Technological trends, global market, and challenges of bio-ethanol production

Biotechnology Advances

Volumn 28, Issue 6, 2010, Pages 817-830

  Mussatto, Solange I ^a   Dragone, Giuliano ^a   Guimarães, Pedro M R ^a   Silva, João Paulo A ^b   Carneiro, Lívia M ^b   Roberto, Inês C ^b   Vicente, António ^a   Domingues, Lucília ^a   Teixeira, José A ^a  

^a UNIVERSITY OF MINHO   (Portugal)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Continuous immobilized cell reactor; Corn; Engineered yeast strains; Ethanol; Global market; Lignocellulosic material; Microalgae; Sugarcane

Indexed keywords

CORN; ENGINEERED YEAST STRAINS; GLOBAL MARKET; IMMOBILIZED CELLS; LIGNOCELLULOSIC MATERIAL; MICRO-ALGAE;

ALGAE; BIOETHANOL; CELL CULTURE; CELL IMMOBILIZATION; CELLS; ENVIRONMENTAL REGULATIONS; FUEL ADDITIVES; INTERNATIONAL TRADE; MICROORGANISMS; RAW MATERIALS; YEAST;

ETHANOL;

ALCOHOL; BIOFUEL;

ADVANCED TECHNOLOGY; BIOFUEL; BIOMASS POWER; BIOREACTOR; CELLULOSE; ECONOMIC IMPACT; ENERGY MARKET; ETHANOL; FOSSIL FUEL; FUTURE PROSPECT; GLOBAL ECONOMY; IMMOBILIZATION; LIGNIN; MAIZE; MICROALGA; REGULATORY FRAMEWORK; SUGAR CANE; YEAST;

BIOTECHNOLOGY; ECONOMICS; INTERNATIONAL COOPERATION; MARKETING; REVIEW; SYNTHESIS;

BIOFUELS; BIOTECHNOLOGY; ETHANOL; INTERNATIONALITY; MARKETING;

ZEA MAYS;

EID: 77957021521     PISSN: 07349750     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biotechadv.2010.07.001     Document Type: Review

References (191)

