메뉴 건너뛰기




Volumn 3, Issue 8, 2010, Pages 1015-1025

Cryptotanshinone inhibits cancer cell proliferation by suppressing mammalian target of rapamycin - Mediated cyclin D1 expression and Rb phosphorylation

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CRYPTOTANSHINONE; CYCLIN D1; INITIATION FACTOR 4E; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN P70; RETINOBLASTOMA PROTEIN; S6 KINASE; SOMATOMEDIN C;

EID: 77955452597     PISSN: 19406207     EISSN: 19406215     Source Type: Journal    
DOI: 10.1158/1940-6207.CAPR-10-0020     Document Type: Article
Times cited : (95)

References (56)
  • 1
    • 60749109846 scopus 로고    scopus 로고
    • Cell cycle, CDKs and cancer: A changing paradigm
    • Malumbres M, Barbacid M. Cell cycle, CDKs and cancer: a changing paradigm. Nat Rev Cancer 2009;9:153-66.
    • (2009) Nat Rev Cancer , vol.9 , pp. 153-166
    • Malumbres, M.1    Barbacid, M.2
  • 2
    • 50149120366 scopus 로고    scopus 로고
    • Cellular mechanisms of tumour suppression by the retinoblastoma gene
    • Burkhart DL, Sage J. Cellular mechanisms of tumour suppression by the retinoblastoma gene. Nat Rev Cancer 2008;8:671-82.
    • (2008) Nat Rev Cancer , vol.8 , pp. 671-682
    • Burkhart, D.L.1    Sage, J.2
  • 3
    • 27144458683 scopus 로고    scopus 로고
    • Cyclins and CDKS in development and cancer: Lessons from genetically modified mice
    • Santamaria D, Ortega S. Cyclins and CDKS in development and cancer: lessons from genetically modified mice. Front Biosci 2006;11:1164-88.
    • (2006) Front Biosci , vol.11 , pp. 1164-1188
    • Santamaria, D.1    Ortega, S.2
  • 4
    • 65349102972 scopus 로고    scopus 로고
    • The decision to enter mitosis: Feedback and redundancy in the mitotic entry network
    • Lindqvist A, Rodríguez-Bravo V, Medema RH. The decision to enter mitosis: feedback and redundancy in the mitotic entry network. J Cell Biol 2009;185:193-202.
    • (2009) J Cell Biol , vol.185 , pp. 193-202
    • Lindqvist, A.1    Rodríguez-Bravo, V.2    Medema, R.H.3
  • 5
    • 34347220473 scopus 로고    scopus 로고
    • Defining the role of mTOR in cancer
    • Guertin DA, Sabatini DM. Defining the role of mTOR in cancer. Cancer Cell 2007;12:9-22.
    • (2007) Cancer Cell , vol.12 , pp. 9-22
    • Guertin, D.A.1    Sabatini, D.M.2
  • 6
    • 34548359244 scopus 로고    scopus 로고
    • PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex
    • Fonseca BD, Smith EM, Lee VH, Mackintosh C, Proud CG. PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex. J Biol Chem 2007;282:24514-24.
    • (2007) J Biol Chem , vol.282 , pp. 24514-24524
    • Fonseca, B.D.1    Smith, E.M.2    Lee, V.H.3    Mackintosh, C.4    Proud, C.G.5
  • 7
    • 0037178781 scopus 로고    scopus 로고
    • Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
    • Hara K, Maruki Y, Long X, et al. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell 2002;110:177-89.
    • (2002) Cell , vol.110 , pp. 177-189
    • Hara, K.1    Maruki, Y.2    Long, X.3
  • 8
    • 0037178786 scopus 로고    scopus 로고
    • MTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
    • Kim DH, Sarbassov DD, Ali SM, et al. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 2002;110:163-75.
    • (2002) Cell , vol.110 , pp. 163-175
    • Kim, D.H.1    Sarbassov, D.D.2    Ali, S.M.3
  • 9
    • 0037623417 scopus 로고    scopus 로고
    • GβL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR
    • Kim DH, Sarbassov DD, Ali SM, et al. GβL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol Cell 2003;11:895-904.
