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Volumn 5, Issue 10, 2010, Pages

SIRT1 undergoes alternative splicing in a novel auto-regulatory loop with p53

Author keywords

[No Author keywords available]

Indexed keywords

ISOENZYME; PROTEIN P53; SIRTUIN 1; SIRT1 PROTEIN, HUMAN; SIRT1 PROTEIN, MOUSE;

EID: 78149421022     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0013502     Document Type: Article
Times cited : (45)

References (84)
  • 1
    • 3943071801 scopus 로고    scopus 로고
    • Sirtuin activators mimic caloric restriction and delay ageing in metazoans
    • Wood JG, Rogina B, Lavu S, Howitz K, Helfand SL, et al. (2004) Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 430: 686-689.
    • (2004) Nature , vol.430 , pp. 686-689
    • Wood, J.G.1    Rogina, B.2    Lavu, S.3    Howitz, K.4    Helfand, S.L.5
  • 2
    • 36749087548 scopus 로고    scopus 로고
    • Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
    • Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, et al. (2007) Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 450: 712-716.
    • (2007) Nature , vol.450 , pp. 712-716
    • Milne, J.C.1    Lambert, P.D.2    Schenk, S.3    Carney, D.P.4    Smith, J.J.5
  • 4
    • 53249121556 scopus 로고    scopus 로고
    • Sirtuins -novel therapeutic targets to treat age-associated diseases
    • Lavu S, Boss O, Elliott PJ, Lambert PD (2008) Sirtuins -novel therapeutic targets to treat age-associated diseases. Nat Rev Drug Discov 7: 841-853.
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 841-853
    • Lavu, S.1    Boss, O.2    Elliott, P.J.3    Lambert, P.D.4
  • 5
    • 53049092131 scopus 로고    scopus 로고
    • The anti-aging, metabolism potential of SIRT1
    • Ghosh HS (2008) The anti-aging, metabolism potential of SIRT1. Curr Opin Investig Drugs 9: 1095-1102.
    • (2008) Curr Opin Investig Drugs , vol.9 , pp. 1095-1102
    • Ghosh, H.S.1
  • 6
    • 0037207475 scopus 로고    scopus 로고
    • The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis
    • McBurney MW, Yang X, Jardine K, Hixon M, Boekelheide K, et al. (2003) The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. Mol Cell Biol 23: 38-54.
    • (2003) Mol Cell Biol , vol.23 , pp. 38-54
    • McBurney, M.W.1    Yang, X.2    Jardine, K.3    Hixon, M.4    Boekelheide, K.5
  • 7
    • 47749140333 scopus 로고    scopus 로고
    • SIRT1 regulates circadian clock gene expression through PER2 deacetylation
    • Asher G, Gatfield D, Stratmann M, Reinke H, Dibner C, et al. (2008) SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell 134: 317-328.
    • (2008) Cell , vol.134 , pp. 317-328
    • Asher, G.1    Gatfield, D.2    Stratmann, M.3    Reinke, H.4    Dibner, C.5
  • 8
    • 53149137486 scopus 로고    scopus 로고
    • Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice
    • Wang RH, Sengupta K, Li C, Kim HS, Cao L, et al. (2008) Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell 14: 312-323.
    • (2008) Cancer Cell , vol.14 , pp. 312-323
    • Wang, R.H.1    Sengupta, K.2    Li, C.3    Kim, H.S.4    Cao, L.5
  • 10
    • 65549103855 scopus 로고    scopus 로고
    • Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis
    • Ramsey KM, Yoshino J, Brace CS, Abrassart D, Kobayashi Y, et al. (2009) Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis. Science 324: 651-654.
    • (2009) Science , vol.324 , pp. 651-654
    • Ramsey, K.M.1    Yoshino, J.2    Brace, C.S.3    Abrassart, D.4    Kobayashi, Y.5
  • 12
    • 52749091816 scopus 로고    scopus 로고
    • SirT1 gain of function increases energy efficiency and prevents diabetes in mice
    • Banks AS, Kon N, Knight C, Matsumoto M, Gutie ́rrez-Jua ́rez R, et al. (2008) SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab 8: 333-341
    • (2008) Cell Metab , vol.8 , pp. 333-341
    • Banks, A.S.1    Kon, N.2    Knight, C.3    Matsumoto, M.4    Gutiérrez-Juárez, R.5
  • 14
    • 18344377030 scopus 로고    scopus 로고
    • The p53 pathway: Positive and negative feedback loops
    • Harris SL, Levine AJ (2005) The p53 pathway: positive and negative feedback loops. Oncogene 24: 2899-2908.
