Minocycline delayed photoreceptor death in the rds mice through iNOS-dependent mechanism

Molecular Vision

Volumn 13, Issue , 2007, Pages 1073-1082

  Yang, Li Ping ^a   Li, Ying ^a   Zhu, Xiu An ^a   Tso, Mark O M ^a,b  

^a PEKING UNIVERSITY   (China)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD11B ANTIGEN; CHEMOKINE; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; MINOCYCLINE; NITRIC OXIDE;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL MIGRATION; CONTROLLED STUDY; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; MICROGLIA; NEUROPROTECTION; NEWBORN; NICK END LABELING; NONHUMAN; PHOTORECEPTOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RETINA DEGENERATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; CELLS, CULTURED; CHEMOKINES; ENZYME INHIBITORS; MICE; MICE, MUTANT STRAINS; MICROGLIA; MINOCYCLINE; NITRIC OXIDE SYNTHASE TYPE II; PHOTORECEPTORS, VERTEBRATE; RETINA; RETINAL DEGENERATION; UP-REGULATION;

EID: 34447526586     PISSN: None     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Chang GQ, Hao Y, Wong F. Apoptosis: final common pathway of photoreceptor death in rd, rds, and rhodopsin mutant mice. Neuron 1993; 11:595-605.
2. Sanyal S, De Ruiter A, Hawkins RK. Development and degeneration of retina in rds mutant mice: light microscopy. J Comp Neurol 1980; 194:193-207.
3. Roque RS, Imperial CJ, Caldwell RB. Microglial cells invade the outer retina as photoreceptors degenerate in Royal College of Surgeons rats. Invest Ophthalmol Vis Sci 1996; 37:196-203.
4. Thanos S. Sick photoreceptors attract activated microglia from the ganglion cell layer: a model to study the inflammatory cascades in rats with inherited retinal dystrophy. Brain Res 1992; 588:21-8.
5. Zeng HY, Zhu XA, Zhang C, Yang LP, Wu LM, Tso MO. Identification of sequential events and factors associated with microglial activation, migration, and cytotoxicity in retinal degeneration in rd mice. Invest Ophthalmol Vis Sci 2005; 46:2992-9.
6. Ng TF, Streilein JW. Light-induced migration of retinal microglia into the subretinal space. Invest Ophthalmol Vis Sci 2001; 42:3301-10.
7. Hughes EH, Schlichtenbrede FC, Murphy CC, Sarra GM, Luthert PJ, Ali RR, DickAD. Generation of activated sialoadhesin-positive microglia during retinal degeneration. Invest Ophthalmol Vis Sci 2003; 44:2229-34.
8. Hughes EH, Schlichtenbrede FC, Murphy CC, Broderick C, van Rooijen N, Ali RR, Dick AD. Minocycline delays photoreceptor death in the rds mouse through a microglia-independent mechanism. Exp Eye Res 2004; 78:1077-84.
9. Lyons CR, Orloff GJ, Cunningham JM. Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line. J Biol Chem 1992; 267:6370-4.
10. Kim YJ, Hwang SY, Han IO. Insoluble matrix components of glioma cells suppress LPS-mediated iNOS/NO induction in microglia. Biochem Biophys Res Commun 2006; 347:731-8.
11. Nikodemova M, Duncan ID, Watters JJ. Minocycline exerts inhibitory effects on multiple mitogen-activated protein kinases and Ikappa Balpha degradation in a stimulus-specific manner in microglia. J Neurochem 2006; 96:314-23.
12. Yrjanheikki J, Tikka T, Keinanen R, Goldsteins G, Chan PH, Koistinaho J. A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window. Proc Natl Acad Sci U S A 1999; 96:13496-500.
13. Hoey S, Grabowski PS, Ralston SH, Forrester JV, Liversidge J. Nitric oxide accelerates the onset and increases the severity of experimental autoimmune uveoretinitis through an IFN-gamma- dependent mechanism. J Immunol 1997; 159:5132-42.
