-
1
-
-
70349859881
-
DNA damage, aging, and cancer
-
Hoeijmakers JH. DNA damage, aging, and cancer. N Engl J Med 2009; 361: 1475-85.
-
(2009)
N Engl J Med
, vol.361
, pp. 1475-1485
-
-
Hoeijmakers, J.H.1
-
2
-
-
0035902108
-
Genome maintenance mechanisms for preventingcancer
-
Hoeijmakers JH. Genome maintenance mechanisms for preventingcancer. Nature 2001; 411: 366-74.
-
(2001)
Nature
, vol.411
, pp. 366-374
-
-
Hoeijmakers, J.H.1
-
3
-
-
70350504453
-
The DNA-damage response in humanbiology and disease
-
Jackson SP, Bartek J. The DNA-damage response in humanbiology and disease. Nature 2009; 461: 1071-8.
-
(2009)
Nature
, vol.461
-
-
Jackson, S.P.1
Bartek, J.2
-
4
-
-
73949118293
-
Genomic instability and the selection of treatments for cancer
-
Martin SA, Hewish M, Lord CJ, et al. Genomic instability and the selection of treatments for cancer. J Pathol 220: 281-9.
-
J Pathol
, vol.220
, pp. 281-289
-
-
Martin, S.A.1
Hewish, M.2
Lord, C.J.3
-
5
-
-
10944257674
-
Crosslinks and crosstalk: Human cancersyndromes and DNA repair defects
-
Risinger MA, Groden J. Crosslinks and crosstalk: human cancersyndromes and DNA repair defects. Cancer Cell 2004; 6: 539-45.
-
(2004)
Cancer Cell
, vol.6
, pp. 539-545
-
-
Risinger, M.A.1
Groden, J.2
-
6
-
-
36949005417
-
DNA damage signalling guardsagainst activated oncogenes and tumour progression
-
Bartek J, Bartkova J, Lukas J. DNA damage signalling guardsagainst activated oncogenes and tumour progression. Oncogene 2007; 26: 7773-9.
-
(2007)
Oncogene
, vol.26
-
-
Bartek, J.1
Bartkova, J.2
Lukas, J.3
-
7
-
-
33747376928
-
DNA repair pathways in clinicalpractice: Lessons from pediatric cancer susceptibility syndromes
-
Kennedy RD, D'Andrea AD. DNA repair pathways in clinicalpractice: lessons from pediatric cancer susceptibility syndromes. JClin Oncol 2006; 24: 3799-808.
-
(2006)
JClin Oncol
, vol.24
-
-
Kennedy, R.D.1
D'andrea, A.D.2
-
8
-
-
33847737716
-
DNA damage checkpoints: From initiation torecovery or adaptation
-
Bartek J, Lukas J. DNA damage checkpoints: from initiation torecovery or adaptation. Curr Opin Cell Biol 2007; 19: 238-45.
-
(2007)
Curr Opin Cell Biol
, vol.19
, pp. 238-245
-
-
Bartek, J.1
Lukas, J.2
-
9
-
-
35848949304
-
DNA damage response as an anti-cancer barrier: Damage threshold and the concept of 'conditionalhaploinsufficiency'
-
Bartek J, Lukas J, Bartkova J. DNA damage response as an anti-cancer barrier: damage threshold and the concept of 'conditionalhaploinsufficiency'. Cell Cycle 2007; 6: 2344-7.
-
(2007)
Cell Cycle
, vol.6
-
-
Bartek, J.1
Lukas, J.2
Bartkova, J.3
-
10
-
-
71749111299
-
Impaired DNA damage response-an Achilles' heel sensitizing cancer tochemotherapy and radiotherapy
-
Darzynkiewicz Z, Traganos F, Wlodkowic D. Impaired DNA damage response-an Achilles' heel sensitizing cancer tochemotherapy and radiotherapy. Eur J Pharmacol 2009; 625: 143-50.
-
(2009)
Eur J Pharmacol
, vol.625
, pp. 143-150
-
-
Darzynkiewicz, Z.1
Traganos, F.2
Wlodkowic, D.3
-
11
-
-
68249108128
-
Targeting the DNA damage response forcancer therapy
-
Powell SN, Bindra RS. Targeting the DNA damage response forcancer therapy. DNA Repair (Amst) 2009; 8: 1153-65.
-
(2009)
DNA Repair (Amst)
, vol.8
, pp. 1153-1165
-
-
Powell, S.N.1
Bindra, R.S.2
-
12
-
-
41849101441
-
Carcinogenesis and microsatelliteinstability: The interrelationship between genetics and epigenetics
-
Imai K, Yamamoto H. Carcinogenesis and microsatelliteinstability: the interrelationship between genetics and epigenetics. Carcinogenesis 2008; 29: 673-80.
-
(2008)
Carcinogenesis
, vol.29
, pp. 673-680
-
-
Imai, K.1
Yamamoto, H.2
-
14
-
-
0037202152
-
Chromosome breakage syndromes and cancer
-
Duker NJ. Chromosome breakage syndromes and cancer. Am JMed Genet 2002; 115: 125-9.
-
(2002)
Am JMed Genet
, vol.115
, pp. 125-129
-
-
Duker, N.J.1
-
15
-
-
0141919448
-
Genomic instability and cancer
-
Charames GS, Bapat B. Genomic instability and cancer. Curr MolMed 2003; 3: 589-96.
-
(2003)
Curr MolMed
, vol.3
, pp. 589-596
-
-
Charames, G.S.1
Bapat, B.2
-
16
-
-
49849083943
-
Whole chromosomeinstability and cancer: A complex relationship
-
Ricke RM, van Ree JH, van Deursen JM. Whole chromosomeinstability and cancer: a complex relationship. Trends Genet 2008;24: 457-66.
-
(2008)
Trends Genet
, vol.24
, pp. 457-466
-
-
Ricke, R.M.1
van Ree, J.H.2
van Deursen, J.M.3
-
17
-
-
0032546360
-
Mutations of mitotic checkpointgenes in human cancers
-
Cahill DP, Lengauer C, Yu J, et al. Mutations of mitotic checkpointgenes in human cancers. Nature 1998; 392: 300-3.
