Genetical genomic determinants of alcohol consumption in rats and humans

BMC Biology

Volumn 7, Issue , 2009, Pages 70-

  Tabakoff, Boris ^a   Saba, Laura ^a   Printz, Morton ^b   Flodman, Pam ^c   Hodgkinson, Colin ^d   Goldman, David ^d   Koob, George ^e   Richardson, Heather N ^e,o   Kechris, Katerina ^f   Bell, Richard L ^g   Hübner, Norbert ^h   Heinig, Matthias ^h   Pravenec, Michal ⁱ   Mangion, Jonathan ^j,p   Legault, Lucie ^k   Dongier, Maurice ^k   Conigrave, Katherine M ^l   Whitfield, John B ^m   Saunders, John ⁿ   Grant, Bridget ^d   Hoffman, Paula L ^a   more..

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^e SCRIPPS RESEARCH INSTITUTE   (United States)

^f Global Health and Health Disparities   (United States)

^g INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

ⁱ INSTITUTE OF PHYSIOLOGY   (Czech Republic)

^j MRC CLINICAL SCIENCES CENTRE   (United Kingdom)

^k MCGILL UNIVERSITY   (Canada)

^l ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^m QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

ⁿ UNIVERSITY OF QUEENSLAND   (Australia)

^o UNIVERSITY OF MASSACHUSETTS   (United States)

^p Applied Biosystems   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR;

4 AMINOBUTYRIC ACID RELEASE; ALCOHOL CONSUMPTION; ALCOHOLISM; AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOINFORMATICS; CALORIC INTAKE; CELL ACTIVATION; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; DOPAMINERGIC TRANSMISSION; ENERGY METABOLISM; EXPERIMENTAL RAT; FEMALE; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; GENE INTERACTION; GENE LOCATION; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENOTYPE; HUMAN; HYPOTHALAMUS; MALE; NONHUMAN; PHENOTYPE; PROTEIN TRANSPORT; QUANTITATIVE TRAIT LOCUS; RAT; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; VENTRAL TEGMENTUM;

ANIMALIA; RATTUS;

EID: 70749087732     PISSN: None     EISSN: 17417007     Source Type: Journal    
DOI: 10.1186/1741-7007-7-70     Document Type: Article

References (118)

