-
1
-
-
0028938482
-
Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles
-
Glover G.M., et al. Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles. Cell, 1995. 81: 95-105.
-
(1995)
Cell
, vol.81
, pp. 95-105
-
-
Glover, G.M.1
-
2
-
-
0030946109
-
Cell cycle-dependent expression and spindle pole localization of a novel human protein kinase, Aik, related to Aurora of Drosophila and yeast lpl1
-
Kimura M., et al. Cell cycle-dependent expression and spindle pole localization of a novel human protein kinase, Aik, related to Aurora of Drosophila and yeast lpl1. J. Bio. Chem., 1997. 272: 13766-13771.
-
(1997)
J. Bio. Chem
, vol.272
, pp. 13766-13771
-
-
Kimura, M.1
-
3
-
-
0037155870
-
Cell-cycle-dependent regulation of human Aurora A transcription is mediated by periodic repression of E4TF1
-
Tanaka M., et al. Cell-cycle-dependent regulation of human Aurora A transcription is mediated by periodic repression of E4TF1. J. Biol. Chem., 2002. 277: 10719-10726.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 10719-10726
-
-
Tanaka, M.1
-
4
-
-
1642403599
-
Cell-cycle-dependent regulation of the human Aurora B promoter
-
Kimura M., et al. Cell-cycle-dependent regulation of the human Aurora B promoter. Biochem. Biophys. Res. Commun., 2004. 316: 930-936.
-
(2004)
Biochem. Biophys. Res. Commun
, vol.316
, pp. 930-936
-
-
Kimura, M.1
-
5
-
-
33846988313
-
Roles of Aurora kinases in mitosis and tumorigene- sis
-
Fu J., et al. Roles of Aurora kinases in mitosis and tumorigene- sis. Mol Cancer Res., 2007. 5: 1-10.
-
(2007)
Mol Cancer Res
, vol.5
, pp. 1-10
-
-
Fu, J.1
-
6
-
-
0141429171
-
Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells
-
Hirota T., et al. Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells. Cell, 2003. 114: 585-598.
-
(2003)
Cell
, vol.114
, pp. 585-598
-
-
Hirota, T.1
-
7
-
-
0033135640
-
Centrosomal kinase AIK1 is overexpressed in invasive ductal carcinoma of the breast
-
Tanaka T., et al. Centrosomal kinase AIK1 is overexpressed in invasive ductal carcinoma of the breast. Cancer Res, 1999. 59: 2041-2044.
-
(1999)
Cancer Res
, vol.59
, pp. 2041-2044
-
-
Tanaka, T.1
-
8
-
-
34548253898
-
High copy amplification of the Aurora-a gene is associated with chromosomal instability phenotype in hu- man colorectal cancers
-
Nishida N., et al. High copy amplification of the Aurora-a gene is associated with chromosomal instability phenotype in hu- man colorectal cancers. Cancer Biol Ther., 2007. 6: 525-533.
-
(2007)
Cancer Biol Ther
, vol.6
, pp. 525-533
-
-
Nishida, N.1
-
9
-
-
33947521195
-
Aurora-A/STK-15 is a predictive factor for recurrent behavior in non-invasive bladder carcinoma: A study of 128 cases of non-invasive neoplasms
-
Compérat E., et al. Aurora-A/STK-15 is a predictive factor for recurrent behavior in non-invasive bladder carcinoma: a study of 128 cases of non-invasive neoplasms. Virchows Arch., 2007. 450: 419-424.
