Compulsive alcohol drinking in rodents

Addiction Biology

Volumn 14, Issue 4, 2009, Pages 384-396

  Vengeliene, Valentina ^a   Celerier, Evelyne ^b   Chaskiel, Lea ^b   Penzo, Franco ^b   Spanagel, Rainer ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b Panlab Scientific Department   (Spain)

Author keywords

Alcoholism; Brain neurotransmission; Obsessive compulsive disorder; Prefrontal cortex; Relapse; Striatum

Indexed keywords

ALCOHOL DERIVATIVE; NEUROTRANSMITTER;

ABSTINENCE; ALCOHOL CONSUMPTION; ALCOHOLISM; BRAIN REGION; CINGULATE GYRUS; DRINKING BEHAVIOR; ELECTROENCEPHALOGRAM; EXPERIMENTAL ANIMAL; EXPERIMENTAL MODEL; EXTRAPYRAMIDAL SYSTEM; GENETIC PREDISPOSITION; GENETICS; MONOAMINERGIC SYSTEM; MOTOR SYSTEM; NEUROBIOLOGY; NEUROIMAGING; NEUROTRANSMISSION; NONHUMAN; OBSESSIVE COMPULSIVE DISORDER; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROVOCATION; REVIEW; RODENT; THINKING;

ALCOHOL DRINKING; ANIMALS; BRAIN; COMPULSIVE BEHAVIOR; CORPUS STRIATUM; DISEASE MODELS, ANIMAL; ETHANOL; OBSESSIVE-COMPULSIVE DISORDER; PREFRONTAL CORTEX; RECURRENCE; RODENTIA; SYNAPTIC TRANSMISSION;

EID: 70049114656     PISSN: 13556215     EISSN: 13691600     Source Type: Journal    
DOI: 10.1111/j.1369-1600.2009.00177.x     Document Type: Review

References (112)