1. Drake TA, Schadt EE, Lusis AJ. Integrating genetic and gene expression data: application to cardiovascular and metabolic traits in mice. Mamm Genome 2006, 17(6):466-479. 2679634, 16783628.
2. Tabakoff B, Saba L, Kechris K, Hu W, Bhave SV, Finn DA, Grahame NJ, Hoffman PL. The genomic determinants of alcohol preference in mice. Mamm Genome 2008, 19(5):352-365. 2583933, 18563486.
3. Ganguly K, Stoeger T, Wesselkamper SC, Reinhard C, Sartor MA, Medvedovic M, Tomlinson CR, Bolle I, Mason JM, Leikauf GD. Candidate genes controlling pulmonary function in mice: transcript profiling and predicted protein structure. Physiol Genomics 2007, 31(3):410-421.
4. Tabakoff B, Bhave SV, Hoffman PL. Selective breeding, quantitative trait locus analysis, and gene arrays identify candidate genes for complex drug-related behaviors. J Neurosci 2003, 23(11):4491-4498.
5. Hu W, Saba L, Kechris K, Bhave SV, Hoffman PL, Tabakoff B. Genomic insights into acute alcohol tolerance. J Pharmacol Exp Ther 2008, 326(3):792-800. 2574863, 18550690.
6. Feltenstein MW, See RE. The neurocircuitry of addiction: an overview. Br J Pharmacol 2008, 154(2):261-274. 2442446, 18311189.
7. Bell RL, Rodd ZA, Lumeng L, Murphy JM, McBride WJ. The alcohol-preferring P rat and animal models of excessive alcohol drinking. Addict Biol 2006, 11(3-4):270-288.
8. Koob GF. Drugs of abuse: anatomy, pharmacology and function of reward pathways. Trends Pharmacol Sci 1992, 13(5):177-184.
9. Kalivas PW, O'Brien C. Drug addiction as a pathology of staged neuroplasticity. Neuropsychopharmacology 2008, 33(1):166-180.
10. Kelley AE. Memory and addiction: shared neural circuitry and molecular mechanisms. Neuron 2004, 44(1):161-179.
11. Printz MP, Jirout M, Jaworski R, Alemayehu A, Kren V. Genetic Models in Applied Physiology. HXB/BXH rat recombinant inbred strain platform: a newly enhanced tool for cardiovascular, behavioral, and developmental genetics and genomics. J Appl Physiol 2003, 94(6):2510-2522.
12. The STAR Consortium SNP and haplotype mapping for genetic analysis in the rat. Nature Genetics 2008, 40:560-566.
13. Murphy JM, Stewart RB, Bell RL, Badia-Elder NE, Carr LG, McBride WJ, Lumeng L, Li TK. Phenotypic and genotypic characterization of the Indiana University rat lines selectively bred for high and low alcohol preference. Behav Genet 2002, 32(5):363-388.
14. Hodgkinson CA, Yuan Q, Xu K, Shen PH, Heinz E, Lobos EA, Binder EB, Cubells J, Ehlers CL, Gelernter J. Addictions biology: haplotype-based analysis for 130 candidate genes on a single array. Alcohol Alcohol 2008, 43(5):505-515. 2724863, 18477577.
15. Glanz J, Grant B, Monteiro M, Tabakoff B. WHO/ISBRA Study on State and Trait Markers of Alcohol Use and Dependence: analysis of demographic, behavioral, physiologic, and drinking variables that contribute to dependence and seeking treatment. International Society on Biomedical Research on Alcoholism. Alcohol Clin Exp Res 2002, 26(7):1047-1061.
16. Churchill GA, Doerge RW. Empirical threshold values for quantitative trait mapping. Genetics 1994, 138(3):963-971. 1206241, 7851788.
17. Broman KW, Wu H, Sen T, Churchill GA. R/qtl: QTL mapping in experimental crosses. Bioinformatics 2003, 19(7):889-890.
18. Brown VM, Ossadtchi A, Khan AH, Yee S, Lacan G, Melega WP, Cherry SR, Leahy RM, Smith DJ. Multiplex three-dimensional brain gene expression mapping in a mouse model of Parkinson's disease. Genome Res 2002, 12(6):868-884. 1383741, 12045141.
19. Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, Ellis B, Gautier L, Ge Y, Gentry J. Bioconductor: open software development for computational biology and bioinformatics. Genome Biol 2004, 5(10):R80. 545600, 15461798.
20. Kent WJ. BLAT--the BLAST-like alignment tool. Genome Res 2002, 12(4):656-664. 187518, 11932250.