    • (2005) Oncogene , vol.24 , pp. 2899-2908
    • Harris, S.L.1    Levine, A.J.2
  • 15
  • 16
    • 0030898436 scopus 로고    scopus 로고
    • Transgenic mouse model for studying the transcriptional activity of the p53 protein: Age-and tissue-dependent changes in radiation-induced activation during embryo-genesis
    • Gottlieb E, Haffner R, King A, Asher G, Gruss P, et al. (1997) Transgenic mouse model for studying the transcriptional activity of the p53 protein: age-and tissue-dependent changes in radiation-induced activation during embryo-genesis. EMBO J 16: 1381-1390.
    • (1997) EMBO J , vol.16 , pp. 1381-1390
    • Gottlieb, E.1    Haffner, R.2    King, A.3    Asher, G.4    Gruss, P.5
  • 17
    • 0031003552 scopus 로고    scopus 로고
    • Transgenic mice with p53-responsive lacZ: P53 activity varies dramatically during normal development and determines radiation and drug sensitivity in vivo
    • Komarova EA, Chernov MV, Franks R, Wang K, Armin G, et al. (1997) Transgenic mice with p53-responsive lacZ: p53 activity varies dramatically during normal development and determines radiation and drug sensitivity in vivo. EMBO J 16: 1391-1400.
    • (1997) EMBO J , vol.16 , pp. 1391-1400
    • Komarova, E.A.1    Chernov, M.V.2    Franks, R.3    Wang, K.4    Armin, G.5
  • 18
    • 0033027549 scopus 로고    scopus 로고
    • P53 in embryonic development: Maintaining a fine balance
    • Choi J, Donehower LA (1999) p53 in embryonic development: maintaining a fine balance. Cell Mol Life Sci 55: 38-47.
    • (1999) Cell Mol Life Sci , vol.55 , pp. 38-47
    • Choi, J.1    Donehower, L.A.2
  • 19
    • 69349094006 scopus 로고    scopus 로고
    • Ap53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity
    • Mario ́n RM, Strati K, Li H, Murga M, Blanco R, et al.(2009) Ap53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity. Nature 460: 1149-1153.
    • (2009) Nature , vol.460 , pp. 1149-1153
    • Marión, R.M.1    Strati, K.2    Li, H.3    Murga, M.4    Blanco, R.5
  • 20
    • 69349100179 scopus 로고    scopus 로고
    • Suppression of induced pluripotent stem cell generation by the p53-p21 pathway
    • Hong H, Takahashi K, Ichisaka T, Aoi T, Kanagawa O, et al. (2009) Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. Nature 460: 1132-1135.
    • (2009) Nature , vol.460 , pp. 1132-1135
    • Hong, H.1    Takahashi, K.2    Ichisaka, T.3    Aoi, T.4    Kanagawa, O.5
  • 21
    • 60249088344 scopus 로고    scopus 로고
    • Homeostatic functions of the p53 tumor suppressor: Regulation of energy metabolism and antioxidant defence
    • Olovnikov IA, Kravchenko JE, Chumakov PM (2009) Homeostatic functions of the p53 tumor suppressor: regulation of energy metabolism and antioxidant defence. Semin Cancer Biol 19: 32-41.
    • (2009) Semin Cancer Biol , vol.19 , pp. 32-41
    • Olovnikov, I.A.1    Kravchenko, J.E.2    Chumakov, P.M.3
  • 22
    • 33745020716 scopus 로고    scopus 로고
    • Loss of one p53 allele results in four-fold reduction of p53 mRNA and protein: A basis for p53 haplo-insufficiency
    • Lynch CJ, Milner J (2006) Loss of one p53 allele results in four-fold reduction of p53 mRNA and protein: a basis for p53 haplo-insufficiency. Oncogene 25: 3463-3470.
    • (2006) Oncogene , vol.25 , pp. 3463-3470
    • Lynch, C.J.1    Milner, J.2
  • 23
    • 0026561121 scopus 로고
    • Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
    • Donehower LA, Harvey M, Slagle BL, McArthur MJ, Montgomery CA, Jr., et al. (1992) Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356: 215-221.
    • (1992) Nature , vol.356 , pp. 215-221
    • Donehower, L.A.1    Harvey, M.2    Slagle, B.L.3    McArthur, M.J.4    Montgomery Jr., C.A.5
  • 24
    • 0037011958 scopus 로고    scopus 로고
    • P53 mutant mice that display early ageing-associated phenotypes
    • Tyner SD, Venkatachalam S, Choi J, Jones S, Ghebranious N, et al. (2002) p53 mutant mice that display early ageing-associated phenotypes. Nature 415: 45-53.
