메뉴 건너뛰기




Volumn 101, Issue 6, 2007, Pages 1619-1631

'Mild Uncoupling' does not decrease mitochondrial superoxide levels in cultured cerebellar granule neurons but decreases spare respiratory capacity and increases toxicity to glutamate and oxidative stress

Author keywords

Calcium; Glutamate; Mitochondria; Mitochondrial membrane potential; Oxidative stress; Superoxide

Indexed keywords

CALCIUM; CARBONYL CYANIDE 4 (TRIFLUOROMETHOXY)PHENYLHYDRAZONE; FLUORESCENT DYE; GLUTAMIC ACID; HYDROETHIDINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; SUPEROXIDE;

EID: 34249781383     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2007.04516.x     Document Type: Article
Times cited : (145)

References (53)
  • 1
    • 1642499152 scopus 로고    scopus 로고
    • β-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase
    • Abramov A. Y., Canevari L. Duchen M. R. (2004) β-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase. J. Neurosci. 24, 565 575.
    • (2004) J. Neurosci. , vol.24 , pp. 565-575
    • Abramov, A.Y.1    Canevari, L.2    Duchen, M.R.3
  • 2
    • 27644448810 scopus 로고    scopus 로고
    • Mitochondrial uncoupling proteins in the CNS: in support of function and survival
    • Andrews Z. B., Diano S. Horvath T. L. (2005a) Mitochondrial uncoupling proteins in the CNS: in support of function and survival. Nat. Rev. Neurosci. 6, 829 840.
    • (2005) Nat. Rev. Neurosci. , vol.6 , pp. 829-840
    • Andrews, Z.B.1    Diano, S.2    Horvath, T.L.3
  • 4
    • 0029125857 scopus 로고
    • Aging, energy, and oxidative stress in neurodegenerative diseases
    • Beal M. F. (1995) Aging, energy, and oxidative stress in neurodegenerative diseases. Ann. Neurol. 38, 357 366.
    • (1995) Ann. Neurol. , vol.38 , pp. 357-366
    • Beal, M.F.1
  • 5
    • 0030273295 scopus 로고    scopus 로고
    • Mitochondria, free radicals, and neurodegeneration
    • Beal M. F. (1996) Mitochondria, free radicals, and neurodegeneration. Curr. Opin. Neurobiol. 6, 661 666.
    • (1996) Curr. Opin. Neurobiol. , vol.6 , pp. 661-666
    • Beal, M.F.1
  • 6
    • 0026687312 scopus 로고
    • Modulation of the mitochondrial permeability transition pore. Effect of protons and divalent cations
    • Bernardi P., Vassanelli S., Veronese P., Colonna R., Szabo I. Zoratti M. (1992) Modulation of the mitochondrial permeability transition pore. Effect of protons and divalent cations. J Biol Chem. 267, 2934 2939.
    • (1992) J Biol Chem. , vol.267 , pp. 2934-2939
    • Bernardi, P.1    Vassanelli, S.2    Veronese, P.3    Colonna, R.4    Szabo, I.5    Zoratti, M.6
  • 7
    • 27844484309 scopus 로고    scopus 로고
    • The efficiency and plasticity of mitochondrial energy transduction
    • Brand M. D. (2005) The efficiency and plasticity of mitochondrial energy transduction. Biochem. Soc. Trans. 33, 897 904.
    • (2005) Biochem. Soc. Trans. , vol.33 , pp. 897-904
    • Brand, M.D.1
  • 9
    • 0029827804 scopus 로고    scopus 로고
    • Mitochondrial calcium regulation and acute glutamate excitotoxicity in cultured cerebellar granule cells
    • Budd S. L. Nicholls D. G. (1996) Mitochondrial calcium regulation and acute glutamate excitotoxicity in cultured cerebellar granule cells. J. Neurochem. 67, 2282 2291.
    • (1996) J. Neurochem. , vol.67 , pp. 2282-2291
    • Budd, S.L.1    Nicholls, D.G.2
  • 10
    • 0032535275 scopus 로고    scopus 로고
    • Mitochondrial control of acute glutamate excitotoxicity in cultured cerebellar granule cells
    • Castilho R. F., Hansson O., Ward M. W., Budd S. L. Nicholls D. G. (1998) Mitochondrial control of acute glutamate excitotoxicity in cultured cerebellar granule cells. J. Neurosci. 18, 10 277 10 286.