    • (2003) Mol Cell , vol.11 , pp. 895-904
    • Kim, D.H.1    Sarbassov, D.D.2    Ali, S.M.3
  • 10
    • 0036753494 scopus 로고    scopus 로고
    • Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
    • Loewith R, Jacinto E, Wullschleger S, et al. Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol Cell 2002;10:457-68.
    • (2002) Mol Cell , vol.10 , pp. 457-468
    • Loewith, R.1    Jacinto, E.2    Wullschleger, S.3
  • 11
    • 33947264077 scopus 로고    scopus 로고
    • PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
    • Sancak Y, Thoreen CC, Peterson TR, et al. PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. Mol Cell 2007;25:903-15.
    • (2007) Mol Cell , vol.25 , pp. 903-915
    • Sancak, Y.1    Thoreen, C.C.2    Peterson, T.R.3
  • 13
    • 54949144410 scopus 로고    scopus 로고
    • MTOR inhibitors in the treatment of cancer
    • Fasolo A, Sessa C. mTOR inhibitors in the treatment of cancer. Expert Opin Investig Drugs 2008;17:1717-34.
    • (2008) Expert Opin Investig Drugs , vol.17 , pp. 1717-1734
    • Fasolo, A.1    Sessa, C.2
  • 14
    • 33748471980 scopus 로고    scopus 로고
    • MSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s
    • Frias MA, Thoreen CC, Jaffe JD, et al. mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s. Curr Biol 2006;16:1865-70.
    • (2006) Curr Biol , vol.16 , pp. 1865-1870
    • Frias, M.A.1    Thoreen, C.C.2    Jaffe, J.D.3
  • 15
    • 7944235758 scopus 로고    scopus 로고
    • Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
    • Jacinto E, Loewith R, Schmidt A, et al. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol 2004;6:1122-8.
    • (2004) Nat Cell Biol , vol.6 , pp. 1122-1128
    • Jacinto, E.1    Loewith, R.2    Schmidt, A.3
  • 16
    • 3342895823 scopus 로고    scopus 로고
    • Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
    • Sarbassov DD, Ali SM, Kim DH, et al. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol 2004;14:1296-302.
    • (2004) Curr Biol , vol.14 , pp. 1296-1302
    • Sarbassov, D.D.1    Ali, S.M.2    Kim, D.H.3
  • 17
    • 33749076673 scopus 로고    scopus 로고
    • SIN1/MIP1 maintains rictormTOR complex integrity and regulates Akt phosphorylation and substrate specificity
    • Jacinto E, Facchinetti V, Liu D, et al. SIN1/MIP1 maintains rictormTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell 2006;127:125-37.
    • (2006) Cell , vol.127 , pp. 125-137
    • Jacinto, E.1    Facchinetti, V.2    Liu, D.3
  • 18
    • 34347210090 scopus 로고    scopus 로고
    • Identification of Protor as a novel Rictor-binding component of mTOR complex-2
    • Pearce LR, Huang X, Boudeau J, et al. Identification of Protor as a novel Rictor-binding component of mTOR complex-2. Biochem J 2007;405:513-22.
    • (2007) Biochem J , vol.405 , pp. 513-522
    • Pearce, L.R.1    Huang, X.2    Boudeau, J.3
  • 19
    • 33751079895 scopus 로고    scopus 로고
    • Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity
    • Yang Q, Inoki K, Ikenoue T, Guan KL. Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity. Genes Dev 2006;20:2820-32.
    • (2006) Genes Dev , vol.20 , pp. 2820-2832
    • Yang, Q.1    Inoki, K.2    Ikenoue, T.3    Guan, K.L.4
  • 20
    • 34548509880 scopus 로고    scopus 로고
    • PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor β expression and signaling
    • Woo SY, Kim DH, Jun CB, et al. PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor β expression and signaling. J Biol Chem 2007;282:25604-12.
