.2    Pieper, R.O.3
  • 34
    • 18644377225 scopus 로고    scopus 로고
    • Holland EC. mTOR promotes survival and astrocytic characteristics induced by Pten/AKT signaling in glioblastoma
    • Hu X, Pandolfi PP, Li Y, Koutcher JA, Rosenblum M, Holland EC. mTOR promotes survival and astrocytic characteristics induced by Pten/AKT signaling in glioblastoma. Neoplasia. 2005;7:356-368.
    • (2005) Neoplasia. , vol.7 , pp. 356-368
    • Hu, X.1    Pandolfi, P.P.2    Li, Y.3    Koutcher, J.A.4    Rosenblum, M.5
  • 35
    • 17944377486 scopus 로고    scopus 로고
    • Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR
    • Neshat MS, Mellinghoff IK, Tran C, et al. Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. Proc Natl Acad Sci USA. 2001;98:10314-10319.
    • (2001) Proc Natl Acad Sci USA. , vol.98 , pp. 10314-10319
    • Neshat, M.S.1    Mellinghoff, I.K.2    Tran, C.3
  • 36
    • 0037115523 scopus 로고    scopus 로고
    • Inhibition of the mammalian target of rapamycin sensitizes U87 xenografts to fractionated radiation therapy
    • Eshleman JS, Carlson BL, Mladek AC, Kastner BD, Shide KL, Sarkaria JN. Inhibition of the mammalian target of rapamycin sensitizes U87 xenografts to fractionated radiation therapy. Cancer Res. 2002;62: 7291-7297.
    • (2002) Cancer Res. , vol.62 , pp. 7291-7297
    • Eshleman, J.S.1    Carlson, B.L.2    Mladek, A.C.3    Kastner, B.D.4    Shide, K.L.5    Sarkaria, J.N.6
  • 37
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science. 2005;307:1098-1101.
    • (2005) Science. , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 38
    • 33747819801 scopus 로고    scopus 로고
    • MTOR and cancer: Insights into a complex relationship
    • Sabatini DM. mTOR and cancer: insights into a complex relationship. Nat Rev Cancer. 2006;6:729-734.
    • (2006) Nat Rev Cancer. , vol.6 , pp. 729-734
    • Sabatini, D.M.1
  • 39
    • 33847394119 scopus 로고    scopus 로고
    • PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR
    • Zhang H, Bajraszewski N, Wu E, et al. PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR. J Clin Invest. 2007;117:730-738.
    • (2007) J Clin Invest. , vol.117 , pp. 730-738
    • Zhang, H.1    Bajraszewski, N.2    Wu, E.3
  • 40
    • 69149097363 scopus 로고    scopus 로고
    • The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis
    • Guo D, Hildebrandt IJ, Prins RM, et al. The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis. Proc Natl Acad Sci USA. 2009;106:12932-12937.
    • (2009) Proc Natl Acad Sci USA. , vol.106 , pp. 12932-12937
    • Guo, D.1    Hildebrandt, I.J.2    Prins, R.M.3
  • 41
    • 38849208347 scopus 로고    scopus 로고
    • Antitumor activity of rapamycin in a Phase i trial for patients with recurrent PTEN-deficient glioblastoma
    • Cloughesy TF, Yoshimoto K, Nghiemphu P, et al. Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma. PLoS Med. 2008;5:e8.
    • (2008) PLoS Med. , vol.5
    • Cloughesy, T.F.1    Yoshimoto, K.2    Nghiemphu, P.3
  • 42
    • 65549145048 scopus 로고    scopus 로고
    • An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1
    • Thoreen CC, Kang SA, Chang JW, et al. An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J Biol Chem. 2009;284:8023-8032.
    • (2009) J Biol Chem. , vol.284 , pp. 8023-8032
    • Thoreen, C.C.1    Kang, S.A.2    Chang, J.W.3
  • 43
    • 37549048521 scopus 로고    scopus 로고
    • MTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor
    • Masri J, Bernath A, Martin J, et al. mTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor. Cancer Res. 2007;67:11712-11720.