1. Abbasi T., Abbasi S.A. Biomass energy and the environmental impacts associated with its production and utilization. Renew Sust Energ Rev 2010, 14:919-937.
2. Agbogbo F.K., Coward-Kelly G. Cellulosic ethanol production using the naturally occurring xylose-fermenting yeast, Pichia stipitis. Biotechnol Lett 2008, 30:1515-1524.
3. Albers E., Larsson C. A comparison of stress tolerance in YPD and industrial lignocellulose-based medium among industrial and laboratory yeast strains. J Ind Microbiol Biotechnol 2009, 36:1085-1091.
4. Algenol Biofuels, 2010 (available online last visited: 26 Feb 2010).
5. Almeida E.L.F., Silva C.M.S. Formação de um mercado internacional de etanol e suas inter-relações com os mercados de petróleo e açúcar. XI Congresso Brasileiro de Energia, Rio de Janeiro, Brazil 2006.
6. Almeida J.R., Bertilsson M., Gorwa-Grauslund M.F., Gorsich S., Lidén G. Metabolic effects of furaldehydes and impacts on biotechnological processes. Appl Microbiol Biotechnol 2009, 82:625-638.
7. Alper H., Moxley J., Nevoigt E., Fink G.R., Stephanopoulos G. Engineering yeast transcription machinery for improved ethanol tolerance and production. Science 2006, 314:1565-1568.
8. Amin S. Review on biofuel oil and gas production processes from microalgae. Energy Convers Manage 2009, 50:1834-1840.
9. Amutha R., Gunasekaran P. Production of ethanol from liquefied cassava starch using co-immobilized cells of Zymomonas mobilis and Saccharomyces diastaticus. J Biosci Bioeng 2001, 92:560-564.
10. Andreoli C., Souza S.P. Cana-de-acúcar: a melhor alternativa para conversão da energia solar e fóssil em etanol. Econ Energy 2007, 59:27-33.
11. Andrietta S.R., Steckelberg C., Andrietta Mda G. Study of flocculent yeast performance in tower reactors for bio-ethanol production in a continuous fermentation process with no cell recycling. Bioresour Technol 2008, 99:3002-3008.
12. Anfavea Associação Nacional dos Fabricantes de Veículos Automotores. Anuário estatístico 2005 2005, (available online last visited: 26 Feb 2010).
13. Argueso J.L., Carazzolle M.F., Mieczkowski P.A., Duarte F.M., Netto O.V., Missawa S.K., et al. Genome structure of a Saccharomyces cerevisiae strain widely used in bio-ethanol production. Genome Res 2009, 19:2258-2270.
14. Bai F.W., Anderson W.A., Moo-Young M. Ethanol fermentation technologies from sugar and starch feedstocks. Biotechnol Adv 2008, 26:89-105.
15. Balat M., Balat H. Recent trends in global production and utilization of bio-ethanol fuel. Appl Energy 2009, 86:2273-2282.
16. Ballesteros M., Oliva J.M., Negro M.J., Manzanares P., Ballesteros I. Ethanol from lignocellulosic materials by a simultaneous saccharification and fermentation process (SFS) with Kluyveromyces marxianus CECT 10875. Process Biochem 2004, 39:1843-1848.
17. Basso L.C., de Amorim H.V., de Oliveira A.J., Lopes M.L. Yeast selection for fuel ethanol production in Brazil. FEMS Yeast Res 2008, 8:1155-1163.
18. Bastos V.D. Etanol, alcoolquímica e biorrefinarias. BNDES Setorial 2007, 25:5-38.
19. Biofuels Platform ENERS Energy Concept. Production of biofuels in the world 2010, (available online last visited: 26 Feb 2010).
20. Blieck L., Toye G., Dumortier F., Verstrepen K.J., Delvaux F.R., Thevelein J.M., et al. Isolation and characterization of brewer's yeast variants with improved fermentation performance under high-gravity conditions. Appl Environ Microbiol 2007, 73:815-824.
21. Bothast R.J. New technologies in biofuel production. Agricultural Outlook Forum 2005, (available online: last visited: 26 Feb 2010).
22. Brányik T., Vicente A.A., Machado Cruz J.M., Teixeira J.A. Spent grains - a new support for brewing yeast immobilization. Biotechnol Lett 2001, 23:1073-1078.
23. Brányik T., Vicente A.A., Dostálek P., Teixeira J.A. Continuous beer fermentation using immobilized yeast cell bioreactor systems. Biotechnol Prog 2005, 21:653-663.
24. Bray S.C., Ferreira E.R., Ruas D.G.G. As políticas da agroindústria canavieira e o proálcool no Brasil 2000, Unesp-Marília-Publicações, Marília.
25. Brennan L., Owende P. Biofuels from microalgae - a review of technologies for production, processing, and extractions of biofuels and co-products. Renew Sust Energ Rev 2010, 14:557-577.
26. Brethauer S., Wyman C.E. Review: Continuous hydrolysis and fermentation for cellulosic ethanol production. Bioresour Technol 2010, 101:4862-4874.
27. Brown L.R. Beyond the oil peak. Plan B 2.0 rescuing a planet under stress and a civilization in trouble 2006, 21-40. W.W. Norton & Co., New York. L.R. Brown (Ed.).
28. Budny D. The global dynamics biofuels 2007, (available online last visited: 26 Feb 2010).
29. Çakar Z.P. Metabolic and evolutionary engineering research in Turkey and beyond. Biotechnol J 2009, 4:992-1002.
