Genetic Variation and Brain Gene Expression in Rodent Models of Alcoholism. Implications for medication development

International Review of Neurobiology

Volumn 91, Issue C, 2010, Pages 129-171

  Björk, Karl ^a   Hansson, Anita C ^b   Sommer, Wolfgang H ^b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; ALCOHOL DEHYDROGENASE; ALPHA SYNUCLEIN; BETA ARRESTIN 2; CADHERIN; CADHERIN 13; CYCLIC AMP; DOPAMINE 3 RECEPTOR; EARLY GROWTH RESPONSE FACTOR 1; GUANINE NUCLEOTIDE BINDING PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; JANUS KINASE; LAMOTRIGINE; LISINOPRIL; LITHIUM; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROPEPTIDE Y; OLANZAPINE; ORGANIC CATION TRANSPORTER; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN FOS; PROTEIN KINASE C EPSILON; PROTEIN SLC22A4; SEROTONIN 2 RECEPTOR; STAT PROTEIN; TRANSCRIPTION FACTOR GATA 4; UNCLASSIFIED DRUG; VASOPRESSIN; VOLTAGE GATED SODIUM CHANNEL; ZONISAMIDE;

ADAPTATION; ALCOHOL INTOXICATION; ALCOHOLISM; BOOK; BREEDING; COMPULSION; DISEASE MODEL; DRUG TARGETING; ENVIRONMENTAL EXPOSURE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; GENOMICS; GENOTYPE ENVIRONMENT INTERACTION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 77956163875     PISSN: 00747742     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0074-7742(10)91005-2     Document Type: Chapter

References (174)

1. Diagnostic and Statistical Manual of Mental Disorders 1994, American Psychiatric Association, American Psychiatric Press, Washington, DC. 4th Ed.
2. Arias A., Feinn R., Kranzler H.R. Association of an Asn40Asp (A118G) polymorphism in the mu-opioid receptor gene with substance dependence: A meta-analysis. Drug Alcohol Depend 2006, 83:262-268.
3. Arlinde C., Sommer W., Bjork K., Reimers M., Hyytia P., Kiianmaa K., Heilig M. A cluster of differentially expressed signal transduction genes identified by microarray analysis in a rat genetic model of alcoholism. Pharmacogenomics J. 2004, 4:208-218.
4. Bachteler D., Economidou D., Danysz W., Ciccocioppo R., Spanagel R. The effects of acamprosate and neramexane on cue-induced reinstatement of ethanol-seeking behavior in rat. Neuropsychopharmacology 2005, 30:1104-1110.
5. Barr C.S., Dvoskin R.L., Gupte M., Sommer W., Sun H., Schwandt M.L., Lindell S.G., Kasckow J.W., Suomi S.J., Goldman D., Higley J.D., Heilig M. Functional CRH variation increases stress-induced alcohol consumption in primates. Proc. Natl. Acad. Sci. USA 2009, 106:14593-14598.
6. Barr, C. S., Dvoskin, R. L., Yuan, Q., Lipsky, R. H., Gupte, M., Hu, X., Zhou, Z., Schwandt, M. L., Lindell, S. G., McKee, M., Becker, M. L., Kling, M. A., Gold, P. W., Higley, D., Heilig, M., Suomi, S. J., and Goldman, D. (2008). CRH haplotype as a factor influencing cerebrospinal fluid levels of corticotropin-releasing hormone, hypothalamic-pituitary-adrenal axis activity, temperament, and alcohol consumption in rhesus macaques. Arch. Gen. Psychiatry. 65, 934-944.
7. Becker H.C. Animal models of alcohol withdrawal. Alcohol Res. Health 2000, 24:105-113.
8. Belknap J.K., Atkins A.L. The replicability of QTLs for murine alcohol preference drinking behavior across eight independent studies. Mamm. Genome 2001, 12:893-899.
9. Bell R.L., Kimpel M.W., McClintick J.N., Strother W.N., Carr L.G., Liang T., Rodd Z.A., Mayfield R.D., Edenberg H.J., McBride W.J. Gene expression changes in the nucleus accumbens of alcohol-preferring rats following chronic ethanol consumption. Pharmacol. Biochem. Behav. 2009, 94:131-147.
10. Bhave S.V., Hoffman P.L., Lassen N., Vasiliou V., Saba L., Deitrich R.A., Tabakoff B. Gene array profiles of alcohol and aldehyde metabolizing enzymes in brains of C57BL/6 and DBA/2 mice. Alcohol Clin. Exp. Res. 2006, 30:1659-1669.
11. Björk K., Rimondini R., Hansson A.C., Terasmaa A., Hyytia P., Heilig M., Sommer W.H. Modulation of voluntary ethanol consumption by beta-arrestin 2. FASEB J. 2008, 22:2552-2560.
12. Björk K., Saarikoski S.T., Arlinde C., Kovanen L., Osei-Hyiaman D., Ubaldi M., Reimers M., Hyytia P., Heilig M., Sommer W.H. Glutathione-S-transferase expression in the brain: Possible role in ethanol preference and longevity. FASEB J. 2006, 20:1826-1835.
13. Björk K., Sjögren B., Svenningsson P. Regulation of serotonin receptor function in the nervous system by lipid rafts and adaptor proteins. Exp. Cell Res. 2010, 316:1351-1356.
14. Bohn L.M., Gainetdinov R.R., Sotnikova T.D., Medvedev I.O., Lefkowitz R.J., Dykstra L.A., Caron M.G. Enhanced rewarding properties of morphine, but not cocaine, in beta (arrestin)-2 knock-out mice. J. Neurosci. 2003, 23:10265-10273.
15. Bohn L.M., Lefkowitz R.J., Gainetdinov R.R., Peppel K., Caron M.G., Lin F.T. Enhanced morphine analgesia in mice lacking beta-arrestin 2. Science 1999, 286:2495-2498.
