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Volumn 37, Issue 3, 2005, Pages 233-242

Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; COVARIANCE; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC CORRELATION; GENETIC EPISTASIS; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; GENOME ANALYSIS; HAPLOTYPE; INBRED STRAIN; MOUSE; NERVOUS SYSTEM FUNCTION; NONHUMAN; PHENOTYPE; PLEIOTROPY; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS MAPPING; SYNAPSE; TISSUE SPECIFICITY; ANIMAL; DNA MICROARRAY; GENE EXPRESSION REGULATION; GENETICS; QUANTITATIVE TRAIT LOCUS; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 20144386111     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng1518     Document Type: Article
Times cited : (619)

References (50)
  • 2
    • 0035400051 scopus 로고    scopus 로고
    • Genetical genomics: The added value from segregation
    • Jansen, R. & Nap, J.P. Genetical genomics: the added value from segregation. Trends Genet. 17, 388-391 (2001).
    • (2001) Trends Genet , vol.17 , pp. 388-391
    • Jansen, R.1    Nap, J.P.2
  • 3
    • 0037177625 scopus 로고    scopus 로고
    • Genetic dissection of transcriptional regulation in budding yeast
    • Brem, R., Yvert, G., Clinton, R. & Kruglyak, L. Genetic dissection of transcriptional regulation in budding yeast. Science 296, 725-755 (2002).
    • (2002) Science , vol.296 , pp. 725-755
    • Brem, R.1    Yvert, G.2    Clinton, R.3    Kruglyak, L.4
  • 4
    • 0027215902 scopus 로고
    • Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways
    • Bading, H., Ginty, D.D. & Greenberg, M.E. Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways. Science 260, 181-186 (1993).
    • (1993) Science , vol.260 , pp. 181-186
    • Bading, H.1    Ginty, D.D.2    Greenberg, M.E.3
  • 5
    • 0033852468 scopus 로고    scopus 로고
    • A mouse phenome project
    • Paigen, K. & Eppig, J. A mouse phenome project. Mamm. Genome 111, 715-717 (2000).
    • (2000) Mamm. Genome , vol.111 , pp. 715-717
    • Paigen, K.1    Eppig, J.2
  • 6
    • 0036215090 scopus 로고    scopus 로고
    • Genetic dissection of complex and quantitative traits: From fantasy to reality via a community effort
    • Threadgill, D.W., Hunter, K.W. & Williams, R.W. Genetic dissection of complex and quantitative traits: from fantasy to reality via a community effort. Mamm. Genome 13, 175-178 (2002).
    • (2002) Mamm. Genome , vol.13 , pp. 175-178
    • Threadgill, D.W.1    Hunter, K.W.2    Williams, R.W.3
  • 7
    • 25444501564 scopus 로고    scopus 로고
    • A new set of BXD recombinant inbred lines from advanced intercross populations in mice
    • Peirce, J.L. et al. A new set of BXD recombinant inbred lines from advanced intercross populations in mice. BMC Genet. 5, 7 (2004).
    • (2004) BMC Genet , vol.5 , pp. 7
    • Peirce, J.L.1
  • 8
    • 0035145485 scopus 로고    scopus 로고
    • High-resolution genetic mapping of the saccharin preference locus (Sac) and the putative sweet taste receptor (T1R1) gene (Gpr70) to mouse distal Chromosome 4
    • Li, X. et al. High-resolution genetic mapping of the saccharin preference locus (Sac) and the putative sweet taste receptor (T1R1) gene (Gpr70) to mouse distal Chromosome 4. Mamm. Genome 12, 13-16 (2001).
    • (2001) Mamm. Genome , vol.12 , pp. 13-16
    • Li, X.1
  • 9
    • 0344341625 scopus 로고    scopus 로고
    • The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans
    • Mogil, J.S. et al. The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans. Proc. Natl. Acad. Sci. USA 100, 4867-4872 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 4867-4872
    • Mogil, J.S.1
  • 10
    • 3042696861 scopus 로고    scopus 로고
    • Mpdz is a quantitative trait gene for drug withdrawal seizures
    • Shirley, R.L. et al. Mpdz is a quantitative trait gene for drug withdrawal seizures. Nat. Neurosci. 7, 699-700 (2004).
