A Ser9Gly polymorphism in the dopamine D3 receptor gene (DRD3) and event-related P300 potentials

Neuropsychopharmacology

Volumn 31, Issue 6, 2006, Pages 1335-1344

  Mulert, Christoph ^a   Juckel, Georg ^a   Giegling, Ina ^a   Pogarell, Oliver ^a   Leicht, Gregor ^a   Karch, Susanne ^a   Mavrogiorgou, Paraskevi ^a   Möller, Hans Jürgen ^a   Hegerl, Ulrich ^a   Rujescu, Dan ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Alcoholism; Dopamine D3 receptor; Evoked potential; LORETA; P300; Schizophrenia

Indexed keywords

DOPAMINE 3 RECEPTOR; GLYCINE; SERINE;

ADULT; ALCOHOLISM; ARTICLE; DRD3 GENE; EVENT RELATED POTENTIAL; FEMALE; GENE; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETICS; HERITABILITY; HIGH RISK PATIENT; HOMOZYGOTE; HUMAN; HUMAN EXPERIMENT; MALE; MENTAL DISEASE; MENTAL PATIENT; NORMAL HUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; RECEPTOR GENE; SCHIZOPHRENIA;

ACOUSTIC STIMULATION; ADULT; AGED; BRAIN; BRAIN MAPPING; EVENT-RELATED POTENTIALS, P300; FEMALE; GLYCINE; HUMANS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; POLYMORPHISM, GENETIC; RECEPTORS, DOPAMINE D3; SERINE; STATISTICS, NONPARAMETRIC;

EID: 33745636344     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.npp.1300984     Document Type: Article

References (73)