16. Bond C., LaForge K.S., Tian M.T., Melia D., Zhang S.W., Borg L., Gong J.H., Schluger J., Strong J.A., Leal S.M., Tischfield J.A., Kreek M.J., Yu L. Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: Possible implications for opiate addiction. Proc. Natl. Acad. Sci. USA 1998, 95:9608-9613.
17. Bouza C., Angeles M., Munoz A., Amate J.M. Efficacy and safety of naltrexone and acamprosate in the treatment of alcohol dependence: A systematic review. Addiction 2004, 99:811-828.
18. Bowers B.J., Radcliffe R.A., Smith A.M., Miyamoto-Ditmon J., Wehner J.M. Microarray analysis identifies cerebellar genes sensitive to chronic ethanol treatment in PKCgamma mice. Alcohol 2006, 40:19-33.
19. Braconi S., Sidhpura N., Aujla H., Martin-Fardon R., Weiss F., Ciccocioppo R. Revisiting intragastric ethanol intubation as a dependence induction method for studies of ethanol reward and motivation in rats. Alcohol Clin. Exp. Res. 2010, 34:538-544.
20. Breese G.R., Overstreet D.H., Knapp D.J. Conceptual framework for the etiology of alcoholism: A "kindling"/stress hypothesis. Psychopharmacology (Berl.) 2005, 178:367-380.
21. Breese G.R., Overstreet D.H., Knapp D.J., Navarro M. Prior multiple ethanol withdrawals enhance stress-induced anxiety-like behavior: Inhibition by CRF1- and benzodiazepine-receptor antagonists and a 5-HT1a-receptor agonist. Neuropsychopharmacology 2005, 30:1662-1669.
22. Brooks P.J., Enoch M.A., Goldman D., Li T.K., Yokoyama A. The alcohol flushing response: An unrecognized risk factor for esophageal cancer from alcohol consumption. PLoS Med. 2009, 6:e50.
23. Buck K.J., Metten P., Belknap J.K., Crabbe J.C. Quantitative trait loci involved in genetic predisposition to acute alcohol withdrawal in mice. J. Neurosci. 1997, 17:3946-3955.
24. Caberlotto L., Thorsell A., Rimondini R., Sommer W., Hyytia P., Heilig M. Differential expression of NPY and its receptors in alcohol-preferring AA and alcohol-avoiding ANA rats. Alcohol. Clin. Exp. Res. 2001, 25:1564-1569.
25. Chatterton M.L., Lofland J.H., Shechter A., Curtice W.S., Hu X.H., Lenow J., Smullens S.N., Nash D.B., Silberstein S.D. Reliability and validity of the migraine therapy assessment questionnaire. Headache 2002, 42:1006-1015.
26. Chen A.C., Manz N., Tang Y., Rangaswamy M., Almasy L., Kuperman S., Nurnberger J., O'Connor S.J., Edenberg H.J., Schuckit M.A., Tischfield J., Foroud T., Bierut L.J., Rohrbaugh J., Rice J.P., Goate A., Hesselbrock V., Porjesz B. Single-nucleotide polymorphisms in corticotropin releasing hormone receptor 1 gene (CRHR1) are associated with quantitative trait of event-related potential and alcohol dependence. Alcohol. Clin. Exp. Res 2010, 34:988-996.
27. Chesler E.J., Lu L., Shou S., Qu Y., Gu J., Wang J., Hsu H.C., Mountz J.D., Baldwin N.E., Langston M.A., Threadgill D.W., Manly K.F., Williams R.W. Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function. Nat. Genet. 2005, 37:233-242.
28. Chu K., Koob G.F., Cole M., Zorrilla E.P., Roberts A.J. Dependence-induced increases in ethanol self-administration in mice are blocked by the CRF(1) receptor antagonist antalarmin and by CRF(1) receptor knockout. Pharmacol. Biochem. Behav. 2007, 86:813-821.
29. Ciccocioppo R., Economidou D., Cippitelli A., Cucculelli M., Ubaldi M., Soverchia L., Lourdusamy A., Massi M. Genetically selected Marchigian Sardinian alcohol-preferring (msP) rats: An animal model to study the neurobiology of alcoholism. Addict. Biol. 2006, 11:339-355.
30. Cippitelli A., Damadzic R., Hansson A.C., Singley E., Sommer W.H., Eskay R., Thorsell A., Heilig M. Neuropeptide Y (NPY) suppresses yohimbine-induced reinstatement of alcohol seeking. Psychopharmacology (Berl.) 2010, 208:417-426.
31. Colombo G., Agabio R., Lobina C., Reali R., Zocchi A., Fadda F., Gessa G.L. Sardinian alcohol-preferring rats: A genetic animal model of anxiety. Physiol. Behav. 1995, 57:1181-1185.
32. Crabbe J.C. Consilience of rodent and human phenotypes relevant for alcohol dependence. Addict. Biol. 2010, 15:103-108.
33. Crabbe J.C., Bell R.L., Ehlers C.L. Human and laboratory rodent low response to alcohol: Is better consilience possible?. Addict. Biol. 2010, 15:125-144.
34. Crabbe J.C., Johnson N.A., Gray D.K., Kosobud A., Young E.R. Biphasic effects of ethanol on open-field activity: Sensitivity and tolerance in C57BL/6N and DBA/2N mice. J. Comp. Physiol. Psychol. 1982, 96:440-451.
35. Crabbe J.C., Metten P., Rhodes J.S., Yu C.H., Brown L.L., Phillips T.J., Finn D.A. A line of mice selected for high blood ethanol concentrations shows drinking in the dark to intoxication. Biol. Psychiatry 2009, 65:662-670.
