Efficacy of sauchinone as a novel AMPK-activating lignan for preventing iron-induced oxidative stress and liver injury

Free Radical Biology and Medicine

Volumn 47, Issue 7, 2009, Pages 1082-1092

  Kim, Young Woo ^a   Lee, Sung Min ^a   Shin, Sang Mi ^a   Hwang, Se Jin ^b   Brooks, Janie S ^a   Kang, Hee Eun ^a   Lee, Myung Gull ^a   Kim, Sang Chan ^c   Kim, Sang Geon ^a  

^a Seoul National University   (South Korea)

^b Hanyang University   (South Korea)

^c Daegu Haany University   (South Korea)

Author keywords

AMPK; Arachidonic acid; Free radicals; Iron induced liver injury; Oxidative stress; Sauchinone

Indexed keywords

ARACHIDONIC ACID; FERRITIN; HERBACEOUS AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; METFORMIN; PHENYLHYDRAZINE; PROTEIN KINASE LKB1; SAUCHINONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVATION; FATTY ACID BLOOD LEVEL; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IRON OVERLOAD; LIVER CELL; LIVER INJURY; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STRUCTURE ANALYSIS; TREATMENT DURATION;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ARACHIDONIC ACID; BENZOPYRANS; DIOXOLES; ENZYME ACTIVATION; IRON; LIGNANS; LIVER; MALE; MICE; MICE, INBRED ICR; OXIDATIVE STRESS; PHENYLHYDRAZINES; SAURURACEAE;

MUS;

EID: 69249240216     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2009.07.018     Document Type: Article

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