3-(4-Chloro-2-morpholin-4-yl-thiazol-5-yl)-8-(1-ethylpropyl)-2, 6-dimethyl-imidazo[1,2-b]pyridazine: A novel brain-penetrant, orally available corticotropin-releasing factor receptor 1 antagonist with efficacy in animal models of alcoholism

Journal of Neuroscience

Volumn 27, Issue 10, 2007, Pages 2718-2726

  Gehlert, Donald R ^a   Cippitelli, Andrea ^b,d   Thorsell, Annika ^b   Lê, Anh Dzung ^c   Hipskind, Philip A ^a   Hamdouchi, Chafiq ^a   Lu, Jianliang ^a   Hembre, Erik J ^a   Cramer, Jeffrey ^a   Song, Min ^a   McKinzie, David ^a   Morin, Michelle ^a   Ciccocioppo, Roberto ^d   Heilig, Markus ^b  

^a ELI LILLY AND COMPANY   (United States)

^b NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY OF CAMERINO   (Italy)

Author keywords

Alcoholism; CRF; Drug seeking; Relapse; Self administration; Stress

Indexed keywords

3 (4 CHLORO 2 MORPHOLIN 4 YL THIAZOL 5 YL) 8 (1 ETHYLPROPYL) 2,6 DIMETHYL IMIDAZO[1,2 B]PYRIDAZINE; 3 (6 DIMETHYLAMINO 4 METHYL 3 PYRIDINYL) 7 DIPROPYLAMINO 2,5 DIMETHYLPYRAZOLO[1,5 A]PYRIMIDINE; ALCOHOL; BUTYL[2,5 DIMETHYL 7 (2,4,6 TRIMETHYLPHENYL) 7H PYRROLO[2,3 D]PYRIMIDIN 4 YL]ETHYLAMINE; CORTICOTROPIN RELEASING FACTOR ANTAGONIST; CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; CORTICOTROPIN RELEASING FACTOR RECEPTOR 2; IODINE 125; PYRIDAZINE; SAUVAGINE; UNCLASSIFIED DRUG;

ALCOHOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CELL MEMBRANE; CEREBELLUM CORTEX; CONTROLLED STUDY; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG INHIBITION; DRUG STRUCTURE; DRUG TARGETING; DRUG WITHDRAWAL; EX VIVO STUDY; HUMAN; HUMAN CELL; HYPOPHYSIS CELL; IN VIVO STUDY; MALE; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS;

ADMINISTRATION, ORAL; ALCOHOL DRINKING; ALCOHOLISM; ANIMALS; ANXIETY; BEHAVIOR, ANIMAL; BRAIN; CEREBELLUM; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; MALE; PEPTIDES; PITUITARY GLAND; PYRIDAZINES; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; SELF ADMINISTRATION; STRESS; SUBSTANCE WITHDRAWAL SYNDROME; THIAZOLES;

EID: 33847772007     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4985-06.2007     Document Type: Article

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