    • (2004) Nat. Neurosci. , vol.7 , pp. 699-700
    • Shirley, R.L.1
  • 11
    • 0032770189 scopus 로고    scopus 로고
    • Genotyping new BXD recombinant inbred mouse strains and comparison of BXD and consensus maps
    • Taylor, B.A. et al. Genotyping new BXD recombinant inbred mouse strains and comparison of BXD and consensus maps. Mamm. Genome 10, 335-348 (1999).
    • (1999) Mamm. Genome , vol.10 , pp. 335-348
    • Taylor, B.A.1
  • 12
    • 0037222985 scopus 로고    scopus 로고
    • Analysis of quantitative trait loci that influence animal behavior
    • Flint, J. Analysis of quantitative trait loci that influence animal behavior. J. Neurobiol. 54, 46-77 (2003).
    • (2003) J. Neurobiol. , vol.54 , pp. 46-77
    • Flint, J.1
  • 13
    • 0037456823 scopus 로고    scopus 로고
    • Genetics of gene expression surveyed in maize, mouse and man
    • Schadt, E.E. et al. Genetics of gene expression surveyed in maize, mouse and man. Nature 422, 297-302 (2003).
    • (2003) Nature , vol.422 , pp. 297-302
    • Schadt, E.E.1
  • 14
    • 20144383240 scopus 로고    scopus 로고
    • Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics'
    • advance online publication, 13 February (doi:10.1038/ng1497)
    • Bystrykh, L. et al. Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics'. Nat. Genet. advance online publication, 13 February 2005 (doi:10.1038/ng1497).
    • (2005) Nat. Genet.
    • Bystrykh, L.1
  • 15
    • 0031914691 scopus 로고    scopus 로고
    • Effect of within-strain sample size on QTL detection and mapping using recombinant inbred mouse strains
    • Belknap, J.K. Effect of within-strain sample size on QTL detection and mapping using recombinant inbred mouse strains. Behav. Genet. 28, 29-38 (1998).
    • (1998) Behav. Genet. , vol.28 , pp. 29-38
    • Belknap, J.K.1
  • 16
    • 0242290115 scopus 로고    scopus 로고
    • WebQTL: Web-based complex trait analysis
    • Wang, J., Williams, R.W. & Manly, K.F. WebQTL: Web-based complex trait analysis. Neuroinformatics 1, 299-308 (2003).
    • (2003) Neuroinformatics , vol.1 , pp. 299-308
    • Wang, J.1    Williams, R.W.2    Manly, K.F.3
  • 17
    • 0032407584 scopus 로고    scopus 로고
    • Towards the cloning of genes underlying murine QTLs
    • Rikke, B.A. & Johnson, T.E. Towards the cloning of genes underlying murine QTLs. Mamm. Genome 9, 963-968 (1998).
    • (1998) Mamm. Genome , vol.9 , pp. 963-968
    • Rikke, B.A.1    Johnson, T.E.2
  • 18
    • 0032832016 scopus 로고    scopus 로고
    • Speed congenics: Accelerated genome recovery using genetic markers
    • Visscher, P.M. Speed congenics: accelerated genome recovery using genetic markers. Genet. Res. 74, 81-85 (1999).
    • (1999) Genet. Res. , vol.74 , pp. 81-85
    • Visscher, P.M.1
  • 19
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: A practical and powerful approach to multiple testing
    • Benjamini, Y. & Hochberg, Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Stat. Soc. B 57, 289-300 (1995).
    • (1995) J. R. Stat. Soc. B , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 20
    • 3042562270 scopus 로고    scopus 로고
    • Genomics, prior probability, and statistical tests of multiple hypotheses
    • Manly, K.F., Nettleton, D. & Hwang, J.T. Genomics, prior probability, and statistical tests of multiple hypotheses. Genome Res. 14, 997-1001 (2004).
    • (2004) Genome Res , vol.14 , pp. 997-1001
    • Manly, K.F.1    Nettleton, D.2    Hwang, J.T.3
  • 21
    • 1142273091 scopus 로고    scopus 로고
    • Strong control, conservative point estimation, and simultaneous conservative consistency of false discovery rates: A unified approach
    • Storey, J.D., Taylor, J.E. & Siegmund, D. Strong control, conservative point estimation, and simultaneous conservative consistency of false discovery rates: a unified approach. J. R. Stat. Soc. B 66, 187-205 (2004).