36. Crabbe J.C., Phillips T.J., Harris R.A., Arends M.A., Koob G.F. Alcohol-related genes: Contributions from studies with genetically engineered mice. Addict. Biol. 2006, 11:195-269.
37. Cruz N.F., Lasater A., Zielke H.R., Dienel G.A. Activation of astrocytes in brain of conscious rats during acoustic stimulation: Acetate utilization in working brain. J. Neurochem. 2005, 92:934-947.
38. Davies A.G., Pierce-Shimomura J.T., Kim H., VanHoven M.K., Thiele T.R., Bonci A., Bargmann C.I., McIntire S.L. A central role of the BK potassium channel in behavioral responses to ethanol in C. elegans. Cell 2003, 115:655-666.
39. De Witte P., Pinto E., Ansseau M., Verbanck P. Alcohol and withdrawal: From animal research to clinical issues. Neurosci. Biobehav. Rev. 2003, 27:189-197.
40. Edenberg H.J. The genetics of alcohol metabolism: Role of alcohol dehydrogenase and aldehyde dehydrogenase variants. Alcohol Res. Health 2007, 30:5-13.
41. Edenberg H.J., Strother W.N., McClintick J.N., Tian H., Stephens M., Jerome R.E., Lumeng L., Li T.K., McBride W.J. Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. Genes Brain Behav. 2005, 4:20-30.
42. Egli M. Can experimental paradigms and animal models be used to discover clinically effective medications for alcoholism?. Addict. Biol. 2005, 10:309-319.
43. Ehlers C.L., Li T.K., Lumeng L., Hwang B.H., Somes C., Jimenez P., Math A.A. Neuropeptide Y levels in ethanol-naive, alcohol-preferring, and nonpreferring rats and in Wistar rats after ethanol exposure. Alcohol. Clin. Exp. Res. 1998, 22:1778-1782.
44. Ehlers C.L., Walter N.A., Dick D.M., Buck K.J., Crabbe J.C. A comparison of selected quantitative trait loci associated with alcohol use phenotypes in humans and mouse models. Addict. Biol. 2010, 15:185-199.
45. Frazer K.A., Eskin E., Kang H.M., Bogue M.A., Hinds D.A., Beilharz E.J., Gupta R.V., Montgomery J., Morenzoni M.M., Nilsen G.B., Pethiyagoda C.L., Stuve L.L., Johnson F.M., Daly M.J., Wade C.M., Cox D.R. A sequence-based variation map of 8.27 million SNPs in inbred mouse strains. Nature 2007, 448:1050-1053.
46. Funk C.K., O'Dell L.E., Crawford E.F., Koob G.F. Corticotropin-releasing factor within the central nucleus of the amygdala mediates enhanced ethanol self-administration in withdrawn, ethanol-dependent rats. J. Neurosci. 2006, 26:11324-11332.
47. Gehlert D.R., Cippitelli A., Thorsell A., Le A.D., Hipskind P.A., Hamdouchi C., Lu J., Hembre E.J., Cramer J., Song M., McKinzie D., Morin M., Ciccocioppo R., Heilig M. 3-(4-Chloro-2-morpholin-4-yl-thiazol-5-yl)-8-(1-ethylpropyl)-2,6-dimethyl- imidazo[1,2-b]pyridazine: A novel brain-penetrant, orally available corticotropin-releasing factor receptor 1 antagonist with efficacy in animal models of alcoholism. J. Neurosci. 2007, 27:2718-2726.
48. Gilpin N.W., Smith A.D., Cole M., Weiss F., Koob G.F., Richardson H.N. Operant behavior and alcohol levels in blood and brain of alcohol-dependent rats. Alcohol. Clin. Exp. Res. 2009, 33:2113-2123.
49. Gilpin N.W., Stewart R.B., Murphy J.M., Li T.K., Badia-Elder N.E. Neuropeptide Y reduces oral ethanol intake in alcohol-preferring (P) rats following a period of imposed ethanol abstinence. Alcohol. Clin. Exp. Res. 2003, 27:787-794.
50. Goldman D., Oroszi G., Ducci F. The genetics of addictions: Uncovering the genes. Nat. Rev. Genet. 2005, 6:521-532.
51. Griffin W.C., Lopez M.F., Yanke A.B., Middaugh L.D., Becker H.C. Repeated cycles of chronic intermittent ethanol exposure in mice increases voluntary ethanol drinking and ethanol concentrations in the nucleus accumbens. Psychopharmacology (Berl.) 2009, 201:569-580.
52. Guo A.Y., Webb B.T., Miles M.F., Zimmerman M.P., Kendler K.S., Zhao Z. ERGR: An ethanol-related gene resource. Nucleic Acids Res. 2009, 37:D840-D845.
53. Hansson A.C., Bermudez-Silva F.J., Malinen H., Hyytia P., Sanchez-Vera I., Rimondini R., Rodriguez de F.F., Kunos G., Sommer W.H., Heilig M. Genetic impairment of frontocortical endocannabinoid degradation and high alcohol preference. Neuropsychopharmacology 2007, 32:117-126.
54. Hansson A.C., Cippitelli A., Sommer W., Ciccocioppo R., Heilig M. Region-specific down regulation of Crhr1 gene expression in alcohol preferring msP rats following ad lib access to alcohol. Addict. Biol. 2007, 12:30-34.
55. Hansson A.C., Cippitelli A., Sommer W.H., Fedeli A., Bjork K., Soverchia L., Terasmaa A., Massi M., Heilig M., Ciccocioppo R. Variation at the rat Crhr1 locus and sensitivity to relapse into alcohol seeking induced by environmental stress. Proc. Natl. Acad. Sci. USA 2006, 103:15236-15241.
56. Hansson A.C., Nixon K., Rimondini R., Damadzic R., Sommer W.H., Eskay R., Crews F.T., Heilig M. Long-term suppression of forebrain neurogenesis and loss of neuronal progenitor cells following prolonged alcohol dependence in rats. Int. J. Neuropsychopharmacol. 2010, 583-593.
