Mitochondria control AMPA/kainate receptor-induced cytoplasmic calcium deregulation in rat cerebellar granule cells

Journal of Neuroscience

Volumn 21, Issue 6, 2001, Pages 1893-1901

  Rego, A Cristina ^a,b   Ward, Manus W ^a,c   Nicholls, David G ^a  

^a BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Calcium; Cerebellar granule cells; Glutamate excitotoxicity; Glutamate receptors; Kainate; Mitochondrial membrane potential; NMDA

Indexed keywords

AMPA RECEPTOR; CALCIUM; GLUTAMATE RECEPTOR; GLUTAMIC ACID; KAINIC ACID; KAINIC ACID RECEPTOR; LACTIC ACID; N METHYL DEXTRO ASPARTIC ACID; OLIGOMYCIN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; PYRUVIC ACID; SODIUM CHANNEL; VERATRIDINE;

ANIMAL CELL; ARTICLE; CALCIUM HOMEOSTASIS; CELL PROTECTION; CYTOPLASM; GRANULE CELL; MEMBRANE DEPOLARIZATION; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; RAT; SODIUM TRANSPORT;

EID: 0035869336     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-06-01893.2001     Document Type: Article

References (58)

1. Excitotoxic degeneration is initiated at non-random sites in cultured rat cerebellar neurons
2. Ca entry via AMPA/KA receptors and excitotoxicity in cultured cerebellar Purkinje cells
3. A re-evaluation of the role of mitochondria in neuronal calcium homeostasis
4. Mitochondrial calcium regulation and acute glutamate excitotoxicity in cultured cerebellar granule cells
5. Influx and efflux kinetics of cationic dye binding to respiring mitochondria
6. 2+ rises and consequent oxygen radical production
7. 2+ overload and ROS generation in spinal motor neurons in vitro
8. Mitochondrial control of acute glutamate excitotoxicity in cultured cerebellar granule cells
9. Oxidative stress, mitochondrial function and acute glutamate excitotoxicity in cultured cerebellar granule cells
10. AMPA neurotoxicity in cultured cerebellar granule neurons: Mode of cell death
11. Kainate-induced apoptosis correlates with c-Jun activation in cultured cerebellar granule cells
12. Ionic dependence of glutamate neurotoxicity
13. + influx in rat cortical cultures
14. Growth conditions differentially regulate the expression of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptor subunits in cultured neurons
15. The interactions between plasma membrane depolarization and glutamate receptor activation in the regulation of cytoplasmic free calcium in cultured cerebellar granule cells
16. The calcium response to the excitotoxin kainate is amplified by subsequent reduction of extracellular sodium
17. Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis
18. Membrane potential can be determined in individual cells from the nernstian distribution of cationic dyes
19. Bioenergetics and glutamate excito-toxicity
20. 2+ influx studies
21. Excitotoxicity as a consequence of impairment of energy metabolism: The energy-linked excitotoxic hypothesis
22. Cloned glutamate receptors
23. 2+ independently of voltage gated Ca channels in rat cerebellar granule cells
24. Coupling of glutamatergic receptors to changes in intracellular Ca in cerebellar granule cells in primary culture
25. 2+ changes in rat forebrain neurones
26. Ionized intracellular calcium concentration predicts excitotoxic neuronal death: Observations with low-affinity fluorescent calcium indicators
27. +
28. Localization of mitochondria in living cells with rhodamine 123
29. Developmental time course and ionic dependence of kainate-mediated toxicity in rat cerebellar granule cell cultures
30. 2+ as a tool to study calcium influx pathways
31. The difference between mechanisms of kainate and glutamate excitotoxicity in vitro: Osmotic lesion versus mitochondrial depolarization
32. Glutamate impairs neuronal calcium extrusion while reducing sodium gradient
33. Intracellular sodium concentration in cultured cerebellar granule cells challenged with glutamate
34. Altered mitochondrial oxidative phosphorylation in hippocampal slices of kainatetreated rats
35. Apoptosis induced via AM PA-selective glutamate receptors in cultured murine cortical neurons
36. The changing landscape of ischaemic brain injury mechanisms
37. L-type voltage-gated calcium channels modulate kainic acid neurotoxicity in cerebellar granule cells
38. The release of cytochrome c from mitochondria during apoptosis of NGF-deprived sympathetic neurons is a reversible event
39. α-Latrotoxin releases both vesicular and cytoplasmic glutamate from isolated nerve terminals
40. The regulation of extra-mitochondrial free Ca by rat liver mitochondria
41. The regulation of brain mitochondrial calcium-ion transport: The role of ATP in the discrimination between kinetic and membrane-potential-dependent Ca efflux mechanisms
42. Mitochondrial membrane potential and cell death: Mortality and millivolts
43. Selective modulation of desensitization at AMPA versus kainate receptors by cyclothiazide and concanavalin A
44. Privileged access to mitochondria of calcium influx through N-methyl-D-aspartate receptors
45. Dissociation of nitric oxide generation and kainate-mediated neuronal degeneration in primary cultures of rat cerebellar granule cells
46. Glutamate-induced intracellular calcium changes and neurotoxicity in cortical neurons in vitro: Effect of chemical ischemia
47. Distinct influx pathways, not calcium load. Determine neuronal vulnerability to calcium neurotoxicity
48. 2+-permeable AMPA receptors among cultured rat cerebellar granule cells
49. 2+ permeability and Joro spider toxin sensitivity of AMPA and kainate receptors on cerebellar granule cells
50. Energy transduction in intact synaptosomes: Influence of plasma-membrane depolarization on the respiration and membrane potential of internal mitochondria determined in situ
51. 2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: A neuroprotectant for cerebral ischemia
52. High-affinity calcium indicators underestimate increases in intracellular calcium concentrations associated with excitotoxic glutamate stimulations
53. Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons
54. Mitochondrial membrane potential and glutamate excitoloxicity in cultured cerebellar granule cells
55. Mitochondrial depolarization in glutamate-stimulated neurons: An early signal specific to excitotoxin exposure
56. The role of phosphate in the regulation of the Ca efflux pathway of liver mitochondria
57. The mitochondrial permeability transition