    • (2007) Cancer Res. , vol.67 , pp. 11712-11720
    • Masri, J.1    Bernath, A.2    Martin, J.3
  • 45
    • 27744606737 scopus 로고    scopus 로고
    • Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors
    • Mellinghoff IK, Wang MY, Vivanco I, et al. Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors. N Engl J Med. 2005;353:2012-2024.
    • (2005) N Engl J Med. , vol.353 , pp. 2012-2024
    • Mellinghoff, I.K.1    Wang, M.Y.2    Vivanco, I.3
  • 46
    • 21444450373 scopus 로고    scopus 로고
    • Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib
    • Haas-Kogan DA, Prados MD, Tihan T, et al. Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib. J Natl Cancer Inst. 2005;97:880-887.
    • (2005) J Natl Cancer Inst. , vol.97 , pp. 880-887
    • Haas-Kogan, D.A.1    Prados, M.D.2    Tihan, T.3
  • 47
    • 32944478030 scopus 로고    scopus 로고
    • Phase 1 trial of gefitinib plus sirolimus in adults with recurrent malignant glioma
    • Reardon DA, Quinn JA, Vredenburgh JJ, et al. Phase 1 trial of gefitinib plus sirolimus in adults with recurrent malignant glioma. Clin Cancer Res. 2006;12:860-868.
    • (2006) Clin Cancer Res. , vol.12 , pp. 860-868
    • Reardon, D.A.1    Quinn, J.A.2    Vredenburgh, J.J.3
  • 48
    • 59349089499 scopus 로고    scopus 로고
    • A pilot study of everolimus and gefitinib in the treatment of recurrent glioblastoma (GBM)
    • Kreisl TN, Lassman AB, Mischel PS, et al. A pilot study of everolimus and gefitinib in the treatment of recurrent glioblastoma (GBM). J Neurooncol. 2009;92:99-105.
    • (2009) J Neurooncol. , vol.92 , pp. 99-105
    • Kreisl, T.N.1    Lassman, A.B.2    Mischel, P.S.3
  • 49
    • 33746807790 scopus 로고    scopus 로고
    • Pilot study of the combination of EGFR and mTOR inhibitors in recurrent malignant gliomas
    • Doherty L, Gigas DC, Kesari S, et al. Pilot study of the combination of EGFR and mTOR inhibitors in recurrent malignant gliomas. Neurology. 2006;67:156-158.
    • (2006) Neurology. , vol.67 , pp. 156-158
    • Doherty, L.1    Gigas, D.C.2    Kesari, S.3
  • 50
    • 34147184365 scopus 로고    scopus 로고
    • Identification of molecular characteristics correlated with glioblastoma sensitivity to EGFR kinase inhibition through use of an intracranial xenograft test panel
    • Sarkaria JN, Yang L, Grogan PT, et al. Identification of molecular characteristics correlated with glioblastoma sensitivity to EGFR kinase inhibition through use of an intracranial xenograft test panel. Mol Cancer Ther. 2007;6:1167-1174.
    • (2007) Mol Cancer Ther. , vol.6 , pp. 1167-1174
    • Sarkaria, J.N.1    Yang, L.2    Grogan, P.T.3
  • 51
    • 65949086609 scopus 로고    scopus 로고
    • PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR
    • Sos ML, Koker M, Weir BA, et al. PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR. Cancer Res. 2009;69:3256-3261.
    • (2009) Cancer Res. , vol.69 , pp. 3256-3261
    • Sos, M.L.1    Koker, M.2    Weir, B.A.3
  • 52
    • 33748058820 scopus 로고    scopus 로고
    • Mammalian target of rapamycin inhibition promotes response to epidermal growth factor receptor kinase inhibitors in PTEN- deficient and PTEN-intact glioblastoma cells
    • Wang MY, Lu KV, Zhu S, et al. Mammalian target of rapamycin inhibition promotes response to epidermal growth factor receptor kinase inhibitors in PTEN- deficient and PTEN-intact glioblastoma cells. Cancer Res. 2006;66:7864-7869.