    • (2002) Nature , vol.415 , pp. 45-53
    • Tyner, S.D.1    Venkatachalam, S.2    Choi, J.3    Jones, S.4    Ghebranious, N.5
  • 25
    • 1042266548 scopus 로고    scopus 로고
    • Modulation of mammalian life span by the short isoform of p53
    • Maier B, Gluba W, Bernier B, Turner T, Mohammad K, et al. (2004) Modulation of mammalian life span by the short isoform of p53. Genes Dev 18: 306-319.
    • (2004) Genes Dev , vol.18 , pp. 306-319
    • Maier, B.1    Gluba, W.2    Bernier, B.3    Turner, T.4    Mohammad, K.5
  • 26
    • 43449094349 scopus 로고    scopus 로고
    • Aging and cancer cell biology
    • Campisi J (2008) Aging and cancer cell biology. Aging Cell 7: 281-284.
    • (2008) Aging Cell , vol.7 , pp. 281-284
    • Campisi, J.1
  • 27
    • 0037112844 scopus 로고    scopus 로고
    • ''Super p53'' mice exhibit enhanced DNA damage response, are tumor resistant and age normally
    • García-Cao I, García-Cao M, Martín-Caballero J, Criado LM, Klatt P, et al. (2002) ''Super p53'' mice exhibit enhanced DNA damage response, are tumor resistant and age normally. EMBO J 21: 6225-6235.
    • (2002) EMBO J , vol.21 , pp. 6225-6235
    • García-Cao, I.1    García-Cao, M.2    Martín-Caballero, J.3    Criado, L.M.4    Klatt, P.5
  • 28
    • 34447517413 scopus 로고    scopus 로고
    • Delayed ageing through damage protection by the Arf/p53 pathway
    • Matheu A, Maraver A, Klatt P, Flores I, Garcia-Cao I, et al. (2007) Delayed ageing through damage protection by the Arf/p53 pathway. Nature 448: 375-379.
    • (2007) Nature , vol.448 , pp. 375-379
    • Matheu, A.1    Maraver, A.2    Klatt, P.3    Flores, I.4    Garcia-Cao, I.5
  • 29
    • 51049098347 scopus 로고    scopus 로고
    • The Arf/p53 pathway in cancer and aging
    • Matheu A, Maraver A, Serrano M (2008) The Arf/p53 pathway in cancer and aging. Cancer Res 68: 6031-6034.
    • (2008) Cancer Res , vol.68 , pp. 6031-6034
    • Matheu, A.1    Maraver, A.2    Serrano, M.3
  • 30
    • 43049163953 scopus 로고    scopus 로고
    • Acetylation is indispensable for p53 activation
    • Tang Y, Zhao W, Chen Y, Zhao Y, Gu W (2008) Acetylation is indispensable for p53 activation. Cell 133: 612-626.
    • (2008) Cell , vol.133 , pp. 612-626
    • Tang, Y.1    Zhao, W.2    Chen, Y.3    Zhao, Y.4    Gu, W.5
  • 31
    • 0035913911 scopus 로고    scopus 로고
    • Negative control of p53 by Sir2alpha promotes cell survival under stress
    • Luo J, Nikolaev AY, Imai S, Chen D, Su F, et al. (2001) Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 107: 137-148.
    • (2001) Cell , vol.107 , pp. 137-148
    • Luo, J.1    Nikolaev, A.Y.2    Imai, S.3    Chen, D.4    Su, F.5
  • 32
    • 0035913903 scopus 로고    scopus 로고
    • HSIR2 (SIRT1) functions as an NAD-dependent p53 deacetylase
    • Vaziri H, Dessain K, Ng Eaton E, Imai SI, Frye RA, et al. (2001) hSIR2 (SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107: 149-159.
    • (2001) Cell , vol.107 , pp. 149-159
    • Vaziri, H.1    Dessain, K.2    Ng Eaton, E.3    Imai, S.I.4    Frye, R.A.5
  • 33
    • 34547941973 scopus 로고    scopus 로고
    • The common biology of cancer and ageing
    • Finkel T, Serrano M, Blasco MA (2007) The common biology of cancer and ageing. Nature 448: 767-774.