    • (1998) J. Neurosci. , vol.18 , pp. 10277-10286
    • Castilho, R.F.1    Hansson, O.2    Ward, M.W.3    Budd, S.L.4    Nicholls, D.G.5
  • 11
    • 5444219563 scopus 로고    scopus 로고
    • Inhibition of glutamate-induced delayed calcium deregulation by 2-APB and La3+ in cultured cortical neurones
    • Chinopoulos C., Gerencser A. A., Doczi J., Fiskum G. dam-Vizi V. (2004) Inhibition of glutamate-induced delayed calcium deregulation by 2-APB and La3+ in cultured cortical neurones. J Neurochem. 91, 471 483.
    • (2004) J Neurochem. , vol.91 , pp. 471-483
    • Chinopoulos, C.1    Gerencser, A.A.2    Doczi, J.3    Fiskum, G.4    Dam-Vizi, V.5
  • 12
    • 20244377700 scopus 로고    scopus 로고
    • Uncoupling protein 2 protects dopaminergic neurons from acute 1,2,3,6-methyl-phenyl-tetrahydropyridine toxicity
    • Conti B., Sugama S., Lucero J. et al. (2005) Uncoupling protein 2 protects dopaminergic neurons from acute 1,2,3,6-methyl-phenyl- tetrahydropyridine toxicity. J. Neurochem. 93, 493 501.
    • (2005) J. Neurochem. , vol.93 , pp. 493-501
    • Conti, B.1    Sugama, S.2    Lucero, J.3
  • 13
    • 0025580921 scopus 로고
    • The interactions between plasma membrane depolarization and glutamate receptor activation in the regulation of cytoplasmic free calcium in cultured cerebellar granule cells
    • Courtney M. J., Lambert J. J. Nicholls D. G. (1990) The interactions between plasma membrane depolarization and glutamate receptor activation in the regulation of cytoplasmic free calcium in cultured cerebellar granule cells. J. Neurosci. 10, 3873 3879.
    • (1990) J. Neurosci. , vol.10 , pp. 3873-3879
    • Courtney, M.J.1    Lambert, J.J.2    Nicholls, D.G.3
  • 14
    • 0027686249 scopus 로고
    • Oxidative stress, glutamate and neurodegenerative disorders
    • Coyle J. T. Puttfarcken P. S. (1993) Oxidative stress, glutamate and neurodegenerative disorders. Science 262, 689 695.
    • (1993) Science , vol.262 , pp. 689-695
    • Coyle, J.T.1    Puttfarcken, P.S.2
  • 15
    • 0242468451 scopus 로고    scopus 로고
    • Uncoupling protein 2 prevents neuronal death including that occurring during seizures: a mechanism for preconditioning
    • Diano S., Matthews R. T., Patrylo P., Yang L., Beal M. F., Barnstable C. J. Horvath T. L. (2003) Uncoupling protein 2 prevents neuronal death including that occurring during seizures: a mechanism for preconditioning. Endocrinology 144, 5014 5021.
    • (2003) Endocrinology , vol.144 , pp. 5014-5021
    • Diano, S.1    Matthews, R.T.2    Patrylo, P.3    Yang, L.4    Beal, M.F.5    Barnstable, C.J.6    Horvath, T.L.7
  • 17
    • 0037716303 scopus 로고    scopus 로고
    • Mitochondrial uncoupling protein 2 in the central nervous system: neuromodulator and neuroprotector
    • Horvath T. L., Diano S. Barnstable C. (2003) Mitochondrial uncoupling protein 2 in the central nervous system: neuromodulator and neuroprotector. Biochem. Pharmacol. 65, 1917 1921.
    • (2003) Biochem. Pharmacol. , vol.65 , pp. 1917-1921
    • Horvath, T.L.1    Diano, S.2    Barnstable, C.3
  • 19
    • 3543030406 scopus 로고    scopus 로고
    • In situ respiration and bioenergetic status of mitochondria in primary cerebellar granule neuronal cultures exposed continuously to glutamate
    • Jekabsons M. B. Nicholls D. G. (2004) In situ respiration and bioenergetic status of mitochondria in primary cerebellar granule neuronal cultures exposed continuously to glutamate. J. Biol. Chem. 279, 32 989 33 000.