-
(1998)
Nature
, vol.392
, pp. 300-303
-
-
Cahill, D.P.1
Lengauer, C.2
Yu, J.3
-
20
-
-
70350065725
-
Disorders of nucleotide excisionrepair: The genetic and molecular basis of heterogeneity
-
Cleaver JE, Lam ET, Revet I. Disorders of nucleotide excisionrepair: the genetic and molecular basis of heterogeneity. Nat RevGenet 2009; 10: 756-68.
-
(2009)
Nat RevGenet
, vol.10
, pp. 756-768
-
-
Cleaver, J.E.1
Lam, E.T.2
Revet, I.3
-
22
-
-
41549129244
-
Genetic polymorphisms and head and neck cancer outcomes: A review
-
Hopkins J, Cescon DW, Tse D, et al. Genetic polymorphisms and head and neck cancer outcomes: a review. Cancer EpidemiolBiomarkers Prev 2008; 17: 490-9.
-
(2008)
Cancer EpidemiolBiomarkers Prev
, vol.17
, pp. 490-499
-
-
Hopkins, J.1
Cescon, D.W.2
Tse, D.3
-
23
-
-
34548292501
-
Base excision repair modulation as a risk factor forhuman cancers
-
Tudek B. Base excision repair modulation as a risk factor forhuman cancers. Mol Aspects Med 2007; 28: 258-75.
-
(2007)
Mol Aspects Med
, vol.28
, pp. 258-275
-
-
Tudek, B.1
-
24
-
-
75149189204
-
BRCA1 and its toolbox for themaintenance of genome integrity
-
Huen MS, Sy SM, Chen J. BRCA1 and its toolbox for themaintenance of genome integrity. Nat Rev Mol Cell Biol 11: 138-48.
-
Nat Rev Mol Cell Biol
, vol.11
, pp. 138-148
-
-
Huen, M.S.1
Sy, S.M.2
Chen, J.3
-
25
-
-
77449151205
-
Physiological and oncogenic Aurora-Apathway
-
Saeki T, Ouchi M, Ouchi T. Physiological and oncogenic Aurora-Apathway. Int J Biol Sci 2009; 5: 758-62.
-
(2009)
Int J Biol Sci
, vol.5
, pp. 758-762
-
-
Saeki, T.1
Ouchi, M.2
Ouchi, T.3
-
26
-
-
51649095569
-
The Aurora kinase family in cell division andcancer
-
Vader G, Lens SM. The Aurora kinase family in cell division andcancer. Biochim Biophys Acta 2008; 1786: 60-72.
-
(2008)
Biochim Biophys Acta
, vol.1786
, pp. 60-72
-
-
Vader, G.1
Lens, S.M.2
-
27
-
-
33646187811
-
The multifaceted mismatch-repair system
-
Jiricny J. The multifaceted mismatch-repair system. Nat Rev MolCell Biol 2006; 7: 335-46.
-
(2006)
Nat Rev MolCell Biol
, vol.7
, pp. 335-346
-
-
Jiricny, J.1
-
28
-
-
38049125557
-
Mechanisms and functions of DNA mismatch repair
-
Li GM. Mechanisms and functions of DNA mismatch repair. CellRes 2008; 18: 85-98.
-
(2008)
CellRes
, vol.18
, pp. 85-98
-
-
Li, G.M.1
-
30
-
-
0034500024
-
DNA mismatch repair and geneticinstability
-
Harfe BD, Jinks-Robertson S. DNA mismatch repair and geneticinstability. Annu Rev Genet 2000; 34: 359-99.
-
(2000)
Annu Rev Genet
, vol.34
, pp. 359-399
-
-
Harfe, B.D.1
Jinks-Robertson, S.2
-
31
-
-
0034733597
-
Mismatch repair proteins and mitoticgenome stability
-
Harfe BD, Jinks-Robertson S. Mismatch repair proteins and mitoticgenome stability. Mutat Res 2000; 451: 151-67.
-
(2000)
Mutat Res
, vol.451
, pp. 151-167
-
-
Harfe, B.D.1
Jinks-Robertson, S.2
-
32
-
-
5144234859
-
Meiotic recombination intermediates andmismatch repair proteins
-
Hoffmann ER, Borts RH. Meiotic recombination intermediates andmismatch repair proteins. Cytogenet Genome Res 2004; 107: 232-48.
-
(2004)
Cytogenet Genome Res
, vol.107
, pp. 232-248
-
-
Hoffmann, E.R.1
Borts, R.H.2
-
33
-
-
0024469392
-
The barrier to recom-bination between Escherichia coli and Salmonella typhimurium isdisrupted in mismatch-repair mutants
-
Rayssiguier C, Thaler DS, Radman M. The barrier to recom-bination between Escherichia coli and Salmonella typhimurium isdisrupted in mismatch-repair mutants. Nature 1989; 342: 396-401.
-
(1989)
Nature
, vol.342
, pp. 396-401
-
-
Rayssiguier, C.1
Thaler, D.S.2
Radman, M.3
-
34
-
-
76549111046
-
Defective mismatch repair, microsatellite mutation bias, and variability in clinical cancerphenotypes
-
Shah SN, Hile SE, Eckert KA. Defective mismatch repair, microsatellite mutation bias, and variability in clinical cancerphenotypes. Cancer Res 70: 431-5.
-
Cancer Res
, vol.70
, pp. 431-435
-
-
Shah, S.N.1
Hile, S.E.2
Eckert, K.A.3
-
35
-
-
54549099260
-
Differences and evolution of the methods for the assessment of microsatellite instability
-
Laghi L, Bianchi P, Malesci A. Differences and evolution of the methods for the assessment of microsatellite instability. Oncogene 2008; 27: 6313-21.
-
(2008)
Oncogene
, vol.27
, pp. 6313-6321
-
-
Laghi, L.1
Bianchi, P.2
Malesci, A.3
-
36
-
-
0029066689
-
Inactivation of the type IITGF-beta receptor in colon cancer cells with microsatelliteinstability
-
Markowitz S, Wang J, Myeroff L, et al. Inactivation of the type IITGF-beta receptor in colon cancer cells with microsatelliteinstability. Science 1995; 268: 1336-8.