1. Agabio R, Carai MA, Lobina C, Pani M, Reali R, Vacca G, Gessa GL, Colombo G (2000) Development of short-lasting alcohol deprivation effect in sardinian alcohol-preferring rats. Alcohol 21 : 59 62.
2. Aouizerate B, Guehl D, Cuny E, Rougier A, Bioulac B, Tignol J, Burbaud P (2004) Pathophysiology of obsessive-compulsive disorder: a necessary link between phenomenology, neuropsychology, imagery and physiology. Prog Neurobiol 72 : 195 221.
3. Belin D, Everitt BJ (2008) Cocaine seeking habits depend upon dopamine-dependent serial connectivity linking the ventral with the dorsal striatum. Neuron 57 : 432 441.
4. Bell RL, Rodd ZA, Schultz JA, Peper CL, Lumeng L, Murphy JM, McBride WJ (2008) Effects of short deprivation and re-exposure intervals on the ethanol drinking behavior of selectively bred high alcohol-consuming rats. Alcohol 42 : 407 416.
5. Burish TG, Maisto SA, Cooper AM, Sobell MB (1981) Effects of voluntary short-term abstinence from alcohol on subsequent drinking patterns of college students. J Stud Alcohol 42 : 1013 1020.
6. Bäckstrom P, Hyytia P (2004) Ionotropic glutamate receptor antagonists modulate cue-induced reinstatement of ethanol-seeking behavior. Alcohol Clin Exp Res 28 : 558 565.
7. Chakrabarty K, Bhattacharyya S, Christopher R, Khanna S (2005) Glutamatergic dysfunction in OCD. Neuropsychopharmacology 30 : 1735 1740.
8. Collins MA, Corso TD, Neafsey EJ (1996) Neuronal degeneration in rat cerebrocortical and olfactory regions during subchronic 'binge' intoxication with ethanol: possible explanation for olfactory deficits in alcoholics. Alcohol Clin Exp Res 20 : 284 292.
9. Colombo G, Lobina C, Carai MA, Gessa GL (2006) Phenotypic characterization of genetically selected Sardinian alcohol-preferring (sP) and -non-preferring (sNP) rats. Addict Biol 11 : 324 338.
10. Cummings DE, Naleid AM, Figlewicz Lattemann DP (2007) Ghrelin: a link between energy homeostasis and drug abuse? Addict Biol 12 : 1 5.
11. Daoust M, Chretien P, Moore N, Saligaut C, Lhuintre JP, Boismare F (1985) Isolation and striatal (3H) serotonin uptake: role in the voluntary intake of ethanol by rats. Pharmacol Biochem Behav 22 : 205 208.
12. Dayas CV, Martin-Fardon R, Thorsell A, Weiss F (2004) Chronic footshock, but not a physiological stressor, suppresses the alcohol deprivation effect in dependent rats. Alcohol Alcohol 39 : 190 196.
13. Denys D, Zohar J, Westenberg HG (2004) The role of dopamine in obsessive-compulsive disorder: preclinical and clinical evidence. J Clin Psychiatry 65 : S11 S17.
14. Deroche-Gamonet V, Belin D, Piazza PV (2004) Evidence for addiction-like behavior in the rat. Science 305 : 1014 1017.
15. Di Chiara G, Imperato A (1988) Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proc Natl Acad Sci USA 85 : 5274 5278.
16. Dickinson A, Wood N, Smith JW (2002) Alcohol seeking by rats: action or habit? Q J Exp Psychol B 55 : 331 348.
17. Dom G, Sabbe B, Hulstijn W, van den Brink W (2005) Substance use disorders and the orbitofrontal cortex: systematic review of behavioural decision-making and neuroimaging studies. Br J Psychiatry 187 : 209 220.
18. Everitt BJ, Dickinson A, Robbins TW (2001) The neuropsychological basis of addictive behaviour. Brain Res Rev 36 : 129 138.
19. Friedman I, Dar R, Shilony E (2000) Compulsivity and obsessionality in opioid addiction. J Nerv Ment Dis 188 : 155 162.
20. Gallagher M, McMahan RW, Schoenbaum G (1999) Orbitofrontal cortex and representation of incentive value in associative learning. J Neurosci 19 : 6610 6614.
21. Gebicke-Haerter PJ, Tretter F (2008) The systems view in addiction research. Addict Biol 13 : 449 454.
22. Geller I (1973) Effects of para-chlorophenylalanine and 5-hydroxytryptophan on alcohol intake in the rat. Pharmacol Biochem Behav 1 : 361 365.
23. George MS, Anton RF, Bloomer C, Teneback C, Drobes DJ, Lorberbaum JP, Nahas Z, Vincent DJ (2001) Activation of prefrontal cortex and anterior thalamus in alcoholic subjects on exposure to alcohol-specific cues. Arch Gen Psychiatry 58 : 345 352.
