Chiral mutagenesis of insulin: Contribution of the B20-B23 β-turn to activity and stability

Journal of Biological Chemistry

Volumn 281, Issue 31, 2006, Pages 22386-22396

  Nakagawa, Satoe H ^a   Hua, Qing Xin ^b   Hu, Shi Quan ^b   Jia, Wenhua ^b   Wang, Shuhua ^b   Katsoyannis, Panayotis G ^c   Weiss, Michael A ^b  

^a UNIVERSITY OF CHICAGO   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CRYSTAL GROWTH; MUTAGENESIS; PROTEINS; SUBSTITUTION REACTIONS; THERMODYNAMIC STABILITY;

CHIRAL MUTAGENESIS; GLYCINES; RECEPTOR-BINDING ELEMENTS; STEREOSPECIFIC DIFFERENCE;

INSULIN;

ALANINE; DEXTRO ALANINE; GLUTAMIC ACID; INSULIN;

AMINO ACID SUBSTITUTION; ARTICLE; CHIRALITY; CONTROLLED STUDY; HUMAN; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN STABILITY; RECEPTOR BINDING; STEREOSPECIFICITY; THERMODYNAMICS;

ALANINE; CONSERVED SEQUENCE; GLYCINE; HUMANS; INSULIN; MUTAGENESIS; PROTEIN STRUCTURE, SECONDARY; RECEPTOR, INSULIN; SEQUENCE ALIGNMENT; STEREOISOMERISM; THERMODYNAMICS;

EID: 33746828162     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M603547200     Document Type: Article

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