-
(1995)
Science
, vol.268
-
-
Markowitz, S.1
Wang, J.2
Myeroff, L.3
-
37
-
-
0031018674
-
Somatic frameshiftmutations in the BAX gene in colon cancers of the microsatellitemutator phenotype
-
Rampino N, Yamamoto H, Ionov Y, et al. Somatic frameshiftmutations in the BAX gene in colon cancers of the microsatellitemutator phenotype. Science 1997; 275: 967-9.
-
(1997)
Science
, vol.275
, pp. 967-969
-
-
Rampino, N.1
Yamamoto, H.2
Ionov, Y.3
-
38
-
-
16144368515
-
Microsatellite instability in theinsulin-like growth factor II receptor gene in gastrointestinaltumours
-
Souza RF, Appel R, Yin J, et al. Microsatellite instability in theinsulin-like growth factor II receptor gene in gastrointestinaltumours. Nat Genet 1996; 14: 255-7.
-
(1996)
Nat Genet
, vol.14
, pp. 255-257
-
-
Souza, R.F.1
Appel, R.2
Yin, J.3
-
40
-
-
10744233937
-
Revised BethesdaGuidelines for hereditary nonpolyposis colorectal cancer (Lynchsyndrome) and microsatellite instability
-
Umar A, Boland CR, Terdiman JP, et al. Revised BethesdaGuidelines for hereditary nonpolyposis colorectal cancer (Lynchsyndrome) and microsatellite instability. J Natl Cancer Inst 2004;96: 261-8.
-
(2004)
J Natl Cancer Inst
, vol.96
, pp. 261-268
-
-
Umar, A.1
Boland, C.R.2
Terdiman, J.P.3
-
41
-
-
77949270273
-
Microsatellite instability in colorectal cancer-the stable evidence
-
Vilar E, Gruber SB. Microsatellite instability in colorectal cancer-the stable evidence. Nat Rev Clin Oncol 7: 153-62.
-
Nat Rev Clin Oncol
, vol.7
, pp. 153-162
-
-
Vilar, E.1
Gruber, S.B.2
-
42
-
-
0032534069
-
A National Cancer Institute Workshop on Microsatellite Instability for cancerdetection and familial predisposition: Development of international criteria for the determination of microsatellite instability incolorectal cancer
-
Boland CR, Thibodeau SN, Hamilton SR, et al. A National Cancer Institute Workshop on Microsatellite Instability for cancerdetection and familial predisposition: development of international criteria for the determination of microsatellite instability incolorectal cancer. Cancer Res 1998; 58: 5248-57.
-
(1998)
Cancer Res
, vol.58
, pp. 5248-5257
-
-
Boland, C.R.1
Thibodeau, S.N.2
Hamilton, S.R.3
-
43
-
-
73949154143
-
Colorectal cancer due to deficiency in DNA mismatch repair function: A review
-
Bellizzi AM, Frankel WL. Colorectal cancer due to deficiency in DNA mismatch repair function: a review. Adv Anat Pathol 2009;16: 405-17.
-
(2009)
Adv Anat Pathol
, vol.16
, pp. 405-417
-
-
Bellizzi, A.M.1
Frankel, W.L.2
-
44
-
-
33750237434
-
Complementary analysis of microsatellite tumor profile and mismatch repair defects in colorectal carcinomas
-
Blanes A, Diaz-Cano SJ. Complementary analysis of microsatellite tumor profile and mismatch repair defects in colorectal carcinomas. World J Gastroenterol 2006; 12: 5932-40.
-
(2006)
World J Gastroenterol
, vol.12
, pp. 5932-5940
-
-
Blanes, A.1
Diaz-Cano, S.J.2
-
45
-
-
0031551963
-
A NationalCancer Institute Workshop on Hereditary Nonpolyposis ColorectalCancer Syndrome: Meeting highlights and Bethesda guidelines
-
Rodriguez-Bigas MA, Boland CR, Hamilton SR, et al. A NationalCancer Institute Workshop on Hereditary Nonpolyposis ColorectalCancer Syndrome: meeting highlights and Bethesda guidelines. J Natl Cancer Inst 1997; 89: 1758-62.
-
(1997)
J Natl Cancer Inst
, vol.89
, pp. 1758-1762
-
-
Rodriguez-Bigas, M.A.1
Boland, C.R.2
Hamilton, S.R.3
-
46
-
-
0033063711
-
New clinical criteria forhereditary nonpolyposis colorectal cancer (HNPCC, Lynchsyndrome) proposed by the International Collaborative group on HNPCC
-
Vasen HF, Watson P, Mecklin JP, et al. New clinical criteria forhereditary nonpolyposis colorectal cancer (HNPCC, Lynchsyndrome) proposed by the International Collaborative group on HNPCC. Gastroenterology 1999; 116: 1453-6.
-
(1999)
Gastroenterology
, vol.116
-
-
Vasen, H.F.1
Watson, P.2
Mecklin, J.P.3
-
47
-
-
0034129240
-
Population-basedmolecular detection of hereditary nonpolyposis colorectal cancer
-
Salovaara R, Loukola A, Kristo P, et al. Population-basedmolecular detection of hereditary nonpolyposis colorectal cancer. J Clin Oncol 2000; 18: 2193-200.
-
(2000)
J Clin Oncol
, vol.18
-
-
Salovaara, R.1
Loukola, A.2
Kristo, P.3
-
48
-
-
0032555020
-
Incidence of hereditarynonpolyposis colorectal cancer and the feasibility of molecularscreening for the disease
-
Aaltonen LA, Salovaara R, Kristo P, et al. Incidence of hereditarynonpolyposis colorectal cancer and the feasibility of molecularscreening for the disease. N Engl J Med 1998; 338: 1481-7.
-
(1998)
N Engl J Med
, vol.338
-
-
Aaltonen, L.A.1
Salovaara, R.2
Kristo, P.3
-
49
-
-
0038333245
-
Tumors with microsatellite instability: Manymutations, targets and paradoxes
-
Perucho M. Tumors with microsatellite instability: manymutations, targets and paradoxes. Oncogene 2003; 22: 2223-5.
