NMDA and glutamate evoke excitotoxicity at distinct cellular locations in rat cortical neurons In vitro

Journal of Neuroscience

Volumn 20, Issue 23, 2000, Pages 8831-8837

  Sinor, J D ^a   Du, S ^a   Venneti, S ^a   Blitzblau, R C ^a   Leszkiewicz, D N ^a   Rosenberg, P A ^a   Aizenman, E ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Cortical neurons; Development; Excitotoxicity; Glutamate; Glutamate transport; Haloperidol; NMDA receptors; NR2B subunit; Tissue culture

Indexed keywords

GLUTAMIC ACID; HALOPERIDOL; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RECEPTOR SUBUNIT;

ANIMAL CELL; ARTICLE; BRAIN CELL; CELL CULTURE; ELECTROPHYSIOLOGY; NERVE EXCITABILITY; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR BINDING;

EID: 0034551769     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-23-08831.2000     Document Type: Article

References (52)

1. The action of CGS-19755 on the redox enhancement of NMDA toxicity in rat cortical neurons in vitro
2. The glutamate transport inhibitor L-trans-pyrrolidine-2,4-dicarboxylate indirectly evokes NMDA receptor mediated neurotoxicity in rat cortical cultures
3. Pharmacological properties of acquired excitotoxicity in Chinese hamster ovary cells transfected with N-methyl-o-aspartate receptor subunits
4. Functional consequences of NR2 subunit composition in single recombinant N-methyl-D-aspartate receptors
5. An NR2B point mutation affecting haloperidol and CP101,606 sensitivity of single recombinant N-methyl-D-aspartate receptors
6. Glutamate neurotoxicity in cortical cell culture is calcium dependent
7. Glutamate neurotoxicity in cortical cell culture
8. Oxidative stress, glutamate, and neurodegenerative disorders
9. Rat cortical neurons in cell culture: Culture methods, cell morphology, electrophysiology, and synapse formation
10. The role of excitotoxicity in neurodegenerative diseases: Implications for therapy
11. Glia modulate the response of routine cortical neurons to excitotoxicity: Glia exacerbate AMPA neurotoxicity
12. The actin-severing protein gelsolin modulates calcium channel and NMDA receptor activities and vulnerability to excitotoxicity in hippocampal neurons
13. Cellular uptake disguises action of L-glutamate on N-methyl-D-aspartate receptors
14. Localization of synapses in rat cerebral cortex in dissociated cell culture
15. 2+ -free solutions in rat cortical neurons in vitro
16. Subtype-selective inhibition of N-methyl-D-aspartate receptors by haloperidol
17. Vulnerability of cultured cortical neurons to damage by excitotoxins: Differential susceptibility of neurons containing NADPH-diaphorase
18. Ligand affinities at recombinant N-methyl-D-aspartate receptors depend on subunit composition
19. A role for 12-lipoxygenase in nerve cell death caused by glutathione depletion
20. Aberrant RNA processing in a neurodegenerative disease: The cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosis
21. Inhibition of N-methyl-D-aspartate receptors by haloperidol: Developmental and pharmacological characterization in native and recombinant receptors
22. Oxygen or glucose deprivation-induced neuronal injury in cortical ceil cultures is reduced by tetanus toxin
23. Developmental and regional expression in the rat brain and functional properties of four NMDA receptors
24. Attenuation of focal ischemic brain injury in mice deficient in the epsilon1 (NR2A) subunit of NMDA receptor
25. Immature cortical neurons are uniquely sensitive to glutamate toxicity by inhibition of cystine uptake
26. Characterization of the binding of [3H]CGS-19755: A novel N-methyl-D-aspartate antagonist with nanomolar affinity in rat brain
27. Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress
28. Molecular mechanisms of glutamate receptor clustering at excitatory synapses
29. Vulnerability of oligodendroglia to glutamate: Pharmacology, mechanisms, and prevention
30. Privileged access to mitochondria of calcium influx through N-methyl-D-aspartate receptors
31. N-methyl-D-aspartate receptor proteins NR2A and NR2B are differentially distributed in the developing rat central nervous system as revealed by subunit-specific antibodies
32. Oxidative stress induces apoptosis in embryonic cortical neurons
33. Inhibition of glutamate uptake with L-trans-pyrrolidine-2,4-dicarboxylate potentiates glutamate toxicity in primary hippocampal cultures
34. Accumulation of extracellular glutamate and neuronal death in astrocyte-poor cortical cultures exposed to glutamine
35. Hundred-fold increase in neuronal vulnerability to glutamate toxicity in astrocyte-poor cultures of rat cerebral cortex
36. Glutamate uptake disguises neurotoxic potency of glutamate agonists in cerebral cortex in dissociated cell culture
37. Synaptic activity mediates death of hypoxic neurons
38. Synaptic release of excitatory amino acid neurotransmitter mediates anoxic neuronal death
39. Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis
40. Distinct synaptic and extrasynaptic NMDA receptors in developing cerebellar granule neurons
41. Distinct influx pathways, not calcium load, determine neuronal vulnerability to calcium neurotoxicity
42. Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein
43. Distinct roles of synaptic and extrasynaptic NMDA receptors in excitotoxicity
44. Intrinsic redox properties of N-methyl-D-aspartate receptor can determine the developmental expression of excitotoxicity in rat cortical neurons in vitro
45. Comparison of the potency of competitive NMDA antagonists against the neurotoxicity of glutamate and NMDA
46. Glial uptake of excitatory amino acids influences neuronal survival in cultures of mouse hippocampus
47. The incorporation of NMDA receptors with a distinct subunit composition at nascent hippocampal synapses in vitro
48. Functional and pharmacological differences between recombinant N-methyl-D-aspartate receptors
49. NMDA receptor heterogeneity during postnatal development of the rat brain: Differential expression of the NR2A, NR2B, and NR2C subunit proteins
50. Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: Selectivity and mechanisms at recombinant heteromeric receptors
51. Expression of mRNAs encoding subunits of the N-methyl-D-aspartate receptor in cultured cortical neurons
52. Expression of mRNAs encoding subunits of the NMDA receptor in developing rat brain