    • (2007) Nature , vol.448 , pp. 767-774
    • Finkel, T.1    Serrano, M.2    Blasco, M.A.3
  • 34
    • 34547190674 scopus 로고    scopus 로고
    • Splicing regulator SC35 is essential for genomic stability and cell proliferation during mammalian organogenesis
    • Xiao R, Sun Y, Ding JH, Lin S, Rose DW, et al. (2007) Splicing regulator SC35 is essential for genomic stability and cell proliferation during mammalian organogenesis. Mol Cell Biol 27: 5393-5402.
    • (2007) Mol Cell Biol , vol.27 , pp. 5393-5402
    • Xiao, R.1    Sun, Y.2    Ding, J.H.3    Lin, S.4    Rose, D.W.5
  • 35
    • 58249093940 scopus 로고    scopus 로고
    • The SR protein family of splicing factors: Master regulators of gene expression
    • Long JC, Caceres JF (2009) The SR protein family of splicing factors: master regulators of gene expression. Biochem J 417: 15-27.
    • (2009) Biochem J , vol.417 , pp. 15-27
    • Long, J.C.1    Caceres, J.F.2
  • 37
    • 53649100104 scopus 로고    scopus 로고
    • JNK2-dependent regulation of SIRT1 protein stability
    • Ford J, Ahmed S, Allison S, Jiang M, Milner J (2008) JNK2-dependent regulation of SIRT1 protein stability. Cell Cycle 7: 3091-3097.
    • (2008) Cell Cycle , vol.7 , pp. 3091-3097
    • Ford, J.1    Ahmed, S.2    Allison, S.3    Jiang, M.4    Milner, J.5
  • 38
    • 34250365395 scopus 로고    scopus 로고
    • Nucleocyto-plasmic shuttling of the NAD+-dependent histone deacetylase SIRT1
    • Tanno M, Sakamoto J, Miura T, Shimamoto K, Horio Y (2007) Nucleocyto-plasmic shuttling of the NAD+-dependent histone deacetylase SIRT1. J Biol Chem 282: 6823-6832.
    • (2007) J Biol Chem , vol.282 , pp. 6823-6832
    • Tanno, M.1    Sakamoto, J.2    Miura, T.3    Shimamoto, K.4    Horio, Y.5
  • 39
    • 0642375803 scopus 로고    scopus 로고
    • P73 and p63 protein stability: The way to regulate function?
    • Maisse C, Guerrieri P, Melino G (2003) p73 and p63 protein stability: the way to regulate function? Biochem Pharmacol 66: 1555-1561.
    • (2003) Biochem Pharmacol , vol.66 , pp. 1555-1561
    • Maisse, C.1    Guerrieri, P.2    Melino, G.3
  • 40
    • 22244476115 scopus 로고    scopus 로고
    • The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase
    • Wei W, Jin J, Schlisio S, Harper JW, Kaelin WG, Jr. (2005) The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase. Cancer Cell 8: 25-33.
    • (2005) Cancer Cell , vol.8 , pp. 25-33
    • Wei, W.1    Jin, J.2    Schlisio, S.3    Harper, J.W.4    Kaelin Jr., W.G.5
  • 41
    • 4944245398 scopus 로고    scopus 로고
    • Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin
    • Vaquero A, Scher M, Lee D, Erdjument-Bromage H, Tempst P, et al. (2004) Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. Mol Cell 16: 93-105.
    • (2004) Mol Cell , vol.16 , pp. 93-105
    • Vaquero, A.1    Scher, M.2    Lee, D.3    Erdjument-Bromage, H.4    Tempst, P.5
  • 42
    • 0141618441 scopus 로고    scopus 로고
    • Structure and autoregulation of the yeast Hst2 homolog of Sir2
    • Zhao K, Chai X, Clements A, Marmorstein R (2003) Structure and autoregulation of the yeast Hst2 homolog of Sir2. Nat Struct Biol 10: 864-871.
    • (2003) Nat Struct Biol , vol.10 , pp. 864-871
    • Zhao, K.1    Chai, X.2    Clements, A.3    Marmorstein, R.4
  • 43
    • 62149130110 scopus 로고    scopus 로고
    • Cellular regulation of SIRT1
    • Milner J (2009) Cellular regulation of SIRT1. Curr Pharm Des 15: 39-44.
    • (2009) Curr Pharm Des , vol.15 , pp. 39-44
    • Milner, J.1
  • 44
    • 35349011726 scopus 로고    scopus 로고
    • Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity
    • Kim EJ, Kho JH, Kang MR, Um SJ (2007) Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity. Mol Cell 28: 277-290.
