Effect of naltrexone on subjective alcohol response in subjects at high and low risk for future alcohol dependence

Psychopharmacology

Volumn 129, Issue 1, 1997, Pages 15-22

  King, Andrea C ^a,b   Volpicelli, Joseph R ^a   Frazer, Ari ^a   O'Brien, Charles P ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

Author keywords

alcohol; Biphasic Alcohol Effects Scale; family history of alcoholism; genetics; naltrexone; social drinkers

Indexed keywords

ALCOHOL; NALTREXONE; PLACEBO;

ADULT; ALCOHOLISM; ARTICLE; CLINICAL TRIAL; CONFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FAMILY HISTORY; FATIGUE; HEADACHE; HEREDITY; HIGH RISK PATIENT; HUMAN; HUMAN EXPERIMENT; MALE; MOOD; NAUSEA; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RATING SCALE; SEDATION; VOMITING;

ADULT; ALCOHOL DRINKING; ALCOHOLISM; BREATH TESTS; DOUBLE-BLIND METHOD; ETHANOL; HUMANS; MALE; NALTREXONE; NARCOTIC ANTAGONISTS; RISK FACTORS;

EID: 0031024621     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130050156     Document Type: Article

References (46)

1. Altshuler HL, Phillips PE, Feinhandler DA (1980) Alteration of ethanol self-administration by naltrexone. Life Sci 26 : 679 688
2. Atkinson RL (1984) Endocrine and metabolic effects of opiate antagonists. J Clin Psychiatry 45 : 20 24
3. Cahalan V, Cisin I, Crossley HM (1969) American drinking practices. Rutgers Center for Alcohol Studies. New Jersey
4. Cloninger C, Bohman M, Sivardsson S (1981) Inheritance of alcohol abuse: cross fostering analysis of adopted men. Arch Gen Psychiatry 38 : 861 868
5. Dawson DA, Harford TC, Grant BF (1992) Family history as a predictor of alcohol dependence. Alcohol Clin Exp Res 16 : 572-575
6. Derogatis L (1983) SCL-90-R manual-II. Clinical Psychometric Research, Towson, Maryland
7. de Waele J, Papachristou DM, Gianoulakis C (1992) The alcohol-preferring C57BL/6 mice present an enhanced sensitivity of the hypothalamic ß-endorphin system to ethanol than the alcohol-avoiding DBA/2 mice. J Pharmacol Exp Ther 261 : 788 794
8. Doty P, deWit H (1995) Effects of naltrexone pretreatment on the subjective and performance effects of ethanol in social drinkers. Behav Pharmacol 6 : 386 394
9. Ewing JA (1984) Detecting alcoholism. The CAGE questionnaire. JAMA 252 : 1905 1907
10. Froehlich JC, Harts J, Lumeng L, Li TK (1987) Naloxone attenuation of voluntary alcohol consumption. Alcohol Alcohol Suppl 1 : 333 357
11. Froehlich JC, Harts J, Lumeng L, Li TK (1990) Naloxone attenuates voluntary ethanol intake in rats selectively bred for high ethanol preference. Pharmacol Biochem Behav 35 : 385 390
12. Gianoulakis C, Beliveau D, Angelogianni P, Meaney M, Thavundayil J, Tawar V, Dumas M (1989) Different pituitary β-endorphin and adrenal cortisol response to ethanol in individuals with high and low risk for future development of alcoholism. Life Sci 45 : 1097 1109
13. Gianoulakis C, Krishnan B, Thavundayil J (1996) Enhanced sensitivity of pituitary β-endorphin to ethanol in subjects at high risk of alcoholism. Arch Gen Psychiatry 53 : 250 257
14. Gonzalez JP, Brogden RN (1988) Naltrexone: a review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy in the management of opioid dependence. Drugs 35 : 192 213
15. Goodwin DW, Schulsinger F, Hermansen L, Guze SB, Winokur G (1973) Alcohol problems in adoptees raised apart from alcoholic biological parents. Arch Gen Psychiatry 28 : 238 243
16. Hubbell CL, Marglin SH, Spitalnie SJ, Abelson ML, Wild KD, Reid LD (1991) Opioidergic, serotonergic, and dopaminergic manipulations and rats' intake of a sweetened alcoholic beverage. Alcohol 8 : 355 367
17. Hyytiä P, Sinclair JD (1993) Responding for oral ethanol after naloxone treatment by alcohol-preferring AA rats. Alcoholism Clin Exp Res 17 : 631 636
18. King AC (1995) Effects of naltrexone on alcohol subjective response and neuroendocrine response in subjects at high- and low-risk for future alcohol dependence. In: O'Malley S (ed) Opiate antagonists and alcohol consumption: mechanisms of action. Symposium conducted at the Annual Scientific Meeting of the Research Society on Alcoholism, Steamboat Springs. Col.
19. King AC, Volpicelli JR, Gunduz M, O'Brien CP, Kreek MJ (1996) Naltrexone biotransformation and subjective alcohol response in social drinkers. Alcohol Clin Exp Res 20 [suppl]: 44A