    • (2007) J Biol Chem , vol.282 , pp. 25604-25612
    • Woo, S.Y.1    Kim, D.H.2    Jun, C.B.3
  • 21
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005;307:1098-101.
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 22
    • 45449106969 scopus 로고    scopus 로고
    • MTORC2 regulates PGE2-mediated endothelial cell survival and migration
    • Dada S, Demartines N, Dormond O. mTORC2 regulates PGE2-mediated endothelial cell survival and migration. Biochem Biophys Res Commun 2008;372:875-9.
    • (2008) Biochem Biophys Res Commun , vol.372 , pp. 875-879
    • Dada, S.1    Demartines, N.2    Dormond, O.3
  • 23
    • 47949125486 scopus 로고    scopus 로고
    • The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C
    • Facchinetti V, Ouyang W, Wei H, et al. The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J 2008;27:1932-43.
    • (2008) EMBO J , vol.27 , pp. 1932-1943
    • Facchinetti, V.1    Ouyang, W.2    Wei, H.3
  • 24
    • 47949104258 scopus 로고    scopus 로고
    • Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling
    • Ikenoue T, Inoki K, Yang Q, Zhou X, Guan KL. Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling. EMBO J 2008;27:1919-31.
    • (2008) EMBO J , vol.27 , pp. 1919-1931
    • Ikenoue, T.1    Inoki, K.2    Yang, Q.3    Zhou, X.4    Guan, K.L.5
  • 25
    • 34548079309 scopus 로고    scopus 로고
    • Cardiovascular effects of Danshen
    • Cheng TO. Cardiovascular effects of Danshen. Int J Cardiol 2007;121:9-22.
    • (2007) Int J Cardiol , vol.121 , pp. 9-22
    • Cheng, T.O.1
  • 26
    • 27844511101 scopus 로고    scopus 로고
    • Danshen: An overview of its chemistry, pharmacology, pharmacokinetics, and clinical use
    • Zhou L, Zuo Z, Chow MS. Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use. J Clin Pharmacol 2005;45:1345-59.
    • (2005) J Clin Pharmacol , vol.45 , pp. 1345-1359
    • Zhou, L.1    Zuo, Z.2    Chow, M.S.3
  • 27
    • 33645842478 scopus 로고    scopus 로고
    • Herbs or natural substances as complementary therapies for chronic kidney disease: Ideas for future studies
    • Wojcikowski K, Johnson DW, Gobe G. Herbs or natural substances as complementary therapies for chronic kidney disease: ideas for future studies. J Lab Clin Med 2006;147:160-6.
    • (2006) J Lab Clin Med , vol.147 , pp. 160-166
    • Wojcikowski, K.1    Johnson, D.W.2    Gobe, G.3
  • 28
    • 0033944607 scopus 로고    scopus 로고
    • Treatment of chronic liver diseases with traditional Chinese medicine
    • Wang BE. Treatment of chronic liver diseases with traditional Chinese medicine. J Gastroenterol Hepatol 2000;15 Suppl:E67-70.
    • (2000) J Gastroenterol Hepatol , vol.15 , Issue.SUPPL.
    • Wang, B.E.1
  • 29
    • 34249035885 scopus 로고    scopus 로고
    • Transport of cryptotanshinone, a major active triterpenoid in Salvia miltiorrhiza Bunge widely used in the treatment of stroke and Alzheimer's disease, across the blood-brain barrier
    • Yu XY, Lin SG, Chen X, et al. Transport of cryptotanshinone, a major active triterpenoid in Salvia miltiorrhiza Bunge widely used in the treatment of stroke and Alzheimer's disease, across the blood-brain barrier. Curr Drug Metab 2007;8:365-78.
