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Volumn 16, Issue 30, 2010, Pages 3731-3742

AMPK-associated signaling to bridge the gap between fuel metabolism and hepatocyte viability

Author keywords

Adenosine monophosphate activated protein kinase; Cell survival; Energy metabolism; Fatty liver; Glycogen synthase kinase 3 ; Insulin resistance; p70 ribosomal S6 kinase 1

Indexed keywords

4 ETHYL 5 PYRAZIN 2 YL 1,2 DITHIOLE 3 THIONE; 4 METHYL 5 (2 PYRAZINYL) 1,2 DITHIOL 3 ONE; 4 METHYL 5 PHENYL 1,2 DITHIOLE 3 THIONE; 4,5,6,7 TETRAHYDROBENZO 1,2 DITHIOLE 3 THIONE; 5 (6 ETHOXYPYRAZIN 2 YL) 4 METHYL 1,2 DITHIOLE 3 THIONE; 5 (6 METHOXYPYRAZINYL) 4 METHYL 1,2 DITHIOLE 3 THIONE; 5 BENZO[B]THIOPHEN 3 YL 1,2 DITHIOLE 3 THIONE; 5 METHYL 1,2 DITHIOLE 3 THIONE; 5 PYRAZINYL 1,2 DITHIOLE 3 THIONE; 5,6 DIHYDRO 4H CYCLOPENTA 1,2 DITHIOLE 3 THIONE; 7 METHYL 6,8 BIS(METHYLTHIO)PYRROLO[1,2 A]PYRAZINE; ADENYLATE KINASE; BAICALIN; CJ 11764; CJ 11766; CJ 11780; CJ 11788; CJ 11792; CJ 11840; CJ 11842; CJ 12064; CJ 12073; ISOLIQUIRITIGENIN; LIQUIRITIGENIN; OLTIPRAZ; OLTIPRAZ DERIVATIVE; RESVERATROL; S6 KINASE; SAUCHINONE; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

EID: 77955753666     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v16.i30.3731     Document Type: Editorial
Times cited : (40)

References (116)
  • 1
    • 54049150442 scopus 로고    scopus 로고
    • Molecular mechanisms and therapeutic targets in steatosis and steatohepatitis
    • Anderson N, Borlak J. Molecular mechanisms and therapeutic targets in steatosis and steatohepatitis. Pharmacol Rev 2008; 60: 311-357
    • (2008) Pharmacol Rev , vol.60 , pp. 311-357
    • Anderson, N.1    Borlak, J.2
  • 3
    • 40949141493 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol- and obesity-induced fatty liver diseases
    • Mantena SK, King AL, Andringa KK, Eccleston HB, Bailey SM. Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol- and obesity-induced fatty liver diseases. Free Radic Biol Med 2008; 44: 1259-1272
    • (2008) Free Radic Biol Med , vol.44 , pp. 1259-1272
    • Mantena, S.K.1    King, A.L.2    Andringa, K.K.3    Eccleston, H.B.4    Bailey, S.M.5
  • 4
    • 67650868959 scopus 로고    scopus 로고
    • Mitochondrial dynamics in mammalian health and disease
    • Liesa M, Palacín M, Zorzano A. Mitochondrial dynamics in mammalian health and disease. Physiol Rev 2009; 89: 799-845
    • (2009) Physiol Rev , vol.89 , pp. 799-845
    • Liesa, M.1    Palacín, M.2    Zorzano, A.3
  • 5
    • 23844558266 scopus 로고    scopus 로고
    • A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: A dawn for evolutionary medicine
    • Wallace DC. A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annu Rev Genet 2005; 39: 359-407
    • (2005) Annu Rev Genet , vol.39 , pp. 359-407
    • Wallace, D.C.1
  • 6
    • 33847080728 scopus 로고    scopus 로고
    • AMP-activated protein kinase in metabolic control and insulin signaling
    • Towler MC, Hardie DG. AMP-activated protein kinase in metabolic control and insulin signaling. Circ Res 2007; 100: 328-341
    • (2007) Circ Res , vol.100 , pp. 328-341
    • Towler, M.C.1    Hardie, D.G.2
  • 7
    • 56449117024 scopus 로고    scopus 로고
    • AMPK: A metabolic gauge regulating whole-body energy homeostasis
    • Lage R, Diéguez C, Vidal-Puig A, López M. AMPK: a metabolic gauge regulating whole-body energy homeostasis. Trends Mol Med 2008; 14: 539-549
    • (2008) Trends Mol Med , vol.14 , pp. 539-549
    • Lage, R.1    Diéguez, C.2    Vidal-Puig, A.3    López, M.4
  • 10
    • 33748747706 scopus 로고    scopus 로고
    • Mammalian TAK1 activates Snf1 protein kinase in yeast and phosphorylates AMP-activated protein kinase in vitro
    • Momcilovic M, Hong SP, Carlson M. Mammalian TAK1 activates Snf1 protein kinase in yeast and phosphorylates AMP-activated protein kinase in vitro. J Biol Chem 2006; 281: 25336-25343
    • (2006) J Biol Chem , vol.281 , pp. 25336-25343
    • Momcilovic, M.1    Hong, S.P.2    Carlson, M.3
  • 11
    • 39449096289 scopus 로고    scopus 로고
    • Phosphorylation of LKB1 at serine 428 by protein kinase C-zeta is required for metformin-enhanced activation of the AMPactivated protein kinase in endothelial cells