30. Çakar Z.P., Seker U.O., Tamerler C., Sonderegger M., Sauer U. Evolutionary engineering of multiple-stress resistant Saccharomyces cerevisiae. FEMS Yeast Res 2005, 5:569-578.
31. Cardona C.A., Sánchez J. Fuel ethanol production: process design trends and integration opportunities. Review. Bioresour Technol 2007, 98:2415-2457.
32. Carvalho G., Carneiro A.V., Stock L.A. O mercado de energia e os preços do concentrado: novos desafios. Embrapa Gado de Leite 2007, (available online last visited: 29 Mar 2007).
33. Cheng J.S., Qiao B., Yuan Y.J. Comparative proteome analysis of robust Saccharomyces cerevisiae insights into industrial continuous and batch fermentation. Appl Microbiol Biotechnol 2008, 81:327-338.
34. Cheryl Algae becoming the new biofuel of choice 2008, (available online last visited: 26 Feb 2010).
35. Chisti M.Y. An unusual hydrocarbon. J Ramsay Soc 1980, 27-28:24-26.
36. Chisti Y. Biodiesel from microalgae. Biotechnol Adv 2007, 25:294-306.
37. Chisti Y. Biodiesel from microalgae beats bioethanol. Trends Biotechnol 2008, 26:126-131.
38. Choi G.W., Kang H.W., Moon S.K. Repeated-batch fermentation using flocculent hybrid, Saccharomyces cerevisiae CHFY0321 for efficient production of bio-ethanol. Appl Microbiol Biotechnol 2009, 84:261-269.
39. Cunha A.F., Missawa S.K., Gomes L.H., Reis S.F., Pereira G.A. Control by sugar of Saccharomyces cerevisiae flocculation for industrial ethanol production. FEMS Yeast Res 2006, 6:280-287.
40. Demirbas A. Bio-ethanol from cellulosic materials: a renewable motor fuel from biomass. Energy Source 2005, 27:327-337.
41. Demirbas M.F., Balat M., Balat H. Potential contribution of biomass to the sustainable energy development. Energy Convers Manage 2009, 50:1746-1760.
42. Dinh T.N., Nagahisa K., Yoshikawa K., Hirasawa T., Furusawa C., Shimizu H. Analysis of adaptation to high ethanol concentration in Saccharomyces cerevisiae using DNA microarray. Bioprocess Biosyst Eng 2009, 32:681-688.
43. Domingues L., Teixeira J.A., Lima N. Construction of a flocculent Saccharomyces cerevisiae fermenting lactose. Appl Microbiol Biotechnol 1999, 51:621-626.
44. Domingues L., Dantas M.M., Lima N., Teixeira J.A. Continuous ethanol fermentation of lactose by a recombinant flocculating Saccharomyces cerevisiae strain. Biotechnol Bioeng 1999, 64:692-697.
45. Domingues L., Vicente A.A., Lima N., Teixeira J.A. Applications of yeast flocculation in biotechnological processes. Biotechnol Bioprocess E 2000, 5:288-305.
46. Domingues L., Lima N., Teixeira J.A. Alcohol production from cheese whey permeate using genetically modified flocculent yeast cells. Biotechnol Bioeng 2001, 72:507-514.
47. Domingues L., Teixeira J.A., Penttilä M., Lima N. Construction of a flocculent Saccharomyces cerevisiae strain secreting high levels of Aspergillus niger beta-galactosidase. Appl Microbiol Biotechnol 2002, 58:645-650.
48. Domingues L., Lima N., Teixeira J.A. Aspergillus niger β-galactosidase production by yeast in a continuous high cell density reactor. Proc Biochem 2005, 40:1151-1154.
49. Doucha J., Lívanskỳ K. Outdoor open thin-layer microalgal photobioreactor: potential productivity. J Appl Phycol 2009, 21:111-117.
50. Dragone G., Mussatto S.I., Oliveira J.M., Teixeira J.A. Characterisation of volatile compounds in an alcoholic beverage produced by whey fermentation. Food Chem 2009, 112:929-935.
51. Duailibi J. Ele é o falso vilão. Revista Veja 2008 2008, (available online last visited: 26 Feb 2010).
52. EIA, Energy Information Administration Annual energy review 2005, DOE/EIA-0384 2006, US Department of Energy, Washington, DC.
53. Endo A., Nakamura T., Ando A., Tokuyasu K., Shima J. Genome-wide screening of the genes required for tolerance to vanillin, which is a potential inhibitor of bio-ethanol fermentation, in Saccharomyces cerevisiae. Biotechnol Biofuels 2008, 1:3.
54. Endo A., Nakamura T., Shima J. Involvement of ergosterol in tolerance to vanillin, a potential inhibitor of bio-ethanol fermentation, in Saccharomyces cerevisiae. FEMS Microbiol Lett 2009, 299:95-99.
55. Fang X., Shen Y., Zhao J., Bao X., Qu Y. Status and prospect of lignocellulosic bioethanol production in China. Bioresource Technol 2010, 101:4814-4819.
56. Fujita K., Matsuyama A., Kobayashi Y., Iwahashi H. The genome-wide screening of yeast deletion mutants to identify the genes required for tolerance to ethanol and other alcohols. FEMS Yeast Res 2006, 6:744-750.
57. Gaspar M., Kálmán G., Réczey K. Corn fiber as a raw material for hemicellulose and ethanol production. Process Biochem 2007, 42:1135-1139.
58. Ge X.M., Bai F.W. Intrinsic kinetics of continuous growth and ethanol production of a flocculating fusant yeast strain SPSC01. J Biotechnol 2006, 124:363-372.