-
(2003)
Oncogene
, vol.22
-
-
Perucho, M.1
-
50
-
-
69049099970
-
DNA mismatch repair deficiency inendometrial carcinoma
-
Karamurzin Y, Rutgers JK. DNA mismatch repair deficiency inendometrial carcinoma. Int J Gynecol Pathol 2009; 28: 239-55.
-
(2009)
Int J Gynecol Pathol
, vol.28
, pp. 239-255
-
-
Karamurzin, Y.1
Rutgers, J.K.2
-
51
-
-
0037408402
-
Phenotype ofmicrosatellite unstable colorectal carcinomas: Well-differentiatedand focally mucinous tumors and the absence of dirty necrosiscorrelate with microsatellite instability
-
Greenson JK, Bonner JD, Ben-Yzhak O, et al. Phenotype ofmicrosatellite unstable colorectal carcinomas: Well-differentiatedand focally mucinous tumors and the absence of dirty necrosiscorrelate with microsatellite instability. Am J Surg Pathol 2003; 27:563-70.
-
(2003)
Am J Surg Pathol
, vol.27
, pp. 563-570
-
-
Greenson, J.K.1
Bonner, J.D.2
Ben-Yzhak, O.3
-
52
-
-
0034642605
-
Tumor microsatellite instabilityand clinical outcome in young patients with colorectal cancer
-
Gryfe R, Kim H, Hsieh ET, et al. Tumor microsatellite instabilityand clinical outcome in young patients with colorectal cancer. N Engl J Med 2000; 342: 69-77.
-
(2000)
N Engl J Med
, vol.342
, pp. 69-77
-
-
Gryfe, R.1
Kim, H.2
Hsieh, E.T.3
-
53
-
-
0030909374
-
Allelic imbalance andmicrosatellite instability in resected Duke's D colorectal cancer
-
Kochhar R, Halling KC, McDonnell S, et al. Allelic imbalance andmicrosatellite instability in resected Duke's D colorectal cancer. Diagn Mol Pathol 1997; 6: 78-84.
-
(1997)
Diagn Mol Pathol
, vol.6
, pp. 78-84
-
-
Kochhar, R.1
Halling, K.C.2
McDonnell, S.3
-
54
-
-
34447121322
-
Reduced likelihood ofmetastases in patients with microsatellite-unstable colorectalcancer
-
Malesci A, Laghi L, Bianchi P, et al. Reduced likelihood ofmetastases in patients with microsatellite-unstable colorectalcancer. Clin Cancer Res 2007; 13: 3831-9.
-
(2007)
Clin Cancer Res
, vol.13
-
-
Malesci, A.1
Laghi, L.2
Bianchi, P.3
-
55
-
-
0032538880
-
Replication errors: Cha(lle)nging the genome
-
Jiricny J. Replication errors: cha(lle)nging the genome. EMBO J 1998; 17: 6427-36.
-
(1998)
EMBO J
, vol.17
, pp. 6427-6436
-
-
Jiricny, J.1
-
56
-
-
0031906084
-
The role of DNA mismatch repair indrug resistance
-
Fink D, Aebi S, Howell SB. The role of DNA mismatch repair indrug resistance. Clin Cancer Res 1998; 4: 1-6.
-
(1998)
Clin Cancer Res
, vol.4
, pp. 1-6
-
-
Fink, D.1
Aebi, S.2
Howell, S.B.3
-
57
-
-
0035687887
-
Mechanisms of tolerance to DNA damaging therapeuticdrugs
-
Karran P. Mechanisms of tolerance to DNA damaging therapeuticdrugs. Carcinogenesis 2001; 22: 1931-7.
-
(2001)
Carcinogenesis
, vol.22
-
-
Karran, P.1
-
58
-
-
0142123326
-
Mismatch repair and response to DNA-damaging antitumour therapies
-
Bignami M, Casorelli I, Karran P. Mismatch repair and response to DNA-damaging antitumour therapies. Eur J Cancer 2003; 39:2142-9.
-
(2003)
Eur J Cancer
, vol.39
-
-
Bignami, M.1
Casorelli, I.2
Karran, P.3
-
59
-
-
33750481557
-
Chemotherapeutic agents for colorectal cancer with a defective mismatch repair system: The state of the art
-
Valentini AM, Armentano R, Pirrelli M, et al. Chemotherapeutic agents for colorectal cancer with a defective mismatch repair system: the state of the art. Cancer Treat Rev 2006; 32: 607-18.
-
(2006)
Cancer Treat Rev
, vol.32
, pp. 607-618
-
-
Valentini, A.M.1
Armentano, R.2
Pirrelli, M.3
-
60
-
-
0028784167
-
Microsatellite instability, mismatch repair deficiency, and genetic defects in human cancer cell lines
-
Boyer JC, Umar A, Risinger JI, et al. Microsatellite instability, mismatch repair deficiency, and genetic defects in human cancer cell lines. Cancer Res 1995; 55: 6063-70.
-
(1995)
Cancer Res
, vol.55
, pp. 6063-6070
-
-
Boyer, J.C.1
Umar, A.2
Risinger, J.I.3
-
62
-
-
0037837443
-
DNA mismatch repair (MMR)mediates 6-thioguanine genotoxicity by introducing single-strandbreaks to signal a G2-M arrest in MMR-proficient RKO cells
-
Yan T, Berry SE, Desai AB, et al. DNA mismatch repair (MMR)mediates 6-thioguanine genotoxicity by introducing single-strandbreaks to signal a G2-M arrest in MMR-proficient RKO cells. ClinCancer Res 2003; 9: 2327-34.
-
(2003)
ClinCancer Res
, vol.9
, pp. 2327-2334
-
-
Yan, T.1
Berry, S.E.2
Desai, A.B.3
-
63
-
-
33744928856
-
Mismatch repair proteins as sensors ofalkylation DNA damage
-
Wang JY, Edelmann W. Mismatch repair proteins as sensors ofalkylation DNA damage. Cancer Cell 2006; 9: 417-8.