1. Almasy L, Porjesz B, Blangero J, Chorlian DB, O'Connor SJ, Kuperman S et al (1999). Heritability of event-related brain potentials in families with a history of alcoholism. Am J Med Genet 88: 383-390.
2. Anderer P, Saletu B, Semlitsch HV, Pascual-Marqui RD (2003). Non-invasive localization of P300 sources in normal aging and age-associated memory impairment. Neurobiol Aging 24: 463-479.
3. Basile VS, Masellis M, Badri F, Paterson AD, Meltzer HY, Lieberman JA et al (1999). Association of the MscI polymorphism of the dopamine D3 receptor gene with tardive dyskinesia in schizophrenia. Neuropsychopharmacology 21: 17-27.
4. Black KJ, Hershey T, Koller JM, Videen TO, Mintun MA, Price JL et al (2002). A possible substrate for dopamine-related changes in mood and behavior: prefrontal and limbic effects of a D3-preferring dopamine agonist. Proc Natl Acad Sci USA 99: 17113-17118.
5. Blackwood D (2000). P300, a state and a trait marker in schizophrenia (In Process Citation). Lancet 355: 771-772.
6. Boyce JM, Risinger FO (2002). Dopamine D3 receptor antagonist effects on the motivational effects of ethanol. Alcohol 28: 47-55.
7. Bramon E, McDonald C, Croft RJ, Landau S, Filbey F, Gruzelier JH et al (2005). Is the P300 wave an endophenotype for schizophrenia? A meta-analysis and a family study. Neuroimage 27: 960-968.
8. Bruder GE, Kayser J, Tenke CE, Friedman M, Malaspina D, Gorman JM et al (2001). Event-related potentials in schizophrenia during tonal and phonetic oddball tasks: relations to diagnostic subtype, symptom features and verbal memory. Biol Psychiatry 50: 447-452.
9. Cohen HL, Wang W, Porjesz B, Begleiter H (1995). Auditory P300 in young alcoholics: regional response characteristics. Alcohol Clin Exp Res 19: 469-475.
10. Crocq MA, Mant R, Asherson P, Williams J, Hode Y, Mayerova A et al (1992). Association between schizophrenia and homozygosity at the dopamine D3 receptor gene. J Med Genet 29: 858-860.
11. Demiralp T, Ucok A, Devrim M, Isoglu-Alkac U, Tecer A, Polich J (2002). N2 and P3 components of event-related potential in first-episode schizophrenic patients: scalp topography, medication, and latency effects. Psychiatry Res 111: 167-179.
12. Eischen SE, Polich J (1994). P300 from families. Electroencephalogr Clin Neurophysiol 92: 369-372.
13. Fallgatter AJ, Bartsch AJ, Zielasek J, Herrmann MJ (2003). Brain electrical dysfunction of the anterior cingulate in schizophrenic patients. Psychiatry Res 124: 37-48.
14. First MB, Spitzer RL, Gibbon M, Williams JB (1997). Structured Clinical Interview for DSM-IV Axis I and II Disorders. American Psychiatric Press: Washington, DC.
15. Frodl-Bauch T, Bottlender R, Hegerl U (1999). Neurochemical substrates and neuroanatomical generators of the event-related P300. Neuropsychobiology 40: 86-94.
16. Gallinat J, Bajbouj M, Bajobouji M, Rentzsch J, Senkowski D, Schunter J et al (2003). Association of the G1947A COMT (Val(108/158)Met) gene polymorphism with prefrontal P300 during information processing. Biol Psychiatry 54: 40-48.
17. Gallinat J, Mulert C, Sander T, Schlattmann P, Xu K, Ferro EF et al (2002). Frontal and temporal dysfunction of auditory stimulus processing in schizophrenia. Neuroimage 17: 110-127.
18. George MR, Potts G, Kothman D, Martin L, Mukundan CR (2004). Frontal deficits in alcoholism: an ERP study. Brain Cogn 54: 245-247.
19. Glatt SJ, Faraone SV, Tsuang MT (2003). Association between a functional catechol O-methyltransferase gene polymorphism and schizophrenia: meta-analysis of case-control and family-based studies. Am J Psychiatry 160: 469-476.
20. Gottesman II, Gould TD (2003). The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 160: 636-645.
21. Gray CM, Konig P, Engel AK, Singer W (1989). Oscillatory responses in cat visual cortex exhibit inter-columnar synchronization which reflects global stimulus properties. Nature 338: 334-337.
22. Gurevich EV, Bordelon Y, Shapiro M, Arnold SE, Gur RE, Joyce JN (1997). Mesolimbic dopamine D3 receptors and use of antipsychotics in patients with schizophrenia. A postmortem study. Arch Gen Psychiatry 54: 225-232.
23. Gurevich EV, Joyce JN (1999). Distribution of dopamine D3 receptor expressing neurons in the human forebrain: comparison with D2 receptor expressing neurons. Neuropsychopharmacology 20: 60-80.
24. Hegerl U, Juckel G, Muller-Schubert A, Pietzcker A, Gaebel W (1995). Schizophrenics with small P300: a subgroup with a neurodevelopmental disturbance and a high risk for tardive dyskinesia? Acta Psychiatr Scand 91: 120-125.
25. Heidbreder CA, Andreoli M, Marcon C, Thanos PK, Ashby Jr CR, Gardner EL (2004). Role of dopamine D3 receptors in the addictive properties of ethanol. Drugs Today (Barc) 40: 355-365.