    • Xie Z, Dong Y, Scholz R, Neumann D, Zou MH. Phosphorylation of LKB1 at serine 428 by protein kinase C-zeta is required for metformin-enhanced activation of the AMPactivated protein kinase in endothelial cells. Circulation 2008; 117: 952-962
    • (2008) Circulation , vol.117 , pp. 952-962
    • Xie, Z.1    Dong, Y.2    Scholz, R.3    Neumann, D.4    Zou, M.H.5
  • 12
    • 0034141636 scopus 로고    scopus 로고
    • LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo
    • Pt 3
    • Collins SP, Reoma JL, Gamm DM, Uhler MD. LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo. Biochem J 2000; 345 Pt 3: 673-680
    • (2000) Biochem J , vol.345 , pp. 673-680
    • Collins, S.P.1    Reoma, J.L.2    Gamm, D.M.3    Uhler, M.D.4
  • 13
    • 0035375261 scopus 로고    scopus 로고
    • Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth
    • Sapkota GP, Kieloch A, Lizcano JM, Lain S, Arthur JS, Williams MR, Morrice N, Deak M, Alessi DR. Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth. J Biol Chem 2001; 276: 19469-19482
    • (2001) J Biol Chem , vol.276 , pp. 19469-19482
    • Sapkota, G.P.1    Kieloch, A.2    Lizcano, J.M.3    Lain, S.4    Arthur, J.S.5    Williams, M.R.6    Morrice, N.7    Deak, M.8    Alessi, D.R.9
  • 14
    • 22544455676 scopus 로고    scopus 로고
    • Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase
    • Holz MK, Blenis J. Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase. J Biol Chem 2005; 280: 26089-26093
    • (2005) J Biol Chem , vol.280 , pp. 26089-26093
    • Holz, M.K.1    Blenis, J.2
  • 15
    • 33744505375 scopus 로고    scopus 로고
    • Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1
    • Um SH, D'Alessio D, Thomas G. Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1. Cell Metab 2006; 3: 393-402
    • (2006) Cell Metab , vol.3 , pp. 393-402
    • Um, S.H.1    D'Alessio, D.2    Thomas, G.3
  • 16
    • 0345167800 scopus 로고    scopus 로고
    • TSC2 mediates cellular energy response to control cell growth and survival
    • Inoki K, Zhu T, Guan KL. TSC2 mediates cellular energy response to control cell growth and survival. Cell 2003; 115: 577-590
    • (2003) Cell , vol.115 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.L.3
  • 20
    • 18244387691 scopus 로고    scopus 로고
    • Contribution of adipose tissue and de novo lipogenesis to nonalcoholic fatty liver disease
    • Tamura S, Shimomura I. Contribution of adipose tissue and de novo lipogenesis to nonalcoholic fatty liver disease. J Clin Invest 2005; 115: 1139-1142
    • (2005) J Clin Invest , vol.115 , pp. 1139-1142
    • Tamura, S.1    Shimomura, I.2
  • 21
    • 18244382304 scopus 로고    scopus 로고
    • Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
    • Donnelly KL, Smith CI, Schwarzenberg SJ, Jessurun J, Boldt MD, Parks EJ. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest 2005; 115: 1343-1351
    • (2005) J Clin Invest , vol.115 , pp. 1343-1351
    • Donnelly, K.L.1    Smith, C.I.2    Schwarzenberg, S.J.3    Jessurun, J.4    Boldt, M.D.5    Parks, E.J.6
  • 23
    • 0037088683 scopus 로고    scopus 로고
    • Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c
    • Liang G, Yang J, Horton JD, Hammer RE, Goldstein JL, Brown MS. Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c. J Biol Chem 2002; 277: 9520-9528
    • (2002) J Biol Chem , vol.277 , pp. 9520-9528
    • Liang, G.1    Yang, J.2    Horton, J.D.3    Hammer, R.E.4    Goldstein, J.L.5    Brown, M.S.6
  • 27
    • 68949091995 scopus 로고    scopus 로고
    • Role of adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway in repression of liver X receptoralpha- dependent lipogenic gene induction and hepatic steatosis by a novel class of dithiolethiones
    • Hwahng SH, Ki SH, Bae EJ, Kim HE, Kim SG. Role of adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway in repression of liver X receptoralpha- dependent lipogenic gene induction and hepatic steatosis by a novel class of dithiolethiones. Hepatology 2009; 49: 1913-1925
    • (2009) Hepatology , vol.49 , pp. 1913-1925
    • Hwahng, S.H.1    Ki, S.H.2    Bae, E.J.3    Kim, H.E.4    Kim, S.G.5