-
(2006)
Cancer Cell
, vol.9
, pp. 417-418
-
-
Wang, J.Y.1
Edelmann, W.2
-
64
-
-
0031975303
-
N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea sensitivity in mismatch repair-defectivehuman cells
-
Aquilina G, Ceccotti S, Martinelli S, et al. N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea sensitivity in mismatch repair-defectivehuman cells. Cancer Res 1998; 58: 135-41.
-
(1998)
Cancer Res
, vol.58
, pp. 135-141
-
-
Aquilina, G.1
Ceccotti, S.2
Martinelli, S.3
-
65
-
-
0030819872
-
Resistance to cytotoxic drugs inDNA mismatch repair-deficient cells
-
Aebi S, Fink D, Gordon R, et al. Resistance to cytotoxic drugs inDNA mismatch repair-deficient cells. Clin Cancer Res 1997; 3:1763-7.
-
(1997)
Clin Cancer Res
, vol.3
-
-
Aebi, S.1
Fink, D.2
Gordon, R.3
-
66
-
-
0025195404
-
Mammalian O6-alkylguanine-DNA alkyltransferase:Regulation and importance in response to alkylating carcinogenicand therapeutic agents
-
Pegg AE. Mammalian O6-alkylguanine-DNA alkyltransferase:regulation and importance in response to alkylating carcinogenicand therapeutic agents. Cancer Res 1990; 50: 6119-29.
-
(1990)
Cancer Res
, vol.50
, pp. 6119-6129
-
-
Pegg, A.E.1
-
67
-
-
0031037835
-
Cytotoxic mechanism of 6-thioguanine: HMutSalpha, the human mismatch binding heterodimer, binds to DNA containing S6-methylthioguanine
-
Waters TR, Swann PF. Cytotoxic mechanism of 6-thioguanine: hMutSalpha, the human mismatch binding heterodimer, binds to DNA containing S6-methylthioguanine. Biochemistry 1997; 36:2501-6.
-
(1997)
Biochemistry
, vol.36
-
-
Waters, T.R.1
Swann, P.F.2
-
68
-
-
8944230189
-
Loss of DNA mismatchrepair in acquired resistance to cisplatin
-
Aebi S, Kurdi-Haidar B, Gordon R, et al. Loss of DNA mismatchrepair in acquired resistance to cisplatin. Cancer Res 1996; 56:3087-90.
-
(1996)
Cancer Res
, vol.56
, pp. 3087-3090
-
-
Aebi, S.1
Kurdi-Haidar, B.2
Gordon, R.3
-
69
-
-
15444350120
-
In vitro and in vivo resistance tocisplatin in cells that have lost DNA mismatch repair
-
Fink D, Zheng H, Nebel S, et al. In vitro and in vivo resistance tocisplatin in cells that have lost DNA mismatch repair. Cancer Res 1997; 57: 1841-5.
-
(1997)
Cancer Res
, vol.57
-
-
Fink, D.1
Zheng, H.2
Nebel, S.3
-
71
-
-
33846404174
-
Molecular mechanisms of resistance andtoxicity associated with platinating agents
-
Rabik CA, Dolan ME. Molecular mechanisms of resistance andtoxicity associated with platinating agents. Cancer Treat Rev 2007;33: 9-23.
-
(2007)
Cancer Treat Rev
, vol.33
, pp. 9-23
-
-
Rabik, C.A.1
Dolan, M.E.2
-
72
-
-
0031741679
-
Oxaliplatin: A review of preclinical and clinical studies
-
Raymond E, Chaney SG, Taamma A, et al. Oxaliplatin: a review of preclinical and clinical studies. Ann Oncol 1998; 9: 1053-71.
-
(1998)
Ann Oncol
, vol.9
, pp. 1053-1071
-
-
Raymond, E.1
Chaney, S.G.2
Taamma, A.3
-
73
-
-
0029904811
-
The role of DNA mismatch repair inplatinum drug resistance
-
Fink D, Nebel S, Aebi S, et al. The role of DNA mismatch repair inplatinum drug resistance. Cancer Res 1996; 56: 4881-6.
-
(1996)
Cancer Res
, vol.56
-
-
Fink, D.1
Nebel, S.2
Aebi, S.3
-
74
-
-
0036089883
-
Human colon cancer cells surviving high doses of cisplatin or oxaliplatin in vitro are notdefective in DNA mismatch repair proteins
-
Sergent C, Franco N, Chapusot C, et al. Human colon cancer cells surviving high doses of cisplatin or oxaliplatin in vitro are notdefective in DNA mismatch repair proteins. Cancer Chemother Pharmacol 2002; 49: 445-52.
-
(2002)
Cancer Chemother Pharmacol
, vol.49
, pp. 445-452
-
-
Sergent, C.1
Franco, N.2
Chapusot, C.3
-
75
-
-
0029144134
-
Topoisomerase poisons: Harnessing the dark side of enzyme mechanism
-
Froelich-Ammon SJ, Osheroff N. Topoisomerase poisons: harnessing the dark side of enzyme mechanism. J Biol Chem 1995;270: 21429-32.
-
(1995)
J Biol Chem
, vol.270
, pp. 21429-21432
-
-
Froelich-Ammon, S.J.1
Osheroff, N.2
-
76
-
-
0035882531
-
Resistance to topoisomerase poisons due to loss of DNA mismatch repair
-
Fedier A, Schwarz VA, Walt H, et al. Resistance to topoisomerase poisons due to loss of DNA mismatch repair. Int J Cancer 2001;93: 571-6.
-
(2001)
Int J Cancer
, vol.93
, pp. 571-576
-
-
Fedier, A.1
Schwarz, V.A.2
Walt, H.3
-
77
-
-
0035418619
-
The role of the DNA mismatch repair system in the cytotoxicity of the topoisomerase inhibitors camptothecin and etoposide to human colorectal cancer cells
-
Jacob S, Aguado M, Fallik D, et al. The role of the DNA mismatch repair system in the cytotoxicity of the topoisomerase inhibitors camptothecin and etoposide to human colorectal cancer cells. Cancer Res 2001; 61: 6555-62.