59. Georgieva T.I., Ahring B.K. Evaluation of continuous ethanol fermentation of dilute-acid corn stover hydrolysate using thermophilic anaerobic bacterium Thermoanaerobacter BG1L1. Appl Microbiol Biotechnol 2007, 77:61-68.
60. Georgieva T.I., Mikkelsen M.J., Ahring B.K. Ethanol production from wet-exploded wheat straw hydrolysate by thermophilic anaerobic bacterium Thermoanaerobacter BG1L1 in a continuous immobilized reactor. Appl Biochem Biotechnol 2008, 145:99-110.
61. Giampietro M., Ulgiati S., Pimental D. Feasibility of large-scale biofuel production. Bioscience 1997, 47:587-600.
62. Gnansounou E., Dauriat A., Wyman C.E. Refining sweet sorghum to ethanol and sugar: economic trade-offs in the context of North China. Bioresour Technol 2005, 96:985-1002.
63. Goldemberg J., Guardabassi P. Are biofuels a feasible option?. Energy Policy 2009, 37:10-14.
64. Goldemberg J., Nigro F.E.B., Coelho S.T. Bioenergia no estado de São Paulo: Situação atual, perspectivas, barreiras e propostas 2008, Imprensa Oficial do Estado de São Paulo, São Paulo.
65. Gorsich S.W., Dien B.S., Nichols N.N., Slininger P.J., Liu Z.L., Skory C.D. Tolerance to furfural-induced stress is associated with pentose phosphate pathway genes ZWF1, GND1, RPE1, and TKL1 in Saccharomyces cerevisiae. Appl Microbiol Biotechnol 2006, 71:339-349.
66. Guimarães P.M.R., Londesborough J. The adenylate energy charge and specific fermentation rate of brewer's yeasts fermenting high- and very high-gravity worts. Yeast 2008, 25:47-58.
67. Guimarães P.M.R., François J., Parrou J.L., Teixeira J.A., Domingues L. Adaptive evolution of a lactose-consuming Saccharomyces cerevisiae recombinant. Appl Environ Microbiol 2008, 74:1748-1756.
68. Guimarães P.M.R., Le Berre V., Sokol S., François J., Teixeira J.A., Domingues L. Comparative transcriptome analysis between original and evolved recombinant lactose-consuming Saccharomyces cerevisiae strains. Biotechnol J 2008, 3:1591-1597.
69. Hahn-Hägerdal B., Galbe M., Gorwa-Grauslund M.F., Lidén G., Zacchi G. Bio-ethanol-the fuel of tomorrow from the residues of today. Trends Biotechnol 2006, 24:549-556.
70. Hahn-Hägerdal B., Karhumaa K., Fonseca C., Spencer-Martins I., Gorwa-Grauslund M.F. Towards industrial pentose-fermenting yeast strains. Appl Microbiol Biotechnol 2007, 74:937-953.
71. Hansen R., Pearson S.Y., Brosnan J.M., Meaden P.G., Jamieson D.J. Proteomic analysis of a distilling strain of Saccharomyces cerevisiae during industrial grain fermentation. Appl Microbiol Biotechnol 2006, 72:116-125.
72. Harun R., Danquah M.K., Forde G.M. Microalgal biomass as a fermentation feedstock for bioethanol production. J Chem Technol Biotechnol 2009, 85:199-203.
73. Heer D., Sauer U. Identification of furfural as a key toxin in lignocellulosic hydrolysates and evolution of a tolerant yeast strain. Microb Biotechnol 2008, 1:497-506.
74. Heinimo J., Junginger M. Production and trading of biomass for energy - an overview of the global status. Biomass Bioenerg 2009, 33:1310-1320.
75. Hills F.J., Johnson S.S., Geng S., Abshahi A., Peterson G.R. Comparison of four crops for alcohol yield. Calif Agric 1983, 37:17-19.
76. 2 fixation and ethanol production with microalgal photosynthesis and intracellular anaerobic fermentation. Energy 1997, 22:137-142.
77. Hirasawa T., Yoshikawa K., Nakakura Y., Nagahisa K., Furusawa C., Katakura Y., et al. Identification of target genes conferring ethanol stress tolerance to Saccharomyces cerevisiae based on DNA microarray data analysis. J Biotechnol 2007, 131:34-44.
78. Hou L. Novel methods of genome shuffling in Saccharomyces cerevisiae. Biotechnol Lett 2009, 31:671-677.
79. Hou L. Improved production of ethanol by novel genome shuffling in Saccharomyces cerevisiae. Appl Biochem Biotechnol 2010, 160:1084-1093.
80. Hu X.H., Wang M.H., Tan T., Li J.R., Yang H., Leach L., et al. Genetic dissection of ethanol tolerance in the budding yeast Saccharomyces cerevisiae. Genetics 2007, 175:1479-1487.
81. Huang C.F., Lin T.H., Guo G.L., Hwang W.S. Enhanced ethanol production by fermentation of rice straw hydrolysate without detoxification using a newly adapted strain of Pichia stipitis. Bioresour Technol 2009, 100:3914-3920.
82. Içoz E., Tugrul M.K., Saral A., Içoz E. Research on ethanol production and use from sugar beet in Turkey. Biomass Bioenerg 2009, 33:1-7.
83. Jarboe L.R., Grabar T.B., Yomano L.P., Shanmugan K.T., Ingram L.O. Development of ethanologenic bacteria. Adv Biochem Eng Biotechnol 2007, 108:237-261.
84. Johnson F.X., Rosillo-Calle F. Biomass, livelihoods and international trade 2007, Stockholm Environment Institute, (available onlinelast visited: 26 Feb 2010).