  • 28
    • 0041302377 scopus 로고    scopus 로고
    • The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
    • Xu A, Wang Y, Keshaw H, Xu LY, Lam KS, Cooper GJ. The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J Clin Invest 2003; 112: 91-100
    • (2003) J Clin Invest , vol.112 , pp. 91-100
    • Xu, A.1    Wang, Y.2    Keshaw, H.3    Xu, L.Y.4    Lam, K.S.5    Cooper, G.J.6
  • 30
    • 34547145926 scopus 로고    scopus 로고
    • Combined metadoxine and garlic oil treatment efficaciously abrogates alcoholic steatosis and CYP2E1 induction in rat liver with restoration of AMPK activity
    • Ki SH, Choi JH, Kim CW, Kim SG. Combined metadoxine and garlic oil treatment efficaciously abrogates alcoholic steatosis and CYP2E1 induction in rat liver with restoration of AMPK activity. Chem Biol Interact 2007; 169: 80-90
    • (2007) Chem Biol Interact , vol.169 , pp. 80-90
    • Ki, S.H.1    Choi, J.H.2    Kim, C.W.3    Kim, S.G.4
  • 31
    • 33846429592 scopus 로고    scopus 로고
    • Drug Insight: Mechanisms of action and therapeutic applications for agonists of peroxisome proliferator-activated receptors
    • Gervois P, Fruchart JC, Staels B. Drug Insight: mechanisms of action and therapeutic applications for agonists of peroxisome proliferator-activated receptors. Nat Clin Pract Endocrinol Metab 2007; 3: 145-156
    • (2007) Nat Clin Pract Endocrinol Metab , vol.3 , pp. 145-156
    • Gervois, P.1    Fruchart, J.C.2    Staels, B.3
  • 32
    • 0037067666 scopus 로고    scopus 로고
    • The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways
    • Fryer LG, Parbu-Patel A, Carling D. The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways. J Biol Chem 2002; 277: 25226-25232
    • (2002) J Biol Chem , vol.277 , pp. 25226-25232
    • Fryer, L.G.1    Parbu-Patel, A.2    Carling, D.3
  • 34
    • 0034708832 scopus 로고    scopus 로고
    • The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)
    • Aguirre V, Uchida T, Yenush L, Davis R, White MF. The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307). J Biol Chem 2000; 275: 9047-9054
    • (2000) J Biol Chem , vol.275 , pp. 9047-9054
    • Aguirre, V.1    Uchida, T.2    Yenush, L.3    Davis, R.4    White, M.F.5
  • 36
    • 0037853260 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling- 3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes
    • Senn JJ, Klover PJ, Nowak IA, Zimmers TA, Koniaris LG, Furlanetto RW, Mooney RA. Suppressor of cytokine signaling- 3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes. J Biol Chem 2003; 278: 13740-13746
    • (2003) J Biol Chem , vol.278 , pp. 13740-13746
    • Senn, J.J.1    Klover, P.J.2    Nowak, I.A.3    Zimmers, T.A.4    Koniaris, L.G.5    Furlanetto, R.W.6    Mooney, R.A.7
  • 38
    • 0033944531 scopus 로고    scopus 로고
    • Effect of proinflammatory interleukins on jejunal nutrient transport
    • Hardin J, Kroeker K, Chung B, Gall DG. Effect of proinflammatory interleukins on jejunal nutrient transport. Gut 2000; 47: 184-191
    • (2000) Gut , vol.47 , pp. 184-191
    • Hardin, J.1    Kroeker, K.2    Chung, B.3    Gall, D.G.4
  • 39
    • 0035892752 scopus 로고    scopus 로고
    • Cytokine regulation of facilitated glucose transport in human articular chondrocytes
    • Shikhman AR, Brinson DC, Valbracht J, Lotz MK. Cytokine regulation of facilitated glucose transport in human articular chondrocytes. J Immunol 2001; 167: 7001-7008
    • (2001) J Immunol , vol.167 , pp. 7001-7008
    • Shikhman, A.R.1    Brinson, D.C.2    Valbracht, J.3    Lotz, M.K.4
  • 40
    • 65549128076 scopus 로고    scopus 로고
    • Interleukin-6 attenuates insulin-mediated increases in endothelial cell signaling but augments skeletal muscle insulin action via differential effects on tumor necrosis factor-alpha expression
    • Yuen DY, Dwyer RM, Matthews VB, Zhang L, Drew BG, Neill B, Kingwell BA, Clark MG, Rattigan S, Febbraio MA. Interleukin-6 attenuates insulin-mediated increases in endothelial cell signaling but augments skeletal muscle insulin action via differential effects on tumor necrosis factor-alpha expression. Diabetes 2009; 58: 1086-1095
    • (2009) Diabetes , vol.58 , pp. 1086-1095