-
(2001)
Cancer Res
, vol.61
, pp. 6555-6562
-
-
Jacob, S.1
Aguado, M.2
Fallik, D.3
-
78
-
-
0036722801
-
Cellular effects of CPT-11 on colon carcinoma cells: Dependence on p53 and hMLH1status
-
Magrini R, Bhonde MR, Hanski ML, et al. Cellular effects of CPT-11 on colon carcinoma cells: dependence on p53 and hMLH1status. Int J Cancer 2002; 101: 23-31.
-
(2002)
Int J Cancer
, vol.101
, pp. 23-31
-
-
Magrini, R.1
Bhonde, M.R.2
Hanski, M.L.3
-
79
-
-
55949099916
-
Microsatellite instability dueto hMLH1 deficiency is associated with increased cytotoxicity toirinotecan in human colorectal cancer cell lines
-
Vilar E, Scaltriti M, Balmana J, et al. Microsatellite instability dueto hMLH1 deficiency is associated with increased cytotoxicity toirinotecan in human colorectal cancer cell lines. Br J Cancer 2008;99: 1607-12.
-
(2008)
Br J Cancer
, vol.99
, pp. 1607-1612
-
-
Vilar, E.1
Scaltriti, M.2
Balmana, J.3
-
80
-
-
0141731323
-
Microsatellite instability is apredictive factor of the tumor response to irinotecan in patientswith advanced colorectal cancer
-
Fallik D, Borrini F, Boige V, et al. Microsatellite instability is apredictive factor of the tumor response to irinotecan in patientswith advanced colorectal cancer. Cancer Res 2003; 63: 5738-44.
-
(2003)
Cancer Res
, vol.63
, pp. 5738-5744
-
-
Fallik, D.1
Borrini, F.2
Boige, V.3
-
81
-
-
2342467382
-
Mutations of an intronicrepeat induce impaired MRE11 expression in primary humancancer with microsatellite instability
-
Giannini G, Rinaldi C, Ristori E, et al. Mutations of an intronicrepeat induce impaired MRE11 expression in primary humancancer with microsatellite instability. Oncogene 2004; 23: 2640-7.
-
(2004)
Oncogene
, vol.23
-
-
Giannini, G.1
Rinaldi, C.2
Ristori, E.3
-
82
-
-
27744432600
-
Impaired nonhomologous end-joining in mismatch repair-deficient colon carcinomas
-
Koh KH, Kang HJ, Li LS, et al. Impaired nonhomologous end-joining in mismatch repair-deficient colon carcinomas. Lab Invest 2005; 85: 1130-8.
-
(2005)
Lab Invest
, vol.85
-
-
Koh, K.H.1
Kang, H.J.2
Li, L.S.3
-
83
-
-
35148887112
-
Frequent alteration of DNA damage signalling and repair pathways in human colorectal cancers with microsatellite instability
-
Miquel C, Jacob S, Grandjouan S, et al. Frequent alteration of DNA damage signalling and repair pathways in human colorectal cancers with microsatellite instability. Oncogene 2007; 26: 5919-26.
-
(2007)
Oncogene
, vol.26
, pp. 5919-5926
-
-
Miquel, C.1
Jacob, S.2
Grandjouan, S.3
-
84
-
-
3142658762
-
Hypersensitivity of tumor cell lines with microsatellite instability to DNA double strand break producing chemotherapeutic agent bleomycin
-
Li HR, Shagisultanova EI, Yamashita K, et al. Hypersensitivity of tumor cell lines with microsatellite instability to DNA double strand break producing chemotherapeutic agent bleomycin. Cancer Res 2004; 64: 4760-7.
-
(2004)
Cancer Res
, vol.64
-
-
Li, H.R.1
Shagisultanova, E.I.2
Yamashita, K.3
-
85
-
-
0642374238
-
A role for DNAmismatch repair in sensing and responding to fluoropyrimidinedamage
-
Meyers M, Hwang A, Wagner MW, et al. A role for DNAmismatch repair in sensing and responding to fluoropyrimidinedamage. Oncogene 2003; 22: 7376-88.
-
(2003)
Oncogene
, vol.22
, pp. 7376-7388
-
-
Meyers, M.1
Hwang, A.2
Wagner, M.W.3
-
86
-
-
14044264185
-
DNA mismatch repair-dependent response to fluoropyrimidine-generated damage
-
Meyers M, Wagner MW, Mazurek A, et al. DNA mismatch repair-dependent response to fluoropyrimidine-generated damage. J Biol Chem 2005; 280: 5516-26.
-
(2005)
J Biol Chem
, vol.280
, pp. 5516-5526
-
-
Meyers, M.1
Wagner, M.W.2
Mazurek, A.3
-
87
-
-
52049121297
-
DNA mismatch repair-dependent activation of c-Abl/p73alpha/GADD45alpha-mediatedapoptosis
-
Li LS, Morales JC, Hwang A, et al. DNA mismatch repair-dependent activation of c-Abl/p73alpha/GADD45alpha-mediatedapoptosis. J Biol Chem 2008; 283: 21394-403.
-
(2008)
J Biol Chem
, vol.283
, pp. 21394-21403
-
-
Li, L.S.1
Morales, J.C.2
Hwang, A.3
-
88
-
-
52049122158
-
Role of c-Abl kinase inDNA mismatch repair-dependent G2 cell cycle checkpoint arrestresponses
-
Wagner MW, Li LS, Morales JC, et al. Role of c-Abl kinase inDNA mismatch repair-dependent G2 cell cycle checkpoint arrestresponses. J Biol Chem 2008; 283: 21382-93.
-
(2008)
J Biol Chem
, vol.283
, pp. 21382-21393
-
-
Wagner, M.W.1
Li, L.S.2
Morales, J.C.3
-
89
-
-
33748092909
-
Prognostic impact ofmicrosatellite instability and DNA ploidy in human coloncarcinoma patients
-
Sinicrope FA, Rego RL, Halling KC, et al. Prognostic impact ofmicrosatellite instability and DNA ploidy in human coloncarcinoma patients. Gastroenterology 2006; 131: 729-37.