    • (2004) J. Biol. Chem. , vol.279 , pp. 32989-33000
    • Jekabsons, M.B.1    Nicholls, D.G.2
  • 20
    • 33747149006 scopus 로고    scopus 로고
    • Bioenergetic analysis of cerebellar granule neurons undergoing apoptosis by potassium/serum deprivation
    • Jekabsons M. B. Nicholls D. G. (2006) Bioenergetic analysis of cerebellar granule neurons undergoing apoptosis by potassium/serum deprivation. Cell Death Differ. 13, 1595 1610.
    • (2006) Cell Death Differ. , vol.13 , pp. 1595-1610
    • Jekabsons, M.B.1    Nicholls, D.G.2
  • 21
    • 34249806883 scopus 로고    scopus 로고
    • The mitochondrial uncoupler 2,4-dinitrophenol attenuates tissue damage and improves mitochondrial homeostasis following transient focal cerebral ischemia
    • Korde A. S., Pettigrew L. C., Craddock S. D. Maragos W. F. (2005) The mitochondrial uncoupler 2,4-dinitrophenol attenuates tissue damage and improves mitochondrial homeostasis following transient focal cerebral ischemia. J. Neurochem. 91, 257 262.
    • (2005) J. Neurochem. , vol.91 , pp. 257-262
    • Korde, A.S.1    Pettigrew, L.C.2    Craddock, S.D.3    Maragos, W.F.4
  • 22
    • 0030729851 scopus 로고    scopus 로고
    • High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria
    • Korshunov S. S., Skulachev V. P. Starkov A. A. (1997) High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria. FEBS Lett. 416, 15 18.
    • (1997) FEBS Lett. , vol.416 , pp. 15-18
    • Korshunov, S.S.1    Skulachev, V.P.2    Starkov, A.A.3
  • 23
    • 4043090717 scopus 로고    scopus 로고
    • Superoxide production by NADH: ubiquinone oxidoreductase (complex I) depends on the pH gradient across the mitochondrial inner membrane
    • Lambert A. J. Brand M. D. (2004) Superoxide production by NADH: ubiquinone oxidoreductase (complex I) depends on the pH gradient across the mitochondrial inner membrane. Biochem. J. 382, 511 517.
    • (2004) Biochem. J. , vol.382 , pp. 511-517
    • Lambert, A.J.1    Brand, M.D.2
  • 24
    • 0041464712 scopus 로고    scopus 로고
    • Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma
    • Mattiasson G., Shamloo M., Gido G. et al. (2003) Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma. Nature Med. 9, 1062 1068.
    • (2003) Nature Med. , vol.9 , pp. 1062-1068
    • Mattiasson, G.1    Shamloo, M.2    Gido, G.3
  • 25
    • 0037253404 scopus 로고    scopus 로고
    • The 'novel''uncoupling' proteins UCP2 and UCP3: what do they really do? Pros and cons for suggested functions
    • Nedergaard J. Cannon B. (2003) The 'novel''uncoupling' proteins UCP2 and UCP3: what do they really do? Pros and cons for suggested functions Exp. Physiol 88, 65 84.
    • (2003) Exp. Physiol , vol.88 , pp. 65-84
    • Nedergaard, J.1    Cannon, B.2
  • 26
    • 0017638174 scopus 로고
    • The effective proton conductances of the inner membrane of mitochondria from brown adipose tissue: dependency on proton electrochemical gradient
    • Nicholls D. G. (1977) The effective proton conductances of the inner membrane of mitochondria from brown adipose tissue: dependency on proton electrochemical gradient. Eur. J. Biochem. 77, 349 356.
    • (1977) Eur. J. Biochem. , vol.77 , pp. 349-356
    • Nicholls, D.G.1
  • 27
    • 1842430709 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and glutamate excitotoxicity studied in primary neuronal cultures
    • Nicholls D. G. (2004) Mitochondrial dysfunction and glutamate excitotoxicity studied in primary neuronal cultures. Curr. Mol. Med. 4, 149 177.
    • (2004) Curr. Mol. Med. , vol.4 , pp. 149-177
    • Nicholls, D.G.1
  • 28
    • 33744952060 scopus 로고    scopus 로고
    • Simultaneous monitoring of ionophore- and inhibitor-mediated plasma and mitochondrial membrane potential changes in cultured neurons
    • Nicholls D. G. (2006a) Simultaneous monitoring of ionophore- and inhibitor-mediated plasma and mitochondrial membrane potential changes in cultured neurons. J. Biol. Chem. 281, 14 864 14 874.