21. Carlborg O, De Koning DJ, Manly KF, Chesler E, Williams RW, Haley CS. Methodological aspects of the genetic dissection of gene expression. Bioinformatics 2005, 21(10):2383-2393.
22. Visscher PM, Thompson R, Haley CS. Confidence intervals in QTL mapping by bootstrapping. Genetics 1996, 143(2):1013-1020. 1207319, 8725246.
23. Bengtsson H, Simpson K, Bullard J, Hansen K. aroma.affymetrix: A generic framework in R for analyzing small to very large Affymetrix data sets in bounded memory. Tech Report #745 2008, Berkeley: Department of Statistics, University of California.
24. Affymetrix Quality assessment of exon and gene arrays. Affymetrix GeneChip® Gene and Exon Array Whitepaper Collection 2003,
25. Irizarry RA, Bolstad BM, Collin F, Cope LM, Hobbs B, Speed TP. Summaries of Affymetrix GeneChip probe level data. Nucleic Acids Res 2003, 31(4):e15. 150247, 12582260.
26. Pritchard JK, Rosenberg NA. Use of unlinked genetic markers to detect population stratification in association studies. Am J Hum Genet 1999, 65(1):220-228. 1378093, 10364535.
27. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005, 21(2):263-265.
28. Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B, Higgins J, DeFelice M, Lochner A, Faggart M. The structure of haplotype blocks in the human genome. Science 2002, 296(5576):2225-2229.
29. The International HapMap Consortium The International HapMap Project. Nature 2003, 426:789-796.
30. Schwarz G. Estimating the dimension of a model. Annals of Statistics 1978, 6:461-464.
31. Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. JR Statist Soc B 1995, 57:289-300.
32. Rhee SH, Hewitt JK, Young SE, Corley RP, Crowley TJ, Stallings MC. Genetic and environmental influences on substance initiation, use, and problem use in adolescents. Arch Gen Psychiatry 2003, 60(12):1256-1264.
33. Kendler KS, Schmitt E, Aggen SH, Prescott CA. Genetic and environmental influences on alcohol, caffeine, cannabis, and nicotine use from early adolescence to middle adulthood. Arch Gen Psychiatry 2008, 65(6):674-682.
34. Kuo PH, Aggen SH, Prescott CA, Kendler KS, Neale MC. Using a factor mixture modeling approach in alcohol dependence in a general population sample. Drug Alcohol Depend 2008, 98(1-2):105-114. 2572186, 18586414.
35. Hasin D, Hatzenbuehler ML, Keyes K, Ogburn E. Substance use disorders: diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) and International Classification of Diseases, tenth edition (ICD-10). Addiction 2006, 101(Suppl 1):59-75.
36. Moss HB, Chen CM, Yi HY. DSM-IV criteria endorsement patterns in alcohol dependence: relationship to severity. Alcohol Clin Exp Res 2008, 32(2):306-313.
37. Koob GF. Neurobiological substrates for the dark side of compulsivity in addiction. Neuropharmacology 2009, 56(Suppl 1):18-31.
38. Saha TD, Chou SP, Grant BF. Toward an alcohol use disorder continuum using item response theory: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Psychol Med 2006, 36(7):931-941.
39. Kozell LB, Hitzemann R, Buck KJ. Acute alcohol withdrawal is associated with c-Fos expression in the basal ganglia and associated circuitry: C57BL/6J and DBA/2J inbred mouse strain analyses. Alcohol Clin Exp Res 2005, 29(11):1939-1948.
40. Yoneyama N, Crabbe JC, Ford MM, Murillo A, Finn DA. Voluntary ethanol consumption in 22 inbred mouse strains. Alcohol 2008, 42(3):149-160. 2396347, 18358676.
41. Bachmanov AA, Kiefer SW, Molina JC, Tordoff MG, Duffy VB, Bartoshuk LM, Mennella JA. Chemosensory factors influencing alcohol perception, preferences, and consumption. Alcohol Clin Exp Res 2003, 27(2):220-231. 1940064, 12605071.
42. Buemann B, Astrup A. How does the body deal with energy from alcohol?. Nutrition 2001, 17(7-8):638-641.
43. Gao Q, Horvath TL. Neuronal control of energy homeostasis. FEBS Lett 2008, 582(1):132-141.
