Complement component 1Q (C1Q) upregulation in retina of murine, primate, and human glaucomatous eyes

Investigative Ophthalmology and Visual Science

Volumn 47, Issue 3, 2006, Pages 1024-1029

  Stasi, Kalliopi ^a   Nagel, Dalia ^a   Yang, Xiaoyan ^a   Wang, Rong Fang ^a   Ren, Lizhen ^a   Podos, Steven M ^a   Mittag, Thom ^a   Danias, John ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C1Q; COMPLEMENT COMPONENT C1Q ANTIBODY; MESSENGER RNA;

ADULT; AGED; ANIMAL CELL; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ARTICLE; BRAIN; CELL DEATH; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GLAUCOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LASER; MALE; MONKEY; MOUSE; MUELLER CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIMATE; PRIORITY JOURNAL; RETINA; RETINA GANGLION CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; UPREGULATION; ANIMAL; C57BL MOUSE; DBA MOUSE; DISEASE MODEL; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; MACACA; METABOLISM; MIDDLE AGED; PATHOLOGY;

ANIMALS; CELL DEATH; COMPLEMENT C1Q; DISEASE MODELS, ANIMAL; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GLAUCOMA; HUMANS; IMMUNOBLOTTING; MACACA FASCICULARIS; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MIDDLE AGED; RETINA; RETINAL GANGLION CELLS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; UP-REGULATION;

EID: 33645402376     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.05-0830     Document Type: Article

References (25)

1. Volanakis JE, Frank MM. The Human Complement System in Health and Disease. New York: Marcel Dekker Inc.; 1998.
2. Eggleton P, Reid KB, Tenner AJ. C1q-how many functions? How many receptors? Trends Cell Biol. 1998;8:428-431.
3. Kishore U, Reid KB. C1q: structure, function, and receptors. Immunopharmacology. 2000;49:159-170.
4. Yasojima K, Schwab C, McGeer EG, McGeer PL. Human heart generates complement proteins that are upregulated and activated after myocardial infarction. Circ Res. 1998;83:860-869.
5. Johnson SA, Pasinetti GM, Finch CE. Expression of complement C1qB and C4 mRNAs during rat brain development. Brain Res Dev Brain Res. 1994;80:163-174.
6. Goldsmith SK, Wals P, Rozovsky I, Morgan TE, Finch CE. Kainic acid and decorticating lesions stimulate the synthesis of C1q protein in adult rat brain. J Neurochem. 1997;68:2046-2052.
7. Dandoy-Dron F, Guillo F, Benboudjema L, et al. Gene expression in scrapie: cloning of a new scrapie-responsive gene and the identification of increased levels of seven other mRNA transcripts. J Biol Chem. 1998;273:7691-7697.
8. Mabbott NA, Bruce ME, Botto M, Walport MJ, Pepys MB. Temporary depletion of complement component C3 or genetic deficiency of C1q significantly delays onset of scrapie. Nat Med. 2001;7:485-487.
9. Emmerling MR, Watson MD, Raby CA, Spiegel K. The role of complement in Alzheimer's disease pathology. Biochim Biophys Acta. 2000;1502:158-171.
10. Head E, Azizeh BY, Lott IT, Tenner AJ, Cotman CW, Cribbs DH. Complement association with neurons and beta-amyloid deposition in the brains of aged individuals with Down syndrome. Neurobiol Dis. 2001;8:252-265.
11. Itagaki S, Akiyama H, Saito H, McGeer PL. Ultrastructural localization of complement membrane attack complex (MAC)-like immunoreactivity in brains of patients with Alzheimer's disease. Brain Res. 1994;645:78-84.
12. Yasojima K, McGeer EG, McGeer PL. Complement regulators C1 inhibitor and CD59 do not significantly inhibit complement activation in Alzheimer disease. Brain Res. 1999;833:297-301.
13. Afagh A, Cummings BJ, Cribbs DH, Cotman CW, Tenner AJ. Localization and cell association of C1q in Alzheimer's disease brain. Exp Neurol. 1996;138:22-32.
14. Webster SD, Yang AJ, Margol L, Garzon-Rodriguez W, Glabe CG, Tenner AJ. Complement component C1q modulates the phagocytosis of Abeta by microglia. Exp Neurol. 2000;161:127-138.
15. Miyahara T, Kikuchi T, Akimoto M, Kurokawa T, Shibuki H, Yoshimura N. Gene microarray analysis of experimental glaucomatous retina from cynomolgus monkey. Invest Ophthalmol Vis Sci. 2003;44:4347-4356.
16. Ahmed F, Brown KM, Stephan DA, Morrison JC, Johnson EC, Tomarev SI. Microarray analysis of changes in mRNA levels in the rat retina after experimental elevation of intraocular pressure. Invest Ophthalmol Vis Sci. 2004;45:1247-1258.
17. Danias J, Lee KC, Zamora MF, et al. Quantitative analysis of retinal ganglion cell (RGC) loss in aging DBA/2NNia glaucomatous mice: comparison with RGC loss in aging C57/BL6 mice. Invest Ophthalmol Vis Sci. 2003;44:5151-5162.
18. Reid KB, Porter RR. Subunit composition and structure of subcomponent C1q of the first component of human complement. Biochem J. 1976;155:19-23.
19. Reid KB, Lowe DM, Porter RR. Isolation and characterization of C1q, a subcomponent of the first component of complement, from human and rabbit sera. Biochem J. 1972;130:749-763.
20. Botto M, Dell'Agnola C, Bygrave AE, et al. Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies. Nat Genet. 1998;19:56-59.
21. Arlaud GJ, Gaboriaud C, Thielens NM, Rossi V. Structural biology of C1. Biochem Soc Trans. 2001;30:1001-1006.
22. Arlaud GJ, Gaboriaud C, Thielens NM, Budayova-Spano M, Rossi V, Fontecilla-Camps JC. Structural biology of the C1 complex of complement unveils the mechanisms of its activation and proteolytic activity. Mol Immunol. 2002;39:383-394.
23. Reid KB. Chemistry and molecular genetics of C1q. Behring Inst Mitt. 1989;84:8-19.
24. John SW, Smith RS, Savinova OV, et al. Essential iris atrophy, pigment dispersion, and glaucoma in DBA/2J mice. Invest Ophthalmol Vis Sci. 1998;39:951-962.
25. Mo JS, Anderson MG, Gregory M, et al. By altering ocular immune privilege, bone marrow-derived cells pathogenically contribute to DBA/2J pigmentary glaucoma. J Exp Med. 2003;197:1335-1344.