Regulator of G signaling 16 is a marker for the distinct endoplasmic reticulum stress state associated with aggregated mutant α1- antitrypsin Z in the classical form of α1-antitrypsin deficiency

Journal of Biological Chemistry

Volumn 282, Issue 38, 2007, Pages 27769-27780

  Hidvegi, Tunda ^a   Mirnics, Karoly ^b   Hale, Pamela ^a   Ewing, Michael ^a   Beckett, Caroline ^a   Perlmutter, David H ^a  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^b VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ORGANS; CELLS; GENE EXPRESSION; HORMONES; POLYMERIZATION; PROTEINS; STRESS ANALYSIS;

ANTITRYPSIN; CARCINOGENESIS; ENDOPLASMIC RETICULUM; GENOMIC ANALYSIS; MUTANTS; STRESS STATES;

BIOMARKERS;

ALPHA 1 ANTITRYPSIN; CALCIUM IONOPHORE; MUTANT PROTEIN; RGS PROTEIN; TUNICAMYCIN;

ALPHA 1 ANTITRYPSIN DEFICIENCY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL LINE; CELL STRESS; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; LIVER CELL; MOUSE; NONHUMAN; POINT MUTATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN FOLDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

ALPHA 1-ANTITRYPSIN; ANIMALS; ENDOPLASMIC RETICULUM; HELA CELLS; HEPATOCYTES; HUMANS; LIVER; MICE; MICE, TRANSGENIC; MODELS, BIOLOGICAL; MUTATION; PROTEIN CONFORMATION; PROTEIN DENATURATION; RGS PROTEINS; SIGNAL TRANSDUCTION;

MUS MUSCULUS;

EID: 34948871658     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M704330200     Document Type: Article

References (34)

1. Perlmutter, D. H. (2006) Pediatr. Res. 60, 233-238
2. Perlmutter, D. H. (2002) J. Clin. Investig. 110, 1579-1583
3. Lomas, D. A., Evans, D. L., Finch, J. T., and Carrell, R. W. (1992) Nature 357, 605-607
4. Lomas, D. A., and Mahadeva, R. (2002) J. Clin. Investig. 110, 1585-1590
5. Hidvegi, T., Schmidt, B. Z., Hale, P., and Perlmutter, D. H. (2005) J. Biol. Chem. 280, 39002-39015
6. Sveger, T. (1976) N. Engl. J. Med. 294, 1316-1321
7. Sveger, T. (1998) Acta Paediatr. Scand. 77, 847-851
8. Kamimoto, T., Shoji, S., Hidvegi, T., Mizushima, N., Umebayashi, K., Perlmutter, D. H., and Yoshimori, T. (2006) J. Biol. Chem. 281, 4467-4476
9. Kruse, K. B., Brodsky, J. L., and McCracken, A. A. (2006) Mol. Biol. Cell 17, 203-212
10. Kruse, K. B., Dear, A., Kaltenbrun, E. R., Crum, B. E., George, P. M., Brennan, S. O., and McCracken, A. A. (2006) Am. J. Pathol. 168, 1299-1308
11. Perlmutter, D. H. (2006) Autophagy 2, 258-263
12. Carlson, J. A., Rogers, B. B., Sifers, R. N., Finegold, M. J., Clift, S. M., DeMayo, F. J., Bullock, D. W., and Woo, S. L. C. (1989) J. Clin. Investig. 83, 1183-1190
13. Lepre, J., Rice, J. J., Tu, Y., and Stolovitzky, G. (2004) Bioinformatics (Oxf.) 20, 1033-1044
14. Livak, K. J., and Schmittgen, T. D. (2001) Methods (San Diego) 25, 402-408
15. Nair, S., Xu, C., Shen, G., Hebbar, V., Gopalakrishnan, A., Hu, R., Jain, M. R., Liew, C., Chan, J. Y., and Kong, A. N. (2007) Toxicol. Lett. 168, 21-39
16. Reimertz, C., Kogel, D., Rami, A., Chittenden, T., and Prehn, J. H. (2003) J. Cell Biol. 162, 587-597
17. Kimata, Y., Ishiwata-Kimata, Y., Yamada, S., and Kohno, K. (2006) Genes Cell 11, 59-69
18. Travers, K. J., Patil, C. K., Wodicka, L., Lockhart, D. J., Weissman, J. S., and Walter, P. (2000) Cell 101, 249-258
19. Casagrande, R., Stern, P., Diehn, M., Shamu, C., Osario, M., Zuniga, M., Brown, P. O., and Ploegh, H. (2000) Mol. Cell 5, 729-735
20. Kamauchi, S., Nakatani, H., Nakano, C., and Urade, R. (2005) FEBS J. 272, 3461-3476
21. Chen, C., and Sheng-Cai, L. (1998) FEBS Lett. 422, 359-362
22. Gohla, A., Klement, K., Piekorz, R. P., Pexa, K., vom Dahl, S., Spicher, K., Dreval, V., Haussinger, D., Birnbaumer, L., and Nurnberg, B. (2007) Proc. Natl. Acad. Sci. U. S. A. 104, 3003-3008
23. Lin, L., Schmidt, B. Z., Teckman, J., and Perlmutter, D. H. (2001) J. Biol. Chem. 276, 33893-33898
24. Graham, K. S., Le, A., and Sifers, R. N. (1990) J. Biol. Chem. 265, 20463-20468
25. Lawless, M. W., Greene, C. M., Mulgrew, A., Taggart, C. C., O'Neill, S. J., and McElvaney, N. G. (2004) J. Immunol. 172, 5722-5726
26. Bernales, S., McDonald, K. L., and Walter, P. (2006) Plos Biol. 4, e423
27. Lee, M. J., Tasaki, T., Moroi, K., An, J. Y., Kimura, S., Davydov, I. V., and Kwon, Y. T. (2005) Proc. Natl. Acad. Sci. U. S. A. 102, 15030-15035
28. Pattingre, S., DeVries, L., Bauvy, C., Chantret, I., Cluzeaud, F., Ogier-Denis, E., Vandewalle, A., and Codogna, P. (2003) J. Biol. Chem. 278, 20995-21002
29. Huang, J., Pashkov, V., Kurrasch, D. M., Yu, K., Gold, S. J., and Wilkie, T. M. (2006) Comp. Hepatol. 5, 8-18
30. Fremin, C., Ezan, F., Boisselier, P., Bessard, A., Pages, G., Pouyssegur, J., and Baffet, G. (2007) Hepatology 45, 1035-1045
31. Rudnick, D. A., Liao, Y., An, J. K., Muglia, L. J., Perlmutter, D. H., and Teckman, J. H. (2004) Hepatology 39, 1048-1055
32. Rudnick, D. A., and Perlmutter, D. H. (2005) Hepatology 42, 514-521
33. Teckman, J. H., An, J. K., Blomenkamp, K., Schmidt, B., and Perlmutter, D. H. (2004) Am. J. Physiol. 286, G851-G862
34. Rudnick, D. A. (2005) Hepatology 42, 1001-1003