    • Yuen, D.Y.1    Dwyer, R.M.2    Matthews, V.B.3    Zhang, L.4    Drew, B.G.5    Neill, B.6    Kingwell, B.A.7    Clark, M.G.8    Rattigan, S.9    Febbraio, M.A.10
  • 42
    • 0242580711 scopus 로고    scopus 로고
    • Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects
    • Rotter V, Nagaev I, Smith U. Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects. J Biol Chem 2003; 278: 45777-45784
    • (2003) J Biol Chem , vol.278 , pp. 45777-45784
    • Rotter, V.1    Nagaev, I.2    Smith, U.3
  • 43
    • 36849061190 scopus 로고    scopus 로고
    • Targeting AMP-activated protein kinase as a novel therapeutic approach for the treatment of metabolic disorders
    • Viollet B, Mounier R, Leclerc J, Yazigi A, Foretz M, Andreelli F. Targeting AMP-activated protein kinase as a novel therapeutic approach for the treatment of metabolic disorders. Diabetes Metab 2007; 33: 395-402
    • (2007) Diabetes Metab , vol.33 , pp. 395-402
    • Viollet, B.1    Mounier, R.2    Leclerc, J.3    Yazigi, A.4    Foretz, M.5    Andreelli, F.6
  • 45
    • 17844368938 scopus 로고    scopus 로고
    • Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver
    • Foretz M, Ancellin N, Andreelli F, Saintillan Y, Grondin P, Kahn A, Thorens B, Vaulont S, Viollet B. Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver. Diabetes 2005; 54: 1331-1339
    • (2005) Diabetes , vol.54 , pp. 1331-1339
    • Foretz, M.1    Ancellin, N.2    Andreelli, F.3    Saintillan, Y.4    Grondin, P.5    Kahn, A.6    Thorens, B.7    Vaulont, S.8    Viollet, B.9
  • 46
    • 0035029874 scopus 로고    scopus 로고
    • Effect of 5-aminoimidazole- 4-carboxamide-1-beta-D-ribofuranoside infusion on in vivo glucose and lipid metabolism in lean and obese Zucker rats
    • Bergeron R, Previs SF, Cline GW, Perret P, Russell RR 3rd, Young LH, Shulman GI. Effect of 5-aminoimidazole- 4-carboxamide-1-beta-D-ribofuranoside infusion on in vivo glucose and lipid metabolism in lean and obese Zucker rats. Diabetes 2001; 50: 1076-1082
    • (2001) Diabetes , vol.50 , pp. 1076-1082
    • Bergeron, R.1    Previs, S.F.2    Cline, G.W.3    Perret, P.4    Russell III, R.R.5    Young, L.H.6    Shulman, G.I.7
  • 50
    • 34548757301 scopus 로고    scopus 로고
    • Identification of a novel class of dithiolethiones that prevent hepatic insulin resistance via the adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway
    • Bae EJ, Yang YM, Kim JW, Kim SG. Identification of a novel class of dithiolethiones that prevent hepatic insulin resistance via the adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway. Hepatology 2007; 46: 730-739
    • (2007) Hepatology , vol.46 , pp. 730-739
    • Bae, E.J.1    Yang, Y.M.2    Kim, J.W.3    Kim, S.G.4
  • 51
    • 0034947869 scopus 로고    scopus 로고
    • Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin
    • Takano A, Usui I, Haruta T, Kawahara J, Uno T, Iwata M, Kobayashi M. Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin. Mol Cell Biol 2001; 21: 5050-5062
    • (2001) Mol Cell Biol , vol.21 , pp. 5050-5062
    • Takano, A.1    Usui, I.2    Haruta, T.3    Kawahara, J.4    Uno, T.5    Iwata, M.6    Kobayashi, M.7
  • 55
    • 58949093454 scopus 로고    scopus 로고
    • Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance
    • Singh R, Wang Y, Xiang Y, Tanaka KE, Gaarde WA, Czaja MJ. Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance. Hepatology 2009; 49: 87-96
    • (2009) Hepatology , vol.49 , pp. 87-96
    • Singh, R.1    Wang, Y.2    Xiang, Y.3    Tanaka, K.E.4    Gaarde, W.A.5    Czaja, M.J.6
  • 57
    • 41549115946 scopus 로고    scopus 로고
    • Reactive oxygen species-mediated pancreatic beta-cell death is regulated by interactions between stress-activated protein kinases, p38 and c-Jun N-terminal kinase, and mitogen-activated protein kinase phosphatases
    • Hou N, Torii S, Saito N, Hosaka M, Takeuchi T. Reactive oxygen species-mediated pancreatic beta-cell death is regulated by interactions between stress-activated protein kinases, p38 and c-Jun N-terminal kinase, and mitogen-activated protein kinase phosphatases. Endocrinology 2008; 149: 1654-1665