26. Heinz A (2002). Dopaminergic dysfunction in alcoholism and schizophrenia - psychopathological and behavioral correlates. Eur Psychiatry 17: 9-16.
27. Ioannidis JP, Ntzani EE, Trikalinos TA, Contopoulos-Ioannidis DG (2001). Replication validity of genetic association studies. Nat Genet 29: 306-309.
28. Jonsson EG, Flyckt L, Burgert E, Crocq MA, Forslund K, Mattila-Evenden M et al (2003). Dopamine D3 receptor gene Ser9Gly variant and schizophrenia: association study and meta-analysis. Psychiatr Genet 13: 1-12.
29. Jonsson EG, Kaiser R, Brockmoller J, Nimgaonkar VL, Crocq MA (2004). Meta-analysis of the dopamine D3 receptor gene (DRD3) Ser9Gly variant and schizophrenia. Psychiatr Genet 14: 9-12.
30. Joyce JN (2001). D2 but not D3 receptors are elevated after 9 or 11 months chronic haloperidol treatment: influence of withdrawal period. Synapse 40: 137-144.
31. Joyce PR, Rogers GR, Miller AL, Mulder RT, Luty SE, Kennedy MA (2003). Polymorphisms of DRD4 and DRD3 and risk of avoidant and obsessive personality traits and disorders. Psychiatry Res 119: 1-10.
32. Juckel G, Muller-Schubert A, Gaebel W, Hegerl U (1996). Residual symptoms and P300 in schizophrenic outpatients. Psychiatry Res 65: 23-32.
33. Katsanis J, Iacono WG, McGue MK, Carlson SR (1997). P300 event-related potential heritability in monozygotic and dizygotic twins. Psychophysiology 34: 47-58.
34. Krebs MO, Sautel F, Bourdel MC, Sokoloff P, Schwartz JC, Olie JP et al (1998). Dopamine D3 receptor gene variants and substance abuse in schizophrenia. Mol Psychiatry 3: 337-341.
35. Landwehrmeyer B, Mengod G, Palacios JM (1993). Dopamine D3 receptor mRNA and binding sites in human brain. Brain Res Mol Brain Res 18: 187-192.
36. Lerer B, Segman RH, Fangerau H, Daly AK, Basile VS, Cavallaro R et al (2002). Pharmacogenetics of tardive dyskinesia: combined analysis of 780 patients supports association with dopamine D3 receptor gene Ser9Gly polymorphism. Neuropsychopharmacology 27: 105-119.
37. Llinas RR (1988). The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function. Science 242: 1654-1664.
38. Martin-Loeches M, Molina V, Munoz F, Hinojosa JA, Reig S, Desco M et al (2001). P300 amplitude as a possible correlate of frontal degeneration in schizophrenia. Schizophr Res 49: 121-128.
39. Mash DC, Staley JK (1999). D3 dopamine and kappa opioid receptor alterations in human brain of cocaine-overdose victims. Ann NY Acad Sci 877: 507-522.
40. Meador-Woodruff JH, Little KY, Damask SP, Watson SJ (1995). Effects of cocaine on D3 and D4 receptor expression in the human striatum. Biol Psychiatry 38: 263-266.
41. Mulert C, Gallinat J, Pascual-Marqui H, Dorn H, Frick K, Schlattmann P et al (2001). Reduced event-related current density in the anterior cingulate cortex in schizophrenia. Neuroimage 13: 589-600.
42. Mulert C, Jager L, Schmitt R, Bussfeld P, Pogarell O, Moller HJ et al (2004a). Integration of fMRI and simultaneous EEG: towards a comprehensive understanding of localization and time-course of brain activity in target detection. Neuroimage 22: 83-94.
43. Mulert C, Jager L, Juckel G, Rujescu D, Giegling I, Rupp D et al (2005). Sound level dependence of the primary auditory cortex: Simultaneous measurement with 61-channel EEG and fMRI. Neuroimage 28: 49-58.
44. Mulert C, Pogarell O, Propp S, Karch S, Stormann S, Pogarell O et al (2004b). The neural basis of the P300 potential. Focus on the time-course of the underlying cortical generators. Eur Arch Psychiatry Clin Neurosci 254: 190-198.
45. Olichney JM, Iragui VJ, Kutas M, Nowacki R, Morris S, Jeste DV et al (1998). Relationship between auditory P300 amplitude and age of onset of schizophrenia in older patients. Psychiatry Res 79: 241-254.
46. Pae JS, Kwon JS, Youn T, Park HJ, Kim MS, Lee B et al (2003). LORETA imaging of P300 in schizophrenia with individual MRI and 128-channel EEG. Neuroimage 20: 1552-1560.
47. Pascual-Marqui RD, Lehmann D, Lehmann D (1999). Low resolution brain electromagnetic tomography (LORETA) functional imaging in acute, neuroleptic-naive, first-episode, productive schizophrenia. Psychiatry Res 90: 169-179.
48. Pascual-Marqui RD, Michel CM, Koenig T, Kochi K, Merlo MC, Hell D et al (1994). Low resolution electromagnetic tomography: a new method for localizing electrical activity in the brain. Int J Psychophysiol 18: 49-65.
49. Pfefferbaum A, Ford JM, White PM, Mathalon D (1991). Event-related potentials in alcoholic men: P3 amplitude reflects family history but not alcohol consumption. Alcohol Clin Exp Res 15: 839-850.