    • (2007) Mol Cell , vol.28 , pp. 277-290
    • Kim, E.J.1    Kho, J.H.2    Kang, M.R.3    Um, S.J.4
  • 45
    • 38749132992 scopus 로고    scopus 로고
    • Negative regulation of the deacetylase SIRT1 by DBC1
    • Zhao W, Kruse JP, Tang Y, Jung SY, Qin J, et al. (2008) Negative regulation of the deacetylase SIRT1 by DBC1. Nature 451: 587-590.
    • (2008) Nature , vol.451 , pp. 587-590
    • Zhao, W.1    Kruse, J.P.2    Tang, Y.3    Jung, S.Y.4    Qin, J.5
  • 46
    • 38749088678 scopus 로고    scopus 로고
    • DBC1 is a negative regulator of SIRT1
    • Kim JE, Chen J, Lou Z (2008) DBC1 is a negative regulator of SIRT1. Nature 451: 583-586.
    • (2008) Nature , vol.451 , pp. 583-586
    • Kim, J.E.1    Chen, J.2    Lou, Z.3
  • 48
    • 0035917536 scopus 로고    scopus 로고
    • Crystal structure of a SIR2 homolog-NAD complex
    • Min J, Landry J, Sternglanz R, Xu RM (2001) Crystal structure of a SIR2 homolog-NAD complex. Cell 105: 269-279.
    • (2001) Cell , vol.105 , pp. 269-279
    • Min, J.1    Landry, J.2    Sternglanz, R.3    Xu, R.M.4
  • 49
    • 21844480060 scopus 로고    scopus 로고
    • A combinatorial code for splicing silencing: UAGG and GGGG motifs
    • Han K, Yeo G, An P, Burge CB, Grabowski PJ (2005) A combinatorial code for splicing silencing: UAGG and GGGG motifs. PLoS Biol 3: e158.
    • (2005) PLoS Biol , vol.3
    • Han, K.1    Yeo, G.2    An, P.3    Burge, C.B.4    Grabowski, P.J.5
  • 50
    • 33846994060 scopus 로고    scopus 로고
    • Exon silencing by UAGG motifs in response to neuronal excitation
    • An P, Grabowski PJ (2007) Exon silencing by UAGG motifs in response to neuronal excitation. PLoS Biol 5: e36.
    • (2007) PLoS Biol , vol.5
    • An, P.1    Grabowski, P.J.2
  • 51
    • 0035881504 scopus 로고    scopus 로고
    • Sir2p exists in two nucleosome-binding complexes with distinct deacetylase activities
    • Ghidelli S, Donze D, Dhillon N, Kamakaka RT (2001) Sir2p exists in two nucleosome-binding complexes with distinct deacetylase activities. EMBO J 20: 4522-4535.
    • (2001) EMBO J , vol.20 , pp. 4522-4535
    • Ghidelli, S.1    Donze, D.2    Dhillon, N.3    Kamakaka, R.T.4
  • 52
    • 66049150672 scopus 로고    scopus 로고
    • SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair
    • McCord RA, Michishita E, Hong T, Berber E, Boxer LD, et al. (2009) SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair. Aging 1: 109-121.
    • (2009) Aging , vol.1 , pp. 109-121
    • McCord, R.A.1    Michishita, E.2    Hong, T.3    Berber, E.4    Boxer, L.D.5
  • 53
    • 46249100836 scopus 로고    scopus 로고
    • Tissue-specific regulation of SIRT1 by calorie restriction
    • Chen D, Bruno J, Easlon E, Lin SJ, Cheng HL, et al. (2008) Tissue-specific regulation of SIRT1 by calorie restriction. Genes Dev 22: 1753-1757.
    • (2008) Genes Dev , vol.22 , pp. 1753-1757
    • Chen, D.1    Bruno, J.2    Easlon, E.3    Lin, S.J.4    Cheng, H.L.5
  • 54
    • 72849130743 scopus 로고    scopus 로고
    • Neuronal SIRT1 regulates endocrine and behavioural responses to calorie restriction
    • Cohen DE, Supinski AM, Bonkowski MS, Donmez G, Guarente LP (2009) Neuronal SIRT1 regulates endocrine and behavioural responses to calorie restriction. Genes Dev 23: 2812-2817.
