Cell type specificity of PI3K signaling in Pdk1- and Pten-deficient brains

Genes and Development

Volumn 23, Issue 14, 2009, Pages 1619-1624

  Chalhoub, Nader ^a   Zhu, Guo ^a,b   Zhu, Xiaoyan ^a   Baker, Suzanne J ^a,b  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Brain; Feedback; Migration; Pdk1; PI3K; Pten

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN KINASE B; AKT1 PROTEIN, MOUSE; PIK3CD PROTEIN, MOUSE; PROTEIN SERINE THREONINE KINASE; PYRUVATE DEHYDROGENASE (ACETYL TRANSFERRING) KINASE; PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING) KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CELL MIGRATION; CELL SPECIFICITY; CONTROLLED STUDY; ENZYME INACTIVATION; GENE DELETION; GLIA; HYPERTROPHY; MACROCEPHALY; MICROCEPHALY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; BRAIN; CELL MOTION; CELL NUCLEUS; CEREBELLUM; GENETICS; JACOBSEN SYNDROME; METABOLISM; MOUSE MUTANT; NERVE CELL; PHOSPHORYLATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BRAIN; CELL MOVEMENT; CELL NUCLEUS; CEREBELLUM; JACOBSEN DISTAL 11Q DELETION SYNDROME; MICE; MICE, KNOCKOUT; NEURONS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; SIGNAL TRANSDUCTION;

EID: 67650601691     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.1799609     Document Type: Article

References (40)

