Central angiotensin II controls alcohol consumption via its AT1 receptor

FASEB Journal

Volumn 19, Issue 11, 2005, Pages 1474-1481

  Maul, Björn ^a   Krause, Winfried ^a   Pankow, Kristin ^a   Becker, Matthias ^a   Gembardt, Florian ^b,c   Alenina, Natalia ^d   Walther, Thomas ^b,c   Bader, Michael ^d   Siems, Wolf Eberhard ^a  

^a LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

Alcohol; Angiotensin; Dopamine; Knockout mice; Transgenic rats

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSINOGEN; BRADYKININ B2 RECEPTOR; COMPLEMENTARY RNA; DOPAMINE; SPIRAPRIL;

ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DOPAMINERGIC TRANSMISSION; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SIGNAL TRANSDUCTION; TASTE PREFERENCE; VENTRAL TEGMENTUM;

3,4-DIHYDROXYPHENYLACETIC ACID; ALCOHOL DRINKING; ANGIOTENSIN II; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANGIOTENSINOGEN; ANIMALS; BRAIN; DOPAMINE; ENALAPRIL; MICE; MICE, INBRED C57BL; RATS; RECEPTOR, ANGIOTENSIN, TYPE 1;

EID: 24644458576     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.05-3742com     Document Type: Article

References (40)

