Limitations of cyclosporin A inhibition of the permeability transition in CNS mitochondria

Journal of Neuroscience

Volumn 20, Issue 22, 2000, Pages 8229-8237

  Brustovetsky, N ^a   Dubinsky, J M ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Cyclophilin; Cyclosporin A; Excitotoxicity; Mitochondria; Neurodegeneration; Permeability transition

Indexed keywords

CYCLOPHILIN; CYCLOSPORIN A; GLUTAMIC ACID; MAGNESIUM ION; OLIGOMYCIN;

ABSORPTIOMETRY; ANIMAL CELL; ARTICLE; BRAIN MITOCHONDRION; CALCIUM TRANSPORT; CELL MEMBRANE PERMEABILITY; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DEPOLARIZATION; MITOCHONDRIAL MEMBRANE; NERVE CELL NECROSIS; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0034668844     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-22-08229.2000     Document Type: Article

References (67)

1. 2+-induced permeabilization of rat liver mitochondria
2. Calcium-induced release of mitochondrial cytochrome c by different mechanisms selective for brain versus liver
3. Cytochrome c release from brain mitochondria is independent of the mitochondrial permeability transition
4. Calcineurin and mitochondrial function in glutamate-induced neuronal cell death
5. Modulation of the mitochondrial permeability transition pore: Effect of protons and divalent cations
6. 2+ binding sites with opposing effects on the pore open probability
7. Recent progress on regulation of the mitochondrial permeability transition pore, a cyclosporin-sensitive pore in the inner mitochondrial membrane
8. 31P nuclear magnetic resonance
9. Albumin antagonism of fatty acid effect on oxidation and phosphorylation reactions in rat liver mitochondria
10. Effects of potassium, veratridine, and scorpion venom on calcium accumulation and transmitter release by nerve terminals in vitro
11. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
12. Inhibition of the mitochondrial permeability transition by cyclosporin A during long time frame experiments - Relationship between pore opening and the activity of mitochondrial phospholipases
13. 2+ release from mitochondria
14. Cyclosporin A is a potent inhibitor of the inner membrane permeability transition in liver mitochondria
15. 2+ uniporter by pure and impure ruthenium red
16. Proton selective substate of the mitochondrial permeability transition pore - Regulation by the redox state of the electron transport chain
17. Dual responses of CNS mitochondria to elevated calcium
18. 2+]
19. The mitochondrial permeability transition pore and its role in cell death
20. 2+ uniporter
21. 2+ -dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress
22. Immunosuppressant FK-506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity
23. 2: Effect of calcium ions and calmodulin
24. Intracellular calcium levels during the period of delayed excitotoxicity
25. Calcium-induced activation of the mitochondrial permeability transition in hippocampal neurons
26. The mitochondrial permeability transition: The brain's point of view
27. Changes in the bioenergetic state of rat hippocampus during 2.5 min of ischemia, and prevention of cell damage by cyclosporin A in hyperglycemic subjects
28. Action of cyclosporine on mitochondrial calcium fluxes
29. Cyclosporin A, but not FK 506, protects mitochondria and neurons against hypoglycemic damage and implicates the mitochondrial permeability transition in cell death
30. Cation transport in mitochondria - The potassium cycle
31. Mitochondrial nonspecific pores remain closed during cardiac ischemia, but open upon reperfusion
32. 2+-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adenine nucleotide translocase
33. Oxidative stress, thiol reagents, and membrane potential modulate the mitochondrial permeability transition by affecting nucleotide binding to the adenine nucleotide translocase
34. 2+ trigger site
35. 2+-activated hydrophilic channel of the mitochondrial inner membrane by nucleotides
36. 2+ -induced membrane transition in mitochondria. I. The protective mechanisms
37. 2+ trigger site
38. 2+ release
39. Ionized intracellular calcium concentration predicts excitotoxic neuronal death: Observations with low-affinity fluorescent calcium indicators
40. Membrane potential of mitochondria measured with electrode sensitive to tetraphenylphosphonium and relationship between proton electrochemical potential and phosphorylation potential in steady state
41. 2+ uniporter a voltage-modulated transport pathway?
42. Mitochondrial permeability transition in the central nervous system: Induction by calcium-cycling dependent and independent pathways
43. Amelioration by cyclosporin A of brain damage following 5 or 10 min of ischemia in rats subjected to preischemic hyperglycemia
44. 2+ uniporter by external adenine nucleotides: The uniporter behaves like a gated channel which is regulated by nucleotides and divalent cations
45. Cyclosporine induces neuronal apoptosis and selective oligodendrocyte death in cortical cultures
46. Susceptibility to apoptosis is enhanced in immature cortical neurons
47. Transport of protons across membranes by weak acids
48. Interactions of cyclophilin with the mitochondrial inner membrane and regulation of the permeability transition pore and cyclosporin A-sensitive channel
49. Contribution of the mitochondrial permeability transition to lethal injury after exposure of hepatocytes to t-butylhydroperoxide
50. Cyclosporin A delays mitochondrial depolarization induced by N-methyl-D-aspartate in cortical neurons: Evidence of the mitochondrial permeability transition
51. The permeability transition in heart mitochondria is regulated synergistically by ADP and cyclosporin A
52. Magnesium ion modulates the sensitivity of the mitochondrial permeability transition pore to cyclosporin A and ADP
53. 2+ by rat liver mitochondria
54. The peptide mastoparan is a potent facilitator of the mitochondrial permeability transition
55. Depolarization-induced mitochondrial Ca accumulation in sympathetic neurons: Spatial and temporal characteristics
56. Glutamate-induced intracellular calcium changes and neurotoxicity in cortical neurons in vitro: Effect of chemical ischemia
57. 2+-mediated permeability changes in mitochondria
58. Mitochondrial dysfunction is a primary event in glutamate neurotoxicity
59. 2+ on the protonophoric activity of palmitic acid
60. High-affinity calcium indicators underestimate increases in intracellular calcium concentrations associated with excitotoxic glutamate stimulations
61. Glutamate-induced mitochondrial depolarisation and perturbation of calcium homeostasis in cultured rat hippocampal neurones
62. Differentiation of phospholipase A in mitochondria and lysosomes of rat liver
63. Mitochondrial depolarization in glutamate-stimulated neurons: An early signal specific to excitotoxin exposure
64. Fatty acid-induced uncoupling of oxidative phosphorylation is partly due to opening of the mitochondrial permeability transition pore
65. Effect of fatty acids on energy coupling processes in mitochondria
66. Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis
67. The mitochondrial permeability transition