    • (2009) Genes Dev , vol.23 , pp. 2812-2817
    • Cohen, D.E.1    Supinski, A.M.2    Bonkowski, M.S.3    Donmez, G.4    Guarente, L.P.5
  • 55
    • 33748331132 scopus 로고    scopus 로고
    • Progressive loss of SIRT1 with cell cycle withdrawal
    • Sasaki T, Maier B, Bartke A, Scrable H (2006) Progressive loss of SIRT1 with cell cycle withdrawal. Aging Cell 5: 413-422.
    • (2006) Aging Cell , vol.5 , pp. 413-422
    • Sasaki, T.1    Maier, B.2    Bartke, A.3    Scrable, H.4
  • 56
    • 36248975293 scopus 로고    scopus 로고
    • SIRT1 transgenic mice show phenotypes resembling calorie restriction
    • Bordone L, Cohen D, Robinson A, Motta MC, van Veen E, et al. (2007) SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell 6: 759-767.
    • (2007) Aging Cell , vol.6 , pp. 759-767
    • Bordone, L.1    Cohen, D.2    Robinson, A.3    Motta, M.C.4    van Veen, E.5
  • 57
    • 56749156405 scopus 로고    scopus 로고
    • SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging
    • Oberdoerffer P, Michan S, McVay M, Mostoslavsky R, Vann J, et al. (2008) SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell 135: 907-918.
    • (2008) Cell , vol.135 , pp. 907-918
    • Oberdoerffer, P.1    Michan, S.2    McVay, M.3    Mostoslavsky, R.4    Vann, J.5
  • 58
    • 66749129781 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1
    • Dioum EM, Chen R, Alexander MS, Zhang Q, Hogg RT, et al. (2009) Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1. Science 324: 1289-1293.
    • (2009) Science , vol.324 , pp. 1289-1293
    • Dioum, E.M.1    Chen, R.2    Alexander, M.S.3    Zhang, Q.4    Hogg, R.T.5
  • 59
    • 3142740860 scopus 로고    scopus 로고
    • Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
    • Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, et al. (2004) Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 305: 390-392.
    • (2004) Science , vol.305 , pp. 390-392
    • Cohen, H.Y.1    Miller, C.2    Bitterman, K.J.3    Wall, N.R.4    Hekking, B.5
  • 61
    • 69949138641 scopus 로고    scopus 로고
    • CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage
    • Kang H, Jung JW, Kim MK, Chung JH (2009) CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage. PLoS One 4: e6611.
    • (2009) PLoS One , vol.4
    • Kang, H.1    Jung, J.W.2    Kim, M.K.3    Chung, J.H.4
  • 62
    • 34248640428 scopus 로고    scopus 로고
    • Lysine propionylation and butyrylation are novel post-translational modifications in histones
    • Chen Y, Sprung R, Tang Y, Ball H, Sangras B, et al. (2007) Lysine propionylation and butyrylation are novel post-translational modifications in histones. Mol Cell Proteomics 6: 812-819.
    • (2007) Mol Cell Proteomics , vol.6 , pp. 812-819
    • Chen, Y.1    Sprung, R.2    Tang, Y.3    Ball, H.4    Sangras, B.5
  • 63
    • 59149086584 scopus 로고    scopus 로고
    • Molecular characterization of propionyllysines in non-histone proteins
    • Cheng Z, Tang Y, Chen Y, Kim S, Liu H, et al. (2009) Molecular characterization of propionyllysines in non-histone proteins. Mol Cell Proteomics 8: 45-52.
    • (2009) Mol Cell Proteomics , vol.8 , pp. 45-52
    • Cheng, Z.1    Tang, Y.2    Chen, Y.3    Kim, S.4    Liu, H.5
  • 64
    • 70450277232 scopus 로고    scopus 로고
    • Identification and characterization of propionylation at histone H3 lysine 23 in mammalian cells
    • Liu B, Lin Y, Darwanto A, Song X, Xu G, et al. (2009) Identification and characterization of propionylation at histone H3 lysine 23 in mammalian cells. J Biol Chem 284: 32288-32295.
    • (2009) J Biol Chem , vol.284 , pp. 32288-32295
    • Liu, B.1    Lin, Y.2    Darwanto, A.3    Song, X.4    Xu, G.5
  • 65
    • 36248935670 scopus 로고    scopus 로고
    • Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor kappaB-mediated transcription
    • Ghosh HS, Spencer JV, Ng B, McBurney MW, Robbins PD (2007) Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor kappaB-mediated transcription. Biochem J 408: 105-111.
    • (2007) Biochem J , vol.408 , pp. 105-111
    • Ghosh, H.S.1    Spencer, J.V.2    Ng, B.3    McBurney, M.W.4    Robbins, P.D.5
  • 66
    • 36248954501 scopus 로고    scopus 로고
    • SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation
    • Vaquero A, Scher M, Erdjument-Bromage H, Tempst P, Serrano L, et al. (2007) SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation. Nature 450: 440-444.