    • (2004) J. R. Stat. Soc. B , vol.66 , pp. 187-205
    • Storey, J.D.1    Taylor, J.E.2    Siegmund, D.3
  • 22
    • 0034069495 scopus 로고    scopus 로고
    • Gene ontology: Tool for the unification of biology
    • The Gene Ontology Consortium
    • Ashburner, M. et al. Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat. Genet. 25, 25-29 (2000).
    • (2000) Nat. Genet. , vol.25 , pp. 25-29
    • Ashburner, M.1
  • 23
    • 2942550697 scopus 로고    scopus 로고
    • GOTree Machine (GOTM): A web-based platform for interpreting interesting sets of genes using Gene Ontology hierarchies
    • Zhang, B., Schmoyer, D., Kirov, S. & Snoddy, J. GOTree Machine (GOTM): a web-based platform for interpreting interesting sets of genes using Gene Ontology hierarchies. BMC Bioinformatics 5, 16 (2004).
    • (2004) BMC Bioinformatics , vol.5 , pp. 16
    • Zhang, B.1    Schmoyer, D.2    Kirov, S.3    Snoddy, J.4
  • 24
    • 2142652098 scopus 로고    scopus 로고
    • WebQTL: Rapid exploratory analysis of gene expression and genetic networks for brain and behavior
    • Chesler, E.J., Lu, L., Wang, J., Williams, R.W. & Manly, K.F. WebQTL: rapid exploratory analysis of gene expression and genetic networks for brain and behavior. Nat. Neurosci. 7, 485-486 (2004).
    • (2004) Nat. Neurosci. , vol.7 , pp. 485-486
    • Chesler, E.J.1    Lu, L.2    Wang, J.3    Williams, R.W.4    Manly, K.F.5
  • 25
    • 0242353110 scopus 로고    scopus 로고
    • Genetic correlates of gene expression in recombinant inbred strains: A relational model system to explore neurobehavioral phenotypes
    • Chesler, E.J. et al. Genetic correlates of gene expression in recombinant inbred strains: a relational model system to explore neurobehavioral phenotypes. Neuroinformatics 1, 343-357 (2003).
    • (2003) Neuroinformatics , vol.1 , pp. 343-357
    • Chesler, E.J.1
  • 26
    • 14644441018 scopus 로고    scopus 로고
    • The Collaborative Cross, a community resource for the genetic analysis of complex traits
    • Churchill, G.A. et al. The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat. Genet. 36, 1133-1137 (2004).
    • (2004) Nat. Genet. , vol.36 , pp. 1133-1137
    • Churchill, G.A.1
  • 27
    • 0035873157 scopus 로고    scopus 로고
    • Complex trait analysis of the hippocampus: Mapping and biometric analysis of two novel gene loci with specific effects on hippocampal structure in mice
    • Lu, L., Airey, D.C. & Williams, R.W. Complex trait analysis of the hippocampus: mapping and biometric analysis of two novel gene loci with specific effects on hippocampal structure in mice. J. Neurosci. 21, 3503-3514 (2001).
    • (2001) J. Neurosci. , vol.21 , pp. 3503-3514
    • Lu, L.1    Airey, D.C.2    Williams, R.W.3
  • 28
    • 0041466244 scopus 로고    scopus 로고
    • Genetic architecture of the mouse hippocampus: Identification of gene loci with selective regional effects
    • Peirce, J.L., Chesler, E.J., Williams, R.W. & Lu, L. Genetic architecture of the mouse hippocampus: identification of gene loci with selective regional effects. Genes Brain Behav. 2, 238-252 (2003).
    • (2003) Genes Brain Behav , vol.2 , pp. 238-252
    • Peirce, J.L.1    Chesler, E.J.2    Williams, R.W.3    Lu, L.4
  • 29
    • 0347917102 scopus 로고    scopus 로고
    • Quantitative genetic analysis of ventral midbrain and liver iron in BXD recombinant inbred mice
    • Jones, B.C. et al. Quantitative genetic analysis of ventral midbrain and liver iron in BXD recombinant inbred mice. Nutr. Neurosci. 6, 369-377 (2003).
