The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling

Journal of Biological Chemistry

Volumn 272, Issue 5, 1997, Pages 2927-2935

  Su Huang, H J ^a,b,e   Nagane, Motoo ^a   Klingbeil, Candice K ^a   Lin, Hong ^a   Nishikawa, Ryo ^a,f   Ji, Xiang Dong ^c   Huang, Chun Ming ^c   Gill, Gordon N ^a,b   Wiley, H Steven ^d   Cavenee, Webster K ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c BD Technologies   (United States)

^d UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^e LUDWIG INSTITUTE FOR CANCER RESEARCH   (United States)

^f SAITAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; MONOCLONAL ANTIBODY; PHOSPHOTYROSINE; PROTEIN TYROSINE KINASE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHOSPHORYLATION; CARBOXY TERMINAL SEQUENCE; CARCINOGENICITY; CONTROLLED STUDY; ENDOCYTOSIS; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; TUMOR GROWTH;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BRAIN NEOPLASMS; CELL LINE; DNA PRIMERS; DOWN-REGULATION; ENDOCYTOSIS; EPIDERMAL GROWTH FACTOR; GLIOBLASTOMA; HUMANS; MICE; MICE, NUDE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PHOSPHOTYROSINE; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; TRANSFECTION; TRANSPLANTATION, HETEROLOGOUS;

ANIMALIA;

EID: 14444288522     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.5.2927     Document Type: Article

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