57. Hansson A.C., Rimondini R., Neznanova O., Sommer W.H., Heilig M. Neuroplasticity in brain reward circuitry following a history of ethanol dependence. Eur. J. Neurosci. 2008, 27:1912-1922.
58. Harris R.A., Trudell J.R., Mihic S.J. Ethanol's molecular targets. Sci. Signal. 2008, 1:re7.
59. Heilig M., Egli M. Models for alcohol dependence: A clinical perspective. Drug Discov. Today Dis. Models 2005, 2:313-318.
60. Heilig M., Egli M., Crabbe J.C., Becker H.C. Acute withdrawal, protracted abstinence and negative affect in alcoholism: Are they linked?. Addict. Biol. 2010, 15:169-184.
61. Heilig M., Koob G.F. A key role for corticotropin-releasing factor in alcohol dependence. Trends Neurosci. 2007, 30:399-406.
62. Heilig M., Thorsell A., Sommer W.H., Hansson A.C., Ramchandani V.A., George D.T., Hommer D., Barr C.S. Translating the neuroscience of alcoholism into clinical treatments: From blocking the buzz to curing the blues. Neurosci. Biobehav. Rev. 2009, 10.1016/j.neubiorev.2009.11.018.
63. Hoffman P.L., Bennett B., Saba L.M., Bhave S.V., Carosone-Link P.J., Hornbaker C.K., Kechris K.J., Williams R.W., Tabakoff B. Using the phenoGen website for "In Silico" analysis of morphine-induced analgesia: Identifying candidate genes 2010.
64. Hoffman P.L., Miles M., Edenberg H.J., Sommer W., Tabakoff B., Wehner And J.M., Lewohl J. Gene expression in brain: A window on ethanol dependence, neuroadaptation, and preference. Alcohol. Clin. Exp. Res. 2003, 27:155-168.
65. Holter S.M., Engelmann M., Kirschke C., Liebsch G., Landgraf R., Spanagel R. Long-term ethanol self-administration with repeated ethanol deprivation episodes changes ethanol drinking pattern and increases anxiety-related behaviour during ethanol deprivation in rats. Behav. Pharmacol. 1998, 9:41-48.
66. Hu W., Saba L., Kechris K., Bhave S.V., Hoffman P.L., Tabakoff B. Genomic insights into acute alcohol tolerance. J. Pharmacol. Exp. Ther. 2008, 326:792-800.
67. Jansen R.C., Nap J.P. Genetical genomics: The added value from segregation. Trends Genet 2001, 17:388-391.
68. Kakko J., von W.J., Svanborg K.D., Lidstrom J., Barr C.S., Heilig M. Mood and neuroendocrine response to a chemical stressor, metyrapone, in buprenorphine-maintained heroin dependence. Biol. Psychiatry 2008, 63:172-177.
69. Kanis J.A., Johansson H., Johnell O., Oden A., De Laet C., Eisman J.A., Pols H., Tenenhouse A. Alcohol intake as a risk factor for fracture. Osteoporos. Int. 2005, 16:737-742.
70. Karlsson R.M. Neuropeptide Y (NPY) and Glutamate Transporter (GLAST) in Behavioral Models of Psychiatric Disorders 2009, Karolinska Institute, Stockholm, Sweden.
71. Karpyak V.M., Biernacka J.M., Weg M.W., Stevens S.R., Cunningham J.M., Mrazek D.A., Black J.L. Interaction of SLC6A4 and DRD2 polymorphisms is associated with a history of delirium tremens. Addict. Biol. 2010, 15:23-34.
72. Katner S.N., Magalong J.G., Weiss F. Reinstatement of alcohol-seeking behavior by drug-associated discriminative stimuli after prolonged extinction in the rat. Neuropsychopharmacology 1999, 20:471-479.
73. Kerns R.T., Ravindranathan A., Hassan S., Cage M.P., York T., Sikela J.M., Williams R.W., Miles M.F. Ethanol-responsive brain region expression networks: Implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. J. Neurosci. 2005, 25:2255-2266.
74. Kimpel M.W., Strother W.N., McClintick J.N., Carr L.G., Liang T., Edenberg H.J., McBride W.J. Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. Alcohol 2007, 41:95-132.
75. King A.C., Volpicelli J.R., Frazer A., O'Brien C.P. Effect of naltrexone on subjective alcohol response in subjects at high and low risk for future alcohol dependence. Psychopharmacology (Berl.) 1997, 129:15-22.
76. Koob G.F. Alcoholism: Allostasis and beyond. Alcohol. Clin. Exp. Res. 2003, 27:232-243.
77. Koob G.F., Le Moal M. Drug addiction, dysregulation of reward, and allostasis. Neuropsychopharmacology 2001, 24:97-129.
78. Koob G.F., Volkow N.D. Neurocircuitry of addiction. Neuropsychopharmacology 2010, 35:217-238.
79. Kosobud A., Crabbe J.C. Ethanol withdrawal in mice bred to be genetically prone or resistant to ethanol withdrawal seizures. J. Pharmacol. Exp. Ther. 1986, 238:170-177.
80. Leeman R.F., Heilig M., Cunningham C.L., Stephens D.N., Duka T., O'Malley S.S. Ethanol consumption: How should we measure it? Achieving consilience between human and animal phenotypes. Addict. Biol. 2010, 15:109-124.
81. Lefkowitz R.J., Shenoy S.K. Transduction of receptor signals by beta-arrestins. Science 2005, 308:512-517.
82. Levine L., Grossfield J., Rockwell R.F. Functional relationships between genotypes and environments in behavior. Effects of different kinds of early social experience on interstrain fighting in male mice. J. Hered 1979, 70:317-320.