    • (2006) Cancer Res. , vol.66 , pp. 7864-7869
    • Wang, M.Y.1    Lu, K.V.2    Zhu, S.3
  • 53
    • 33646382364 scopus 로고    scopus 로고
    • A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma
    • Fan QW, Knight ZA, Goldenberg DD, et al. A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. Cancer Cell. 2006;9:341-349.
    • (2006) Cancer Cell. , vol.9 , pp. 341-349
    • Fan, Q.W.1    Knight, Z.A.2    Goldenberg, D.D.3
  • 54
    • 34548596728 scopus 로고    scopus 로고
    • A dual phosphoinositide-3- kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma
    • Fan QW, Cheng CK, Nicolaides TP, et al. A dual phosphoinositide-3- kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma. Cancer Res. 2007;67:7960-7965.
    • (2007) Cancer Res. , vol.67 , pp. 7960-7965
    • Fan, Q.W.1    Cheng, C.K.2    Nicolaides, T.P.3
  • 55
    • 75049084471 scopus 로고    scopus 로고
    • Phase 2 trial of erlotinib plus sirolimus in adults with recurrent glioblastoma
    • Reardon DA, Desjardins A, Vredenburgh JJ, et al. Phase 2 trial of erlotinib plus sirolimus in adults with recurrent glioblastoma. JNeurooncol. 2010;96:219-230.
    • (2010) JNeurooncol. , vol.96 , pp. 219-230
    • Reardon, D.A.1    Desjardins, A.2    Vredenburgh, J.J.3
  • 56
    • 21044431575 scopus 로고    scopus 로고
    • Phase II study of CCI-779 in patients with recurrent glioblastoma multiforme
    • Chang SM, Wen P, Cloughesy T, et al. Phase II study of CCI-779 in patients with recurrent glioblastoma multiforme. Invest New Drugs. 2005;23:357-361.
    • (2005) Invest New Drugs. , vol.23 , pp. 357-361
    • Chang, S.M.1    Wen, P.2    Cloughesy, T.3
  • 58
    • 17944368972 scopus 로고    scopus 로고
    • An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten + /- mice
    • Podsypanina K, Lee RT, Politis C, et al. An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten + /- mice. Proc Natl Acad Sci USA. 2001;98:10320-10325.
    • (2001) Proc Natl Acad Sci USA. , vol.98 , pp. 10320-10325
    • Podsypanina, K.1    Lee, R.T.2    Politis, C.3
  • 59
    • 0034790016 scopus 로고    scopus 로고
    • MTOR, a novel target in breast cancer: The effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer
    • Yu K, Toral-Barza L, Discafani C, et al. mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer. Endocr Relat Cancer. 2001;8:249-258.
    • (2001) Endocr Relat Cancer. , vol.8 , pp. 249-258
    • Yu, K.1    Toral-Barza, L.2    Discafani, C.3
  • 60
    • 0036735346 scopus 로고    scopus 로고
    • Enhanced sensitivity of multiple myeloma cells containing PTEN mutations to CCI-779
    • Shi Y, Gera J, Hu L, et al. Enhanced sensitivity of multiple myeloma cells containing PTEN mutations to CCI-779. Cancer Res. 2002;62:5027-5034.
    • (2002) Cancer Res. , vol.62 , pp. 5027-5034
    • Shi, Y.1    Gera, J.2    Hu, L.3
  • 61
    • 2942724235 scopus 로고    scopus 로고
    • MTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
    • Majumder PK, Febbo PG, Bikoff R, et al. mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. Nat Med. 2004;10:594-601.
    • (2004) Nat Med. , vol.10 , pp. 594-601
    • Majumder, P.K.1    Febbo, P.G.2    Bikoff, R.3
  • 62
    • 1642586272 scopus 로고    scopus 로고
    • Survival signallingbyAkt and eIF4E in oncogenesis and cancer therapy
    • Wendel HG, DeStanchina E, Fridman JS, et al. Survival signallingbyAkt and eIF4E in oncogenesis and cancer therapy. Nature. 2004;428:332-337.
    • (2004) Nature. , vol.428 , pp. 332-337
    • Wendel, H.G.1    Destanchina, E.2    Fridman, J.S.3
  • 63
    • 33646376411 scopus 로고    scopus 로고
    • Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
    • Yilmaz OH, Valdez R, Theisen BK, et al. Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature. 2006;441:475-482.