85. Karagöz P., Erhan E., Keskinler B., Özkan M. The use of microporous divinyl benzene copolymer for yeast cell immobilization and ethanol production in packed-bed reactor. Appl Biochem Biotechnol 2009, 152:66-73.
86. Kim S., Dale B.E. Environmental aspects of ethanol derived from no-tilled corn grain: nonrenewable energy consumption and greenhouse gas emissions. Biomass Bioenerg 2005, 28:475-489.
87. Kline K.L., Oladosu G.A., Wolfe A.K., Perlack R.D., Dale V.H., Mcmahon M. Biofuel feedstock assessment for selected countries. ORNL biofuel feedstock assessment 2008, February.
88. Knight P. Sugar and ethanol in Brazil and South America. Int Sugar J 2006, 108:472.
89. Kosugi A., Kondo A., Ueda M., Murata Y., Vaithanomsat P., Thanapase W., et al. Production of ethanol from cassava pulp via fermentation with a surface-engineered yeast strain displaying glucoamylase. Renew Energy 2009, 34:1354-1358.
90. Kourkoutas Y., Bekatorou A., Banat I.M., Marchant R., Koutinas A.A. Immobilization technologies and support materials suitable in alcohol beverages production: a review. Food Microbiol 2004, 21:377-397.
91. Krylova A.Y., Kozyukov E.A., Lapidus A.L. Ethanol and diesel fuel from plant raw materials: a review. Solid Fuel Chem 2008, 42:358-364.
92. Kuyper M., Toirkens M.J., Diderich J.A., Winkler A.A., van Dijken J.P., Pronk J.T. Evolutionary engineering of mixed-sugar utilization by a xylose-fermenting Saccharomyces cerevisiae strain. FEMS Yeast Res 2005, 5:925-934.
93. Lashinky A., Schwartz N.D. How to beat the high cost of gasoline. Forever! 2006, (available online last visited 26 Feb 2010).
94. Leite R.C.C., Leal M.R.L.V., Cortez L.A.B., Barbosa L.A., Griffin W.M., Scandiffio M.I.G. Can Brazil replace 5% of the 2025 gasoline world demand with ethanol?. Energy 2009, 34:655-661.
95. Li S.Z., Chan-Halbrendt C. Ethanol production in (the) People's Republic of China: potential and technologies. Appl Energy 2009, 86:S162-S169.
96. Li Y., Horsman M., Wu N., Lan C.Q., Dubois-Calero N. Biofuels from microalgae. Biotechnol Prog 2008, 24:815-820.
97. Li L., Ye Y., Pan L., Zhu Y., Zheng S., Lin Y. The induction of trehalose and glycerol in Saccharomyces cerevisiae in response to various stresses. Biochem Biophys Res Commun 2009, 387:778-783.
98. Li F., Zhao X.Q., Ge X.M., Bai F.W. An innovative consecutive batch fermentation process for very high gravity ethanol fermentation with self-flocculating yeast. Appl Microbiol Biotechnol 2009, 84:1079-1086.
99. Licht F.O. World ethanol markets: the outlook to 2015. Tunbridge Wells, Agra Europe special report, UK 2006.
100. Lin Y., Tanaka S. Ethanol fermentation from biomass resources: current state and prospects. Appl Microbiol Biotechnol 2006, 69:627-642.
101. Lin F.M., Qiao B., Yuan Y.J. Comparative proteomic analysis of tolerance and adaptation of ethanologenic Saccharomyces cerevisiae to furfural, a lignocellulosic inhibitory compound. Appl Environ Microbiol 2009, 75:3765-3776.
102. Lin F.M., Tan Y., Yuan Y.J. Temporal quantitative proteomics of Saccharomyces cerevisiae in response to a nonlethal concentration of furfural. Proteomics 2009, 9:5471-5483.
103. Ling K.C. Whey to ethanol. Is there a biofuel role for dairy cooperatives? Rural Cooperatives 2008, (available onlinelast visited 26 Feb 2010).
104. Linko M., Haikara A., Ritala A., Penttilä M. Recent advances in the malting and brewing industry. J Biotechnol 1998, 65:85-98.
105. Liu N., Wang D., Wang Z.Y., He X.P., Zhang B. Genetic basis of flocculation phenotype conversion in Saccharomyces cerevisiae. FEMS Yeast Res 2007, 7:1362-1370.
106. Liu Z.L., Moon J., Andersh B.J., Slininger P.J., Weber S. Multiple gene-mediated NAD(P)H-dependent aldehyde reduction is a mechanism of in situ detoxification of furfural and 5-hydroxymethylfurfural by Saccharomyces cerevisiae. Appl Microbiol Biotechnol 2008, 81:743-753.
107. Liu Z.L., Ma M., Song M. Evolutionarily engineered ethanologenic yeast detoxifies lignocellulosic biomass conversion inhibitors by reprogrammed pathways. Mol Genet Genomics 2009, 282:233-244.
108. Liu C.-Z., Wang F., Ou-Yang F. Ethanol fermentation in a magnetically fluidized bed reactor with immobilized Saccharomyces cerevisiae in magnetic particles. Bioresour Technol 2009, 100:878-882.
109. Lueschen W., Putnam D., Kanne B., Hoverstad T. Agronomic practices for production of ethanol from sweet sorghum. J Prod Agric 1991, 4:619-625.
110. Ma K., Wakisaka M., Sakai K., Shirai Y. Flocculation characteristics of an isolated mutant flocculent Saccharomyces cerevisiae strain and its application for fuel ethanol production from kitchen refuse. Bioresour Technol 2009, 100:2289-2292.