20. Levenson RW, Oyama ON, Meek PS (1987) Greater reinforcement from alcohol for those at risk: parental risk, personality risk, and gender. J Abnorm Psychol 96 : 242 253
21. Martin CS, Earleywine M, Musty RE, Perrine MW, Swift RM (1993) Development and validation of the Biphasic Alcohol Effects Scale. Alcohol Clin Exp Res 17 : 140 146
22. Mason BJ, Ritvo EC, Morgan RO, Salvato FR, Goldberg G, Welch B. Mantero-Atienza E (1994) A double-blind, placebo-controlled pilot study to evaluate the efficacy and safety of oral nalmefene HCl for alcohol dependence. Alcohol Clin Exp Res 81 : 1162 1167
23. Mayfield DG, McLeod G, Hall P (1974) The CAGE questionnaire: validation of a new alcoholism screening instrument. Am J Psychiatry 131 : 1121 1123
24. McNair DM, Lorr M, Droppleman LF (1971) Manual for the profile of mood states. Educational and Industrial Testing Service, San Diego
25. Meyer MC, Straughn AB, Lo MW, Schary WL, Whitney CC (1984) Bioequivalence, dose-proportionality, and pharmacokinetics of naltrexone after oral administration. J Clin Psychiatry 45 : 15 19
26. Newlin DB, Pretorius MB (1991) Prior exposures to the laboratory enhance the effect of alcohol. J Stud Alcohol 52 : 470 473
27. Newlin DB, Thomson JB (1990) Alcohol challenge with sons of alcoholics: a critical review and analysis. Psychol Bull 108 : 383 402
28. Newlin DB, Waits RC. Wong CJ, Froehlich JC (1995) Greater reward from alcohol in sons of alcoholics: a five session laboratory study. Alcohol Clin Exp Res 19 [suppl]:80A
29. O'Boyle DJ, Binns AS, Sumner JJ (1994) On the efficacy of alcohol placebos in inducing feelings of intoxication. Psychopharmacology 115 : 229 236
30. O'Malley SS, Carey KB, Maisto SA (1986) Validity of young adults reports of parental drinking practices. J Stud Alcohol 47 : 433 435
31. O'Malley SS, Jaffe A, Chang G, Schottenfeld RS, Meyer RE, Rounsaville B (1992) Naltrexone and coping skills therapy for alcohol dependence: a controlled study. Arch Gen Psychiatry 49 : 881 887
32. O'Malley SS, Jaffe AJ, Rode S, Rounsaville BJ (1996) Experience of a "slip" among alcoholics treated with naltrexone or placebo. Am J Psychiatry 153 : 281 283
33. Pokorny AD, Miller BA, Kaplan HB (1972) The brief MAST: a shortened version of the Michigan alcoholism screening test. Am J Psychiatry 129 : 342 345
34. Pollock VE (1992) Meta-analysis of subjective sensitivity to alcohol in sons of alcoholics. Am J Psychiatry 149 : 1534-1538
35. Schacham S (1983) A shortened version of the profile of mood states. J Person Assess 47 : 305 306
36. Schuckit MA (1994) Low level of response to alcohol as a predictor of future alcoholism. Am J Psychiatry 151 : 184-189
37. Slier KJ, Descutner C (1986) Reports of paternal alcoholism: reliability across siblings. Addict Behav 11 : 25 30
38. Swift RM, Whelihan W, Kuznetsov O, Buongiorno G, Hsuing H (1994) Naltrexone-induced alterations in human ethanol intoxication. Am J Psychiatry 151 : 1463 1467
39. Ulm RR, Volpicelli JR, Volpicelli LA (1995) Opiates and alcohol self-administration in animals. J Clin Psychiatry 56 [suppl 7]:5 14
40. Volpicelli JR (1987) Uncontrollable events and alcohol drinking. Br J Addict 82 : 385 396
41. Volpicelli JR, Davis MA, Olgin JE (1986) Naltrexone blocks the post-shock increase in ethanol consumption. Life Sci 38 : 841 847
42. Volpicelli JR, Alterman AI, Hayashida M, O'Brien CP (1992) Naltrexone in the treatment of alcohol dependence. Arch Gen Psychiatry 49 : 876 880
43. Volpicelli JR, Watson NT, King AC, Sherman CE, O'Brien CP (1995) Effect of naltrexone on alcohol "high" in alcoholics. Am J Psychiatry 152 : 613 615
44. Wall ME, Brine DR, Perez-Reyes M (1981) Metabolism and disposition of naltrexone in man after oral and intravenous administration. Drug Metab Dispos 9 : 369 375
45. Weiss F, Mitchiner M, Blood FE, Koob GF (1990) Free-choice responding for ethanol versus water in alcohol preferring (P) and unselected Wistar rats is differentially modified by naloxone. bromocriptine, and methysergide. Psychopharmacology 101 : 178 186
46. Widdowson PS, Holman RB (1992) Ethanol-induced increase in endogenous dopamine release may involve endogenous opiates. J Neurochem 59 : 157 163