83. Liang T., Habegger K., Spence J.P., Foroud T., Ellison J.A., Lumeng L., Li T.K., Carr L.G. Glutathione S-transferase 8-8 expression is lower in alcohol-preferring than in alcohol-nonpreferring rats. Alcohol. Clin. Exp. Res. 2004, 28:1622-1628.
84. Liang T., Kimpel M.W., McClintick J.N., Skillman A.R., McCall K., Edenberg H.J., Carr L.G. Candidate genes for alcohol preference identified by expression profiling in alcohol-preferring and -nonpreferring reciprocal congenic rats. Genome Biol. 2010, 11:R11.
85. Lindell S.G., Schwandt M.L., Sun H., Sparenborg J.D., Bjork K., Kasckow J.W., Sommer W.H., Goldman D., Higley J.D., Suomi S.J., Heilig M., Barr C.S. Functional NPY variation as a factor in stress resilience and alcohol consumption in rhesus macaques. Arch. Gen. Psychiatry 2010, 67:423-431.
86. Lopez M.F., Becker H.C. Effect of pattern and number of chronic ethanol exposures on subsequent voluntary ethanol intake in C57BL/6J mice. Psychopharmacology (Berl.) 2005, 181:688-696.
87. Maclaren E.J., Bennett B., Johnson T.E., Sikela J.M. Expression profiling identifies novel candidate genes for ethanol sensitivity QTLs. Mamm. Genome 2006, 17:147-156.
88. Majchrowicz E. Induction of physical dependence upon ethanol and the associated behavioral changes in rats. Psychopharmacologia 1975, 43:245-254.
89. Mardones J., Segovia N., Hederra A. Heredity of experimental alcohol preference in rats. II. Coefficient of heredity. Q. J. Stud. Alcohol 1953, 14:1-2.
90. Matsumoto I., Abe K., Arai S. Molecular logic of alcohol and taste. Nihon Arukoru Yakubutsu Igakkai Zasshi 2006, 41:431-444.
91. Matthaus F., Smith V.A., Fogtman A., Sommer W.H., Leonardi-Essmann F., Lourdusamy A., Reimers M.A., Spanagel R., Gebicke-Haerter P.J. Interactive molecular networks obtained by computer-aided conversion of microarray data from brains of alcohol-drinking rats. Pharmacopsychiatry 2009, 42(Suppl. 1):S118-S128.
92. Maul B., Krause W., Pankow K., Becker M., Gembardt F., Alenina N., Walther T., Bader M., Siems W.E. Central angiotensin II controls alcohol consumption via its AT1 receptor. FASEB J. 2005, 19:1474-1481.
93. Maul B., Siems W.E., Hoehe M.R., Grecksch G., Bader M., Walther T. Alcohol consumption is controlled by angiotensin II. FASEB J. 2001, 15:1640-1642.
94. McClearn G.E., Rodgers D.A. Differences in alcohol preference among inbred strain of mice. Q. J. Stud. Alcohol. 1959, 20:691-695.
95. Melendez, R. I., Kalivas, P. W., McGinty, G. F., and Becker, H. C. (2006). Differential gene expression alterations induced by chronic ethanol exposure and withdrawal in C57BL/6J mice. Alcohol. Clin. Exp. Res. 12, 2017-2025.
96. Metten P., Sorensen M.L., Cameron A.J., Yu C.-H., Crabbe J.C. Withdrawal severity after chronic intermittent ethanol in inbred mouse strains. Alcohol. Clin. Exp. Res. 2010, 34:1-14.
97. Möller C., Wiklund L., Thorsell A., Hyytia P., Heilig M. Decreased measures of experimental anxiety in rats bred for high alcohol preference. Alcohol. Clin. Exp. Res. 1997, 21:656-660.
98. Moore M.S., DeZazzo J., Luk A.Y., Tully T., Singh C.M., Heberlein U. Ethanol intoxication in Drosophila: Genetic and pharmacological evidence for regulation by the cAMP signaling pathway. Cell 1998, 93:997-1007.
99. Mottagui-Tabar S., Prince J.A., Wahlestedt C., Zhu G., Goldman D., Heilig M. A novel single nucleotide polymorphism of the neuropeptide Y (NPY) gene associated with alcohol dependence. Alcohol. Clin. Exp. Res. 2005, 29:702-707.
100. Mueller H.T., Meador-Woodruff J.H. NR3A NMDA receptor subunit mRNA expression in schizophrenia, depression and bipolar disorder. Schizophr. Res. 2004, 71:361-370.
101. Mulert C., Juckel G., Giegling I., Pogarell O., Leicht G., Karch S., Mavrogiorgou P., Moller H.J., Hegerl U., Rujescu D. A Ser9Gly polymorphism in the dopamine D3 receptor gene (DRD3) and event-related P300 potentials. Neuropsychopharmacology 2006, 31:1335-1344.
102. Mulligan M.K., Ponomarev I., Hitzemann R.J., Belknap J.K., Tabakoff B., Harris R.A., Crabbe J.C., Blednov Y.A., Grahame N.J., Phillips T.J., Finn D.A., Hoffman P.L., Iyer V.R., Koob G.F., Bergeson S.E. Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. Proc. Natl. Acad. Sci. USA 2006, 103:6368-6373.
103. Nelson E.C., Agrawal A., Pergadia M.L., Wang J.C., Whitfield J.B., Saccone F.S., Kern J., Grant J.D., Schrage A.J., Rice J.P., Montgomery G.W., Heath A.C., Goate A.M., Martin N.G., Madden P.A. H2 haplotype at chromosome 17q21.31 protects against childhood sexual abuse-associated risk for alcohol consumption and dependence. Addict. Biol. 2010, 15:1-11.