24. Gessa GL, Muntoni F, Collu M, Vargiu L, Mereu G (1985) Low doses of ethanol activate dopaminergic neurons in the ventral tegmental area. Brain Res 348 : 201 203.
25. Gill K, Amit Z, Koe BK (1988) Treatment with sertraline, a new serotonin uptake inhibitor, reduces voluntary ethanol consumption in rats. Alcohol 5 : 349 354.
26. Gilman JM, Hommer DW (2008) Modulation of brain response to emotional images by alcohol cues in alcohol-dependent patients. Addict Biol 13 : 423 434.
27. Goddard AW, Shekhar A, Whiteman AF, McDougle CJ (2008) Serotoninergic mechanisms in the treatment of obsessive-compulsive disorder. Drug Discov Today 13 : 325 332.
28. Goodman WK, Price LH, Rasmussen SA, Mazure C, Fleischmann RL, Hill CL, Heninger GR, Charney DS (1989) The Yale-Brown Obsessive Compulsive Scale: I. development, use, and reliability. Arch Gen Psychiatry 6 : 1006 1011.
29. Gorelick DA, Paredes A (1992) Effect of fluoxetine on alcohol consumption in male alcoholics. Alcohol Clin Exp Res 16 : 261 265.
30. Grüsser SM, Wrase J, Klein S, Hermann D, Smolka MN, Ruf M, Weber-Fahr W, Flor H, Mann K, Braus DF, Heinz A (2004) Cue-induced activation of the striatum and medial prefrontal cortex is associated with subsequent relapse in abstinent alcoholics. Psychopharmacology 175 : 296 302.
31. Heidbreder CA, Andreoli M, Marcon C, Hutcheson DM, Gardner EL, Ashby CR Jr. (2007) Evidence for the role of dopamine D3 receptors in oral operant alcohol self-administration and reinstatement of alcohol-seeking behavior in mice. Addict Biol 12 : 35 50.
32. Heinz A, Beck A, Grüsser SM, Grace AA, Wrase J (2009) Identifying the neural circuitry of alcohol craving and relapse vulnerability. Addict Biol 14 : 108 118.
33. Hölter SM, Engelmann M, Kirschke C, Liebsch G, Landgraf R, Spanagel R (1998) Long-term ethanol self-administration with repeated ethanol deprivation episodes changes ethanol drinking pattern and increases anxiety-related behaviour during ethanol deprivation in rats. Behav Pharmacol 9 : 41 48.
34. Hölter SM, Spanagel R (1999) Effects of opiate antagonist treatment on the alcohol deprivation effect in long-term ethanol-experienced rats. Psychopharmacology 145 : 360 369.
35. Ito R, Dalley JW, Robbins TW, Everitt BJ (2002) Dopamine release in the dorsal striatum during cocaine-seeking behavior under the control of a drug-associated cue. J Neurosci 22 : 6247 6253.
36. Jeanblanc J, He DY, McGough NN, Logrip ML, Phamluong K, Janak PH, Ron D (2006) The dopamine D3 receptor is part of a homeostatic pathway regulating ethanol consumption. J Neurosci 26 : 1457 1464.
37. Jerlhag E (2008) Systemic administration of ghrelin induces conditioned place preference and stimulates accumbal dopamine. Addict Biol 13 : 358 363.
38. Jerlhag E, Egecioglu E, Dickson SL, Douhan A, Svensson L, Engel JA (2007) Ghrelin administration into tegmental areas stimulates locomotor activity and increases extracellular concentration of dopamine in the nucleus accumbens. Addict Biol 12 : 6 16.
39. Jerlhag E, Egecioglu E, Landgren S, Salomé N, Heilig M, Moechars D, Datta R, Perrissoud D, Dickson SL, Engel JA (2009) Requirement of central ghrelin signaling for alcohol reward. Proc Natl Acad Sci USA 106 : 11318 11323.
40. Jog MS, Kubota Y, Connolly CI, Hillegaart V, Graybiel AM (1999) Building neural representations of habits. Science 286 : 1745 1749.
41. Johnson BA (2005) Serotonergic compounds: clinical data. In : Spanagel R, Mann K, eds. Drugs for Relapse Prevention of Alcoholism, pp. 107 116. Basel : Birkhäuser.
42. Kabel DI, Petty F (1996) A placebo-controlled, double-blind study of fluoxetine in severe alcohol dependence: adjunctive pharmacotherapy during and after inpatient treatment. Alcohol Clin Exp Res 20 : 780 784.