    • (2007) Curr Drug Metab , vol.8 , pp. 365-378
    • Yu, X.Y.1    Lin, S.G.2    Chen, X.3
  • 30
    • 33748981088 scopus 로고    scopus 로고
    • Cryptotanshinone inhibits cyclooxygenase-2 enzyme activity but not its expression
    • Jin DZ, Yin LL, Ji XQ, Zhu XZ. Cryptotanshinone inhibits cyclooxygenase-2 enzyme activity but not its expression. Eur J Pharmacol 2006;549:166-72.
    • (2006) Eur J Pharmacol , vol.549 , pp. 166-172
    • Jin, D.Z.1    Yin, L.L.2    Ji, X.Q.3    Zhu, X.Z.4
  • 31
    • 33751119071 scopus 로고    scopus 로고
    • Cryptotanshinone from Salvia miltiorrhiza BUNGE has an inhibitory effect on TNF-α-induced matrix metalloproteinase-9 production and HASMC migration via down-regulated NF-κB and AP-1
    • Suh SJ, Jin UH, Choi HJ, et al. Cryptotanshinone from Salvia miltiorrhiza BUNGE has an inhibitory effect on TNF-α-induced matrix metalloproteinase-9 production and HASMC migration via down-regulated NF-κB and AP-1. Biochem Pharmacol 2006;72:1680-9.
    • (2006) Biochem Pharmacol , vol.72 , pp. 1680-1689
    • Suh, S.J.1    Jin, U.H.2    Choi, H.J.3
  • 32
    • 34347208670 scopus 로고    scopus 로고
    • Antidiabetes and antiobesity effect of cryptotanshinone via activation of AMP-activated protein kinase
    • Kim EJ, Jung SN, Son KH, et al. Antidiabetes and antiobesity effect of cryptotanshinone via activation of AMP-activated protein kinase. Mol Pharmacol 2007;72:62-72.
    • (2007) Mol Pharmacol , vol.72 , pp. 62-72
    • Kim, E.J.1    Jung, S.N.2    Son, K.H.3
  • 33
    • 34347337539 scopus 로고    scopus 로고
    • Cryptotanshinone inhibits chemotactic migration in macrophages through negative regulation of the PI3K signaling pathway
    • Don MJ, Liao JF, Lin LY, Chiou WF. Cryptotanshinone inhibits chemotactic migration in macrophages through negative regulation of the PI3K signaling pathway. Br J Pharmacol 2007;151:638-46.
    • (2007) Br J Pharmacol , vol.151 , pp. 638-646
    • Don, M.J.1    Liao, J.F.2    Lin, L.Y.3    Chiou, W.F.4
  • 34
    • 59449107703 scopus 로고    scopus 로고
    • Cryptotanshinone protects primary rat cortical neurons from glutamate-induced neurotoxicity via the activation of the phosphatidylinositol 3-kinase/Akt signaling pathway
    • Zhang F, Zheng W, Pi R, et al. Cryptotanshinone protects primary rat cortical neurons from glutamate-induced neurotoxicity via the activation of the phosphatidylinositol 3-kinase/Akt signaling pathway. Exp Brain Res 2008;193:109-18.
    • (2008) Exp Brain Res , vol.193 , pp. 109-118
    • Zhang, F.1    Zheng, W.2    Pi, R.3
  • 35
    • 54849187400 scopus 로고    scopus 로고
    • Tanshinone I effectively induces apoptosis in estrogen receptor-positive (MCF-7) and estrogen receptor-negative (MDA-MB-231) breast cancer cells
    • Nizamutdinova IT, Lee GW, Son KH, et al. Tanshinone I effectively induces apoptosis in estrogen receptor-positive (MCF-7) and estrogen receptor-negative (MDA-MB-231) breast cancer cells. Int J Oncol 2008;33:485-91.
    • (2008) Int J Oncol , vol.33 , pp. 485-491
    • Nizamutdinova, I.T.1    Lee, G.W.2    Son, K.H.3
  • 36
    • 58249119435 scopus 로고    scopus 로고
    • Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells
    • Shin DS, Kim HN, Shin KD, et al. Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells. Cancer Res 2009;69:193-202.