44. Chen ZW, Chang CS, Leil TA, Olcese R, Olsen RW. GABAA receptor-associated protein regulates GABAA receptor cell-surface number in Xenopus laevis oocytes. Mol Pharmacol 2005, 68(1):152-159.
45. Cowley MA, Pronchuk N, Fan W, Dinulescu DM, Colmers WF, Cone RD. Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: evidence of a cellular basis for the adipostat. Neuron 1999, 24(1):155-163.
46. Barnes S, Whistler HL, Hughes J, Woodruff GN, Hunter JC. Effect of cholecystokinin octapeptide on endogenous amino acid release from the rat ventromedial nucleus of the hypothalamus and striatum. J Neurochem 1991, 56(4):1409-1416.
47. Berridge KC. Food reward: brain substrates of wanting and liking. Neurosci Biobehav Rev 1996, 20(1):1-25.
48. Kelley AE. Ventral striatal control of appetitive motivation: role in ingestive behavior and reward-related learning. Neurosci Biobehav Rev 2004, 27(8):765-776.
49. Palmiter RD. Is dopamine a physiologically relevant mediator of feeding behavior?. Trends Neurosci 2007, 30(8):375-381.
50. Di Marzo V, Ligresti A, Cristino L. The endocannabinoid system as a link between homoeostatic and hedonic pathways involved in energy balance regulation. Int J Obes (Lond) 2009, 33(Suppl 2):S18-24.
51. Lovinger DM. Presynaptic modulation by endocannabinoids. Handb Exp Pharmacol 2008, (184):435-477.
52. Viveros MP, de Fonseca FR, Bermudez-Silva FJ, McPartland JM. Critical role of the endocannabinoid system in the regulation of food intake and energy metabolism, with phylogenetic, developmental, and pathophysiological implications. Endocr Metab Immune Disord Drug Targets 2008, 8(3):220-230.
53. Kola B, Farkas I, Christ-Crain M, Wittmann G, Lolli F, Amin F, Harvey-White J, Liposits Z, Kunos G, Grossman AB. The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system. PLoS One 2008, 3(3):e1797. 2258435, 18335063.
54. Hentges ST, Low MJ, Williams JT. Differential regulation of synaptic inputs by constitutively released endocannabinoids and exogenous cannabinoids. J Neurosci 2005, 25(42):9746-9751.
55. Matias I, Bisogno T, Di Marzo V. Endogenous cannabinoids in the brain and peripheral tissues: regulation of their levels and control of food intake. Int J Obes (Lond) 2006, 30(Suppl 1):S7-S12.
56. Shi Y, Cheng D. Beyond triglyceride synthesis: the dynamic functional roles of MGAT and DGAT enzymes in energy metabolism. Am J Physiol Endocrinol Metab 2009, 297(1):E10-18.
57. Mercer LD, Le VQ, Nunan J, Jones NM, Beart PM. Direct visualization of cholecystokinin subtype2 receptors in rat central nervous system using anti-peptide antibodies. Neurosci Lett 2000, 293(3):167-170.
58. Ghijsen WE, Leenders AG, Wiegant VM. Regulation of cholecystokinin release from central nerve terminals. Peptides 2001, 22(8):1213-1221.
59. Miller KK, Hoffer A, Svoboda KR, Lupica CR. Cholecystokinin increases GABA release by inhibiting a resting K+ conductance in hippocampal interneurons. J Neurosci 1997, 17(13):4994-5003.
60. Deng PY, Lei S. Bidirectional modulation of GABAergic transmission by cholecystokinin in hippocampal dentate gyrus granule cells of juvenile rats. J Physiol 2006, 572(Pt 2):425-442. 1779673, 16455686.
61. Hugel S, Schlichter R. Presynaptic P2X receptors facilitate inhibitory GABAergic transmission between cultured rat spinal cord dorsal horn neurons. J Neurosci 2000, 20(6):2121-2130.
62. Tiran Z, Peretz A, Attali B, Elson A. Phosphorylation-dependent regulation of Kv2.1 Channel activity at tyrosine 124 by Src and by protein-tyrosine phosphatase epsilon. J Biol Chem 2003, 278(19):17509-17514.
63. Lindblom J, Opmane B, Mutulis F, Mutule I, Petrovska R, Klusa V, Bergstrom L, Wikberg JE. The MC4 receptor mediates alpha-MSH induced release of nucleus accumbens dopamine. Neuroreport 2001, 12(10):2155-2158.