    • (2007) Nature , vol.450 , pp. 440-444
    • Vaquero, A.1    Scher, M.2    Erdjument-Bromage, H.3    Tempst, P.4    Serrano, L.5
  • 67
    • 68949129008 scopus 로고    scopus 로고
    • Sirtuin 1 functionally and physically interacts with disruptor of telomeric silencing-1 to regulate alpha-ENaC transcription in collecting duct
    • Zhang D, Li S, Cruz P, Kone BC (2009) Sirtuin 1 functionally and physically interacts with disruptor of telomeric silencing-1 to regulate alpha-ENaC transcription in collecting duct. J Biol Chem 284: 20917-20926.
    • (2009) J Biol Chem , vol.284 , pp. 20917-20926
    • Zhang, D.1    Li, S.2    Cruz, P.3    Kone, B.C.4
  • 68
    • 58149339917 scopus 로고    scopus 로고
    • Opposing effects of sirtuins on neuronal survival: SIRT1-mediated neuroprotection is independent of its deacetylase activity
    • Pfister JA, Ma C, Morrison BE, D'Mello SR (2008) Opposing effects of sirtuins on neuronal survival: SIRT1-mediated neuroprotection is independent of its deacetylase activity. PLoS One 3: e4090.
    • (2008) PLoS One , vol.3
    • Pfister, J.A.1    Ma, C.2    Morrison, B.E.3    D'mello, S.R.4
  • 69
    • 0027284915 scopus 로고
    • P53-catalyzed annealing of complementary single-stranded nucleic acids
    • Oberosler P, Hloch P, Ramsperger U, Stahl H (1993) p53-catalyzed annealing of complementary single-stranded nucleic acids. EMBO J 12: 2389-2396.
    • (1993) EMBO J , vol.12 , pp. 2389-2396
    • Oberosler, P.1    Hloch, P.2    Ramsperger, U.3    Stahl, H.4
  • 70
    • 0029115918 scopus 로고
    • Negative feedback regulation of wild-type p53 biosynthesis
    • Mosner J, Mummenbrauer T, Bauer C, Sczakiel G, Grosse F, et al. (1995) Negative feedback regulation of wild-type p53 biosynthesis. EMBO J 14: 4442-4449.
    • (1995) EMBO J , vol.14 , pp. 4442-4449
    • Mosner, J.1    Mummenbrauer, T.2    Bauer, C.3    Sczakiel, G.4    Grosse, F.5
  • 71
    • 0033756586 scopus 로고    scopus 로고
    • P53 binds selectively to the 5' untranslated region of cdk4, an RNA element necessary and sufficient for transforming growth factor beta- and p53-mediated translational inhibition of cdk4
    • Miller SJ, Suthiphongchai T, Zambetti GP, Ewen ME (2000) p53 binds selectively to the 5' untranslated region of cdk4, an RNA element necessary and sufficient for transforming growth factor beta- and p53-mediated translational inhibition of cdk4. Mol Cell Biol 20: 8420-8431.
    • (2000) Mol Cell Biol , vol.20 , pp. 8420-8431
    • Miller, S.J.1    Suthiphongchai, T.2    Zambetti, G.P.3    Ewen, M.E.4
  • 72
    • 0035797499 scopus 로고    scopus 로고
    • P53 directs conformational change and translation initiation blockade of human fibroblast growth factor 2 mRNA
    • Galy B, Cre ́ancier L, Prado-Lourenço L, Prats AC, Prats H (2001) p53 directs conformational change and translation initiation blockade of human fibroblast growth factor 2 mRNA. Oncogene 20: 4613-4620.
    • (2001) Oncogene , vol.20 , pp. 4613-4620
    • Galy, B.1    Créancier, L.2    Prado-Lourenço, L.3    Prats, A.C.4    Prats, H.5
  • 74
    • 35548940665 scopus 로고    scopus 로고
    • Neuronal regulation of alternative pre-mRNA splicing
    • Li Q, Lee JA, Black DL (2007) Neuronal regulation of alternative pre-mRNA splicing. Nat Rev Neurosci 8: 819-831.
