The genomic, biochemical, and cellular responses of the retina in inherited photoreceptor degenerations and prospects for the treatment of these disorders

Annual Review of Neuroscience

Volumn 33, Issue , 2010, Pages 441-472

  Bramall, Alexa N ^a,b   Wright, Alan F ^d   Jacobson, Samuel G ^e   McInnes, Roderick R ^a,b,c  

^a HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c MCGILL UNIVERSITY   (Canada)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

^e UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

and cellular responses to mutation; biochemical; gene therapy; genomic; human histology; pathogenesis of photoreceptor death; retinal degeneration

Indexed keywords

ADENOVIRUS VECTOR; ANTIOXIDANT; ENDOTHELIN 2; NEUROTROPHIN; NEUROTROPHIN RPE65; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

AEROBIC METABOLISM; CELL THERAPY; CHEMICAL ANALYSIS; CYTOLOGY; GENE MUTATION; GENOMICS; HISTOPATHOLOGY; HUMAN; INHERITED PHOTORECEPTOR DEGENERATION; LEBER CONGENITAL AMAUROSIS; METABOLIC STRESS; MICROGLIA; MITOCHONDRION; MUELLER CELL; NERVE CELL NECROSIS; NONHUMAN; PHOTORECEPTOR; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN FOLDING; RETINA; RETINA BLOOD VESSEL; RETINA DEGENERATION; REVIEW; RNA PROCESSING; USHER SYNDROME; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; DISEASE MODELS, ANIMAL; GENE THERAPY; GENETIC PREDISPOSITION TO DISEASE; GENOMICS; HUMANS; NERVE DEGENERATION; PHOTORECEPTOR CELLS, VERTEBRATE; RETINAL DEGENERATION;

EID: 77956985453     PISSN: 0147006X     EISSN: 15454126     Source Type: Book Series    
DOI: 10.1146/annurev-neuro-060909-153227     Document Type: Review

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