64. Navarro M, Cubero I, Chen AS, Chen HY, Knapp DJ, Breese GR, Marsh DJ, Thiele TE. Effects of melanocortin receptor activation and blockade on ethanol intake: a possible role for the melanocortin-4 receptor. Alcohol Clin Exp Res 2005, 29(6):949-957. 1360238, 15976520.
65. Polidori C, Geary N, Massi M. Effect of the melanocortin receptor stimulation or inhibition on ethanol intake in alcohol-preferring rats. Peptides 2006, 27(1):144-149.
66. Reum T, Schafer U, Marsden CA, Fink H, Morgenstern R. Cholecystokinin increases extracellular dopamine overflow in the anterior nucleus accumbens via CCK(B) receptors in the VTA assessed by in vivo voltammetry. Neuropeptides 1997, 31(1):82-88.
67. Stuber GD, Hopf FW, Hahn J, Cho SL, Guillory A, Bonci A. Voluntary ethanol intake enhances excitatory synaptic strength in the ventral tegmental area. Alcohol Clin Exp Res 2008, 32(10):1714-1720.
68. Davies DL, Machu TK, Guo Y, Alkana RL. Ethanol sensitivity in ATP-gated P2X receptors is subunit dependent. Alcohol Clin Exp Res 2002, 26(6):773-778.
69. Xiao C, Ye JH. Ethanol dually modulates GABAergic synaptic transmission onto dopaminergic neurons in ventral tegmental area: role of mu-opioid receptors. Neuroscience 2008, 153(1):240-248. 2424267, 18343590.
70. Ridley AJ. Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking. Trends Cell Biol 2006, 16(10):522-529.
71. Kneussel M, Betz H. Clustering of inhibitory neurotransmitter receptors at developing postsynaptic sites: the membrane activation model. Trends Neurosci 2000, 23(9):429-435.
72. Shen F, Lin Q, Gu Y, Childress C, Yang W. Activated Cdc42-associated kinase 1 is a component of EGF receptor signaling complex and regulates EGF receptor degradation. Mol Biol Cell 2007, 18(3):732-742. 1805115, 17182860.
73. Urena JM, La Torre A, Martinez A, Lowenstein E, Franco N, Winsky-Sommerer R, Fontana X, Casaroli-Marano R, Ibanez-Sabio MA, Pascual M. Expression, synaptic localization, and developmental regulation of Ack1/Pyk1, a cytoplasmic tyrosine kinase highly expressed in the developing and adult brain. J Comp Neurol 2005, 490(2):119-132.
74. Striggow F, Riek-Burchardt M, Kiesel A, Schmidt W, Henrich-Noack P, Breder J, Krug M, Reymann KG, Reiser G. Four different types of protease-activated receptors are widely expressed in the brain and are up-regulated in hippocampus by severe ischemia. Eur J Neurosci 2001, 14(4):595-608.
75. Luo W, Wang Y, Reiser G. Protease-activated receptors in the brain: receptor expression, activation, and functions in neurodegeneration and neuroprotection. Brain Res Rev 2007, 56(2):331-345.
76. Wang P, Kumar P, Wang C, Defea KA. Differential regulation of class IA phosphoinositide 3-kinase catalytic subunits p110 alpha and beta by protease-activated receptor 2 and beta-arrestins. Biochem J 2007, 408(2):221-230. 2267348, 17680774.
77. Jacob TC, Moss SJ, Jurd R. GABA(A) receptor trafficking and its role in the dynamic modulation of neuronal inhibition. Nat Rev Neurosci 2008, 9(5):331-343. 2709246, 18382465.
78. Motil J, Dubey M, Chan WK, Shea TB. Inhibition of dynein but not kinesin induces aberrant focal accumulation of neurofilaments within axonal neurites. Brain Res 2007, 1164:125-131.
79. Raff EC, Hoyle HD, Popodi EM, Turner FR. Axoneme beta-tubulin sequence determines attachment of outer dynein arms. Curr Biol 2008, 18(12):911-914. 2766918, 18571413.
80. Samson HH, Tolliver GA, Schwarz-Stevens K. Oral ethanol self-administration: a behavioral pharmacological approach to CNS control mechanisms. Alcohol 1990, 7(3):187-191.
81. Hyytiä P, Koob GF. GABAA receptor antagonism in the extended amygdala decreases ethanol self-administration in rats. Eur J Pharmacol 1995, 283(1-3):151-159.
82. Di Chiara G, Acquas E, Tanda G. Ethanol as a neurochemical surrogate of conventional reinforcers: the dopamine-opioid link. Alcohol 1996, 13(1):13-17.
