Dysregulation of PTEN and protein kinase B is associated with glioma histology and patient survival

Clinical Cancer Research

Volumn 8, Issue 5, 2002, Pages 1100-1106

  Ermoian, Ralph P ^a   Furniss, Constance S ^a   Lamborn, Kathleen R ^a   Basila, Daniel ^a   Berger, Mitchel S ^a   Gottschalk, Alexander R ^a   Nicholas, M Kelly ^a   Stokoe, David ^a   Haas Kogan, Daphne A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN P27;

ADOLESCENT; ADULT; ARTICLE; ASTROCYTOMA; CANCER GRADING; CANCER GROWTH; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GLIOBLASTOMA; GLIOMA; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SURVIVAL TIME;

ADOLESCENT; ADULT; AGED; BRAIN NEOPLASMS; CELL CYCLE PROTEINS; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DOWN-REGULATION; FEMALE; GLIOMA; HUMANS; IMMUNOBLOTTING; MALE; MIDDLE AGED; PHOSPHORIC MONOESTER HYDROLASES; PREDICTIVE VALUE OF TESTS; PROGNOSIS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; SURVIVAL ANALYSIS; TUMOR SUPPRESSOR PROTEINS;

EID: 0036094711     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Genetic alterations in adult diffuse glioma: Occurrence, significance, and prognostic implications
2. Deletion mapping of the long arm of chromosome 10 in glioblastoma multiforme
3. A molecular genetic model of astrocytoma histopathology
4. PTEN/MMAC1 mutations in primary glioblastomas and short-term cultures of malignant gliomas
5. PTEN mutations in gliomas and glioneuronal tumors
6. PTEN/MMACI mutations and EGFR amplification in glioblastomas
7. MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines
8. Somatic mutations of PTEN in glioblastoma multiforme
9. Parsons life as a tumor suppressor
10. 1growth arrest in glioma cells
11. 1growth arrest
12. kip1into cyclin E/CDK2 complexes
13. PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells
14. kip1
15. kip1
16. kip1
17. Molecular analysis of the PTEN, TP53 and CDKN2A tumor suppressor genes in long-term survivors of glioblastoma multiforme
18. Mutational analysis of the PTEN gene in endometrial carcinoma and hyperplasia
19. Racial disparity in the frequency of PTEN mutations, but not microsatellite instability, in advanced endometrial cancers
20. Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC
21. Phosphorylation of the PTEN tail regulates protein stability and function
22. kip1: Regulation and function of a haploinsufficient tumor suppressor and its misregulation in cancer
23. Mechanism of activation of protein kinase B by insulin and IGF-1
24. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
25. PTEN mutation, EGFR amplification, and outcome in patients with anaplastic astrocytoma and glioblastoma multiforme
26. Analysis of oncogene and tumor suppressor gene alterations in pediatric malignant astrocytomas reveals reduced survival for patients with PTEN mutations
27. Differential expression of MMAC/PTEN in glioblastoma multiforme: Relationship to localization and prognosis
28. Frequent loss of PTEN expression is linked to elevated phosphorylated Akt levels, but not associated with p27 and cyclin D1 expression, in primary epithelial ovarian carcinomas
29. Direct control of the Forkhead transcription factor AFX by protein kinase B
30. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
31. PTEN gene mutations are seen in high-grade but not in low-grade gliomas