-
(2007)
Virchows Arch
, vol.450
, pp. 419-424
-
-
Compérat, E.1
-
10
-
-
0037343237
-
Overexpression of oncogenic STK15/BTAK/Aurora A kinase in human pancreatic cancer
-
Li D., et al. Overexpression of oncogenic STK15/BTAK/Aurora A kinase in human pancreatic cancer. Clin Cancer Res., 2003. 9: 991-997.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 991-997
-
-
Li, D.1
-
11
-
-
34547135182
-
Predictive value of Aurora-A/STK15 ex- pression for late stage epithelial ovarian cancer patients treated by adjuvant chemotherapy
-
Lassmann S., et al. Predictive value of Aurora-A/STK15 ex- pression for late stage epithelial ovarian cancer patients treated by adjuvant chemotherapy. Clin Cancer Res., 2007. 13: 4083-4091.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 4083-4091
-
-
Lassmann, S.1
-
12
-
-
8444220396
-
Overexpression of Aurora-A contributes to ma- lignant development of human esophageal squamous cell car- cinoma
-
Tong T., et al. Overexpression of Aurora-A contributes to ma- lignant development of human esophageal squamous cell car- cinoma. Clin Cancer Res., 2004. 10: 7304-7310.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 7304-7310
-
-
Tong, T.1
-
13
-
-
0032100685
-
A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers
-
Bischoff J.R., et al. A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. EMBO J., 1998. 17: 3052-3065.
-
(1998)
Embo J
, vol.17
, pp. 3052-3065
-
-
Bischoff, J.R.1
-
14
-
-
2442584567
-
BRCA1 phosphorylation by Aurora-a in the regulation of G2 to M transition
-
Ouchi M., et al. BRCA1 phosphorylation by Aurora-a in the regulation of G2 to M transition. J Biol Chem., 2004. 279: 19643-19648.
-
(2004)
J Biol Chem
, vol.279
, pp. 19643-19648
-
-
Ouchi, M.1
-
15
-
-
0037449747
-
Cell cycle differences in DNA dam- age-induced BRCA1 phosphorylation affects its subcellular lo- calization
-
Okada S, and Ouchi T. Cell cycle differences in DNA dam- age-induced BRCA1 phosphorylation affects its subcellular lo- calization. J Biol Chem., 2003. 278: 2015-2020.
-
(2003)
J Biol Chem
, vol.278
, pp. 2015-2020
-
-
Okada, S.1
Ouchi, T.2
-
16
-
-
33751085368
-
Overexpression of aurora kinase A in mouse mammary epithelium induces genetic instability preceding mammary tumor formation
-
Wang X., et al. Overexpression of aurora kinase A in mouse mammary epithelium induces genetic instability preceding mammary tumor formation. Oncogene, 2006. 25: 7148-7158.
-
(2006)
Oncogene
, vol.25
, pp. 7148-7158
-
-
Wang, X.1
-
17
-
-
70249092975
-
Essential Roles of mTOR/Akt Pathway in Aurora-A Cell Transformation
-
Taga M., et al. Essential Roles of mTOR/Akt Pathway in Aurora-A Cell Transformation. Int J Biol Sci., 2009. 19: 444-450.
-
(2009)
Int J Biol Sci
, vol.19
, pp. 444-450
-
-
Taga, M.1
-
18
-
-
18644380150
-
Roles of aurora-a kinase in mitotic entry and G2 checkpoint in mammalian cells
-
Marumoto T., et al. Roles of aurora-a kinase in mitotic entry and G2 checkpoint in mammalian cells. Genes Cell, 2002. 7:1173-1182.
-
(2002)
Genes Cell
, vol.7
, pp. 1173-1182
-
-
Marumoto, T.1
-
19
-
-
0037084163
-
Aurora-A overexpression reveals tetraploidi- zation as a major route to centrosome amplification in p53-/- cells
-
Meraldi P., et al. Aurora-A overexpression reveals tetraploidi- zation as a major route to centrosome amplification in p53-/- cells. EMBO J., 2002. 21: 483-492.
-
(2002)
Embo J
, vol.21
, pp. 483-492
-
-
Meraldi, P.1
-
20
-
-
0037586498
-
Aurora-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to taxol
-
Anand S., et al. Aurora-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to taxol. Cancer Cell, 2003. 3: 51-62.
-
(2003)
Cancer Cell
, vol.3
, pp. 51-62
-
-
Anand, S.1
-
21
-
-
0033106326
-
Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells
-
Xu X., et al. Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells. Mol Cell, 1999. 3: 389-395.
-
(1999)
Mol Cell
, vol.3
, pp. 389-395
-
-
Xu, X.1
-
22
-
-
0032573068
-
BRCA1 is associated with the centro- some during mitosis
-
Hsu L.C, and White R.L. BRCA1 is associated with the centro- some during mitosis. Proc Natl Acad Sci USA, 1998. 95: 2983-12988.