104. Neznanova O., Bjork K., Rimondini R., Hansson A.C., Hyytia P., Heilig M., Sommer W.H. Acute ethanol challenge inhibits glycogen synthase kinase-3beta in the rat prefrontal cortex. Int. J. Neuropsychopharmacol. 2009, 12:275-280.
105. O'Dell L.E., Roberts A.J., Smith R.T., Koob G.F. Enhanced alcohol self-administration after intermittent versus continuous alcohol vapor exposure. Alcohol. Clin. Exp. Res. 2004, 28:1676-1682.
106. Overstreet D.H., Knapp D.J., Breese G.R. Accentuated decrease in social interaction in rats subjected to repeated ethanol withdrawals. Alcohol. Clin. Exp. Res. 2002, 26:1259-1268.
107. Pawlosky R.J., Kashiwaya Y., Srivastava S., King M.T., Crutchfield C., Volkow N., Kunos G., Li T.K., Veech R.L. Alterations in brain glucose utilization accompanying elevations in blood ethanol and acetate concentrations in the rat. Alcohol. Clin. Exp. Res. 2010, 34:375-381.
108. Peng J., Wagle M., Mueller T., Mathur P., Lockwood B.L., Bretaud S., Guo S. Ethanol-modulated camouflage response screen in zebrafish uncovers a novel role for cAMP and extracellular signal-regulated kinase signaling in behavioral sensitivity to ethanol. J. Neurosci. 2009, 29:8408-8418.
109. Pignataro L., Varodayan F.P., Tannenholz L.E., Harrison N.L. The regulation of neuronal gene expression by alcohol. Pharmacol. Ther. 2009, 124:324-335.
110. Quintanilla M.E., Israel Y., Sapag A., Tampier L. The UChA and UChB rat lines: Metabolic and genetic differences influencing ethanol intake. Addict. Biol. 2006, 11:310-323.
111. Ramchandani V.A., Umhau J., Pavon F.J., Ruiz-Velasco V., Margas W., Sun H., Damadzic R., Eskay R., Schoor M., Thorsell A., Schwandt M.L., Sommer W.H., George D.T., Parsons L.H., Herscovitch P., Hommer D., Heilig M. A genetic determinant of the striatal dopamine response to alcohol in men. Mol. Psychiatry. 2010, 10.1038/mp.2010.56.
112. Ray L.A., Hutchison K.E. A polymorphism of the mu-opioid receptor gene (OPRM1) and sensitivity to the effects of alcohol in humans. Alcohol. Clin. Exp. Res. 2004, 28:1789-1795.
113. Repunte-Canonigo V., Lutjens R., van der Stap L.D., Sanna P.P. Increased expression of protein kinase A inhibitor alpha (PKI-alpha) and decreased PKA-regulated genes in chronic intermittent alcohol exposure. Brain Res. 2007, 1138:48-56.
114. Repunte-Canonigo V., van der Stap L.D., Chen J., Sabino V., Wagner U., Zorrilla E.P., Schumann G., Roberts A.J., Sanna P.P. Genome-wide gene expression analysis identifies K-ras as a regulator of alcohol intake. Brain Res. 2010, 1339:11-17.
115. Rhodes J.S., Best K., Belknap J.K., Finn D.A., Crabbe J.C. Evaluation of a simple model of ethanol drinking to intoxication in C57BL/6J mice. Physiol. Behav. 2005, 84:53-63.
116. Rhodes J.S., Ford M.M., Yu C.H., Brown L.L., Finn D.A., Garland T., Crabbe J.C. Mouse inbred strain differences in ethanol drinking to intoxication. Genes Brain Behav. 2007, 6:1-18.
117. Rimondini R., Arlinde C., Sommer W., Heilig M. Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. FASEB J. 2002, 16:27-35.
118. Rimondini R., Sommer W., Heilig M. A temporal threshold for induction of persistent alcohol preference: Behavioral evidence in a rat model of intermittent intoxication. J. Stud. Alcohol 2003, 64:445-449.
119. Rimondini R., Sommer W.H., Dall'olio R., Heilig M. Long-lasting tolerance to alcohol following a history of dependence. Addict. Biol. 2008, 13:26-30.
120. Rimondini R., Thorsell A., Heilig M. Suppression of ethanol self-administration by the neuropeptide Y (NPY) Y2 receptor antagonist BIIE0246: Evidence for sensitization in rats with a history of dependence. Neurosci. Lett. 2005, 375:129-133.
121. Roberts A.J., Heyser C.J., Cole M., Griffin P., Koob G.F. Excessive ethanol drinking following a history of dependence: Animal model of allostasis. Neuropsychopharmacology 2000, 22:581-594.
122. Rodd Z.A., Bertsch B.A., Strother W.N., Le-Niculescu H., Balaraman Y., Hayden E., Jerome R.E., Lumeng L., Nurnberger J.I., Edenberg H.J., McBride W.J., Niculescu A.B. Candidate genes, pathways and mechanisms for alcoholism: An expanded convergent functional genomics approach. Pharmacogenomics J. 2006, 6:1-3.
123. Rogers J., Wiener S.G., Bloom F.E. Long-term ethanol administration methods for rats: Advantages of inhalation over intubation or liquid diets. Behav. Neural Biol. 1979, 27:466-486.
124. Rulten S.L., Ripley T.L., Hunt C.L., Stephens D.N., Mayne L.V. Sp1 and NFkappaB pathways are regulated in brain in response to acute and chronic ethanol. Genes Brain Behav. 2006, 5:257-273.
125. Saba L., Bhave S.V., Grahame N., Bice P., Lapadat R., Belknap J., Hoffman P.L., Tabakoff B. Candidate genes and their regulatory elements: Alcohol preference and tolerance. Mamm. Genome 2006, 17:669-688.
126. Sanchis-Segura C., Spanagel R. Behavioural assessment of drug reinforcement and addictive features in rodents: An overview. Addict. Biol. 2006, 11:2-38.