83. Hodge CW, Haraguchi M, Chappelle AM, Samson HH. Effects of ventral tegmental microinjections of the GABAA agonist muscimol on self-administration of ethanol and sucrose. Pharmacol Biochem Behav 1996, 53(4):971-977.
84. Samson HH, Chappell A. Muscimol injected into the medial prefrontal cortex of the rat alters ethanol self-administration. Physiol Behav 2001, 74(4-5):581-587.
85. Samson HH, Chappell A. Injected muscimol in pedunculopontine tegmental nucleus alters ethanol self-administration. Alcohol 2001, 23(1):41-48.
86. Tabakoff B, Hoffman PL. Alcohol addiction: an enigma among us. Neuron 1996, 16(5):909-912.
87. Roberto M, Madamba SG, Moore SD, Tallent MK, Siggins GR. Ethanol increases GABAergic transmission at both pre- and postsynaptic sites in rat central amygdala neurons. Proc Natl Acad Sci USA 2003, 100(4):2053-2058. 149957, 12566570.
88. Nie Z, Schweitzer P, Roberts AJ, Madamba SG, Moore SD, Siggins GR. Ethanol augments GABAergic transmission in the central amygdala via CRF1 receptors. Science 2004, 303(5663):1512-1514.
89. Lobo IA, Harris RA. GABA(A) receptors and alcohol. Pharmacol Biochem Behav 2008, 90(1):90-94. 2574824, 18423561.
90. Hodge CW, Chappelle AM, Samson HH. GABAergic transmission in the nucleus accumbens is involved in the termination of ethanol self-administration in rats. Alcohol Clin Exp Res 1995, 19(6):1486-1493.
91. Hnasko TS, Perez FA, Scouras AD, Stoll EA, Gale SD, Luquet S, Phillips PE, Kremer EJ, Palmiter RD. Cre recombinase-mediated restoration of nigrostriatal dopamine in dopamine-deficient mice reverses hypophagia and bradykinesia. Proc Natl Acad Sci USA 2006, 103(23):8858-8863. 1466546, 16723393.
92. Mountjoy KG, Mortrud MT, Low MJ, Simerly RB, Cone RD. Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain. Mol Endocrinol 1994, 8(10):1298-1308.
93. Kishi T, Aschkenasi CJ, Lee CE, Mountjoy KG, Saper CB, Elmquist JK. Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat. J Comp Neurol 2003, 457(3):213-235.
94. Balthasar N, Dalgaard LT, Lee CE, Yu J, Funahashi H, Williams T, Ferreira M, Tang V, McGovern RA, Kenny CD. Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell 2005, 123(3):493-505.
95. Chung L, Moore SD. Cholecystokinin enhances GABAergic inhibitory transmission in basolateral amygdala. Neuropeptides 2007, 41(6):453-463.
96. Chhatwal JP, Gutman AR, Maguschak KA, Bowser ME, Yang Y, Davis M, Ressler KJ. Functional interactions between endocannabinoid and CCK neurotransmitter systems may be critical for extinction learning. Neuropsychopharmacology 2009, 34(2):509-521.
97. Jhou TC, Fields HL, Baxter MG, Saper CB, Holland PC. The rostromedial tegmental nucleus (RMTg), a GABAergic afferent to midbrain dopamine neurons, encodes aversive stimuli and inhibits motor responses. Neuron 2009, 61(5):786-800.
98. Hernández-Rabaza V, Hontecillas-Prieto L, Velazquez-Sanchez C, Ferragud A, Perez-Villaba A, Arcusa A, Barcia JA, Trejo JL, Canales JJ. The hippocampal dentate gyrus is essential for generating contextual memories of fear and drug-induced reward. Neurobiol Learn Mem 2008, 90(3):553-559.
99. Balasubramanian S, Fam SR, Hall RA. GABAB receptor association with the PDZ scaffold Mupp1 alters receptor stability and function. J Biol Chem 2007, 282(6):4162-4171.
100. Fehr C, Shirley RL, Belknap JK, Crabbe JC, Buck KJ. Congenic mapping of alcohol and pentobarbital withdrawal liability loci to a <1 centimorgan interval of murine chromosome 4: identification of Mpdz as a candidate gene. J Neurosci 2002, 22(9):3730-3738.
101. Miller AD, Blaha CD. Midbrain muscarinic receptor mechanisms underlying regulation of mesoaccumbens and nigrostriatal dopaminergic transmission in the rat. Eur J Neurosci 2005, 21(7):1837-1846.