1. Tracy, H. A., Jr., Wayner, M. J., and Armstrong, D. L. (1997) Losanan improves the performance of ethanol-intoxicated rats in an eight-arm radial maze. Alcohol 14, 511-517
2. Wyss, J. M., Kadish, I., and van Groen, T. (2003) Age-related decline in spatial learning and memory, attenuation by captopril. Clin. Exp. Hypertens. 25, 455-474
3. Walther, T., Voigt, J.-P., Fukamizu, A., Kink, H., and Bader, M. (1999) Learning and anxiety in angiotensin-deficient mice. Behav. Brain Res. 100, 1-4
4. Grupp, L. A., Killian, M., Perlanski, E., and Stewart, R. B. (1988) Angiotensin II reduces voluntary alcohol intake in the rat. Pharmacol. Biochem. Behav. 29, 479-482
5. Grupp, L. A. (1993). The renin-angiolensin system as a regulator ol alcohol consumption, a review and some new insights. In Alcohol and the Endocrine System (Zakhari, S., ed) pp. 37-65, NIAAA Research Monograph 23, Belhesda, MD
6. Fitts, D. A. (1993) Angiotensin and captopril increase alcohol intake. Pharmacol. Biochem. Behav. 45, 35-43
7. Weisinger, R. S., Blair-West, J. R., Denton, D. A., and McBurnie, M. I. (1999) Angiotensin II stimulates intake of ethanol in C57BL/6J mice. Physiol. Behav. 67, 369-376
8. Maul, B., Siems, W.-E., Hoche, M. R., Bader, M., and Walther, T. (2001) Alcohol consumption is controlled by angiotensin II. FASEB J. 15, 1640-1642
9. Schinke, M., Balatu, O., Bohm, M., Peters, J., Rascher, W., Bricca, G., Lippodt, A., Ganten, D., and Bader, M. (1999) Blood pressure reduction and diabetes insipidus in transgenic rats deficient in brain angiotensinogen. Proc. Natl. Acad. Sci. USA 96, 3975-3980
10. Ito, M., Oliverio, M. I., Mannon, J. P., Best, C. F., Maeda, N., Smithies, O., and Coffman, T. M. (1995) Regulation of blood pressure by the type IA angiotensin II receptor gene. Proc. Natl. Acad. Sci. USA 92, 3521-3525
11. Ichiki, T., Labosky, P. A., Shiota, C., Okuyama, S., Imagawa, V., Fogo, A., Niimura, F., Ichikawa, I., Hogan, B. L. M., and Inagami, T. (1995) Effects on blood pressure and exploratory behavior of mice lacking angiotensin II type-2 receptor. Nature (London) 377, 748-750
12. Borkowski, J. A., Ransom, R. W., Seabrook, G. R., Trumbauer, M., Chen, H., Hill, R. G., Strader, C. D., and Hess, J. F. (1995) Targeted disruption of a B2 braclykinin receptor gene in mice eliminates bradykinin action in smooth muscle and neurons. J. Biol. Chem. 270, 13706-13710
13. Bradford, M. M. (1976) A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254
14. Winkler, A., Rottman, M., Heder, G., Hyytia, P., Siems, W. E., and Melzig, M. F. (1998) Gene expression and activity of specific opioid-degrading enzymes in different brain regions of the AA and ANA lines of rats. Biochim. Biophys. Acta 1406, 219-227
15. Popov, N., Pohle, W., Lossner, B., Schulzeck, S., Schmidt, S., Ou, T., and Matthies, H. (1973) Regional distribution of RNA and protein radioactivity in the rat brain after intraventricular application of labeled precursors. Acta Biol. Med. Ger. 31, 51-62
16. Monti, J., Schinke, M., Bohm, M., Ganten, D., Bader, M., and Bricca, G. (2001) Glial angiotensinogen regulates brain angiotensin II receptors in transgenic rats TGR ASrAOGEN. Am. J. Physiol. 280, R233-R240
17. Sybertz, E. J., Watkins, R. W., Ahn, H. S., Baum, T., La-Rocca, P., Patrick, J., and Leitz, F. (1987) Pharmacologic, metabolic, and toxicologic profile of spirapril (SCH 33844), a new angiotensin converting inhibitor. J. Cardiovasc. Pharmacol. 10, Suppl. 7, S105-S108
18. Takai, S., Song, K., Tanaka, T., Okunishi, H., and Miyazaki, M. (1996) Antinociceptive effects of angiotensin-converting enzyme inhibitors and an angiotensin II receptor antagonist in mice. Life Sci. 59, PL331-336
19. Jenkins, T. A., Allen, A. M., Chai, S. Y., MacGregor, D. P., Paxinos, G., and Mendelsohn, F. A. (1996) Interactions of angiotensin II with central dopamine (review). Adv. Exp. Med. Biol. 396, 93-103
20. Crabbe, J. C., Phillips, T. J., Feller, D.J., Hen, R., Wenger, C. D., Lessov, C. N., and Schafer, G. L. (1996) Elevated alcohol consumption in null mutant mice lacking 5-HT1B serotonin receptors. Nat. Genet. 14, 98-101
21. Roberts, A. J., McDonald, J. S., Heyser, C. J., Kieffer, B. L., Matthes, H. W., Koob, G. F., and Gold, L. H. (2000) μ-Opioid receptor knockout mice do not self-administer alcohol. J. Pharmacol. Exp. Ther. 293, 1002-1008
22. Thorsell, A., and Heilig, M. (2002) Diverse functions of neuropeptide Y revealed using genetically modified animals. Neuropeptides 36, 182-193
23. Spanagel, R. (2003) Alcohol addiction research: from animal models to clinics. Best Pract. Res. Clin. Gastroenterol. 17, 507-518
24. Kimura, S., Mullins, J. J., Bunnemann, B., Metzger, R., Hilgenfeldt, U., Zimmermann, F., Jacob, H., Fuxe, K., Ganten, D., and Riling, M. (1992) High blood pressure in transgenic mice carrying the rat angiotensinogen gene. EMBO J. 11, 821-827
25. Little, H. J., O'Callaghan, M. J., Butterworth, A. R., Wilson, J., Cole, J., and Watson, W. P. (1999) Low alcohol preference among the "high alcohol preference" C57 strain of mice; preference increased by saline injections. Psychopharmacology (Berl) 147, 182-189
26. O'Callaghan, M. J., Croft, A. P., Watson, W. P., Brooks, S. P., and Little, H. J. (2002) Low alcohol preference among the "high alcohol preference" C57/BL10 mice; factors affecting such preference. Pharmacol. Biochem. Behav. 72, 475-481
27. O'Callaghan, M. J., Croft, A. P., and Little, H. J. (2002) Effects of intraperitoneal injections of saline on the alcohol and sucrose consumption of C57/BL10 mice. Psychopharmacology (Berl) 160, 206-212
28. Baltatu, O., Silva, J. A., Ganten, D., and Bader, M. (2000) The brain renin-angiotensin system modulates angiotensin II-induced hypertension and cardiac hypertrophy. Hypertension 35, 409-412
29. Baltatu, O., Campos, L. A., and Bader, M. (2004) Genetic targeting of the brain renin-angiotensin system in transgenic rats: impact on stress-induced renin release. Acta Physiol. Scand. 181, 579-584
30. Tom, B., Dendorfer, A., de Vries, R., Saxena, P. R., and Danser, J. A. H. (2002) Bradykinin potentiation by ACE inhibitors, a matter of metabolism. Br. J. Pharmacol. 137, 276-284
31. Robertson, J. M., Harding, S., and Grupp, L. A. (1993) Bradykinin suppresses alcohol intake and plays a role in the suppression produced by an ACE inhibitor. Pharmacol. Biochem. Behav. 46, 751-758
32. Mendelsohn, F. A. O., Jenkins, T. A., and Berkovic, S. F. (1993) Effects of angiotensin II on dopamine and serotonin turnover in the striatum of conscious rats. Brain Res. 613, 221-229
33. Herz, A. (1997) Endogenous opioid systems and alcohol addiction. Psychopharmacology (Berl) 129, 99-111
34. Spanagel, R., and Weiss, F. (1999) The dopamine hypothesis of reward, past and current status. Trends Neurosci. 22, 521-527
35. Koob, G. F., and Le Moal, M. (2001) Drug addiction, dysregulation of reward, and allostasis. Neuropsychopharmacology 24, 97-124
36. Phillips, T. J., Brown, K. J., Burkhart-Kasch, S., Wenger, C. D., Kelly, M. A., Rubinstein, M., Grandy, D. K., and Low, M. J. (1998) Alcohol preference and sensitivity are markedly reduced in mice lacking dopamine D2 receptors. Nat. Neurosci. 1, 610-615
37. Kakinuma, Y., Hama, H., Sugiyama, F., Goto, K., Murakanii, K., and Fukamizu, A. (1997) Anti-apoptotic action of angiotensin fragments to neuronal cells from angiotensinogen knock-out mice. Neurosci. Lett. 232, 167-170
38. von Bohlen und Halbach, O., Walther, T., Bader, M., and Albrecht, D. (2001). Genetic deletion of angiotensin AT2 receptor leads to increased cell numbers in different brain structures. Regul Pept. 99, 209-216
39. Vervoort, V. S., Beachem, M. A., Edwards, P. S., Ladd, S., Miller, K. E., de Mollerat, X., Clarkson, K., DuPont, B., Schwartz, C. E., Stevenson, R. E., et al. (2002) AGTR2 mutations in X-linked mental retardation. Science 296, 2401-2403
40. Ogier, M., Bezin, L., Cottet-Emard, J.-M., Bader, M., Vincent, M., Pequignot, J. M., McGregor, J., and Bricca, G. (2003) Delayed maturation of catecholamine phenotype in nucleus tractus solilarius of rats with glial angiotensinogen depletion. Hypertension 42, 978-984