    • (2008) Endocrinology , vol.149 , pp. 1654-1665
    • Hou, N.1    Torii, S.2    Saito, N.3    Hosaka, M.4    Takeuchi, T.5
  • 59
    • 68949107216 scopus 로고    scopus 로고
    • AMP-activated protein kinase (AMPK) molecular crossroad for metabolic control and survival of neurons
    • Spasić MR, Callaerts P, Norga KK. AMP-activated protein kinase (AMPK) molecular crossroad for metabolic control and survival of neurons. Neuroscientist 2009; 15: 309-316
    • (2009) Neuroscientist , vol.15 , pp. 309-316
    • Spasić, M.R.1    Callaerts, P.2    Norga, K.K.3
  • 61
    • 34548301663 scopus 로고    scopus 로고
    • Cellular energy sensing and signaling by AMP-activated protein kinase
    • Winder WW, Thomson DM. Cellular energy sensing and signaling by AMP-activated protein kinase. Cell Biochem Biophys 2007; 47: 332-347
    • (2007) Cell Biochem Biophys , vol.47 , pp. 332-347
    • Winder, W.W.1    Thomson, D.M.2
  • 62
    • 0032562094 scopus 로고    scopus 로고
    • Inhibition of glucocorticoid-induced apoptosis with 5-aminoimidazole-4-carboxamide ribonucleoside, a cell-permeable activator of AMP-activated protein kinase
    • Stefanelli C, Stanic I, Bonavita F, Flamigni F, Pignatti C, Guarnieri C, Caldarera CM. Inhibition of glucocorticoid-induced apoptosis with 5-aminoimidazole-4-carboxamide ribonucleoside, a cell-permeable activator of AMP-activated protein kinase. Biochem Biophys Res Commun 1998; 243: 821-826
    • (1998) Biochem Biophys Res Commun , vol.243 , pp. 821-826
    • Stefanelli, C.1    Stanic, I.2    Bonavita, F.3    Flamigni, F.4    Pignatti, C.5    Guarnieri, C.6    Caldarera, C.M.7
  • 63
    • 0036095269 scopus 로고    scopus 로고
    • Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: Inhibition by the AMP-activated protein kinase activation
    • Ido Y, Carling D, Ruderman N. Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: inhibition by the AMP-activated protein kinase activation. Diabetes 2002; 51: 159-167
    • (2002) Diabetes , vol.51 , pp. 159-167
    • Ido, Y.1    Carling, D.2    Ruderman, N.3
  • 64
    • 0035189594 scopus 로고    scopus 로고
    • Adenosine monophosphate-activated protein kinase mediates the protective effects of ischemic preconditioning on hepatic ischemia-reperfusion injury in the rat
    • Peralta C, Bartrons R, Serafin A, Blázquez C, Guzmán M, Prats N, Xaus C, Cutillas B, Gelpí E, Roselló-Catafau J. Adenosine monophosphate-activated protein kinase mediates the protective effects of ischemic preconditioning on hepatic ischemia-reperfusion injury in the rat. Hepatology 2001; 34: 1164-1173
    • (2001) Hepatology , vol.34 , pp. 1164-1173
    • Peralta, C.1    Bartrons, R.2    Serafin, A.3    Blázquez, C.4    Guzmán, M.5    Prats, N.6    Xaus, C.7    Cutillas, B.8    Gelpí, E.9    Roselló-Catafau, J.10
  • 65
    • 77649183809 scopus 로고    scopus 로고
    • AMPK-mediated GSK3beta inhibition by isoliquiritigenin contributes to protecting mitochondria against iron-catalyzed oxidative stress
    • Choi SH, Kim YW, Kim SG. AMPK-mediated GSK3beta inhibition by isoliquiritigenin contributes to protecting mitochondria against iron-catalyzed oxidative stress. Biochem Pharmacol 2010; 79: 1352-1362
    • (2010) Biochem Pharmacol , vol.79 , pp. 1352-1362
    • Choi, S.H.1    Kim, Y.W.2    Kim, S.G.3
  • 66
    • 70349324339 scopus 로고    scopus 로고
    • Resveratrol protects mitochondria against oxidative stress through AMP-activated protein kinase-mediated glycogen synthase kinase-3beta inhibition downstream of poly(ADP-ribose)polymerase-LKB1 pathway
    • Shin SM, Cho IJ, Kim SG. Resveratrol protects mitochondria against oxidative stress through AMP-activated protein kinase-mediated glycogen synthase kinase-3beta inhibition downstream of poly(ADP-ribose)polymerase-LKB1 pathway. Mol Pharmacol 2009; 76: 884-895
    • (2009) Mol Pharmacol , vol.76 , pp. 884-895
    • Shin, S.M.1    Cho, I.J.2    Kim, S.G.3
  • 67
    • 58849093275 scopus 로고    scopus 로고
    • Inhibition of arachidonic acid and ironinduced mitochondrial dysfunction and apoptosis by oltipraz and novel 1,2-dithiole-3-thione congeners