102. Katner SN, McBride WJ, Lumeng L, Li TK, Murphy JM. Alcohol intake of P rats is regulated by muscarinic receptors in the pedunculopontine nucleus and VTA. Pharmacol Biochem Behav 1997, 58(2):497-504.
103. Hsu R, Taylor JR, Newton SS, Alvaro JD, Haile C, Han G, Hruby VJ, Nestler EJ, Duman RS. Blockade of melanocortin transmission inhibits cocaine reward. Eur J Neurosci 2005, 21(8):2233-2242. 2694749, 15869520.
104. Landgren S, Jerlhag E, Zetterberg H, Gonzalez-Quintela A, Campos J, Olofsson U, Nilsson S, Blennow K, Engel JA. Association of pro-ghrelin and GHS-R1A gene polymorphisms and haplotypes with heavy alcohol use and body mass. Alcohol Clin Exp Res 2008, 32(12):2054-2061.
105. Hansell NK, Agrawal A, Whitfield JB, Morley KI, Gordon SD, Lind PA, Pergadia ML, Montgomery GW, Madden PA, Todd RD. Can we identify genes for alcohol consumption in samples ascertained for heterogeneous purposes?. Alcohol Clin Exp Res 2009, 33(4):729-739.
106. Belknap JK, Belknap ND, Berg JH, Coleman R. Preabsorptive vs. postabsorptive control of ethanol intake in C57BL/6J and DBA/2J mice. Behav Genet 1977, 7(6):413-425.
107. Gentry RT, Dole VP. Why does a sucrose choice reduce the consumption of alcohol in C57BL/6J mice?. Life Sci 1987, 40(22):2191-2194.
108. Jerlhag E, Egecioglu E, Landgren S, Salome N, Heilig M, Moechars D, Datta R, Perrissoud D, Dickson SL, Engel JA. Requirement of central ghrelin signaling for alcohol reward. Proc Natl Acad Sci USA 2009, 106(27):11318-11323. 2703665, 19564604.
109. de Andrade M, Olswold CL, Slusser JP, Tordsen LA, Atkinson EJ, Rabe KG, Slager SL. Identification of genes involved in alcohol consumption and cigarettes smoking. BMC Genet 2005, 6(Suppl 1):S112. 1866826, 16451569.
110. Treutlein J, Cichon S, Ridinger M, Wodarz N, Soyka M, Zill P, Maier W, Moessner R, Gaebel W, Dahmen N. Genome-wide association study of alcohol dependence. Arch Gen Psychiatry 2009, 66(7):773-784.
111. Bice P, Valdar W, Zhang L, Liu L, Lai D, Grahame N, Flint J, Li TK, Lumeng L, Foroud T. Genomewide SNP screen to detect quantitative trait loci for alcohol preference in the high alcohol preferring and low alcohol preferring mice. Alcohol Clin Exp Res 2009, 33(3):531-537.
112. Bergeson SE, Kyle Warren R, Crabbe JC, Metten P, Gene Erwin V, Belknap JK. Chromosomal loci influencing chronic alcohol withdrawal severity. Mamm Genome 2003, 14(7):454-463.
113. Agrawal A, Hinrichs AL, Dunn G, Bertelsen S, Dick DM, Saccone SF, Saccone NL, Grucza RA, Wang JC, Cloninger CR. Linkage scan for quantitative traits identifies new regions of interest for substance dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample. Drug Alcohol Depend 2008, 93(1-2):12-20. 2266629, 17942244.
114. Guerrini I, Cook CC, Kest W, Devitgh A, McQuillin A, Curtis D, Gurling HM. Genetic linkage analysis supports the presence of two susceptibility loci for alcoholism and heavy drinking on chromosome 1p22.1-11.2 and 1q21.3-24.2. BMC Genet 2005, 6(1):11. 554783, 15740611.
115. Bergen AW, Yang XR, Bai Y, Beerman MB, Goldstein AM, Goldin LR. Genomic regions linked to alcohol consumption in the Framingham Heart Study. BMC Genet 2003, 4(Suppl 1):S101. 1866439, 14975169.
116. Wan S, Browning KN, Coleman FH, Sutton G, Zheng H, Butler A, Berthoud HR, Travagli RA. Presynaptic melanocortin-4 receptors on vagal afferent fibers modulate the excitability of rat nucleus tractus solitarius neurons. J Neurosci 2008, 28(19):4957-4966. 2681297, 18463249.
117. Kawaguchi Y, Kondo S. Parvalbumin, somatostatin and cholecystokinin as chemical markers for specific GABAergic interneuron types in the rat frontal cortex. J Neurocytol 2002, 31(3-5):277-287.
118. Xiao C, Zhou C, Li K, Davies DL, Ye JH. Purinergic type 2 receptors at GABAergic synapses on ventral tegmental area dopamine neurons are targets for ethanol action. J Pharmacol Exp Ther 2008, 327(1):196-205.