-
(2006)
Gastroenterology
, vol.131
, pp. 729-737
-
-
Sinicrope, F.A.1
Rego, R.L.2
Halling, K.C.3
-
90
-
-
33744818489
-
Immunohistochemical test forMLH1 and MSH2 expression predicts clinical outcome in stage IIand III colorectal cancer patients
-
Lanza G, Gafa R, Santini A, et al. Immunohistochemical test forMLH1 and MSH2 expression predicts clinical outcome in stage IIand III colorectal cancer patients. J Clin Oncol 2006; 24: 2359-67.
-
(2006)
J Clin Oncol
, vol.24
, pp. 2359-2367
-
-
Lanza, G.1
Gafa, R.2
Santini, A.3
-
91
-
-
0034852772
-
Microsatellite instability insporadic colon cancer is associated with an improved prognosis atthe population level
-
Samowitz WS, Curtin K, Ma KN, et al. Microsatellite instability insporadic colon cancer is associated with an improved prognosis atthe population level. Cancer Epidemiol Biomarkers Prev 2001; 10:917-23.
-
(2001)
Cancer Epidemiol Biomarkers Prev
, vol.10
, pp. 917-923
-
-
Samowitz, W.S.1
Curtin, K.2
Ma, K.N.3
-
92
-
-
14544300998
-
Systematic review ofmicrosatellite instability and colorectal cancer prognosis
-
Popat S, Hubner R, Houlston RS. Systematic review ofmicrosatellite instability and colorectal cancer prognosis. J ClinOncol 2005; 23: 609-18.
-
(2005)
J ClinOncol
, vol.23
, pp. 609-618
-
-
Popat, S.1
Hubner, R.2
Houlston, R.S.3
-
93
-
-
77949274921
-
Stage-specific prognostic value of molecular markers incolon cancer: Results of the translational study on the PETACC 3-EORTC 40993-SAMK 60-00 trial
-
Roth AD. Stage-specific prognostic value of molecular markers incolon cancer: Results of the translational study on the PETACC 3-EORTC 40993-SAMK 60-00 trial. J Clin Oncol 2009; 27: a4002.
-
(2009)
J Clin Oncol
, vol.27
-
-
Roth, A.D.1
-
94
-
-
33846990102
-
Alterations in cellproliferation and apoptosis in colon cancers with microsatelliteinstability
-
Sinicrope FA, Rego RL, Garrity-Park MM, et al. Alterations in cellproliferation and apoptosis in colon cancers with microsatelliteinstability. Int J Cancer 2007; 120: 1232-8.
-
(2007)
Int J Cancer
, vol.120
-
-
Sinicrope, F.A.1
Rego, R.L.2
Garrity-Park, M.M.3
-
95
-
-
33947546541
-
Prognostic andpredictive roles of high-degree microsatellite instability in coloncancer: A National Cancer Institute-National Surgical AdjuvantBreast and Bowel Project Collaborative Study
-
Kim GP, Colangelo LH, Wieand HS, et al. Prognostic andpredictive roles of high-degree microsatellite instability in coloncancer: a National Cancer Institute-National Surgical AdjuvantBreast and Bowel Project Collaborative Study. J Clin Oncol 2007;25: 767-72.
-
(2007)
J Clin Oncol
, vol.25
, pp. 767-772
-
-
Kim, G.P.1
Colangelo, L.H.2
Wieand, H.S.3
-
96
-
-
33845709023
-
Microsatelliteinstability did not predict individual survival of unselected patientswith colorectal cancer
-
Lamberti C, Lundin S, Bogdanow M, et al. Microsatelliteinstability did not predict individual survival of unselected patientswith colorectal cancer. Int J Colorectal Dis 2007; 22: 145-52.
-
(2007)
Int J Colorectal Dis
, vol.22
, pp. 145-152
-
-
Lamberti, C.1
Lundin, S.2
Bogdanow, M.3
-
97
-
-
33645819367
-
Clinicopathologicsignificance of defective DNA mismatch repair in endometrialcarcinoma
-
Black D, Soslow RA, Levine DA, et al. Clinicopathologicsignificance of defective DNA mismatch repair in endometrialcarcinoma. J Clin Oncol 2006; 24: 1745-53.
-
(2006)
J Clin Oncol
, vol.24
, pp. 1745-1753
-
-
Black, D.1
Soslow, R.A.2
Levine, D.A.3
-
98
-
-
67650333857
-
ATR mutations in endometrial cancer: A window intothe role of mismatch repair defects
-
Kauff ND. ATR mutations in endometrial cancer: a window intothe role of mismatch repair defects. J Clin Oncol 2009; 27: 3077-8.
-
(2009)
J Clin Oncol
, vol.27
-
-
Kauff, N.D.1
-
99
-
-
33750515665
-
Improved survival withan intact DNA mismatch repair system in endometrial cancer
-
Cohn DE, Frankel WL, Resnick KE, et al. Improved survival withan intact DNA mismatch repair system in endometrial cancer. Obstet Gynecol 2006; 108: 1208-15.
-
(2006)
Obstet Gynecol
, vol.108
, pp. 1208-1215
-
-
Cohn, D.E.1
Frankel, W.L.2
Resnick, K.E.3
-
100
-
-
34249949422
-
Microsatelliteinstability and epigenetic inactivation of MLH1 and outcome ofpatients with endometrial carcinomas of the endometrioid type
-
Zighelboim I, Goodfellow PJ, Gao F, et al. Microsatelliteinstability and epigenetic inactivation of MLH1 and outcome ofpatients with endometrial carcinomas of the endometrioid type. JClin Oncol 2007; 25: 2042-8.
-
(2007)
JClin Oncol
, vol.25
-
-
Zighelboim, I.1
Goodfellow, P.J.2
Gao, F.3
-
101
-
-
67650306169
-
ATR mutation inendometrioid endometrial cancer is associated with poor clinicaloutcomes
-
Zighelboim I, Schmidt AP, Gao F, et al. ATR mutation inendometrioid endometrial cancer is associated with poor clinicaloutcomes. J Clin Oncol 2009; 27: 3091-6.