    • (2006) J. Biol. Chem. , vol.281 , pp. 14864-14874
    • Nicholls, D.G.1
  • 29
    • 33745615380 scopus 로고    scopus 로고
    • The physiological regulation of uncoupling proteins
    • Nicholls D. G. (2006b) The physiological regulation of uncoupling proteins. Biochim. Biophys. Acta Bio-Energetics 1757, 459 466.
    • (2006) Biochim. Biophys. Acta Bio-Energetics , vol.1757 , pp. 459-466
    • Nicholls, D.G.1
  • 30
    • 0017373769 scopus 로고
    • Inter-relationships between proton electrochemical gradient, adenine nucleotide phosphorylation potential and respiration during substrate-level and oxidative phosphorylation by mitochondria from brown adipose tissue of cold-adapted guinea-pigs
    • Nicholls D. G. Bernson V. S. M. (1977) Inter-relationships between proton electrochemical gradient, adenine nucleotide phosphorylation potential and respiration during substrate-level and oxidative phosphorylation by mitochondria from brown adipose tissue of cold-adapted guinea-pigs. Eur. J. Biochem. 75, 601 612.
    • (1977) Eur. J. Biochem. , vol.75 , pp. 601-612
    • Nicholls, D.G.1    Bernson, V.S.M.2
  • 31
    • 34249810794 scopus 로고    scopus 로고
    • Metabotropic glutamate receptors, protein kinase C and the control of glutamate exocytosis
    • in. Moroni, F., Nicoletti, F. Pellegrini, D., eds. pp. Portland Press, London.
    • Nicholls D. G., McLaughlin M. Budd D. C. (1998) Metabotropic glutamate receptors, protein kinase C and the control of glutamate exocytosis, in Metabotropic Glutamate Receptors and Brain Function (Moroni F., Nicoletti F. Pellegrini D., eds pp. 179 190. Portland Press, London.
    • (1998) Metabotropic Glutamate Receptors and Brain Function , pp. 179-190
    • Nicholls, D.G.1    McLaughlin, M.2    Budd, D.C.3
  • 32
    • 0030298459 scopus 로고    scopus 로고
    • Cyclosporin a delays mitochondrial depolarization induced by N-methyl-D-aspaparte in cortical neurons: evidence of the mitochondrial permeability transition
    • Nieminen A. L., Petrie T. G., Lemasters J. J. Selman W. R. (1996) Cyclosporin a delays mitochondrial depolarization induced by N-methyl-D-aspaparte in cortical neurons: evidence of the mitochondrial permeability transition. Neurosci. 75, 993 997.
    • (1996) Neurosci. , vol.75 , pp. 993-997
    • Nieminen, A.L.1    Petrie, T.G.2    Lemasters, J.J.3    Selman, W.R.4
  • 33
    • 3042595335 scopus 로고    scopus 로고
    • Excitotoxic calcium overload in a subpopulation of mitochondria triggers delayed death in hippocampal neurons
    • Pivovarova N. B., Nguyen H. V., Winters C. A., Brantner C. A., Smith C. L. Andrews S. B. (2004) Excitotoxic calcium overload in a subpopulation of mitochondria triggers delayed death in hippocampal neurons. J. Neurosci. 24, 5611 5622.
    • (2004) J. Neurosci. , vol.24 , pp. 5611-5622
    • Pivovarova, N.B.1    Nguyen, H.V.2    Winters, C.A.3    Brantner, C.A.4    Smith, C.L.5    Andrews, S.B.6
  • 34
    • 0034661024 scopus 로고    scopus 로고
    • Superoxides from mitochondrial complex III: the role of manganese superoxide dismutase
    • Raha S., McEachern G. E., Myint A. T. Robinson B. H. (2000) Superoxides from mitochondrial complex III: the role of manganese superoxide dismutase. Free Radic. Biol. Med. 29, 170 180.
    • (2000) Free Radic. Biol. Med. , vol.29 , pp. 170-180
    • Raha, S.1    McEachern, G.E.2    Myint, A.T.3    Robinson, B.H.4
  • 35
    • 0141705360 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and reactive oxygen species in excitotoxicity and apoptosis: Implications for the pathogenesis of neurodegenerative diseases
    • Rego A. C. Oliveira C. R. (2003) Mitochondrial dysfunction and reactive oxygen species in excitotoxicity and apoptosis: Implications for the pathogenesis of neurodegenerative diseases. Neurochem. Res. 28, 1563 1574.