    • Shin SM, Kim SG. Inhibition of arachidonic acid and ironinduced mitochondrial dysfunction and apoptosis by oltipraz and novel 1,2-dithiole-3-thione congeners. Mol Pharmacol 2009; 75: 242-253
    • (2009) Mol Pharmacol , vol.75 , pp. 242-253
    • Shin, S.M.1    Kim, S.G.2
  • 68
    • 66649086553 scopus 로고    scopus 로고
    • Oxidized metabolites of oltipraz exert cytoprotective effects against arachidonic acid through AMP-activated protein kinase-dependent cellular antioxidant effect and mitochondrial protection
    • Kwon YN, Shin SM, Cho IJ, Kim SG. Oxidized metabolites of oltipraz exert cytoprotective effects against arachidonic acid through AMP-activated protein kinase-dependent cellular antioxidant effect and mitochondrial protection. Drug Metab Dispos 2009; 37: 1187-1197
    • (2009) Drug Metab Dispos , vol.37 , pp. 1187-1197
    • Kwon, Y.N.1    Shin, S.M.2    Cho, I.J.3    Kim, S.G.4
  • 71
    • 27144489669 scopus 로고    scopus 로고
    • AMP-activated protein kinase protects cardiomyocytes against hypoxic injury through attenuation of endoplasmic reticulum stress
    • Terai K, Hiramoto Y, Masaki M, Sugiyama S, Kuroda T, Hori M, Kawase I, Hirota H. AMP-activated protein kinase protects cardiomyocytes against hypoxic injury through attenuation of endoplasmic reticulum stress. Mol Cell Biol 2005; 25: 9554-9575
    • (2005) Mol Cell Biol , vol.25 , pp. 9554-9575
    • Terai, K.1    Hiramoto, Y.2    Masaki, M.3    Sugiyama, S.4    Kuroda, T.5    Hori, M.6    Kawase, I.7    Hirota, H.8
  • 72
    • 44349184864 scopus 로고    scopus 로고
    • Etoposide induces ATMdependent mitochondrial biogenesis through AMPK activation
    • Fu X, Wan S, Lyu YL, Liu LF, Qi H. Etoposide induces ATMdependent mitochondrial biogenesis through AMPK activation. PLoS One 2008; 3: e2009
    • (2008) PLoS One , vol.3
    • Fu, X.1    Wan, S.2    Lyu, Y.L.3    Liu, L.F.4    Qi, H.5
  • 73
    • 32644486277 scopus 로고    scopus 로고
    • AMP-activated protein kinase is a positive regulator of poly(ADP-ribose) polymerase
    • Walker JW, Jijon HB, Madsen KL. AMP-activated protein kinase is a positive regulator of poly(ADP-ribose) polymerase. Biochem Biophys Res Commun 2006; 342: 336-341
    • (2006) Biochem Biophys Res Commun , vol.342 , pp. 336-341
    • Walker, J.W.1    Jijon, H.B.2    Madsen, K.L.3
  • 75
    • 61649093766 scopus 로고    scopus 로고
    • To die or to live: The dual role of poly(ADP-ribose) polymerase-1 in autophagy and necrosis under oxidative stress and DNA damage
    • Huang Q, Shen HM. To die or to live: the dual role of poly(ADP-ribose) polymerase-1 in autophagy and necrosis under oxidative stress and DNA damage. Autophagy 2009; 5: 273-276
    • (2009) Autophagy , vol.5 , pp. 273-276
    • Huang, Q.1    Shen, H.M.2
  • 76
    • 36249025723 scopus 로고    scopus 로고
    • Autophagy: Process and function
    • Mizushima N. Autophagy: process and function. Genes Dev 2007; 21: 2861-2873
    • (2007) Genes Dev , vol.21 , pp. 2861-2873
    • Mizushima, N.1
  • 77
    • 27644466759 scopus 로고    scopus 로고
    • Autophagy and signaling: Their role in cell survival and cell death
    • Codogno P, Meijer AJ. Autophagy and signaling: their role in cell survival and cell death. Cell Death Differ 2005; 12 Suppl 2: 1509-1518
    • (2005) Cell Death Differ , vol.12 , Issue.SUPPL 2 , pp. 1509-1518
    • Codogno, P.1    Meijer, A.J.2
  • 79
    • 72549095406 scopus 로고    scopus 로고
    • Regulation mechanisms and signaling pathways of autophagy
    • He C, Klionsky DJ. Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet 2009; 43: 67-93
    • (2009) Annu Rev Genet , vol.43 , pp. 67-93
    • He, C.1    Klionsky, D.J.2
  • 83
    • 0031587781 scopus 로고    scopus 로고
    • Release of cytochrome c from liver mitochondria during permeability transition
    • Kantrow SP, Piantadosi CA. Release of cytochrome c from liver mitochondria during permeability transition. Biochem Biophys Res Commun 1997; 232: 669-671
    • (1997) Biochem Biophys Res Commun , vol.232 , pp. 669-671
    • Kantrow, S.P.1    Piantadosi, C.A.2
  • 86
    • 2542448093 scopus 로고    scopus 로고
    • Participation of endoplasmic reticulum and mitochondrial calcium handling in apoptosis: More than just neighborhood?