-
(2009)
J Clin Oncol
, vol.27
-
-
Zighelboim, I.1
Schmidt, A.P.2
Gao, F.3
-
102
-
-
11844273837
-
Colorectal cancer
-
Weitz J, Koch M, Debus J, et al. Colorectal cancer. Lancet 2005;365: 153-65.
-
(2005)
Lancet
, vol.365
, pp. 153-165
-
-
Weitz, J.1
Koch, M.2
Debus, J.3
-
103
-
-
77949901120
-
Adjuvant therapy incolon cancer
-
Lombardi L, Gebbia V, Silvestris N, et al. Adjuvant therapy incolon cancer. Oncology 2009; 77 (Suppl 1): 50-6.
-
(2009)
Oncology
, vol.77
, Issue.SUPPL. 1
, pp. 50-56
-
-
Lombardi, L.1
Gebbia, V.2
Silvestris, N.3
-
104
-
-
28544446428
-
Microsatellite instability andcolorectal cancer prognosis
-
Benatti P, Gafa R, Barana D, et al. Microsatellite instability andcolorectal cancer prognosis. Clin Cancer Res 2005; 11: 8332-40.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 8332-8340
-
-
Benatti, P.1
Gafa, R.2
Barana, D.3
-
105
-
-
0038002279
-
Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-basedadjuvant chemotherapy for colon cancer
-
Ribic CM, Sargent DJ, Moore MJ, et al. Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-basedadjuvant chemotherapy for colon cancer. N Engl J Med 2003; 349:247-57.
-
(2003)
N Engl J Med
, vol.349
, pp. 247-257
-
-
Ribic, C.M.1
Sargent, D.J.2
Moore, M.J.3
-
106
-
-
59249097606
-
The efficacy of adjuvantchemotherapy with 5-fluorouracil in colorectal cancer depends onthe mismatch repair status
-
Jover R, Zapater P, Castells A, et al. The efficacy of adjuvantchemotherapy with 5-fluorouracil in colorectal cancer depends onthe mismatch repair status. Eur J Cancer 2009; 45: 365-73.
-
(2009)
Eur J Cancer
, vol.45
, pp. 365-373
-
-
Jover, R.1
Zapater, P.2
Castells, A.3
-
107
-
-
0034690610
-
Association of tumour site andsex with survival benefit from adjuvant chemotherapy in colorectalcancer
-
Elsaleh H, Joseph D, Grieu F, et al. Association of tumour site andsex with survival benefit from adjuvant chemotherapy in colorectalcancer. Lancet 2000; 355: 1745-50.
-
(2000)
Lancet
, vol.355
, pp. 1745-1750
-
-
Elsaleh, H.1
Joseph, D.2
Grieu, F.3
-
108
-
-
0033778049
-
Microsatelliteinstability is a favorable prognostic indicator in patients withcolorectal cancer receiving chemotherapy
-
Hemminki A, Mecklin JP, Jarvinen H, et al. Microsatelliteinstability is a favorable prognostic indicator in patients withcolorectal cancer receiving chemotherapy. Gastroenterology 2000;119: 921-8.
-
(2000)
Gastroenterology
, vol.119
, pp. 921-928
-
-
Hemminki, A.1
Mecklin, J.P.2
Jarvinen, H.3
-
109
-
-
53749096264
-
Confirmatory of deficient mismatch repair (dMMR) asa predicitive marker for lack of benefit from 5-FU basedchemotherapy in stage II and III colon cancer (CC): A pooledmolecular reananlysis of randomized chemotherapy trails
-
Sargent DL. Confirmatory of deficient mismatch repair (dMMR) asa predicitive marker for lack of benefit from 5-FU basedchemotherapy in stage II and III colon cancer (CC): A pooledmolecular reananlysis of randomized chemotherapy trails. J Clin Oncol 2008: a4008.
-
(2008)
J Clin Oncol
-
-
Sargent, D.L.1
-
110
-
-
77749277597
-
DNA mismatch repair and adjuvant chemotherapy insporadic colon cancer
-
Sinicrope FA. DNA mismatch repair and adjuvant chemotherapy insporadic colon cancer. Nat Rev Clin Oncol 7: 174-7.
-
Nat Rev Clin Oncol
, vol.7
, pp. 174-177
-
-
Sinicrope, F.A.1
-
111
-
-
64649096900
-
Microsatelliteinstability predicts improved response to adjuvant therapy withirinotecan, fluorouracil, and leucovorin in stage III colon cancer:Cancer and Leukemia Group B Protocol 89803
-
Bertagnolli MM, Niedzwiecki D, Compton CC, et al. Microsatelliteinstability predicts improved response to adjuvant therapy withirinotecan, fluorouracil, and leucovorin in stage III colon cancer:Cancer and Leukemia Group B Protocol 89803. J Clin Oncol 2009;27: 1814-21.
-
(2009)
J Clin Oncol
, vol.27
, pp. 1814-1821
-
-
Bertagnolli, M.M.1
Niedzwiecki, D.2
Compton, C.C.3
-
112
-
-
34548160680
-
Irinotecan fluorouracilplus leucovorin is not superior to fluorouracil plus leucovorin aloneas adjuvant treatment for stage III colon cancer: Results of CALGB89803
-
Saltz LB, Niedzwiecki D, Hollis D, et al. Irinotecan fluorouracilplus leucovorin is not superior to fluorouracil plus leucovorin aloneas adjuvant treatment for stage III colon cancer: results of CALGB89803. J Clin Oncol 2007; 25: 3456-61.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3456-3461
-
-
Saltz, L.B.1
Niedzwiecki, D.2
Hollis, D.3
-
113
-
-
77949274921
-
Microsatellite instability (MSI) in stage II and III cooncancer treated with 5FU-LV or 5FU-LV and iritotecan (PETACC3-EORTC 40993-SAKK 60/00 trial)
-
Tejpar S. Microsatellite instability (MSI) in stage II and III cooncancer treated with 5FU-LV or 5FU-LV and iritotecan (PETACC3-EORTC 40993-SAKK 60/00 trial). J Clin Oncol 2009; 27:a4001.
-
(2009)
J Clin Oncol
, vol.27
-
-
Tejpar, S.1
|