Oxidized metabolites of oltipraz exert cytoprotective effects against arachidonic acid through AMP-activated protein kinase-dependent cellular antioxidant effect and mitochondrial protection

Drug Metabolism and Disposition

Volumn 37, Issue 6, 2009, Pages 1187-1197

  Young, Nam Kwon ^a   Sang, Mi Shin ^a   Il, Je Cho ^a   Sang, Geon Kim ^a  

^a Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

4 METHYL 5 (PYRAZIN 2 YL) 3H 1,2 DITHIOL 3 ONE; 5 AMINOIMIDAZOLE 4 CARBOXAMIDE 1 BETA DEXTRO RIBOFURANOSIDE; 7 METHYL 6,8 BIS(METHYLSULFINYL) H PYRROLO[1,2 A]PYRAZINE; 7 METHYL 6,8 BIS(METHYLTHIO) H PYRROLO[1,2 A]PYRAZINE; 7 METHYL 8 (METHYLSULFINYL) 6 (METHYLTHIO) H PYRROLO[1,2 A]PYRAZINE; AMIDE; AMINE; AMP ACTIVATED PROTEIN KINASE ALPHA; ARACHIDONIC ACID; BETA ACTIN; DRUG METABOLITE; GLUTATHIONE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; IMIDAZOLE DERIVATIVE; MUTANT PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; OLTIPRAZ; PROCASPASE 3; PROTEIN BCL XL; REACTIVE OXYGEN METABOLITE; TROLOX C; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL PROTECTION; CELL STRAIN HEPG2; CELL SURVIVAL; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AMP-ACTIVATED PROTEIN KINASES; ANTIOXIDANTS; APOPTOSIS; ARACHIDONIC ACID; CYTOPROTECTION; DRUG ANTAGONISM; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; PYRAZINES; REACTIVE OXYGEN SPECIES; TUMOR CELLS, CULTURED;

EID: 66649086553     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.108.025908     Document Type: Article

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