1. Backman SA, Stambolic V, Suzuki A, Haight J, Elia A, Pretorius J, Tsao MS, Shannon P, Bolon B, Ivy GO, et al. 2001. Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease. Nat Genet 29: 396-403.
2. Bajenaru ML, Zhu Y, Hedrick NM, Donahoe J, Parada LF, Gutmann DH. 2002. Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation. Mol Cell Biol 22: 5100-5113.
3. +/- mice. Curr Biol 15: 1839-1846.
4. Behesti H, Marino S. 2008. Cerebellar granule cells: Insights into proliferation, differentiation, and role in medulloblastoma pathogenesis. Int J Biochem Cell Biol 41: 435-445.
5. Chalhoub N, Baker SJ. 2009. PTEN and the PI3-kinase pathway in cancer. Annu Rev Pathol 4: 127-150.
6. Chalhoub N, Kozma SC, Baker SJ. 2006. S6k1 is not required for Ptendeficient neuronal hypertrophy. Brain Res 1100: 32-41.
7. Chow LM, Zhang J, Baker SJ. 2008. Inducible Cre recombinase activity in mouse mature astrocytes and adult neural precursor cells. Transgenic Res 17: 919-928.
8. Cloughesy TF, Yoshimoto K, Nghiemphu P, Brown K, Dang J, Zhu S, Hsueh T, Chen Y, Wang W, Youngkin D, et al. 2008. Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma. PLoS Med 5: e8. doi: 10.1371/journal. pmed.0050008.
9. Collins BJ, Deak M, Arthur JS, Armit LJ, Alessi DR. 2003. In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation. EMBO J 22: 4202-4211.
10. Di Cristofano A, Pesce B, Cordon-Cardo C, Pandolfi PP. 1998. Pten is essential for embryonic development and tumour suppression. Nat Genet 19: 348-355.
11. Dudek H, Datta SR, Franke TF, Birnbaum MJ, Yao R, Cooper GM, Segal RA, Kaplan DR, Greenberg ME. 1997. Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 275: 661-665.
12. Engelman JA, Luo J, Cantley LC. 2006. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet 7: 606-619.
13. Fraser MM, Zhu X, Kwon CH, Uhlmann EJ, Gutmann DH, Baker SJ. 2004. Pten loss causes hypertrophy and increased proliferation of astrocytes in vivo. Cancer Res 64: 7773-7779.
14. Fraser MM, Bayazitov IT, Zakharenko SS, Baker SJ. 2008. Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities. Neuroscience 151: 476-488.
15. Groszer M, Erickson R, Scripture-Adams DD, Lesche R, Trumpp A, Zack JA, Kornblum HI, Liu X, Wu H. 2001. Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo. Science 294: 2186-2189.
16. Haga S, Ozaki M, Inoue H, Okamoto Y, Ogawa W, Takeda K, Akira S, Todo S. 2008. The survival pathways phosphatidylinositol-3 kinase (PI3-K)/ phosphoinositide-dependent protein kinase 1 (PDK1)/Akt modulate liver regeneration through hepatocyte size rather than proliferation. Hepatology 49: 204-214.
17. Hashimoto N, Kido Y, Uchida T, Asahara S, Shigeyama Y, Matsuda T, Takeda A, Tsuchihashi D, Nishizawa A, Ogawa W, et al. 2006. Ablation of PDK1 in pancreatic b cells induces diabetes as a result of loss of b cell mass. Nat Genet 38: 589-593.
18. Kenney AM, Widlund HR, Rowitch DH. 2004. Hedgehog and PI-3 kinase signaling converge on Nmyc1 to promote cell cycle progression in cerebellar neuronal precursors. Development 131: 217-228.
19. Kolsch V, Charest PG, Firtel RA. 2008. The regulation of cell motility and chemotaxis by phospholipid signaling. J Cell Sci 121: 551-559.
20. Kwon CH, Zhu X, Zhang J, Knoop LL, Tharp R, Smeyne RJ, Eberhart CG, Burger PC, Baker SJ. 2001. Pten regulates neuronal soma size: A mouse model of Lhermitte-Duclos disease. Nat Genet 29: 404-411.
21. Kwon CH, Zhu X, Zhang J, Baker SJ. 2003. mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo. Proc Natl Acad Sci 100: 12923-12928.
22. Lawlor MA, Mora A, Ashby PR, Williams MR, Murray-Tait V, Malone L, Prescott AR, Lucocq JM, Alessi DR. 2002. Essential role of PDK1 in regulating cell size and development in mice. EMBO J 21: 3728-3738.
23. Li L, Liu F, Salmonsen RA, Turner TK, Litofsky NS, Di Cristofano A, Pandolfi PP, Jones SN, Recht LD, Ross AH. 2002. PTEN in neural precursor cells: Regulation of migration, apoptosis, and proliferation. Mol Cell Neurosci 20: 21-29.
24. Maira SM, Stauffer F, Brueggen J, Furet P, Schnell C, Fritsch C, Brachmann S, Chene P, De Pover A, Schoemaker K, et al. 2008. Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity. Mol Cancer Ther 7: 1851-1863.
25. Marino S, Krimpenfort P, Leung C, van der Korput HA, Trapman J, Camenisch I, Berns A, Brandner S. 2002. PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum. Development 129: 3513-3522.
26. Mora A, Davies AM, Bertrand L, Sharif I, Budas GR, Jovanovic S, Mouton V, Kahn CR, Lucocq JM, Gray GA, et al. 2003. Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia. EMBO J 22: 4666-4676.
27. Mora A, Komander D, van Aalten DM, Alessi DR. 2004. PDK1, the master regulator of AGC kinase signal transduction. Semin Cell Dev Biol 15: 161-170.
28. Mora A, Lipina C, Tronche F, Sutherland C, Alessi DR. 2005. Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulinregulated gene expression and liver failure. Biochem J 385: 639-648.
29. O'Reilly KE, Rojo F, She QB, Solit D, Mills GB, Smith D, Lane H, Hofmann F, Hicklin DJ, Ludwig DL, et al. 2006. mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res 66: 1500-1508.
30. Podsypanina K, Ellenson LH, Nemes A, Gu J, Tamura M, Yamada KM, Cordon-Cardo C, Catoretti G, Fisher PE, Parsons R. 1999. Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems. Proc Natl Acad Sci 96: 1563-1568.
31. Raftopoulou M, Etienne-Manneville S, Self A, Nicholls S, Hall A. 2004. Regulation of cell migration by the C2 domain of the tumor suppressor PTEN. Science 303: 1179-1181.
32. Rintelen F, Stocker H, Thomas G, Hafen E. 2001. PDK1 regulates growth through Akt and S6K in Drosophila. Proc Natl Acad Sci 98: 15020-15025.
33. Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. 2005. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307: 1098-1101.
34. Suzuki A, de la Pompa JL, Stambolic V, Elia AJ, Sasaki T, del Barco Barrantes I, Ho A, Wakeham A, Itie A, Khoo W, et al. 1998. High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Curr Biol 8: 1169-1178.
35. Tamura M, Gu J, Matsumoto K, Aota S, Parsons R, Yamada KM. 1998. Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Science 280: 1614-1617.
36. Um SH, Frigerio F, Watanabe M, Picard F, Joaquin M, Sticker M, Fumagalli S, Allegrini PR, Kozma SC, Auwerx J, et al. 2004. Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature 431: 200-205.
37. Williams MR, Arthur JS, Balendran A, van der Kaay J, Poli V, Cohen P, Alessi DR. 2000. The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells. Curr Biol 10: 439-448.
38. Yang Y, Herrup K. 2007. Cell division in the CNS: Protective response or lethal event in post-mitotic neurons? Biochim Biophys Acta 1772: 457-466.
39. Yue Q, Groszer M, Gil JS, Berk AJ, Messing A, Wu H, Liu X. 2005. PTEN deletion in Bergmann glia leads to premature differentiation and affects laminar organization. Development 132: 3281-3291.
40. Zhao H, Sapolsky RM, Steinberg GK. 2006. Phosphoinositide-3-kinase/ akt survival signal pathways are implicated in neuronal survival after stroke. Mol Neurobiol 34: 249-270.