    • (2006) Nature. , vol.441 , pp. 475-482
    • Yilmaz, O.H.1    Valdez, R.2    Theisen, B.K.3
  • 64
    • 32944457518 scopus 로고    scopus 로고
    • MTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
    • O'Reilly KE, Rojo F, She QB, et al. mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res. 2006;66:1500-1508.
    • (2006) Cancer Res. , vol.66 , pp. 1500-1508
    • O'Reilly, K.E.1    Rojo, F.2    She, Q.B.3
  • 65
    • 66449106340 scopus 로고    scopus 로고
    • Increased AKT S473 phosphorylation after mTORC1 inhibition is rictor dependent and does not predict tumor cell response to PI3K/mTOR inhibition
    • Breuleux M, Klopfenstein M, Stephan C, et al. Increased AKT S473 phosphorylation after mTORC1 inhibition is rictor dependent and does not predict tumor cell response to PI3K/mTOR inhibition. Mol Cancer Ther. 2009;8:742-753.
    • (2009) Mol Cancer Ther. , vol.8 , pp. 742-753
    • Breuleux, M.1    Klopfenstein, M.2    Stephan, C.3
  • 66
    • 51049109033 scopus 로고    scopus 로고
    • Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity
    • Maira SM, Stauffer F, Brueggen J, et al. Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity. Mol Cancer Ther. 2008;7:1851-1863.
    • (2008) Mol Cancer Ther. , vol.7 , pp. 1851-1863
    • Maira, S.M.1    Stauffer, F.2    Brueggen, J.3
  • 67
    • 42649112409 scopus 로고    scopus 로고
    • Amino acids activatemTORcomplex 1 via Ca2+/CaM signaling to hVps34
    • Gulati P, Gaspers LD, Dann SG, et al.Amino acids activatemTORcomplex 1 via Ca2+/CaM signaling to hVps34. Cell Metab. 2008;7:456-465.
    • (2008) Cell Metab. , vol.7 , pp. 456-465
    • Gulati, P.1    Gaspers, L.D.2    Dann, S.G.3
  • 68
    • 67749111502 scopus 로고    scopus 로고
    • The LKB1-AMPK pathway: Metabolism and growth control in tumour suppression
    • Shackelford DB, Shaw RJ. The LKB1-AMPK pathway: metabolism and growth control in tumour suppression. Nat Rev Cancer. 2009;9:563-575.
    • (2009) Nat Rev Cancer. , vol.9 , pp. 563-575
    • Shackelford, D.B.1    Shaw, R.J.2
  • 69
    • 33947493332 scopus 로고    scopus 로고
    • Regulation of endothelial cell cycle by laminar versus oscillatory flow: Distinct modes of interactions of AMP-activated protein kinase and Akt pathways
    • Guo D, Chien S, Shyy JY. Regulation of endothelial cell cycle by laminar versus oscillatory flow: distinct modes of interactions of AMP-activated protein kinase and Akt pathways. Circ Res. 2007;100:564-571.
    • (2007) Circ Res. , vol.100 , pp. 564-571
    • Guo, D.1    Chien, S.2    Shyy, J.Y.3
  • 70
    • 0345167800 scopus 로고    scopus 로고
    • TSC2 mediates cellular energy response to control cell growth and survival
    • Inoki K, Zhu T, Guan KL. TSC2 mediates cellular energy response to control cell growth and survival. Cell. 2003;115:577-590.
    • (2003) Cell. , vol.115 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.L.3
  • 71
    • 42949139481 scopus 로고    scopus 로고
    • AMPK phosphorylation of raptor mediates a metabolic checkpoint
    • Gwinn DM, Shackelford DB, Egan DF, et al. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell. 2008;30:214-226.