111. Macedo I.C., Seabra J.E.A., Silva J.E.A.R. Green house gases emissions in the production and use of ethanol from sugarcane in Brazil: the 2005/2006 averages and a prediction for 2020. Biomass Bioenerg 2008, 32:582-595.
112. Mamma D., Christakopoulos P., Koullas D., Kekos D., Macris B.J., Kouki E. An alternative approach to the bioconversion ff sweet sorghum carbohydrates to ethanol. Biomass Bioenerg 1995, 8:99-103.
113. Margeot A., Hahn-Hagerdal B., Edlund M., Slade R., Monot F. New improvements for lignocellulosic ethanol. Curr Opin Biotechnol 2009, 20:372-380.
114. Martin G.J.O., Knepper A., Zhou B., Pamment N.B. Performance and stability of ethanologenic Escherichia coli strain FBR5 during continuous culture on xylose and glucose. J Ind Microbiol Biotechnol 2006, 33:834-844.
115. Martín C., Marcet M., Almazán O., Jönsson L.J. Adaptation of a recombinant xylose-utilizing Saccharomyces cerevisiae strain to a sugarcane bagasse hydrolysate with high content of fermentation inhibitors. Bioresour Technol 2007, 98:1767-1773.
116. Matsushika A., Inoue H., Kodaki T., Sawayama S. Ethanol production from xylose in engineered Saccharomyces cerevisiae strains: current state and perspectives. Appl Microbiol Biotechnol 2009, 84:37-53.
117. Mcaloon A., Taylor F., Yee W., Ibsen K., Wooley R. Determining the cost of producing ethanol from corn starch and lignocellulosic feedstocks 2000, (available online last visited: 26 Feb 2010).
118. Mensour N.A., Margaritis A., Briens C.L., Pîlkington H., Russel I. New developments in the brewing industry using immobilised yeast cell bioreactor systems. J Inst Brew 1997, 103:363-370.
119. Modig T., Almeida J.R., Gorwa-Grauslund M.F., Lidén G. Variability of the response of Saccharomyces cerevisiae strains to lignocellulose hydrolysate. Biotechnol Bioeng 2008, 100:423-429.
120. Moreira J.R., Velázquez S.M.S.G., Apolinário S.M., Melo E.H., Elmadjian P.H. CENBIO. Bioetanol para o transporte sustentável 2008, (available online last visited: 26 Feb 2010).
121. Mussatto S.I., Roberto I.C. Alternatives for detoxification of diluted-acid lignocellulosic hydrolyzates for use in fermentative processes: a review. Bioresour Technol 2004, 93:1-10.
122. Nevoigt E. Progress in metabolic engineering of Saccharomyces cerevisiae. Microbiol Mol Biol Rev 2008, 72:379-412.
123. Nielsen J. Metabolic engineering. Appl Microbiol Biotechnol 2001, 55:263-283.
124. Nigam J.N. Ethanol production from wheat straw hemicellulose hydrolysate by Pichia stipitis. J Biotechnol 2001, 87:17-27.
125. Notícias Globo Álcool brasileiro custa menos da metade do etanol dos EUA 2007, (available online last visited: 31 Jan 2007).
126. Ogbonna J.C., Mashima H., Tanaka H. Scale up of fuel ethanol production from sugar beet juice using loofa sponge immobilized bioreactor. Bioresour Technol 2001, 76:1-8.
127. Ooi B.G., Lankford K.R. Strategy for adapting wine yeasts for bio-ethanol production. Int J Mol Sci 2009, 10:387-394.
128. Openpr Worldwide cellulosic ethanol production in 2020 at least 16.5billion gallons 2010, (available online last visited: 26 Feb 2010).
129. Orellana C., Bonalume Neto R. Brazil and Japan give fuel to ethanol market. Nat Biotechnol 2006, 24:232.
130. Parekh S., Vinci V.A., Strobel R.J. Improvement of microbial strains and fermentation processes. Appl Microbiol Biotechnol 2000, 54:287-301.
131. Persson T., Garcia A., Paz J., Jones J., Hoogenbooma G. Maize ethanol feedstock production and net energy value as affected by climate variability and crop management practices. Agric Syst 2009, 100:11-21.
132. Petersson A., Almeida J.R., Modig T., Karhumaa K., Hahn-Hägerdal B., Gorwa-Grauslund M.F., et al. A 5-hydroxymethyl furfural reducing enzyme encoded by the Saccharomyces cerevisiae ADH6 gene conveys HMF tolerance. Yeast 2006, 23:455-464.
133. Posten C., Schaub G. Microalgae and terrestrial biomass as source for fuels - a process view. J Biotechnol 2009, 142:64-69.
134. Prasad S., Singh A., Jain N., Joshi H.C. Ethanol production from sweet sorghum syrup for utilization as automotive fuel in India. Energ Fuel 2007, 21:2415-2420.
135. Prasad S., Singh A., Joshi H.C. Ethanol as an alternative fuel from agricultural, industrial and urban residues. Resour Conserv Recy 2007, 50:1-39.
136. Prieur-Vernat A., His S. Biofuels in Europe. Panorame 2007 2006, IFP, Paris.
137. Purwadi R., Brandberg T., Taherzadeh M.J. A possible industrial solution to ferment lignocellulosic hydrolyzate to ethanol: continuous cultivation with flocculating yeast. Int J Mol Sci 2007, 8:920-932.
138. Ragauskas A.J., Williams C.K., Davison B.H., Britovsek G., Cairney J., Eckert C.A., et al. The path forward for biofuels and biomaterials. Science 2006, 311:484-489.