    • Szabadkai G, Rizzuto R. Participation of endoplasmic reticulum and mitochondrial calcium handling in apoptosis: more than just neighborhood? FEBS Lett 2004; 567: 111-115
    • (2004) FEBS Lett , vol.567 , pp. 111-115
    • Szabadkai, G.1    Rizzuto, R.2
  • 87
    • 0031772126 scopus 로고    scopus 로고
    • The mitochondrial permeability transition is required for tumor necrosis factor alpha-mediated apoptosis and cytochrome c release
    • Bradham CA, Qian T, Streetz K, Trautwein C, Brenner DA, Lemasters JJ. The mitochondrial permeability transition is required for tumor necrosis factor alpha-mediated apoptosis and cytochrome c release. Mol Cell Biol 1998; 18: 6353-6364
    • (1998) Mol Cell Biol , vol.18 , pp. 6353-6364
    • Bradham, C.A.1    Qian, T.2    Streetz, K.3    Trautwein, C.4    Brenner, D.A.5    Lemasters, J.J.6
  • 88
    • 1642493646 scopus 로고    scopus 로고
    • Mitochondria permeability transition-dependent tertbutyl hydroperoxide-induced apoptosis in hepatoma HepG2 cells
    • Piret JP, Arnould T, Fuks B, Chatelain P, Remacle J, Michiels C. Mitochondria permeability transition-dependent tertbutyl hydroperoxide-induced apoptosis in hepatoma HepG2 cells. Biochem Pharmacol 2004; 67: 611-620
    • (2004) Biochem Pharmacol , vol.67 , pp. 611-620
    • Piret, J.P.1    Arnould, T.2    Fuks, B.3    Chatelain, P.4    Remacle, J.5    Michiels, C.6
  • 89
    • 0029116916 scopus 로고
    • The mitochondrial permeability transition
    • Zoratti M, Szabò I. The mitochondrial permeability transition. Biochim Biophys Acta 1995; 1241: 139-176
    • (1995) Biochim Biophys Acta , vol.1241 , pp. 139-176
    • Zoratti, M.1    Szabò, I.2
  • 90
    • 0030715323 scopus 로고    scopus 로고
    • Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
    • Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, Wang X. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 1997; 91: 479-489
    • (1997) Cell , vol.91 , pp. 479-489
    • Li, P.1    Nijhawan, D.2    Budihardjo, I.3    Srinivasula, S.M.4    Ahmad, M.5    Alnemri, E.S.6    Wang, X.7
  • 95
    • 0037189947 scopus 로고    scopus 로고
    • Sustained activation of AMP-activated protein kinase induces c-Jun N-terminal kinase activation and apoptosis in liver cells
    • Meisse D, Van de Casteele M, Beauloye C, Hainault I, Kefas BA, Rider MH, Foufelle F, Hue L. Sustained activation of AMP-activated protein kinase induces c-Jun N-terminal kinase activation and apoptosis in liver cells. FEBS Lett 2002; 526: 38-42
    • (2002) FEBS Lett , vol.526 , pp. 38-42
    • Meisse, D.1    van de Casteele, M.2    Beauloye, C.3    Hainault, I.4    Kefas, B.A.5    Rider, M.H.6    Foufelle, F.7    Hue, L.8
  • 96
    • 0029053451 scopus 로고
    • Superoxide radical and superoxide dismutases
    • Fridovich I. Superoxide radical and superoxide dismutases. Annu Rev Biochem 1995; 64: 97-112
    • (1995) Annu Rev Biochem , vol.64 , pp. 97-112
    • Fridovich, I.1
  • 97
    • 0018858325 scopus 로고
    • Enhancement of mitochondrial, cyanide-resistant superoxide dismutase in the livers of rats treated with 2,4-dinitrophenol
    • Dryer SE, Dryer RL, Autor AP. Enhancement of mitochondrial, cyanide-resistant superoxide dismutase in the livers of rats treated with 2,4-dinitrophenol. J Biol Chem 1980; 255: 1054-1107
    • (1980) J Biol Chem , vol.255 , pp. 1054-1107
    • Dryer, S.E.1    Dryer, R.L.2    Autor, A.P.3
  • 99
    • 33750867472 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3--an overview of an over-achieving protein kinase
    • Kockeritz L, Doble B, Patel S, Woodgett JR. Glycogen synthase kinase-3--an overview of an over-achieving protein kinase. Curr Drug Targets 2006; 7: 1377-1388
    • (2006) Curr Drug Targets , vol.7 , pp. 1377-1388