    • (2003) Neurochem. Res. , vol.28 , pp. 1563-1574
    • Rego, A.C.1    Oliveira, C.R.2
  • 36
    • 0029064518 scopus 로고
    • Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation
    • Reynolds I. J. Hastings T. G. (1995) Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation. J. Neurosci. 15, 3318 3327.
    • (1995) J. Neurosci. , vol.15 , pp. 3318-3327
    • Reynolds, I.J.1    Hastings, T.G.2
  • 37
    • 0021207554 scopus 로고
    • Membrane potential and surface potential in mitochondria: uptake and binding of lipophilic cations
    • Rottenberg H. (1984) Membrane potential and surface potential in mitochondria: uptake and binding of lipophilic cations. J. Membr. Biol. 81, 127 138.
    • (1984) J. Membr. Biol. , vol.81 , pp. 127-138
    • Rottenberg, H.1
  • 39
    • 0029810095 scopus 로고    scopus 로고
    • Mitochondrial dysfunction is a primary event in glutamate excitotoxicity
    • Schinder A. F., Olson E. C., Spitzer N. C. Montal M. (1996) Mitochondrial dysfunction is a primary event in glutamate excitotoxicity. J. Neurosci. 16, 6125 6133.
    • (1996) J. Neurosci. , vol.16 , pp. 6125-6133
    • Schinder, A.F.1    Olson, E.C.2    Spitzer, N.C.3    Montal, M.4
  • 40
    • 0031869004 scopus 로고    scopus 로고
    • NMDA-induced superoxide production and neurotoxicity in cultured rat hippocampal neurons: role of mitochondria
    • Sengpiel B., Preis E., Krieglstein J. Prehn J. H. M. (1998) NMDA-induced superoxide production and neurotoxicity in cultured rat hippocampal neurons: role of mitochondria. Eur. J. Neurosci. 10, 1903 1910.
    • (1998) Eur. J. Neurosci. , vol.10 , pp. 1903-1910
    • Sengpiel, B.1    Preis, E.2    Krieglstein, J.3    Prehn, J.H.M.4
  • 41
    • 0141482026 scopus 로고    scopus 로고
    • The production of reactive oxygen species in intact isolated nerve terminals is independent of the mitochondrial membrane potential
    • Sipos I., Tretter L. Adam-Vizi V. (2003) The production of reactive oxygen species in intact isolated nerve terminals is independent of the mitochondrial membrane potential. Neurochem. Res. 28, 1575 1581.
    • (2003) Neurochem. Res. , vol.28 , pp. 1575-1581
    • Sipos, I.1    Tretter, L.2    Adam-Vizi, V.3
  • 42
    • 0037160091 scopus 로고    scopus 로고
    • Topology of superoxide production from different sites in the mitochondrial electron transport chain
    • St Pierre J., Buckingham J. A., Roebuck S. J. Brand M. D. (2002) Topology of superoxide production from different sites in the mitochondrial electron transport chain. J. Biol. Chem. 277, 44 784 44 790.
    • (2002) J. Biol. Chem. , vol.277 , pp. 44784-44790
    • St Pierre, J.1    Buckingham, J.A.2    Roebuck, S.J.3    Brand, M.D.4
  • 43
    • 0034811384 scopus 로고    scopus 로고
    • Myxothiazol induces H2O2 production from mitochondrial respiratory chain
    • Starkov A. A. Fiskum G. (2001) Myxothiazol induces H2O2 production from mitochondrial respiratory chain. Biochem. Biophys. Res. Commun. 281, 645 650.
    • (2001) Biochem. Biophys. Res. Commun. , vol.281 , pp. 645-650
    • Starkov, A.A.1    Fiskum, G.2
  • 45
    • 33947592809 scopus 로고    scopus 로고
    • Moderate dependence of ROS formation on DeltaPsim in isolated brain mitochondria supported by NADH-linked substrates
    • in press).
    • Tretter L. Adam-Vizi V. (2007) Moderate dependence of ROS formation on DeltaPsim in isolated brain mitochondria supported by NADH-linked substrates. Neurochem. Res. (in press).
    • (2007) Neurochem. Res.
    • Tretter, L.1    Adam-Vizi, V.2
  • 46
    • 0033199019 scopus 로고    scopus 로고
    • Glutamate-induced mitochondrial depolarization and perturbation of calcium homeostasis in cultured rat hippocampal neurones
    • Vergun O., Keelan J., Khodorov B. I. Duchen M. R. (1999) Glutamate-induced mitochondrial depolarization and perturbation of calcium homeostasis in cultured rat hippocampal neurones. J. Physiol. (Lond.) 519, 451 466.