50. Polich J, Pollock VE, Bloom FE (1994). Meta-analysis of P300 amplitude from males at risk for alcoholism. Psychol Bull 115: 55-73.
51. Reynolds GP, Yao Z, Zhang X, Sun J, Zhang Z (2005). Pharmacogenetics of treatment in first-episode schizophrenia: D3 and 5-HT2C receptor polymorphisms separately associate with positive and negative symptom response. Eur Neuropsychopharmacol 15: 143-151.
52. Rice JP, Reich T, Bucholz KK, Neuman RJ, Fishman R, Rochberg N (1995). Comparison of direct interview and family history diagnoses of alcohol dependence. Alcohol Clin Exp Res 19: 1018-1023.
53. Rietschel M, Krauss H, Muller DJ, Schulze TG, Knapp M, Marwinski K et al (2000). Dopamine D3 receptor variant and tardive dyskinesia. Eur Arch Psychiatry Clin Neurosci 250: 31-35.
54. Roth WT, Pfefferbaum A, Kelly AF, Berger PA, Kopell BS (1981). Auditory event-related potentials in schizophrenia and depression. Psychiatry Res 4: 199-212.
55. Sabate O, Campion D, d'Amato T, Martres MP, Sokoloff P, Giros B et al (1994). Failure to find evidence for linkage or association between the dopamine D3 receptor gene and schizophrenia. Am J Psychiatry 151: 107-111.
56. Schuckit MA, Kelsoe JR, Braff DL, Wilhelmsen KC (2003). Some possible genetic parallels across alcoholism, bipolar disorder and schizophrenia. J Stud Alcohol 64: 157-159.
57. Segman R, Neeman T, Heresco-Levy U, Finkel B, Karagichev L, Schlafman M et al (1999). Genotypic association between the dopamine D3 receptor and tardive dyskinesia in chronic schizophrenia. Mol Psychiatry 4: 247-253.
58. Silva LR, Amitai Y, Connors BW (1991). Intrinsic oscillations of neocortex generated by layer 5 pyramidal neurons. Science 251: 432-435.
59. Staley JK, Mash DC (1996). Adaptive increase in D3 dopamine receptors in the brain reward circuits of human cocaine fatalities. J Neurosci 16: 6100-6106.
60. Stanzione P, Fattapposta F, Tagliati M, D'Alessio C, Marciani MG, Foti A et al (1990). Dopaminergic pharmacological manipulations in normal humans confirm the specificity of the visual (PERG-VEP) and cognitive (P300) electrophysiological alterations in Parkinson's disease. Electroencephalogr Clin Neurophysiol Suppl 41: 216-220.
61. Stanzione P, Fattapposta F, Giunti P, D'Alessio C, Tagliati M, Affricano C et al (1991). P300 variations in parkinsonian patients before and during dopaminergic monotherapy: a suggested dopamine component in P300. Electroencephalogr Clin Neurophysiol 80: 446-453.
62. Steen VM, Lovlie R, MacEwan T, McCreadie RG (1997). Dopamine D3-receptor gene variant and susceptibility to tardive dyskinesia in schizophrenic patients. Mol Psychiatry 2: 139-145.
63. Strik WK, Dierks T, Franzek E, Stober G, Maurer K (1994). P300 in schizophrenia: interactions between amplitudes and topography. Biol Psychiatry 35: 850-856.
64. Suzuki M, Hurd YL, Sokoloff P, Schwartz JC, Sedvall G (1998). D3 dopamine receptor mRNA is widely expressed in the human brain. Brain Res 779: 58-74.
65. Takeshita S, Ogura C (1994). Effect of the dopamine D2 antagonist sulpiride on event-related potentials and its relation to the law of initial value. Int J Psychophysiol 16: 99-106.
66. Talairach J, Tournoux P (1988). Co-Planar Stereotaxic Atlas of the Human Brain. Stuttgart: Thieme.
67. Towle VL, Bolanos J, Suarez D, Tan K, Grzeszczuk R, Levin DN et al (1993). The spatial location of EEG electrodes: locating the best-fitting sphere relative to cortical anatomy. Electroencephalogr Clin Neurophysiol 86: 1-6.
68. Tsai SJ, Yu YW, Chen TJ, Chen CM, Hong CJ (2003). Association analysis for dopamine D3 receptor, dopamine D4 receptor and dopamine transporter genetic polymorphisms and P300 event-related potentials for normal young females. Psychiatr Genet 13: 51-53.
69. van Beijsterveldt CE, van Baal GC (2002). Twin and family studies of the human electroencephalogram: a review and a meta-analysis. Biol Psychol 61: 111-138.
70. Winterer G, Egan MF, Raedler T, Sanchez C, Jones DW, Coppola R et al (2003). P300 and genetic risk for schizophrenia. Arch Gen Psychiatry 60: 1158-1167.
71. Wittchen HU, Zaudig M, Fydrich T (1997). Strukturiertes Klinisches Interview für DSM-IV, Achse I und II: Persönlichkeitsstörungen (Structured clinical interviews for DSM-IV Axis I and II disorders). Hogrefe: Goettingen, Germany.
72. Woo SI, Kim JW, Rha E, Han SH, Hahn KH, Park CS et al (2002). Association of the Ser9Gly polymorphism in the dopamine D3 receptor gene with tardive dyskinesia in Korean schizophrenics. Psychiatr Clin Neurosci 56: 469-474.
73. Wright MJ, Hansell NK, Geffen GM, Geffen LB, Smith GA, Martin NG (2001). Genetic influence on the variance in P3 amplitude and latency. Behav Genet 31: 555-565.