43. Kelaï S, Aïssi F, Lesch KP, Cohen-Salmon C, Hamon M, Lanfumey L (2003) Alcohol intake after serotonin transporter inactivation in mice. Alcohol Alcohol 38 : 386 389.
44. Kiefer F, Wiedemann K (2004) Neuroendocrine pathways of addictive behaviour. Addict Biol 9 : 205 212.
45. Koob GF, Le Moal M (2008) Addiction and the brain antireward system. Annu Rev Psychol 59 : 29 53.
46. LeMarquand D, Pihl RO, Benkelfat C (1994) Serotonin and alcohol intake, abuse, and dependence: findings of animal studies. Biol Psychiatry 36 : 395 421. (Pubitemid 24305947)
47. Liu X, Weiss F (2002) Reversal of ethanol-seeking behavior by D1 and D2 antagonists in an animal model of relapse: differences in antagonist potency in previously ethanol-dependent versus nondependent rats. J Pharmacol Exp Ther 300 : 882 889.
48. Lopez JF, Akil H, Watson SJ (1999) Role of biological and psychological factors in early development and their impact on adult life: neural circuits mediating stress. Biol Psychiatry 46 : 1461 1471.
49. Lê AD, Funk R (2005) Serotonergic compounds: preclinical data. In : Spanagel R, Mann K, eds. Drugs for Relapse Prevention of Alcoholism, pp. 95 106. Basel : Birkhäuser.
50. Lê AD, Harding S, Juzytsch W, Fletcher PJ, Shaham Y (2002) The role of corticotropin-releasing factor in the median raphe nucleus in relapse to alcohol. J Neurosci 22 : 7844 7849.
51. Lê AD, Poulos CX, Harding S, Watchus J, Juzytsch W, Shaham Y (1999) Effects of naltrexone and fluoxetine on alcohol selfadministration and reinstatement of alcohol seeking induced by priming injections of alcohol and exposure to stress. Neuropsychopharmacology 21 : 435 444.
52. Lê AD, Shaham Y (2002) Neurobiology of relapse to alcohol in rats. Pharmacol Ther 94 : 137 156.
53. Löf E, Olausson P, deBejczy A, Stomberg R, McIntosh JM, Taylor JR, Söderpalm B (2007) Nicotinic acetylcholine receptors in the ventral tegmental area mediate the dopamine activating and reinforcing properties of ethanol cues. Psychopharmacology 195 : 333 343.
54. McEwen BS (2007) Physiology and neurobiology of stress and adaptation: central role of the brain. Physiol Rev 87 : 873 904.
55. Mataix-Cols D, Cullen S, Lange K, Zelaya F, Andrew C, Amaro E, Brammer MJ, Williams SC, Speckens A, Phillips ML (2003) Neural correlates of anxiety associated with obsessive-compulsive symptom dimensions in normal volunteers. Biol Psychiatry 53 : 482 493.
56. Modell JG, Glaser FB, Mountz JM, Schmaltz S, Cyr L (1992) Obsessive and compulsive characteristics of alcohol abuse and dependence: quantification by a newly developed questionnaire. Alcohol Clin Exp Res 16 : 266 271.
57. Naranjo CA, Bremner KE, Lanctot KL (1995) Effects of citalopram and a brief psycho-social intervention on alcohol intake, dependence and problems. Addiction 90 : 87 99.
58. Naranjo CA, Sellers EM (1989) Serotonin uptake inhibitors attenuate ethanol intake in problem drinkers. Recent Dev Alcohol 7 : 255 266.
59. Naranjo CA, Sellers EM, Sullivan JT, Woodley DV, Kadlec K, Sykora K (1987) The serotonin uptake inhibitor citalopram attenuates ethanol intake. Clin Pharmacol Ther 41 : 266 274.
60. Pettinati HM, Volpicelli JR, Kranzler HR, Luck G, Rukstalis MR, Cnaan A (2000) Sertraline treatment for alcohol dependence: interactive effects of medication and alcoholic subtype. Alcohol Clin Exp Res 24 : 1041 1049.
61. Pfefferbaum A (2004) Alcoholism damages the brain, but does moderate alcohol use? Lancet Neurol 3 : 143 144.
62. Porter RJ, Sellman D, Joyce PR, Davies J, Frampton C (2008) Prolactin response to fenfluramine in abstinent, alcohol-dependent patients. Addict Biol 13 : 380 385.
63. Quertemont E, de Neuville J, De Witte P (1998) Changes in the amygdala amino acid microdialysate after conditioning with a cue associated with ethanol. Psychopharmacology 139 : 71 78.
64. Reznikov LR, Grillo CA, Piroli GG, Pasumarthi RK, Reagan LP, Fadel J (2007) Acute stress-mediated increases in extracellular glutamate levels in the rat amygdala: differential effects of antidepressant treatment. Eur J Neurosci 25 : 3109 3114.