139. Rattanachomsri U., Tanapongpipat S., Eurwilaichitr L., Champreda V. Simultaneous non-thermal saccharification of cassava pulp by multi-enzyme activity and ethanol fermentation by Candida tropicalis. J Biosci Bioeng 2009, 107:488-493.
140. Rautio J.J., Huuskonen A., Vuokko H., Vidgren V., Londesborough J. Monitoring yeast physiology during very high gravity wort fermentations by frequent analysis of gene expression. Yeast 2007, 24:741-760.
141. Rebros M., Rosenberg M., Grosová Z., Kristofíková L., Paluch M., Sipöcz M. Ethanol production from starch hydrolyzates using Zymomonas mobilis and glucoamylase entrapped in polyvinylalcohol hydrogel. Appl Biochem Biotechnol 2009, 158:561-570.
142. RFA, Renewable Fuels Association (available online lastvisited:26Feb2010).
143. Rogers P.L., Jeon Y.J., Lee K.J., Lawford H.G. Zymomonas mobilis for fuel ethanol and higher value products. Adv Biochem Eng Biotechnol 2007, 108:263-288.
144. Rossillo-Calle F., Walter A. Global market for bio-ethanol: historical trends and future prospects. Energ Sustain Dev 2006, 10:20-32.
145. Roukas T. Ethanol production from non-sterilized beet molasses by free and immobilized Saccharomyces cerevisiae cells using fed-batch culture. J Food Eng 1996, 27:87-96.
146. Sánchez O.J., Cardona C.A. Trends in biotechnological production of fuel ethanol from different feedstocks. Bioresour Technol 2008, 99:5270-5295.
147. Sanchez-Gonzalez Y., Cameleyre X., Molina-Jouve C., Goma G., Alfenore S. Dynamic microbial response under ethanol stress to monitor Saccharomyces cerevisiae activity in different initial physiological states. Bioprocess Biosyst Eng 2009, 32:459-466.
148. Sauer U. Evolutionary engineering of industrially important microbial phenotypes. Adv Biochem Eng Biotechnol 2001, 73:129-169.
149. 2 fixation and oil production through microalga. Energy Convers Manage 1995, 36:729-731.
150. Shapouri H., Gallagher P. USDA's 2002 ethanol cost-of-production survey. United States Department of Agriculture, Agricultural Economic Report Number 841 2005, July.
151. Shen Goh C., Lee K.T. A visionary and conceptual macroalgae-based third-generation bioethanol (TGB) biorefinery in Sabah, Malaysia as an underlay for renewable and sustainable development. Renew Sust Energ Rev 2010, 14:842-848.
152. Shi D.J., Wang C.L., Wang K.M. Genome shuffling to improve thermotolerance, ethanol tolerance and ethanol productivity of Saccharomyces cerevisiae. J Ind Microbiol Biotechnol 2009, 36:139-147.
153. Silalertruksa T., Gheewala S.H. Environmental sustainability assessment of bio-ethanol production in Thailand. Energy 2009, 34:1933-1946.
154. Silva J.P.A., Mussatto S.I., Roberto I.C. The influence of initial xylose concentration, agitation, and aeration on ethanol production by Pichia stipitis from rice straw hemicellulosic hydrolysate. Appl Biochem Biotechnol 2010, 10.1007/s12010-009-8867-6.
155. Silveira W.B., Passos F.J.V., Mantovani H.C., Passos F.M.L. Ethanol production from cheese whey permeate by Kluyveromyces marxianus UFV-3: a flux analysis of oxido-reductive metabolismas a function of lactose concentration and oxygen levels. Enzyme Microb Technol 2005, 36:930-936.
156. Sinício MF. Produção e utilização do etanol como carburante: Países que se destacam neste sector e recentes desenvolvimentos tecnológicos internacionais. PhD Thesis, Faculty of Mechanical Engineering, State University of Campinas, Campinas/SP, Brazil, 1997.
157. Solomon B.D., Barnes J.R., Halvorsen K.E. Grain and cellulosic ethanol: history, economics, and energy policy. Biomass Bioenerg 2007, 31:416-425.
158. Sonderegger M., Sauer U. Evolutionary engineering of Saccharomyces cerevisiae for anaerobic growth on xylose. Appl Environ Microbiol 2003, 69:1990-1998.
159. Song M., Ouyang Z., Liu Z.L. Discrete dynamical system modelling for gene regulatory networks of 5-hydroxymethylfurfural tolerance for ethanologenic yeast. IET Syst Biol 2009, 3:203-218.
160. Souza RR. Panorama, oportunidades e desafios para o mercado mundial de álcool automotivo. MSc Dissertation, Federal University of Rio de Janeiro, Rio de Janeiro/RJ, Brazil, 2006.
161. Stephanopoulos G. Challenges in engineering microbes for biofuels production. Science 2007, 315:801-804.
162. Sukumaran R.K., Surender V.J., Sindhu R., Binod P., Janu K.U., Sajna K.V., et al. Lignocellulosic ethanol in India: prospects, challenges and feedstock availability. Bioresour Technol 2010, 101:4826-4833.
163. Tabak J. Biofuels 2009, Infobase Publishing, New York.
164. Talebnia F., Taherzadeh M.J. In situ detoxification and continuous cultivation of dilute-acid hydrolyzate to ethanol by encapsulated S. cerevisiae. J Biotechnol 2006, 125:377-384.