    • (2003) Nutr. Neurosci. , vol.6 , pp. 369-377
    • Jones, B.C.1
  • 30
    • 0029029347 scopus 로고
    • Localization of genes influencing ethanol-induced conditioned place preference and locomotor activity in BXD recombinant inbred mice
    • Cunningham, C.L. Localization of genes influencing ethanol-induced conditioned place preference and locomotor activity in BXD recombinant inbred mice. Psychopharmacology 120, 28-24 (1995).
    • (1995) Psychopharmacology , vol.120 , pp. 28-124
    • Cunningham, C.L.1
  • 31
    • 0031689868 scopus 로고    scopus 로고
    • Ethanol-induced conditioned taste aversion in BXD recombinant inbred mice
    • Risinger, F.O. & Cunningham, C.L. Ethanol-induced conditioned taste aversion in BXD recombinant inbred mice. Alcohol. Clin. Exp. Res. 22, 1234-1244 (1998).
    • (1998) Alcohol. Clin. Exp. Res. , vol.22 , pp. 1234-1244
    • Risinger, F.O.1    Cunningham, C.L.2
  • 32
    • 0020641441 scopus 로고
    • Polygenic and single-gene determination of responses to ethanol in BXD/Ty recombinant inbred mouse strains
    • Crabbe, J.C., Kosobud, A., Young, E.R. & Janowsky, J.S. Polygenic and single-gene determination of responses to ethanol in BXD/Ty recombinant inbred mouse strains. Neurobehav. Toxicol. Teratol. 5, 181-187 (1983).
    • (1983) Neurobehav. Toxicol. Teratol. , vol.5 , pp. 181-187
    • Crabbe, J.C.1    Kosobud, A.2    Young, E.R.3    Janowsky, J.S.4
  • 34
    • 0028937958 scopus 로고
    • Effects of acute and repeated ethanol exposures on the locomotor activity of BXD recombinant inbred mice
    • Phillips, T.J., Huson, M., Gwiazdon, C., Burkhart-Kasch, S. & Shen, E.H. Effects of acute and repeated ethanol exposures on the locomotor activity of BXD recombinant inbred mice. Alcohol. Clin. Exp. Res. 19, 269-278 (1995).
    • (1995) Alcohol. Clin. Exp. Res. , vol.19 , pp. 269-278
    • Phillips, T.J.1    Huson, M.2    Gwiazdon, C.3    Burkhart-Kasch, S.4    Shen, E.H.5
  • 35
    • 0037260411 scopus 로고    scopus 로고
    • Dopamine D2 receptor binding, Drd2 expression and the number of dopamine neurons in the BXD recombinant inbred series: Genetic relationships to alcohol and other drug associated phenotypes
    • Hitzemann, R. et al. Dopamine D2 receptor binding, Drd2 expression and the number of dopamine neurons in the BXD recombinant inbred series: genetic relationships to alcohol and other drug associated phenotypes. Alcohol. Clin. Exp. Res. 27, 1-11 (2003).
    • (2003) Alcohol. Clin. Exp. Res. , vol.27 , pp. 1-11
    • Hitzemann, R.1
  • 36
    • 0042424602 scopus 로고    scopus 로고
    • Statistical significance for genomewide studies
    • Storey, J.D. & Tibshirani, R. Statistical significance for genomewide studies. Proc. Natl. Acad. Sci. USA 100, 9440-9445 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 9440-9445
    • Storey, J.D.1    Tibshirani, R.2
  • 37
    • 0033570305 scopus 로고    scopus 로고
    • Identification of a cis-acting dendritic targeting element in MAP2 mRNAs
    • Blichenberg, A. et al. Identification of a cis-acting dendritic targeting element in MAP2 mRNAs. J. Neurosci. 19, 8818-8829 (1999).
    • (1999) J. Neurosci. , vol.19 , pp. 8818-8829
    • Blichenberg, A.1
  • 39
    • 25844464750 scopus 로고    scopus 로고
    • Computational, integrative and comparative methods for the elucidation of genetic co-expression networks
    • in the press
    • Baldwin, N.E. et al. Computational, integrative and comparative methods for the elucidation of genetic co-expression networks. J. Biomed. Biotechnol. (in the press).