    • (2009) Cancer Res , vol.69 , pp. 193-202
    • Shin, D.S.1    Kim, H.N.2    Shin, K.D.3
  • 37
    • 33745918631 scopus 로고    scopus 로고
    • Curcumin inhibits the mammalian target of rapamycin-mediated signaling pathways in cancer cells
    • Beevers CS, Li F, Liu L, Huang S. Curcumin inhibits the mammalian target of rapamycin-mediated signaling pathways in cancer cells. Int J Cancer 2006;119:757-64.
    • (2006) Int J Cancer , vol.119 , pp. 757-764
    • Beevers, C.S.1    Li, F.2    Liu, L.3    Huang, S.4
  • 38
    • 0031940393 scopus 로고    scopus 로고
    • Controlling signaling with a specifically designed Gi-coupled receptor
    • Coward P, Wada HG, Falk MS, et al. Controlling signaling with a specifically designed Gi-coupled receptor. Proc Natl Acad Sci U S A 1998;95:352-7.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 352-357
    • Coward, P.1    Wada, H.G.2    Falk, M.S.3
  • 39
    • 12544252740 scopus 로고    scopus 로고
    • Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in β-cells
    • Briaud I, Dickson LM, Lingohr MK, McCuaig JF, Lawrence JC, Rhodes CJ. Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in β-cells. J Biol Chem 2005;280:2282-93.
    • (2005) J Biol Chem , vol.280 , pp. 2282-2293
    • Briaud, I.1    Dickson, L.M.2    Lingohr, M.K.3    McCuaig, J.F.4    Lawrence, J.C.5    Rhodes, C.J.6
  • 40
    • 50649123206 scopus 로고    scopus 로고
    • Rapamycin inhibits F-actin reorganization and phosphorylation of focal adhesion proteins
    • Liu L, Chen L, Chung J, Huang S. Rapamycin inhibits F-actin reorganization and phosphorylation of focal adhesion proteins. Oncogene 2008;27:4998-5010.
    • (2008) Oncogene , vol.27 , pp. 4998-5010
    • Liu, L.1    Chen, L.2    Chung, J.3    Huang, S.4
  • 41
    • 33750858427 scopus 로고    scopus 로고
    • Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways
    • Liu L, Li F, Cardelli JA, Martin KA, Blenis J, Huang S. Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways. Oncogene 2006;25:7029-40.
    • (2006) Oncogene , vol.25 , pp. 7029-7040
    • Liu, L.1    Li, F.2    Cardelli, J.A.3    Martin, K.A.4    Blenis, J.5    Huang, S.6
  • 42
    • 0032485937 scopus 로고    scopus 로고
    • Rapamycin inhibition of the G1 to S transition is mediated by effects on cyclin D1 mRNA and protein stability
    • Hashemolhosseini S, Nagamine Y, Morley SJ, Desrivieres S, Mercep L, Ferrari S. Rapamycin inhibition of the G1 to S transition is mediated by effects on cyclin D1 mRNA and protein stability. J Biol Chem 1998;273:14424-29.
    • (1998) J Biol Chem , vol.273 , pp. 14424-14429
    • Hashemolhosseini, S.1    Nagamine, Y.2    Morley, S.J.3    Desrivieres, S.4    Mercep, L.5    Ferrari, S.6
  • 44
    • 0030881836 scopus 로고    scopus 로고
    • Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin
    • Brunn GJ, Hudson CC, Sekuliæ A, et al. Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin. Science 1997;277:99-101.
    • (1997) Science , vol.277 , pp. 99-101
    • Brunn, G.J.1    Hudson, C.C.2    Sekuliæ, A.3
  • 45
    • 22544455676 scopus 로고    scopus 로고
    • Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase
    • Holz MK, Blenis J. Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase. J Biol Chem 2005;280:26089-93.