14. Chen M, Ona VO, Li M, Ferrante RJ, Fink KB, Zhu S, Bian J, Guo L, Farrell-LA, Hersch SM, Hobbs W, Vonsattel JP, Cha JH, Friedlander RM. Minocycline inhibits caspase- I and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease. Nat Med 2000; 6:797-801.
15. Wu DC, Jackson-Lewis V, Vila M, Men K, Teismann P, Vadseth C, Choi DK, Ischiropoulos H, Przedborski S. Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine mouse model of Parkinson disease. J Neurosci 2002; 22:1763-71.
16. Brundula V, Rewcastle NB, Metz LM, Bernard CC, Yong VW. Targeting leukocyte MMPs and transmigration: minocycline as a potential therapy for multiple sclerosis. Brain 2002; 125:1297-308.
17. Zhang C, Lei B, Lam TT, Yang F, Sinha D, Tso MO. Neuroprotection of photoreceptors by minocycline in light-induced retinal degeneration. Invest Ophthalmol Vis Sci 2004; 45:2753-9.
18. Wu M, Kusukawa N. SDS agarose gels for analysis of proteins. Biotechniques 1998; 24:676-8.
19. Kaufman PL, Gabelt BT. Cholinergic mechanisms and aqueous humor dynamics. In: Drance S, Neufeld A, Van Buskirk E, editors. Applied pharmacology of the glaucomas. Baltimore: Williams and Wilkins; 1992. p. 64-92.
20. Miyachi E, Murakami M, Nakaki T. Arginine blocks gap junctions between retinal horizontal cells. Neuroreport 1990; 1: 107-10.
21. Kurenny DE, Moroz LL, Turner RW, Sharkey KA, Barnes S. Modulation of ion channels in rod photoreceptors by nitric oxide. Neuron 1994; 13315-24.
22. Chao CC, Hu S, Sheng WS, Bu D, Bukrinsky MI, Peterson PK. Cytokine-stimulated astrocytes damage human neurons via a nitric oxide mechanism. Glia 1996; 16:276-84.
23. Cotinet A, Goureau O, Hicks D, Thillaye-Goldenberg B, de Kozak Y. Tumor necrosis factor and nitric oxide production by retinal Muller glial cells from rats exhibiting inherited retinal dystrophy. Glia 1997; 20:59-69.
24. Ehret-Hilberer S, Nullans G, Aunis D, Virmaux N. Mono ADP- ribosylation of transducin catalyzed by rod outer segment extract. FEBS Lett 1992; 309:394-8.
25. Beckman JS, Crow JP. Pathological implications of nitric oxide, superoxide and peroxynitrite formation. Biochem Soc Trans 1993; 21:330-4.
26. Foxman EF, Zhang M, Hurst SD, Muchamuel T. Shen D, Wawrousek EF, Chan CC, Gery I. Inflammatory mediators in uveitis: differential induction of cytokines and chemokines in Thl- versus Th2-mediated ocular inflammation. J Immunol 2002; 168:2483-92.
27. Zhang C, Shen JK, Lam TF, Zeng HY, Chiang SK, Yang F, Tso MO. Activation of microglia and chemoldnes in light-induced retinal degeneration. Mol Vis 2005; 11:887-95.
28. Ponath PD, Qin S, Ringler DJ, Clark-Lewis I, Wang J, Kassam N, Smith H, Shi X, Gonzalo JA, Newman W, Gutierrez-Ramos JC, Mackay CR. Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils. J Clin Invest 1996; 97:604-12.
29. Bakhiet M, Tjernlund A, Mousa A, Gad A, Stromblad S, Kuziel WA, Seiger A, Andersson J. RANTES promotes growth and survival of human first-trimester forebrain astrocytes. Nat Cell Biol 2001; 3:150-7.
30. Tikka TM, Koistinaho JE. Minocycline provides neuroprotection against N-methyl-D-aspartate neurotoxicity by inhibiting microglia. J Inummol 2001; 166:7527-33.
31. Zhu S, Stavrovskaya IG, Drozda M, Kim BY, Ona V, Li M, Sarang S, Liu AS, Hartley DM, Wu DC, Gullans S, Ferrante RJ, Przedborski S, Kristal BS, Friedlander RM. Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice. Nature 2002; 417:74-8.
32. Kim SS, Kong PJ, Kim BS, Sheen DH, Nam SY, Chun W. Inhibitory action of minocycline on lipopolysaccharide-induced release of nitric oxide and prostaglandin E2 in BV2 microglial cells. Arch Pharm Res 2004; 27:314-8.