    • (2008) Mol Cell. , vol.30 , pp. 214-226
    • Gwinn, D.M.1    Shackelford, D.B.2    Egan, D.F.3
  • 72
    • 58749097239 scopus 로고    scopus 로고
    • LKB1/KRAS mutant lung cancers constitute a genetic subset of NSCLC with increased sensitivity to MAPK and mTOR signalling inhibition
    • Mahoney CL, Choudhury B, Davies H, et al. LKB1/KRAS mutant lung cancers constitute a genetic subset of NSCLC with increased sensitivity to MAPK and mTOR signalling inhibition. Br J Cancer. 2009;100:370-375.
    • (2009) Br J Cancer. , vol.100 , pp. 370-375
    • Mahoney, C.L.1    Choudhury, B.2    Davies, H.3
  • 73
    • 10744232660 scopus 로고    scopus 로고
    • Functional analysis of mutations within the kinase activation segment of B-Raf in human colorectal tumors
    • Ikenoue T, Hikiba Y, Kanai F, et al. Functional analysis of mutations within the kinase activation segment of B-Raf in human colorectal tumors. Cancer Res. 2003;63:8132-8137.
    • (2003) Cancer Res. , vol.63 , pp. 8132-8137
    • Ikenoue, T.1    Hikiba, Y.2    Kanai, F.3
  • 74
    • 33846201272 scopus 로고    scopus 로고
    • New insight into BRAF mutations in cancer
    • Dhomen N, Marais R. New insight into BRAF mutations in cancer. Curr Opin Genet Dev. 2007;17:31-39.
    • (2007) Curr Opin Genet Dev. , vol.17 , pp. 31-39
    • Dhomen, N.1    Marais, R.2
  • 75
    • 18444374405 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in human cancer
    • Davies H, Bignell GR, Cox C, et al. Mutations of the BRAF gene in human cancer. Nature. 2002;417:949-954.
    • (2002) Nature. , vol.417 , pp. 949-954
    • Davies, H.1    Bignell, G.R.2    Cox, C.3
  • 76
    • 58649110598 scopus 로고    scopus 로고
    • Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation
    • Zheng B, Jeong JH, Asara JM, et al. Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation. Mol Cell. 2009;33:237-247.
    • (2009) Mol Cell. , vol.33 , pp. 237-247
    • Zheng, B.1    Jeong, J.H.2    Asara, J.M.3
  • 77
    • 74949096470 scopus 로고    scopus 로고
    • AMPK: A metabolic checkpoint that regulates the growth of EGFR activated glioblastomas
    • Guo D, Cloughesy TF, Radu CG, Mischel PS. AMPK: a metabolic checkpoint that regulates the growth of EGFR activated glioblastomas. Cell Cycle. 2010;9:4-5.
    • (2010) Cell Cycle. , vol.9 , pp. 4-5
    • Guo, D.1    Cloughesy, T.F.2    Radu, C.G.3    Mischel, P.S.4
  • 78
    • 0037374550 scopus 로고    scopus 로고
    • Oligodendrogliomas result from the expression of an activated mutant epidermal growth factor receptor in a RAS transgenic mouse astrocytoma model
    • Ding H, Shannon P, Lau N, et al. Oligodendrogliomas result from the expression of an activated mutant epidermal growth factor receptor in a RAS transgenic mouse astrocytoma model. Cancer Res. 2003;63:1106-1113.
    • (2003) Cancer Res. , vol.63 , pp. 1106-1113
    • Ding, H.1    Shannon, P.2    Lau, N.3
  • 79
    • 0037382205 scopus 로고    scopus 로고
    • Genetic determinants of malignancy in a mouse model for oligodendroglioma
    • Weiss WA, Burns MJ, Hackett C, et al. Genetic determinants of malignancy in a mouse model for oligodendroglioma. Cancer Res. 2003;63:1589-1595.
    • (2003) Cancer Res. , vol.63 , pp. 1589-1595
    • Weiss, W.A.1    Burns, M.J.2    Hackett, C.3
  • 80
    • 77649216053 scopus 로고    scopus 로고
    • EGFR signaling through an Akt-SREBP-1-dependent, rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy
    • Guo D, Prins RM, Dang J, et al. EGFR signaling through an Akt-SREBP-1-dependent, rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy. Sci Signal. 2009;2:Ra82.
    • (2009) Sci Signal. , vol.2
    • Guo, D.1    Prins, R.M.2    Dang, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.