127. Schuckit M.A., Smith T.L., Danko G.P., Trim R., Bucholz K.K., Edenberg H.J., Hesselbrock V., Kramer J.J., Dick D.M. An evaluation of the full level of response to alcohol model of heavy drinking and problems in COGA offspring. J. Stud. Alcohol Drugs 2009, 70:436-445.
128. Shaham Y., Shalev U., Lu L., de Wit H., Stewart J. The reinstatement model of drug relapse: History, methodology and major findings. Psychopharmacology (Berl.) 2003, 168:3-20.
129. Shirley R.L., Walter N.A., Reilly M.T., Fehr C., Buck K.J. Mpdz is a quantitative trait gene for drug withdrawal seizures. Nat. Neurosci. 2004, 7:699-700.
130. Sillaber I., Rammes G., Zimmermann S., Mahal B., Zieglgansberger W., Wurst W., Holsboer F., Spanagel R. Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors. Science 2002, 296:931-933.
131. Sinclair D. Deleterious pleiotropic effects of the atypical aldehyde dehydrogenase 2 (ALDH2) allele: Comment on Luo et al., 2005. Biochem. Genet. 2006, 44:385-390.
132. Sommer W., Arlinde C., Caberlotto L., Thorsell A., Hyytia P., Heilig M. Differential expression of diacylglycerol kinase iota and L18A mRNAs in the brains of alcohol-preferring AA and alcohol-avoiding ANA rats. Mol. Psychiatry. 2001, 6:103-108.
133. Sommer W., Arlinde C., Heilig M. The search for candidate genes of alcoholism: Evidence from expression profiling studies. Addict. Biol. 2005, 10:71-79.
134. Sommer W., Hyytia P., Kiianmaa K. The alcohol-preferring AA and alcohol-avoiding ANA rats: Neurobiology of the regulation of alcohol drinking. Addict. Biol. 2006, 11:289-309.
135. Sommer W.H., Lidström J., Sun H., Passer D., Eskay R.L., Parker S., Witt S.H., Zimmermann U., Nieratschker V., Rietschel M., Margulies M., Palkovits M., Laucht M., Heilig M. Human NPY promoter variation rs16147 as a moderator of prefrontal NPY gene expression and negative affect. Hum. Mutat. 2010, 10.1002/humu.21299.
136. Sommer W.H., Rimondini R., Hansson A.C., Hipskind P.A., Gehlert D.R., Barr C.S., Heilig M. Upregulation of voluntary alcohol intake, behavioral sensitivity to stress, and Amygdala crhr1 expression following a history of dependence. Biol. Psychiatry 2008, 63:139-145.
137. Sommer W.H., Rimondini R., Marquitz M., Lidstrom J., Siems W.E., Bader M., Heilig M. Plasticity and impact of the central renin-angiotensin system during development of ethanol dependence. J. Mol. Med. 2007, 85:1089-1097.
138. Sommer W.H., Saavedra J.M. Targeting brain angiotensin and corticotrophin-releasing hormone systems interaction for the treatment of mood and alcohol use disorders. J. Mol. Med. 2008, 86:723-728.
139. Spanagel R. Alcoholism: A systems approach from molecular physiology to addictive behavior. Physiol. Rev. 2009, 89:649-705.
140. Spanagel R., Holter S.M. Pharmacological validation of a new animal model of alcoholism. J. Neural Transm. (Budapest) 2000, 107:669-680.
141. Spanagel R., Kiefer F. Drugs for relapse prevention of alcoholism: Ten years of progress. Trends Pharmacol. Sci. 2008, 29:109-115.
142. Spence J.P., Liang T., Habegger K., Carr L.G. Effect of polymorphism on expression of the neuropeptide Y gene in inbred alcohol-preferring and -nonpreferring rats. Neuroscience 2005, 131:871-876.
143. Steensland P., Simms J.A., Holgate J., Richards J.K., Bartlett S.E. Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, selectively decreases ethanol consumption and seeking. Proc. Natl. Acad. Sci. USA 2007, 104:12518-12523.
144. Stephens D.N., Duka T., Crombag H.S., Cunningham C.L., Heilig M., Crabbe J.C. Reward sensitivity: Issues of measurement, and achieving consilience between human and animal phenotypes. Addict. Biol. 2010, 15:145-168.
145. Stewart R.B., Gatto G.J., Lumeng L., Li T.K., Murphy J.M. Comparison of alcohol-preferring (P) and nonpreferring (NP) rats on tests of anxiety and for the anxiolytic effects of ethanol. Alcohol 1993, 10:1-10.
146. Sun D., Ma J.Z., Payne T.J., Li M.D. Beta-arrestins 1 and 2 are associated with nicotine dependence in European American smokers. Mol. Psychiatry 2008, 13:398-406.
147. Tabakoff B., Saba L., Kechris K., Hu W., Bhave S.V., Finn D.A., Grahame N.J., Hoffman P.L. The genomic determinants of alcohol preference in mice. Mamm. Genome 2008, 19:352-365.
148. Tabakoff B., et al. Genetical genomic determinants of alcohol consumption in rats and humans. BMC Biol. 2009, 7:70.
149. Thorsell A., Karlsson R.M., Heilig M. NPY in alcoholism and psychiatric disorders. EXS 2006, 95:183-192.
150. Thorsell A., Repunte-Canonigo V., O'Dell L.E., Chen S.A., King A.R., Lekic D., Koob G.F., Sanna P.P. Viral vector-induced amygdala NPY overexpression reverses increased alcohol intake caused by repeated deprivations in Wistar rats. Brain 2007, 130:1330-1337.
151. Torricelli P., Fini M., Giavaresi G., Borsari V., Rimondini L., Rimondini R., Carrassi A., Giardino R. Intermittent exposure to ethanol vapor affects osteoblast behaviour more severely than estrogen deficiency does in vitro study on rat osteoblasts. Toxicology 2007, 237:168-176.