    • (2007) Nat Rev Neurosci , vol.8 , pp. 819-831
    • Li, Q.1    Lee, J.A.2    Black, D.L.3
  • 76
    • 0032553485 scopus 로고    scopus 로고
    • Requirement for p53 and p21 to sustain G2 arrest after DNA damage
    • Bunz F, Dutriaux A, Lengauer C, Waldman T, Zhou S, et al. (1998) Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 282: 1497-1501.
    • (1998) Science , vol.282 , pp. 1497-1501
    • Bunz, F.1    Dutriaux, A.2    Lengauer, C.3    Waldman, T.4    Zhou, S.5
  • 77
    • 0029872876 scopus 로고    scopus 로고
    • ARPE-19, a human retinal pigment epithelial cell line with differentiated properties
    • Dunn KC, Aotaki-Keen AE, Putkey FR, Hjelmeland LM (1996) ARPE-19, a human retinal pigment epithelial cell line with differentiated properties. Exp Eye Res 62: 155-169.
    • (1996) Exp Eye Res , vol.62 , pp. 155-169
    • Dunn, K.C.1    Aotaki-Keen, A.E.2    Putkey, F.R.3    Hjelmeland, L.M.4
  • 78
    • 0035921573 scopus 로고    scopus 로고
    • Induction of ser15 and lys382 modifications of p53 by blockage of transcription elongation
    • Ljungman M, O'Hagan HM, Paulsen MT (2001) Induction of ser15 and lys382 modifications of p53 by blockage of transcription elongation. Oncogene 20: 5964-5971.
    • (2001) Oncogene , vol.20 , pp. 5964-5971
    • Ljungman, M.1    O'Hagan, H.M.2    Paulsen, M.T.3
  • 79
    • 0037450761 scopus 로고    scopus 로고
    • P53 is a chromatin accessibility factor for nucleotide excision repair of DNA damage
    • Rubbi CP, Milner J (2003) p53 is a chromatin accessibility factor for nucleotide excision repair of DNA damage. EMBO J 22: 975-986.
    • (2003) EMBO J , vol.22 , pp. 975-986
    • Rubbi, C.P.1    Milner, J.2
  • 80
    • 70350233314 scopus 로고    scopus 로고
    • Basal cancer cell survival involves JNK2 suppression of a novel JNK1/c-Jun/Bcl-3 apoptotic network
    • Ahmed SU, Milner J (2009) Basal cancer cell survival involves JNK2 suppression of a novel JNK1/c-Jun/Bcl-3 apoptotic network. PLoS One 4: e7305.
    • (2009) PLoS One , Issue.4
    • Ahmed, S.U.1    Milner, J.2
  • 81
    • 28544444366 scopus 로고    scopus 로고
    • Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival
    • Ford J, Jiang M, Milner J (2005) Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival. Cancer Res 65: 10457-10463.
    • (2005) Cancer Res , vol.65 , pp. 10457-10463
    • Ford, J.1    Jiang, M.2    Milner, J.3
  • 82
    • 40449110673 scopus 로고    scopus 로고
    • Crosstalk between site-specific modifications on p53 and histone H3
    • Warnock LJ, Adamson R, Lynch CJ, Milner J (2008) Crosstalk between site-specific modifications on p53 and histone H3. Oncogene 27: 1639-1644.
    • (2008) Oncogene , vol.27 , pp. 1639-1644
    • Warnock, L.J.1    Adamson, R.2    Lynch, C.J.3    Milner, J.4
  • 83
    • 16244373960 scopus 로고    scopus 로고
    • The SR protein SC35 is responsible for aberrant splicing of the E1alpha pyruvate dehydrogenase mRNA in a case of mental retardation with lactic acidosis
    • Gabut M, Mine ́ M, Marsac C, Brivet M, Tazi J, et al. (2005) The SR protein SC35 is responsible for aberrant splicing of the E1alpha pyruvate dehydrogenase mRNA in a case of mental retardation with lactic acidosis. Mol Cell Biol 25: 3286-3294.
    • (2005) Mol Cell Biol , vol.25 , pp. 3286-3294
    • Gabut, M.1    Miné, M.2    Marsac, C.3    Brivet, M.4    Tazi, J.5
  • 84
    • 0037026601 scopus 로고    scopus 로고
    • Selective silencing of viral gene expression in HPV positive human cervical carcinoma cells treated with siRNA, a primer of RNA interference
    • Jiang M, Milner J (2002) Selective silencing of viral gene expression in HPV positive human cervical carcinoma cells treated with siRNA, a primer of RNA interference. Oncogene 21: 6041-6048.
    • (2002) Oncogene , vol.21 , pp. 6041-6048
    • Jiang, M.1    Milner, J.2


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