A protein caught in a kinetic trap: Structures and stabilities of insulin disulfide isomers

Biochemistry

Volumn 41, Issue 50, 2002, Pages 14700-14715

  Hua, Qing Xin ^a   Jia, Wenhua ^a   Frank, Bruce H ^b   Phillips, Nelson F B ^a   Weiss, Michael A ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; INSULIN; ISOMERS; PROTEINS; THERMODYNAMICS;

CHAIN RECOMBINATIONS;

BIOCHEMISTRY;

GUANIDINE; INSULIN; INSULIN DISULFIDE; PROINSULIN; SOMATOMEDIN C; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION KINETICS; DISULFIDE BOND; ISOMER; PRIORITY JOURNAL; PROTEIN DENATURATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN STABILITY; PROTEIN STRUCTURE; THERMODYNAMICS; THERMOSTABILITY;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; CIRCULAR DICHROISM; DIMERIZATION; DISULFIDES; HUMANS; INSULIN; ISOMERISM; KINETICS; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDE FRAGMENTS; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN SUBUNITS; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 0037126725     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0202981     Document Type: Article

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