A cluster of differentially expressed signal transduction genes identified by microarray analysis in a rat genetic model of alcoholism

Pharmacogenomics Journal

Volumn 4, Issue 3, 2004, Pages 208-218

  Arlinde, C ^a   Sommer, Wolfgang ^a,c   Bjork K ^a   Reimers, M ^a   Hyytia P ^b   Kiianmaa, K ^b   Heilig, M ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Addiction; Amygdala; Ethanol preference; Gene expression profiling; Nc. accumbens

Indexed keywords

CYTOSKELETON PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; NEUROPEPTIDE Y;

ALCOHOLISM; AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; CINGULATE GYRUS; COMPUTER PROGRAM; CONTROLLED STUDY; DNA MICROARRAY; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE STRUCTURE; GENETIC DIFFERENCE; GENETIC MODEL; GENETIC REGULATION; HIPPOCAMPUS; NONHUMAN; NUCLEUS ACCUMBENS; PHENOTYPE; PRIORITY JOURNAL; RAT; RAT STRAIN; SIGNAL TRANSDUCTION; STRAIN DIFFERENCE;

ALCOHOLISM; ANIMALS; CLUSTER ANALYSIS; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROSENCEPHALON; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION;

RATTUS NORVEGICUS;

EID: 2942716700     PISSN: 1470269X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.tpj.6500243     Document Type: Article

References (50)