    • Kockeritz, L.1    Doble, B.2    Patel, S.3    Woodgett, J.R.4
  • 100
    • 0034859101 scopus 로고    scopus 로고
    • The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling
    • Grimes CA, Jope RS. The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling. Prog Neurobiol 2001; 65: 391-426
    • (2001) Prog Neurobiol , vol.65 , pp. 391-426
    • Grimes, C.A.1    Jope, R.S.2
  • 101
    • 33646116079 scopus 로고    scopus 로고
    • Bradykinin prevents reperfusion injury by targeting mitochondrial permeability transition pore through glycogen synthase kinase 3beta
    • Park SS, Zhao H, Mueller RA, Xu Z. Bradykinin prevents reperfusion injury by targeting mitochondrial permeability transition pore through glycogen synthase kinase 3beta. J Mol Cell Cardiol 2006; 40: 708-716
    • (2006) J Mol Cell Cardiol , vol.40 , pp. 708-716
    • Park, S.S.1    Zhao, H.2    Mueller, R.A.3    Xu, Z.4
  • 102
    • 55449092939 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3 inhibition slows mitochondrial adenine nucleotide transport and regulates voltage-dependent anion channel phosphorylation
    • Das S, Wong R, Rajapakse N, Murphy E, Steenbergen C. Glycogen synthase kinase 3 inhibition slows mitochondrial adenine nucleotide transport and regulates voltage-dependent anion channel phosphorylation. Circ Res 2008; 103: 983-991
    • (2008) Circ Res , vol.103 , pp. 983-991
    • Das, S.1    Wong, R.2    Rajapakse, N.3    Murphy, E.4    Steenbergen, C.5
  • 104
    • 37349053531 scopus 로고    scopus 로고
    • AICAR positively regulate glycogen synthase activity and LDL receptor expression through Raf-1/MEK/p42/44MAPK/p90RSK/ GSK-3 signaling cascade
    • Wang HM, Mehta S, Bansode R, Huang W, Mehta KD. AICAR positively regulate glycogen synthase activity and LDL receptor expression through Raf-1/MEK/p42/44MAPK/p90RSK/ GSK-3 signaling cascade. Biochem Pharmacol 2008; 75: 457-467
    • (2008) Biochem Pharmacol , vol.75 , pp. 457-467
    • Wang, H.M.1    Mehta, S.2    Bansode, R.3    Huang, W.4    Mehta, K.D.5
  • 107
    • 42449162343 scopus 로고    scopus 로고
    • Abrogation of hyperosmotic impairment of insulin signaling by a novel class of 1,2-dithiole- 3-thiones through the inhibition of S6K1 activation
    • Bae EJ, Yang YM, Kim SG. Abrogation of hyperosmotic impairment of insulin signaling by a novel class of 1,2-dithiole- 3-thiones through the inhibition of S6K1 activation. Mol Pharmacol 2008; 73: 1502-1512
    • (2008) Mol Pharmacol , vol.73 , pp. 1502-1512
    • Bae, E.J.1    Yang, Y.M.2    Kim, S.G.3
  • 110
    • 74149092293 scopus 로고    scopus 로고
    • Inhibition of SREBP-1c-mediated hepatic steatosis and oxidative stress by sauchinone, an AMPKactivating lignan in Saururus chinensis
    • Kim YW, Kim YM, Yang YM, Kim TH, Hwang SJ, Lee JR, Kim SC, Kim SG. Inhibition of SREBP-1c-mediated hepatic steatosis and oxidative stress by sauchinone, an AMPKactivating lignan in Saururus chinensis. Free Radic Biol Med 2010; 48: 567-578
    • (2010) Free Radic Biol Med , vol.48 , pp. 567-578
    • Kim, Y.W.1    Kim, Y.M.2    Yang, Y.M.3    Kim, T.H.4    Hwang, S.J.5    Lee, J.R.6    Kim, S.C.7    Kim, S.G.8
  • 111
    • 70449370069 scopus 로고    scopus 로고
    • Long-term baicalin administration ameliorates metabolic disorders and hepatic steatosis in rats given a high-fat diet
    • Guo HX, Liu DH, Ma Y, Liu JF, Wang Y, Du ZY, Wang X, Shen JK, Peng HL. Long-term baicalin administration ameliorates metabolic disorders and hepatic steatosis in rats given a high-fat diet. Acta Pharmacol Sin 2009; 30: 1505-1512
    • (2009) Acta Pharmacol Sin , vol.30 , pp. 1505-1512
    • Guo, H.X.1    Liu, D.H.2    Ma, Y.3    Liu, J.F.4    Wang, Y.5    Du, Z.Y.6    Wang, X.7    Shen, J.K.8    Peng, H.L.9


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