    • (1999) J. Physiol. (Lond.) , vol.519 , pp. 451-466
    • Vergun, O.1    Keelan, J.2    Khodorov, B.I.3    Duchen, M.R.4
  • 47
    • 3342941452 scopus 로고    scopus 로고
    • Relationships between superoxide levels and delayed calcium deregulation in cultured cerebellar granule cells exposed continuously to glutamate
    • Vesce S., Kirk L. Nicholls D. G. (2004) Relationships between superoxide levels and delayed calcium deregulation in cultured cerebellar granule cells exposed continuously to glutamate. J. Neurochem. 90, 683 693.
    • (2004) J. Neurochem. , vol.90 , pp. 683-693
    • Vesce, S.1    Kirk, L.2    Nicholls, D.G.3
  • 48
    • 33644688266 scopus 로고    scopus 로고
    • Acute glutathione depletion restricts mitochondrial ATP export in cerebellar granule neurons
    • Vesce S., Jekabsons M. B., Johnson-Cadwell L. I. Nicholls D. G. (2005) Acute glutathione depletion restricts mitochondrial ATP export in cerebellar granule neurons. J. Biol. Chem. 280, 38 720 38 728.
    • (2005) J. Biol. Chem. , vol.280 , pp. 38720-38728
    • Vesce, S.1    Jekabsons, M.B.2    Johnson-Cadwell, L.I.3    Nicholls, D.G.4
  • 49
    • 0034740585 scopus 로고    scopus 로고
    • Deltapsim-dependent and -independent production of reactive oxygen species by rat brain mitochondria
    • Votyakova T. V. Reynolds I. J. (2001) Deltapsim-dependent and -independent production of reactive oxygen species by rat brain mitochondria. J. Neurochem. 79, 266 277.
    • (2001) J. Neurochem. , vol.79 , pp. 266-277
    • Votyakova, T.V.1    Reynolds, I.J.2
  • 50
    • 33845310692 scopus 로고    scopus 로고
    • The permeability transition pore is not a prerequisite for glutamate-induced calcium deregulation and mitochondrial depolarization in brain neurons
    • Wabnitz A. V., Storozhevykh T. P., Senilova Y. E., Pinelis V. G. Khodorov B. I. (2006) The permeability transition pore is not a prerequisite for glutamate-induced calcium deregulation and mitochondrial depolarization in brain neurons. Biol. Membranes 22, 346 350.
    • (2006) Biol. Membranes , vol.22 , pp. 346-350
    • Wabnitz, A.V.1    Storozhevykh, T.P.2    Senilova, Y.E.3    Pinelis, V.G.4    Khodorov, B.I.5
  • 51
    • 0034307759 scopus 로고    scopus 로고
    • Mitochondrial membrane potential and glutamate excitotoxicity in cultured cerebellar granule cells
    • Ward M. W., Rego A. C., Frenguelli B. G. Nicholls D. G. (2000) Mitochondrial membrane potential and glutamate excitotoxicity in cultured cerebellar granule cells. J. Neurosci. 20, 7208 7219.
    • (2000) J. Neurosci. , vol.20 , pp. 7208-7219
    • Ward, M.W.1    Rego, A.C.2    Frenguelli, B.G.3    Nicholls, D.G.4
  • 52
    • 0028985491 scopus 로고
    • Mitochondria and Na+/Ca2+ exchange buffer glutamate- induced calcium loads in cultured cortical neurons
    • White R. J. Reynolds I. J. (1995) Mitochondria and Na+/Ca2+ exchange buffer glutamate- induced calcium loads in cultured cortical neurons. J. Neurosci. 15, 1318 1328.
    • (1995) J. Neurosci. , vol.15 , pp. 1318-1328
    • White, R.J.1    Reynolds, I.J.2
  • 53
    • 0029788243 scopus 로고    scopus 로고
    • Mitochondrial depolarization in glutamate-stimulated neurons: An early signal specific to excitotoxin exposure
    • White R. J. Reynolds I. J. (1996) Mitochondrial depolarization in glutamate-stimulated neurons: An early signal specific to excitotoxin exposure. J. Neurosci. 16, 5688 5697.
    • (1996) J. Neurosci. , vol.16 , pp. 5688-5697
    • White, R.J.1    Reynolds, I.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.