65. Robinson TE, Berridge KC (2003) Addiction. Annu Rev Psychol 54 : 25 53.
66. Rodd ZA, Bell RL, Kuc KA, Murphy JM, Lumeng L, McBride WJ (2009) Effects of concurrent access to multiple ethanol concentrations and repeated deprivations on alcohol intake of high-alcohol-drinking (HAD) rats. Addict Biol 14 : 152 164.
67. Rodd ZA, McKinzie DL, Bell RL, McQueen VK, Murphy JM, Schoepp DD, McBride WJ (2006) The metabotropic glutamate 2/3 receptor agonist LY 404039 reduces alcohol-seeking but not alcohol self-administration in alcohol-preferring (P) rats. Behav Brain Res 171 : 207 215.
68. Rodd-Henricks ZA, McKinzie DL, Murphy JM, McBride WJ, Lumeng L, Li T-K (2000a) The expression of an alcohol deprivation effect in the high-alcohol-drinking replicate rat lines is dependent on repeated deprivations. Alcohol Clin Exp Res 24 : 747 753. (Pubitemid 30421722)
69. Rodd-Henricks ZA, McKinzie DL, Shaikh SR, Murphy JM, McBride WJ, Lumeng L, Li TK (2000b) Alcohol deprivation effect is prolonged in the alcohol preferring (P) rat after repeated deprivations. Alcohol Clin Exp Res 24 : 8 16.
70. Rolls ET (2000) The orbitofrontal cortex and reward. Cereb Cortex 10 : 284 294.
71. Rosenbloom M, Sullivan EV, Pfefferbaum A (2003) Using magnetic resonance imaging and diffusion tensor imaging to assess brain damage in alcoholics. Alcohol Res Health 27 : 146 152.
72. Salimov RM, Salimova NB (1993) The alcohol deprivation effect in hybrid mice. Drug Alcohol Depend 32 : 187 191.
73. Salimov RM, Salimova NB, Shvets LN, Maisky AI (2000) Haloperidol administered subchronically reduces the alcohol-deprivation effect in mice. Alcohol 20 : 61 68.
74. Sanchis-Segura C, Borchardt T, Vengeliene V, Zghoul T, Bachteler D, Gass P, Sprengel R, Spanagel R (2006) Involvement of the AMPA receptor GluR-C subunit in alcohol-seeking behavior and relapse. J Neurosci 26 : 1231 1238.
75. Sanchis-Segura C, Spanagel R (2006) Behavioural assessment of drug reinforcement and addictive features in rodents: an overview. Addict Biol 11 : 2 38.
76. Saxena S, Bota RG, Brody AL (2001) Brain-behavior relationships in obsessive-compulsive disorder. Semin Clin Neuropsychiatry 6 : 82 101.
77. Schoenbaum G, Setlow B, Ramus SJ (2003) A systems approach to orbitofrontal cortex function: recordings in rat orbitofrontal cortex reveal interactions with different learning systems. Behav Brain Res 146 : 19 29.
78. Schultz W (1998) Predictive reward signal of dopamine neurons. J Neurophysiol 80 : 1 27.
79. Schultz W, Tremblay L, Hollerman JR (2000) Reward processing in primate orbitofrontal cortex and basal ganglia. Cereb Cortex 10 : 272 284.
80. Sinclair JD (1971) The alcohol-deprivation effect in monkeys. Psychonom Sci 25 : 21 22.
81. Sinclair JD, Li TK (1989) Long and short alcohol deprivation: effects on AA and P alcohol-preferring rats. Alcohol 6 : 505 509.
82. Sinclair JD, Senter RJ (1967) Increased preference for ethanol in rats following alcohol deprivation. Psychonom Sci 8 : 11 12.
83. Sinclair JD, Tiihonen K (1988) Lack of alcohol-deprivation effect in AA rats. Alcohol 5 : 85 87.
84. Sinha R (2001) How does stress increase risk of drug abuse and relapse? Psychopharmacology 158 : 343 359.
85. Sinha R (2009) Modeling stress and drug craving in the laboratory: implications for addiction treatment development. Addict Biol 14 : 84 98.
86. Sinha R, Li CS (2007) Imaging stress- and cue-induced drug and alcohol craving: association with relapse and clinical implications. Drug Alcohol Rev 26 : 25 31.
87. Spanagel R (1996) The influence of opioid antagonists on the discriminative stimulus effects of ethanol. Pharmacol Biochem Behav 54 : 645 649.
88. Spanagel R (2003) Alcohol addiction research: from animal models to clinics. Best Pract Res Clin Gastroenterol 17 : 507 518.