    • (2005) J Biol Chem , vol.280 , pp. 26089-26093
    • Holz, M.K.1    Blenis, J.2
  • 46
    • 36048963331 scopus 로고    scopus 로고
    • Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance
    • Zhou J, Wulfkuhle J, Zhang H, et al. Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance. Proc Natl Acad Sci U S A 2007;104:16158-63.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 16158-16163
    • Zhou, J.1    Wulfkuhle, J.2    Zhang, H.3
  • 47
    • 0025940113 scopus 로고
    • Wild-type p53 suppresses growth of human prostate cancer cells containing mutant p53 alleles
    • Isaacs WB, Carter BS, Ewing CM. Wild-type p53 suppresses growth of human prostate cancer cells containing mutant p53 alleles. Cancer Res 1991;51:4716-20.
    • (1991) Cancer Res , vol.51 , pp. 4716-4720
    • Isaacs, W.B.1    Carter, B.S.2    Ewing, C.M.3
  • 48
    • 0030941458 scopus 로고    scopus 로고
    • P53, the cellular gatekeeper for growth and division
    • Levine AJ. p53, the cellular gatekeeper for growth and division. Cell 1997;88:323-31.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 49
    • 40749148985 scopus 로고    scopus 로고
    • Pharmacokinetic characterization of hydroxylpropyl-β-cyclodextrin- included complex of cryptotanshinone, an investigational cardiovascular drug purified from Danshen (Salvia miltiorrhiza)
    • Pan Y, Bi HC, Zhong GP, et al. Pharmacokinetic characterization of hydroxylpropyl-β-cyclodextrin-included complex of cryptotanshinone, an investigational cardiovascular drug purified from Danshen (Salvia miltiorrhiza). Xenobiotica 2008;38:382-98.
    • (2008) Xenobiotica , vol.38 , pp. 382-398
    • Pan, Y.1    Bi, H.C.2    Zhong, G.P.3
  • 50
    • 0035851205 scopus 로고    scopus 로고
    • Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells
    • Tremblay F, Marette A. Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells. J Biol Chem 2001;276:38052-60.
    • (2001) J Biol Chem , vol.276 , pp. 38052-38060
    • Tremblay, F.1    Marette, A.2
  • 51
    • 33644886769 scopus 로고    scopus 로고
    • Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation
    • Tzatsos A, Kandror KV. Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation. Mol Cell Biol 2006;26:63-76.
    • (2006) Mol Cell Biol , vol.26 , pp. 63-76
    • Tzatsos, A.1    Kandror, K.V.2
  • 52
    • 32944457518 scopus 로고    scopus 로고
    • MTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
    • O'Reilly KE, Rojo F, She QB, et al. mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res 2006;66:1500-8.
    • (2006) Cancer Res , vol.66 , pp. 1500-1508
    • O'Reilly, K.E.1    Rojo, F.2    She, Q.B.3
  • 53
    • 33947538050 scopus 로고    scopus 로고
    • Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism
    • Wan X, Harkavy B, Shen N, Grohar P, Helman LJ. Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism. Oncogene 2007;26:1932-40.
    • (2007) Oncogene , vol.26 , pp. 1932-1940
    • Wan, X.1    Harkavy, B.2    Shen, N.3    Grohar, P.4    Helman, L.J.5
  • 54
    • 0028172867 scopus 로고
    • Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin
    • Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin. Nature 1994;372:570-73.
    • (1994) Nature , vol.372 , pp. 570-573
    • Nourse, J.1    Firpo, E.2    Flanagan, W.M.3
  • 55
    • 20244365941 scopus 로고    scopus 로고
    • The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation
    • Beuvink I, Boulay A, Fumagalli S, et al. The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation. Cell 2005;120:747-59.
    • (2005) Cell , vol.120 , pp. 747-759
    • Beuvink, I.1    Boulay, A.2    Fumagalli, S.3
  • 56
    • 54049120956 scopus 로고    scopus 로고
    • E2F - At the crossroads of life and death
    • Polager S, Ginsberg D. E2F - at the crossroads of life and death. Trends Cell Biol 2008;18:528-35.
    • (2008) Trends Cell Biol , vol.18 , pp. 528-535
    • Polager, S.1    Ginsberg, D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.