1. Enoch MA, Goldman D. The genetics of alcoholism and alcohol abuse. Curr. Psychiatry Rep 2001; 3: 144-151.
2. Heilig M, Thorsell A. Brain neuropeptide Y (NPY) in stress and alcohol dependence. Rev. Neurosci 2002; 13: 85-94.
3. Lappalainen J, Kranzler HR, Malison R, Price LH, Van Dyck C, Rosenheck RA et al. A functional neuropeptide Y Leu7Pro polymorphism associated with alcohol dependence in a large population sample from the United States. Arch Gen Psychiatry 2002; 59: 825-831.
4. Zhu G, Pollak L, Mottagui-Tabar S, Wahlestedt C, Taubman J, Virkkunen M et al. NPY leu7pro and alcohol dependence in Finnish and Swedish populations. Alcohol Clin. Exp. Res 2003; 24: 19-24.
5. McBride WJ, Li TK. Animal models of alcoholism: neurobiology of high alcohol-drinking behavior in rodents. Crit. Rev. Neurobiol 1998; 12: 339-369.
6. Sinclair JD, Le AD, Kiianmaa K. The AA and ANA rat lines, selected for differences in voluntary alcohol consumption. Experientia 1989; 45: 798-805.
7. Möller C, Wiklund L, Thorsell A, Hyytia P, Heilig M. Decreased measures of experimental anxiety in rats bred for high alcohol preference. Alcohol Clin Exp Res 1997; 21: 656-660.
8. Sommer W, Arlinde C, Caberlotto L, Thorsell A, Hyytia P, Heilig M. Differential expression of diacylglycerol kinase iota and L18A mRNAs in the brains of alcohol-preferring AA and alcohol-avoiding ANA rats. Mol Psychiatry 2001; 6: 103-108.
9. Rimondini R, Arlinde C, Sommer W, Heilig M. Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. FASEB J 2002; 16: 27-35.
10. Mayfield RD, Lewohl JM, Dodd PR, Herlihy A, Liu J, Harris RA. Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. J Neurochem 2002; 81: 802-813.
11. Koob GF, Le Moal M. Drug addiction, dysregulation of reward, and allostasis. Neuropsychopharmacology 2001; 24: 97-129.
12. Caberlotto L, Thorsell A, Rimondini R, Sommer W, Hyytia P, Heilig M. Differential expression of NPY and its receptors in alcohol-preferring AA and alcohol-avoiding ANA rats. Alcoholism: Clini Exp Res 2001; 25: 1564-1569.
13. Sandberg R, Yasuda R, Pankratz DG, Carter TA, Del Rio JA, Wodicka L et al. Regional and strain-specific gene expression mapping in the adult mouse brain. Proc Nat Acad Sci USA 2000; 97: 11038-11043.
14. Murphy BC, Chiu T, Harrison M, Uddin RK, Singh SM. Examination of ethanol responsive liver and brain specific gene expression, in the mouse strains with variable ethanol preferences, using cDNA expression arrays. Biochem Genet 2002; 40: 395-410.
15. Hoffman PL, Miles M, Edenberg HJ, Sommer W, Tabakoff B, Wehner JM et al. Gene expression in brain: a window on ethanol dependence, neuroadaptation, and preference. Alcohol Clin Exp Res 2003; 27: 155-168.
16. Ferguson SS. Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. Pharmacol Rev 2001; 53: 1-24.
17. Oakley RH, Laporte SA, Holt JA, Caron MG, Barak LS. Differential affinities of visual arrestin, beta arrestin1, and beta arrestin2 for G protein-coupled receptors delineate two major classes of receptors. J Bio Chem 2000; 275: 17201-17210.
18. Zhang J, Barak LS, Anborgh PH, Laporte SA, Caron MG, Ferguson SS. Cellular trafficking of G protein-coupled receptor/beta-arrestin endocytic complexes. J Biol Chem 1999; 274: 10999-11006.
19. Baillie GS, Sood A, McPhee I, Gall I, Perry SJ, Lefkowitz RJ et al. beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from G(s) to G(i). Proc Nat Acad Sci USA 2003; 100: 940-945.
20. Nylander I, Hyytia P, Forsander O, Terenius L. Differences between alcohol-preferring (AA) and alcohol-avoiding (ANA) rats in the prodynorphin and proenkephalin systems. Alcoholism Clin Exp Res 1994; 18: 1272-1279.
21. Honkanen A, Mikkola J, Korpi ER, Hyytia P, Seppala T, Ahtee L. Enhanced morphine- and cocaine-induced behavioral sensitization in alcohol-preferring AA rats. Psychopharmacology (Berl) 1999; 142: 244-252.
22. Kiianmaa K, Stenius K, Sinclair JD. Determinants of alcohol preference in the AA and ANA rat lines selected for differential ethanol intake. Alcohol Alcohol Suppl 1991; 1: 115-120.
23. Bohn LM, Gainetdinov RR, Lin FT, Lefkowitz RJ, Caron MG. Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence. Nature 2000; 408: 720-723.
24. Tibbles LA, Woodgett JR. The stress-activated protein kinase pathways. Cell Mol Life Sci 1999; 55: 1230-1254.
25. Madrigal JLM, Moro MA, Lizasoain I, Lorenzo P, Castrillo A, Bosca L et al. Inducible nitric oxide synthase expression in brain cortex after acute restraint stress is regulated by nuclear factor kappa B-mediated mechanisms. J Neurochem 2001; 762: 532-538.
26. Roche JP, Bounds S, Brown S, Mackie K. A mutation in the second transmembrane region of the CB1 receptor selectively disrupts G protein signaling and prevents receptor internalization. Mol Pharmacol 1999; 56: 611-618.