    • J. Biomed. Biotechnol.
    • Baldwin, N.E.1
  • 40
    • 0032837739 scopus 로고    scopus 로고
    • Down-regulation of striatin, a neuronal calmodulin-binding protein, impairs rat locomotor activity
    • Bartoli, M. et al. Down-regulation of striatin, a neuronal calmodulin-binding protein, impairs rat locomotor activity. J. Neurobiol. 40, 234-243 (1999).
    • (1999) J. Neurobiol. , vol.40 , pp. 234-243
    • Bartoli, M.1
  • 41
    • 0037093469 scopus 로고    scopus 로고
    • Synaptic multiprotein complexes associated with 5-HT(2C) receptors: A proteomic approach
    • Becamel, C. et al. Synaptic multiprotein complexes associated with 5-HT(2C) receptors: a proteomic approach. EMBO J. 21, 2332-2342 (2002).
    • (2002) EMBO J , vol.21 , pp. 2332-2342
    • Becamel, C.1
  • 42
    • 18544382234 scopus 로고    scopus 로고
    • Genetic analysis of the mouse brain proteome
    • Klose, J. et al. Genetic analysis of the mouse brain proteome. Nat. Genet. 30, 385-393 (2002).
    • (2002) Nat. Genet. , vol.30 , pp. 385-393
    • Klose, J.1
  • 43
    • 16544388283 scopus 로고    scopus 로고
    • Brain gene expression: Genomics and genetics
    • Chesler, E.J. & Williams, R.W. Brain gene expression: genomics and genetics. Int. Rev. Neurobiol. 60, 59-95 (2004).
    • (2004) Int. Rev. Neurobiol. , vol.60 , pp. 59-95
    • Chesler, E.J.1    Williams, R.W.2
  • 44
    • 11844254278 scopus 로고    scopus 로고
    • Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice
    • Yalcin, B. et al. Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice. Nat. Genet. 36, 1197-1202 (2004).
    • (2004) Nat. Genet. , vol.36 , pp. 1197-1202
    • Yalcin, B.1
  • 45
    • 0035233644 scopus 로고    scopus 로고
    • The genetic structure of recombinant inbred mice: High-resolution consensus maps for complex trait analysis
    • RESEARCH0046
    • Williams, R.W., Gu, J., Qi, S. & Lu, L. The genetic structure of recombinant inbred mice: high-resolution consensus maps for complex trait analysis. Genome Biol. 2, RESEARCH0046 (2002).
    • (2002) Genome Biol , vol.2
    • Williams, R.W.1    Gu, J.2    Qi, S.3    Lu, L.4
  • 46
    • 12344280017 scopus 로고    scopus 로고
    • Summaries of Affymetrix GeneChip probe level data
    • Irizarry, R.A. et al. Summaries of Affymetrix GeneChip probe level data. Nucleic Acids Res. 31, e15 (2003).
    • (2003) Nucleic Acids Res , vol.31
    • Irizarry, R.A.1
  • 47
    • 0028151261 scopus 로고
    • Empirical threshold values for quantitative trait mapping
    • Churchill, G.A. & Doerge, R.W. Empirical threshold values for quantitative trait mapping. Genetics 13, 963-971 (1994).
    • (1994) Genetics , vol.13 , pp. 963-971
    • Churchill, G.A.1    Doerge, R.W.2
  • 48
    • 0030068965 scopus 로고    scopus 로고
    • Confidence intervals in QTL mapping by bootstrapping
    • Visscher, P.M., Thomopson, R. & Haley, C.S. Confidence intervals in QTL mapping by bootstrapping. Genetics 143, 1013-1020 (1996).
    • (1996) Genetics , vol.143 , pp. 1013-1020
    • Visscher, P.M.1    Thomopson, R.2    Haley, C.S.3
  • 50
    • 0037958742 scopus 로고    scopus 로고
    • R/qtl: QTL mapping in experimental crosses
    • Broman, K., Wu, H., Sen, S. & Churchill, G.A. R/qtl: QTL mapping in experimental crosses. Bioinformatics, 19, 889-890 (2003).
    • (2003) Bioinformatics , vol.19 , pp. 889-890
    • Broman, K.1    Wu, H.2    Sen, S.3    Churchill, G.A.4


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