152. Treadwell J.A., Singh S.M. Microarray analysis of mouse brain gene expression following acute ethanol treatment. Neurochem. Res. 2004, 29:357-369.
153. Treutlein J., et al. Genome-wide association study of alcohol dependence. Arch. Gen. Psychiatry 2009, 66:773-784.
154. Treutlein J., Kissling C., Frank J., Wiemann S., Dong L., Depner M., Saam C., Lascorz J., Soyka M., Preuss U.W., Rujescu D., Skowronek M.H., Rietschel M., Spanagel R., Heinz A., Laucht M., Mann K., Schumann G. Genetic association of the human corticotropin releasing hormone receptor 1 (CRHR1) with binge drinking and alcohol intake patterns in two independent samples. Mol. Psychiatry 2006, 11:594-602.
155. Uddin R.K., Treadwell J.A., Singh S.M. Towards unraveling ethanol-specific neuro-metabolomics based on ethanol responsive genes in vivo. Neurochem. Res. 2005, 30:1179-1190.
156. Valdez G.R., Roberts A.J., Chan K., Davis H., Brennan M., Zorrilla E.P., Koob G.F. Increased ethanol self-administration and anxiety-like behavior during acute ethanol withdrawal and protracted abstinence: Regulation by corticotropin-releasing factor. Alcohol. Clin. Exp. Res. 2002, 26:1494-1501.
157. Valdez G.R., Sabino V., Koob G.F. Increased anxiety-like behavior and ethanol self-administration in dependent rats: Reversal via corticotropin-releasing factor-2 receptor activation. Alcohol. Clin. Exp. Res. 2004, 28:865-872.
158. Valdez G.R., Zorrilla E.P., Roberts A.J., Koob G.F. Antagonism of corticotropin-releasing factor attenuates the enhanced responsiveness to stress observed during protracted ethanol abstinence. Alcohol 2003, 29:55-60.
159. Vanderschuren L.J., Everitt B.J. Behavioral and neural mechanisms of compulsive drug seeking. Eur. J. Pharmacol. 2005, 526:77-88.
160. Vengeliene V., Celerier E., Chaskiel L., Penzo F., Spanagel R. Compulsive alcohol drinking in rodents. Addict. Biol. 2009, 14:384-396.
161. Vengeliene V., Leonardi-Essmann F., Perreau-Lenz S., Gebicke-Haerter P., Drescher K., Gross G., Spanagel R. The dopamine D3 receptor plays an essential role in alcohol-seeking and relapse. FASEB J. 2006, 20:2223-2233.
162. Vengeliene V., Leonardi-Essmann F., Sommer W.H., Spanagel R. Glycine transporter-1 blockade leads to persistently reduced relapse-like alcohol drinking in rats. Biol. Psychiatry. 2010, 10.1016/j.biopsych.2010.05.029.
163. Vengeliene V., Siegmund S., Singer M.V., Sinclair J.D., Li T.K., Spanagel R. A comparative study on alcohol-preferring rat lines: Effects of deprivation and stress phases on voluntary alcohol intake. Alcohol. Clin. Exp. Res. 2003, 27:1048-1054.
164. Vilpoux C., Warnault V., Pierrefiche O., Daoust M., Naassila M. Ethanol-sensitive brain regions in rat and mouse: A cartographic review, using immediate early gene expression. Alcohol. Clin. Exp. Res. 2009, 33:945-969.
165. Volkow N.D., Fowler J.S., Wang G.J. The addicted human brain: Insights from imaging studies. J. Clin. Invest. 2003, 111:1444-1451.
166. Volkow N.D., Wang G.J., Franceschi D., Fowler J.S., Thanos P.P., Maynard L., Gatley S.J., Wong C., Veech R.L., Kunos G., Kai L.T. Low doses of alcohol substantially decrease glucose metabolism in the human brain. Neuroimage 2006, 29:295-301.
167. Wahlsten D., Bachmanov A., Finn D.A., Crabbe J.C. Stability of inbred mouse strain differences in behavior and brain size between laboratories and across decades. Proc. Natl. Acad. Sci. USA 2006, 103:16364-16369.
168. Wand G.S., McCaul M., Yang X., Reynolds J., Gotjen D., Lee S., Ali A. The mu-opioid receptor gene polymorphism (A118G) alters HPA axis activation induced by opioid receptor blockade. Neuropsychopharmacology 2002, 26:106-114.
169. Waniewski R.A., Martin D.L. Preferential utilization of acetate by astrocytes is attributable to transport. J. Neurosci. 1998, 18:5225-5233.
170. Wiens F., Zitzmann A., Lachance M.A., Yegles M., Pragst F., Wurst F.M., von H.D., Guan S.L., Spanagel R. Chronic intake of fermented floral nectar by wild treeshrews. Proc. Natl. Acad. Sci. USA 2008, 105:10426-10431.
171. Wise R.A. Maximization of ethanol intake in the rat. [Review] [51 refs]. Adv. Exp. Med. Biol. 1975, 59:279-294.
172. Wolffgramm J., Galli G., Thimm F., Heyne A. Animal models of addiction: models for therapeutic strategies?. J. Neural Transm. (Budapest) 2000, 107:649-668.
173. Worst T.J., Tan J.C., Robertson D.J., Freeman W.M., Hyytia P., Kiianmaa K., Vrana K.E. Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. J. Neurosci. Res. 2005, 80:529-538.
174. Zhu G., Pollak L., Mottagui-Tabar S., Wahlestedt C., Taubman J., Virkkunen M., Goldman D., Heilig M. NPY leu7pro and alcohol dependence in Finnish and Swedish populations. Alcohol. Clin. Exp. Res. 2003, 27:19-24.