27. Liu J, Gao B, Mirshahi F, Sanyal AJ, Khanolkar AD, Makriyannis A et al. Functional CB1 cannabinoid receptors in human vascular endothelial cells. Biochem. J 2000; 346Part 3: 835-840.
28. Vanhoutte P, Barnier JV, Guibert B, Pages C, Besson MJ, Hipskind RA et al. Glutamate induces phosphorylation of Elk-1 and CREB, along with c-fos activation, via an extracellular signal-regulated kinase-dependent pathway in brain slices. Mol Cell Biol 1999; 19: 136-146.
29. Sanna PP, Simpson C, Lutjens R, Koob G. ERK regulation in chronic ethanol exposure and withdrawal. Brain Res 2002; 948: 186-191.
30. Putzke J, De Beun R, Schreiber R, De Vry J, Tolle TR, Zieglgansberger W et al. Long-term alcohol self-administration and alcohol withdrawal differentially modulate microtubule-associated protein 2 (MAP2) gene expression in the rat brain. Mol Brain Res 1998; 62: 196-205.
31. Watts AG, Sanchez-Watts G, Emanuel JR, Levenson R. Cell-specific expression of mRNAs encoding Na+,K(+)-ATPase alpha- and beta-subunit isoforms within the rat central nervous system. Proc Natl Acad Sci USA 1991; 88: 7425-7429.
32. Rintala J, Jaatinen P, Kiianmaa K, Riikonen J, Kemppainen O, Sarviharju M et al. Dose-dependent decrease in glial fibrillary acidic protein-immunoreactivity in rat cerebellum after lifelong ethanol consumption. Alcohol 2001; 23: 1-8.
33. Foroud T, Ritchotte A, Spence J, Liu L, Lumeng L, Li TK et al. Confirmation of alcohol preference quantitative trait loci in the replicate high alcohol drinking and low alcohol drinking rat lines. Psychiatr Genet 2003; 13: 155-161.
34. Carr LG, Foroud T, Bice P, Gobbett T, Ivashina J, Edenberg H et al. A quantitative trait locus for alcohol consumption in selectively bred rat lines. Alcoholism Clin Exp Res 1998; 22: 884-887.
35. Yuen T, Wurmbach E, Pfeffer RL, Ebersole BJ, Sealfon SC. Accuracy and calibration of commercial oligonucleotide and custom cDNA microarrays. Nucleic Acids Res 2002; 30, art e48.
36. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates, 2nd edn. Academic Press: San Diego 1986.
37. Li C, Wong WH. Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. Proc Natl Acad Sci USA 2001; 98: 31-36.
38. Li C, Wong WH. Model-based analysis of oligonucleotide arrays: model validation, design issues and standard eror application. Genome Biol 2001; 2: 0032.1-0032.11.
39. Phylip (Phylogeny Inference Package). (computer program). Felsenstein J. 3.5c. 1993. ftp://evolution.genetics.washington.edu/.
40. Mengod G, Vilaro MT, Niznik HB, Sunahara RK, Seeman P, O'Dowd BF et al. Visualization of a dopamine D1 receptor mRNA in human and rat brain. Brain Res. Mol. Brain Res 1991; 10: 185-191.
41. Mengod G, Martinez-Mir MI, Vilaro MT, Palacios JM. Localization of the mRNA for the dopamine D2 receptor in the rat brain by in situ hybridization histochemistry. Proc Natl Acad Sci USA 1989; 86: 8560-8564.
42. Berke JD, Paletzki RF, Aronson GJ, Hyman SE, Gerfen CR. A complex program of striatal gene expression induced by dopaminergic stimulation. J Neurosci 1998; 18: 5301-5310.
43. Pompeiano M, Palacios JM, Mengod G. Distribution of the serotonin 5-HT2 receptor family mRNAs: comparison between 5-HT2A and 5-HT2C receptors. Brain Res Mol Brain Res 1994; 23: 163-178.
44. Phillips HS, Hains IM, Laramee GR, Rosenthal A, Winslow JW. Widespread expression of BDNF but not NT3 by target areas of basal forebrain cholinergic neurons. Science 1990; 250: 290-294.
45. Sangameswaran L, Hempstead J, Morgan JI. Molecular cloning of a neuron-specific transcript and its regulation during normal and aberrant cerebellar development. Proc Natl Acad Sci USA 1989; 86: 5651-5655.
46. Chesselet MF, Weiss L, Wuenschell C, Tobin AJ, Affolter HU. Comparative distribution of mRNAs for glutamic acid decarboxylase, tyrosine hydroxylase, and tachykinins in the basal ganglia: an in situ hybridization study in the rodent brain. J Comp Neurol 1987; 262: 125-140.
47. Weaver DR. A2a adenosine receptor gene expression in developing rat brain. Brain Res Mol Brain Res 1993; 20: 313-327.
48. Savasta M, Palacios JM, Mengod G. Regional localization of the mRNA coding for the neuropeptide cholecystokinin in the rat brain studied by in situ hybridization. Neurosci Lett 1988; 93: 132-138.
49. Hugnot JP, Salinas M, Lesage F, Guillemare E, de Weille J, Heurteaux C et al. Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels. EMBO J 1996; 15: 3322-3331.
50. Belluardo N, Wu G, Mudo G, Hansson AC, Pettersson R, Fuxe K. Comparative localization of fibroblast growth factor receptor-1, -2, and -3 mRNAs in the rat brain: in situ hybridization analysis. J Comp Neurol 1997; 379: 226-246.