-
(1998)
Proc Natl Acad Sci Usa
, vol.95
, pp. 2983-12988
-
-
Hsu, L.C.1
White, R.L.2
-
23
-
-
0035502955
-
Identification of a gamma-tubulin-bondong domain of BRCA1
-
Hsu L.C, et al. Identification of a gamma-tubulin-bondong domain of BRCA1. Cancer Res., 2001. 61: 7713-7718.
-
(2001)
Cancer Res
, vol.61
, pp. 7713-7718
-
-
Hsu, L.C.1
-
24
-
-
37049023673
-
Aurora-A kinase regulates breast can- cer-associated gene 1 inhibition of centrosome-dependent microtubule nucleation
-
Sankaran S., et al. Aurora-A kinase regulates breast can- cer-associated gene 1 inhibition of centrosome-dependent microtubule nucleation. Cancer Res. 2007. 67: 11186-11194.
-
(2007)
Cancer Res
, vol.67
, pp. 11186-11194
-
-
Sankaran, S.1
-
25
-
-
21844468767
-
Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase
-
Chiang G.G., et al. Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase. J Biol Chem., 2005. 280: 25485-25490.
-
(2005)
J Biol Chem
, vol.280
, pp. 25485-25490
-
-
Chiang, G.G.1
-
26
-
-
22544455676
-
Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase
-
Holz M.K, and Blenis J. Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase. J Biol Chem., 2005. 280: 26089-26093.
-
(2005)
J Biol Chem
, vol.280
, pp. 26089-26093
-
-
Holz M.K.Blenis, J.1
-
27
-
-
62449266454
-
TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): Phospho-Ser2481 is a marker for intact mTOR signaling complex 2
-
Copp J., et al. TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2. Cancer Res., 2009. 69: 1821-1827.
-
(2009)
Cancer Res
, vol.69
, pp. 1821-1827
-
-
Copp, J.1
-
28
-
-
33749076673
-
SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity
-
Jacinto E., et al. SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell, 2006. 127: 125-137.
-
(2006)
Cell
, vol.127
, pp. 125-137
-
-
Jacinto, E.1
-
29
-
-
34347210090
-
Identification of protor as a novel ric- tor-binding component of mTOR complex-2
-
Pearce L.R., et al. Identification of protor as a novel ric- tor-binding component of mTOR complex-2. Biochem J., 2007. 405: 513-522.
-
(2007)
Biochem J
, vol.405
, pp. 513-522
-
-
Pearce, L.R.1
-
30
-
-
3342895823
-
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent path- way tha regulates the cytoskeleton
-
Sabassov D.D., et al. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent path- way tha regulates the cytoskeleton. Curr Bio., 2004. 14: 1296-1302.
-
(2004)
Curr Bio
, vol.14
, pp. 1296-1302
-
-
Sabassov, D.D.1
-
31
-
-
43249124698
-
PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis
-
Thedieck K., et al. PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis. PLoS ONE, 2007. 2: 1217.
-
(2007)
Plos One
, vol.2
, pp. 1217
-
-
Thedieck, K.1
-
32
-
-
34548509880
-
PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expres- sion and signaling
-
Woo S.Y., et al. PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expres- sion and signaling. J Biol Chem., 2007. 282: 25604-25612.
-
(2007)
J Biol Chem
, vol.282
, pp. 25604-25612
-
-
Woo, S.Y.1
-
33
-
-
33751079895
-
Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity
-
Yang Q., et al. Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity. Genes Dev., 2006. 20: 2820-2832.
-
(2006)
Genes Dev
, vol.20
, pp. 2820-2832
-
-
Yang, Q.1
-
34
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov D.D., et al. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science, 2005. 307: 1098-1101.
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
-
35
-
-
7944235758
-
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
-
Jacinto E., et al. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol., 2004. 6: 1122-1128.