89. Spanagel R (2009) Alcoholism - a systems approach from molecular physiology to addictive behaviour. Physiol Rev 89 : 649 705.
90. Spanagel R, Hölter S, Allingham K, Landgraf R, Zieglgänsberger W (1996a) Acamprosate and alcohol: I. Effects on alcohol intake following alcohol deprivation in the rat. Eur J Pharmacol 305 : 39 44. (Pubitemid 26195983)
91. Spanagel R, Hölter SM (1999) Long-term alcohol self-administration with repeated alcohol deprivation phases: an animal model of alcoholism? Alcohol Alcohol 34 : 231 243.
92. Spanagel R, Hölter SM (2000) Pharmacological validation of a new animal model of alcoholism. J Neural Transm 107 : 669 680.
93. Spanagel R, Kiefer F (2008) Drugs for relapse prevention of alcoholism - 10 years of progress. Trends Pharmacol Sci 29 : 109 115.
94. Spanagel R, Weiss F (1999) The dopamine hypothesis of reward: past and current status. Trends Neurosci 22 : 521 527.
95. Spanagel R, Zieglgänsberger W (1997) Anti-craving compounds for ethanol: new pharmacological tools to study addictive processes. Trends Pharmacol Sci 18 : 54 59.
96. Spanagel R, Zieglgänsberger W, Hundt W (1996b) Acamprosate and alcohol: III. Effects on alcohol discrimination in the rat. Eur J Pharmacol 305 : 51 56. (Pubitemid 26195985)
97. Tessari M, Catalano A, Pellitteri M, Di Francesco C, Marini F, Gerrard PA, Heidbreder CA, Melotto S (2007) Correlation between serum ghrelin levels and cocaine-seeking behaviour triggered by cocaine-associated conditioned stimuli in rats. Addict Biol 12 : 22 29.
98. Tiffany ST, Conklin CA (2000) A cognitive processing model of alcohol craving and compulsive alcohol use. Addiction 95 : S145 S153.
99. Tordoff MG, Bachmanov AA (2003) Influence of the number of alcohol and water bottles on murine alcohol intake. Alcohol Clin Exp Res 27 : 600 606.
100. Uhart M, Wand GS (2009) Stress, alcohol and drug interaction: an update of human research. Addict Biol 14 : 43 64.
101. Uylings HB, Groenewegen HJ, Kolb B (2003) Do rats have a prefrontal cortex? Behav Brain Res 146 : 3 17.
102. Vanderschuren LJ, Everitt BJ (2004) Drug seeking becomes compulsive after prolonged cocaine self-administration. Science 305 : 1017 1019.
103. Vanderschuren LJ, Everitt BJ (2005) Behavioral and neural mechanisms of compulsive drug seeking. Eur J Pharmacol 526 : 77 88.
104. Vengeliene V, Bachteler D, Danysz W, Spanagel R (2005) The role of the NMDA receptor in alcohol relapse: a pharmacological mapping study using the alcohol deprivation effect. Neuropharmacology 48 : 822 829.
105. Vengeliene V, Bilbao A, Molander A, Spanagel R (2008) Neuropharmacology of alcohol addiction. Br J Pharmacol 154 : 299 315.
106. Vengeliene V, Leonardi-Essmann F, Perreau-Lenz S, Gebicke-Haerter P, Drescher K, Gross G, Spanagel R (2006) The dopamine D3 receptor plays an essential role in alcohol-seeking and relapse. FASEB J 20 : 2223 2233.
107. Vengeliene V, Siegmund S, Singer MV, Sinclair JD, Li TK, Spanagel R (2003) A comparative study on alcohol-preferring rat lines: effects of deprivation and stress phases on voluntary alcohol intake. Alcohol Clin Exp Res 27 : 1048 1054.
108. Volkow ND, Fowler JS (2000) Addiction, a disease of compulsion and drive: involvement of the orbitofrontal cortex. Cereb Cortex 10 : 318 325.
109. Volkow ND, Wang GJ, Overall JE, Hitzemann R, Fowler JS, Pappas N, Frecska E, Piscani K (1997) Regional brain metabolic response to lorazepam in alcoholics during early and late alcohol detoxification. Alcohol Clin Exp Res 21 : 1278 1284.
110. Westerink BH (1995) Brain microdialysis and its application for the study of animal behaviour. Behav Brain Res 70 : 103 124.
111. Wolffgramm J (1991) An ethopharmacological approach to the development of drug addiction. Neurosci Biobehav Rev 15 : 515 519.
112. Wolffgramm J, Heyne A (1995) From controlled drug intake to loss of control: the irreversible development of drug addiction in the rat. Behav Brain Res 70 : 77 94.