165. Teixeira M.C., Raposo L.R., Mira N.P., Lourenço A.B., Sá-Correia I. Genome-wide identification of Saccharomyces cerevisiae genes required for maximal tolerance to ethanol. Appl Environ Microbiol 2009, 75:5761-5772.
166. Ueno Y., Kurano N., Miyachi S. Ethanol production by dark fermentation in the marine green alga, Chlorococcum littorale. J Ferment Bioeng 1998, 86:38-43.
167. Van Vleet J.H., Jeffries T.W. Yeast metabolic engineering for hemicellulosic ethanol production. Curr Opin Biotechnol 2009, 20:300-306.
168. van Voorst F., Houghton-Larsen J., Jønson L., Kielland-Brandt M.C., Brandt A. Genome-wide identification of genes required for growth of Saccharomyces cerevisiae under ethanol stress. Yeast 2006, 23:351-359.
169. Verbelen P.J., De Schutter D.P., Delvaux F., Verstrepen K.J., Delvaux F.R. Immobilized yeast cell systems for continuous fermentation applications. Biotechnol Lett 2006, 28:1515-1525.
170. Virkajärvi I., Linko M. Immobilization: a revolution in traditional brewing. Naturwissenschaften 1999, 86:112-122.
171. Von Sivers M., Zacchi G., Olsson L., Hahn-Hägerdal B. Cost analysis of ethanol from willow using recombinant Escherichia coli. Biotechnol Prog 1994, 10:555-560.
172. Walker T.L., Purton S., Becker D.K., Collet C. Microalgae as bioreactors. Plant Cell Rep 2005, 24:629-641.
173. Wang F.Z., Shen W., Rao Z.M., Fang H.Y., Zhan X.B., Zhuge J. Construction of a flocculating yeast for fuel ethanol production. Biotechnol Lett 2008, 30:97-102.
174. Wang D., Wang Z., Liu N., He X., Zhang B. Genetic modification of industrial yeast strains to obtain controllable NewFlo flocculation property and lower diacetyl production. Biotechnol Lett 2008, 30:2013-2018.
175. +-dependent xylitol dehydrogenase. J Biotechnol 2007, 130:316-319.
176. Wei P., Li Z., Lin Y., He P., Jiang N. Improvement of the multiple-stress tolerance of an ethanologenic Saccharomyces cerevisiae strain by freeze-thaw treatment. Biotechnol Lett 2007, 29:1501-1508.
177. Williams R.B., Jenkins B.M., Gildart M.C. Ethanol production potential and costs from lignocellulosic resources in California. 15th European Biomass Conference & Exhibition, Berlin, Germany 2007.
178. Wisselink H.W., Toirkens M.J., del Rosario F.B.M., Winkler A.A., van Dijken J.P., Pronk J.T., et al. Engineering of Saccharomyces cerevisiae for efficient anaerobic alcoholic fermentation of l-arabinose. Appl Environ Microbiol 2007, 73:4881-4891.
179. Wisselink H.W., Toirkens M.J., Wu Q., Pronk J.T., van Maris A.J. Novel evolutionary engineering approach for accelerated utilization of glucose, xylose, and arabinose mixtures by engineered Saccharomyces cerevisiae strains. Appl Environ Microbiol 2009, 75:907-914.
180. Wu C.Z., Yin X.L., Yuan Z.H., Zhou Z.Q., Zhuang X.S. The development of bioenergy technology in China. Energy 2009, 10.1016/j.energy.2009.04.006.
181. Wyman C.E. Biomass ethanol: technical progress, opportunities, and commercial challenges. Annu Rev Energ Env 1999, 24:189-226.
182. Xu T.J., Zhao X.Q., Bai F.W. Continuous ethanol production using self-flocculating yeast in a cascade of fermentors. Enz Microb Technol 2005, 37:634-640.
183. Yazawa H., Iwahashi H., Uemura H. Disruption of URA7 and GAL6 improves the ethanol tolerance and fermentation capacity of Saccharomyces cerevisiae. Yeast 2007, 24:551-560.
184. Yoshikawa K., Tanaka T., Furusawa C., Nagahisa K., Hirasawa T., Shimizu H. Comprehensive phenotypic analysis for identification of genes affecting growth under ethanol stress in Saccharomyces cerevisiae. FEMS Yeast Res 2009, 9:32-44.
185. Yu J., Zhang X., Tan T. An novel immobilization method of Saccharomyces cerevisiae to sorghum bagasse for ethanol production. J Biotechnol 2007, 129:415-420.
186. Yu J., Xuzhang, Tan T. Ethanol production by solid state fermentation of sweet sorghum using thermotolerant yeast strain. Fuel Process Technol 2008, 89:1056-1059.
187. Zanin G.M., Santana C.C., Bon E.P.S., Giordano R.C.L., Moraes F.F., Andrietta S.R., et al. Brazilian bioethanol program. Appl Biochem Biotechnol 2000, 84-86:1147-1161.
188. Zhao X.Q., Bai F.W. Yeast flocculation: new story in fuel ethanol production. Biotechnol Adv 2009, 27:849-856.
189. Zhao X.Q., Xue C., Ge X.M., Yuan W.J., Wang J.Y., Bai F.W. Impact of zinc supplementation on the improvement of ethanol tolerance and yield of self-flocculating yeast in continuous ethanol fermentation. J Biotechnol 2009, 139:55-60.
190. Zhou B., Martin G.J.O., Pamment N.B. Increased phenotypic stability and ethanol tolerance of recombinant Escherichia coli KO11 when immobilized in continuous fluidized bed culture. Biotechnol Bioeng 2008, 100:627-633.
191. Zhu J.Y., Pan X.J. Woody biomass pretreatment for cellulosic ethanol production: technology and energy consumption evaluation. Bioresour Technol 2010, 101:4992-5002.