-
(2004)
Nat Cell Biol
, vol.6
, pp. 1122-1128
-
-
Jacinto, E.1
-
36
-
-
47949125486
-
The mammalian target of rapamycin com- plex 2 controls folding and stability of Akt and protein kinase C
-
Facchinetti V., et al. The mammalian target of rapamycin com- plex 2 controls folding and stability of Akt and protein kinase C. EMBO J., 2008. 27: 1932-1943.
-
(2008)
Embo J
, vol.27
, pp. 1932-1943
-
-
Facchinetti, V.1
-
37
-
-
47949104258
-
Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signaling
-
Ikenoue T., et al. Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signaling. EMBO J., 2008. 27: 1919-1931.
-
(2008)
Embo J
, vol.27
, pp. 1919-1931
-
-
Ikenoue, T.1
-
38
-
-
58649092475
-
mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
-
Garcia-Martinez J.M., and Alessi D.R. mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1). Biochem J., 2008. 416: 375-385.
-
(2008)
Biochem J
, vol.416
, pp. 375-385
-
-
Garcia-Martinez, J.M.1
Alessi, D.R.2
-
39
-
-
68749116494
-
Functional interaction of mTOR complexes in regulating mammalian cell size and cell cycle
-
Rosner M., et al. Functional interaction of mTOR complexes in regulating mammalian cell size and cell cycle. Hum Mol Genet., 2009. 18: 3298-3310.
-
(2009)
Hum Mol Genet
, vol.18
, pp. 3298-3310
-
-
Rosner, M.1
-
40
-
-
43049151493
-
Polo on the Rise-from mitotic entry to cytokinesis with Plk1
-
Petronczki M., et al. Polo on the Rise-from mitotic entry to cytokinesis with Plk1. Dev Cell, 2008. 14: 646-659.
-
(2008)
Dev Cell
, vol.14
, pp. 646-659
-
-
Petronczki, M.1
-
41
-
-
34948901399
-
Aurora-A: The maker and breaker of spindle poles
-
Barr A.R, and Gergely F. Aurora-A: the maker and breaker of spindle poles. J Cell Sci., 2007. 120: 2987-2996.
-
(2007)
J Cell Sci
, vol.120
, pp. 2987-2996
-
-
Barr, A.R.1
Gergely, F.2
-
42
-
-
0034717818
-
TPX2, a novel xenopus MAP involved in spindle pole organization
-
Wittmann T., et al. TPX2, a novel xenopus MAP involved in spindle pole organization. J Cell Biol., 2000. 149: 1405-1418.
-
(2000)
J Cell Biol
, vol.149
, pp. 1405-1418
-
-
Wittmann, T.1
-
43
-
-
0037135979
-
Human TPX2 is required for targeting Aurora-A kinase to the spindle
-
Kufer T.A., et al. Human TPX2 is required for targeting Aurora-A kinase to the spindle. J Cell Biol., 2002. 158: 617-623.
-
(2002)
J Cell Biol
, vol.158
, pp. 617-623
-
-
Kufer, T.A.1
-
44
-
-
0037446847
-
A novel mechanism for activation of the pro- tein kinase Aurora A
-
Eyers P.A., et al. A novel mechanism for activation of the pro- tein kinase Aurora A. Curr Biol., 2003. 13: 691-697.
-
(2003)
Curr Biol
, vol.13
, pp. 691-697
-
-
Eyers, P.A.1
-
45
-
-
0242330123
-
Structural basis of Aurora-A activation by TPX2 at the mitotic spindle
-
Bayliss R., et al. Structural basis of Aurora-A activation by TPX2 at the mitotic spindle. Mol Cell, 2003. 12: 851-862.
-
(2003)
Mol Cell
, vol.12
, pp. 851-862
-
-
Bayliss, R.1
-
46
-
-
26944442735
-
The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A
-
Zhao Z.S., et al. The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A. Moll Cell, 2005. 20: 237-249.
-
(2005)
Moll Cell
, vol.20
, pp. 237-249
-
-
Zhao, Z.S.1
-
47
-
-
34250758641
-
HEF1-dependent Aurora A activation induces disassembly of the primary cilium
-
Pugacheva E.N., et al. HEF1-dependent Aurora A activation induces disassembly of the primary cilium. Cell, 2007. 129: 1351-1363.
-
(2007)
Cell
, vol.129
, pp. 1351-1363
-
-
Pugacheva, E.N.1
-
48
-
-
51549085203
-
PLK1 regulates mitotic Aurora A function through βTrCP-dependent degradation of hBora
-
Chan E.H., et al. PLK1 regulates mitotic Aurora A function through βTrCP-dependent degradation of hBora. Chromosoma, 2008. 117: 457-469.
-
(2008)
Chromosoma
, vol.117
, pp. 457-469
-
-
Chan, E.H.1
-
49
-
-
42049096542
-
Plk1- and bTrCP-dependent degradation of Bora controls mitotic progression
-
Seki A., et al. Plk1- and bTrCP-dependent degradation of Bora controls mitotic progression. J Cell Biol., 2008. 181: 65-78.
-
(2008)
J Cell Biol
, vol.181
, pp. 65-78
-
-
Seki, A.1
-
50
-
-
51349144633
-
Polo-like kinase-1 is activated by Aurora A to promote checkpoint recovery
-
Macurek L., et al. Polo-like kinase-1 is activated by Aurora A to promote checkpoint recovery. Nature, 2008. 455: 119-123.
-
(2008)
Nature
, vol.455
, pp. 119-123
-
-
Macurek, L.1
-
51
-
-
46249084662
-
Bora and the kinase Aurora A cooperatively acti- vate the kinase Plk1 and control mitotic entry
-
Seki A., et al. Bora and the kinase Aurora A cooperatively acti- vate the kinase Plk1 and control mitotic entry. Science, 2008 320: 1655-1658.
-
(2008)
Science
, vol.320
, pp. 1655-1658
-
-
Seki, A.1
-
52
-
-
66349112569
-
Aurora-A and hBora jointhe game of polo
-
Macurek L, et al. Aurora-A and hBora jointhe game of polo. Cancer Res. 2009. 69: 4555-4558.
-
(2009)
Cancer Res
, vol.69
, pp. 4555-4558
-
-
Macurek, L.1
-
53
-
-
0034721154
-
Chfr defines a mitotic stress checkpoint that delays entry into metaphase
-
Scolnick D.M, and Halazonetis T.D. Chfr defines a mitotic stress checkpoint that delays entry into metaphase. Nature, 2000. 406: 430-435.
-
(2000)
Nature
, vol.406
, pp. 430-435
-
-
Scolnick, D.M.1
Halazonetis, T.D.2
-
54
-
-
20144386737
-
Chfr is required for tumor suppression and Aurora A regulation
-
Yu X., et al. Chfr is required for tumor suppression and Aurora A regulation. Nat Genet., 2005. 37: 401-406.
-
(2005)
Nat Genet
, vol.37
, pp. 401-406
-
-
Yu, X.1
-
55
-
-
45849111392
-
Loss of CHFR expression in mammary epithelial cells causes genomic instability by disrupting the mitotic spindle assembly checkpoint
-
Privette L.M., et al. Loss of CHFR expression in mammary epithelial cells causes genomic instability by disrupting the mitotic spindle assembly checkpoint. Neoplasia, 2008. 10: 643-652.
-
(2008)
Neoplasia
, vol.10
, pp. 643-652
-
-
Privette, L.M.1
-
56
-
-
17844387881
-
The CHFR mitotic checkpoint protein delays cell cycle progression by excluding cyclin B1 from the nucleus
-
Summers M.K., et al. The CHFR mitotic checkpoint protein delays cell cycle progression by excluding cyclin B1 from the nucleus. Oncogene, 2005. 24: 2589-2598.
-
(2005)
Oncogene
, vol.24
, pp. 2589-2598
-
-
Summers, M.K.1
-
57
-
-
0345305711
-
Promotion of mitosis by activated protein kinase B after DNA damage involves polo-like kinase 1 and check- point protein CHFR
-
Shtivelman E. Promotion of mitosis by activated protein kinase B after DNA damage involves polo-like kinase 1 and check- point protein CHFR. Mol Cancer Res., 2003. 1: 959-969.
-
(2003)
Mol Cancer Res
, vol.1
, pp. 959-969
-
-
Shtivelman, E.1
|