Transport of cryptotanshinone, a major active triterpenoid in Salvia miltiorrhiza Bunge widely used in the treatment of stroke and Alzheimer's disease, across the blood-brain barrier

Current Drug Metabolism

Volumn 8, Issue 4, 2007, Pages 365-377

  Yu, Xi Yong ^a   Lin, Shu Guang ^a   Chen, Xiao ^b   Zhou, Zhi Wei ^c   Liang, Jun ^d   Duan, Wei ^e   Chowbay, Balram ^f   Wen, Jing Yuan ^g   Chan, Eli ^h   Cao, Jie ⁱ   Li, Chun Guang ^j   Zhou, Shu Feng ^k  

^a GUANGDONG PROVINCIAL PEOPLE'S HOSPITAL   (China)

^b SUN YAT SEN UNIVERSITY   (China)

^c NANCHANG UNIVERSITY   (China)

^d UNIVERSITY OF SYDNEY   (Australia)

^e DEAKIN UNIVERSITY   (Australia)

^f DIVISION OF MEDICAL ONCOLOGY   (Singapore)

^g THE UNIVERSITY OF AUCKLAND   (New Zealand)

^h NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

ⁱ GUANGZHOU FIRST PEOPLE'S HOSPITAL   (China)

^j RMIT UNIVERSITY   (Australia)

^k QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

more..

Author keywords

Alzheimer's disease; Blood brain barrier; Cryptotanshinone; Middle cerebral artery occlusion; Multidrug resistance associated protein; P glycoprotein

Indexed keywords

CRYPTOTANSHINONE; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN 1; PROBENECID; QUINIDINE; QUINOLINIC ACID; SALVIA MILTIORRHIZA EXTRACT; SUCROSE; TANSHINONE; TRITERPENOID; VERAPAMIL; VERLUKAST;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; BLOOD BRAIN BARRIER; BRAIN PERFUSION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; DRUG METABOLISM; DRUG STRUCTURE; DRUG TRANSPORT; DRUG UPTAKE; ENDOTHELIUM CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NONHUMAN; RAT; REVIEW; RODENT; STROKE; TIME TO MAXIMUM PLASMA CONCENTRATION; WILD TYPE;

ALZHEIMER DISEASE; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; BRAIN; CAPILLARY PERMEABILITY; CELLS, CULTURED; CEREBROVASCULAR ACCIDENT; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; ENDOTHELIAL CELLS; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; MICE; MICE, KNOCKOUT; MICROCIRCULATION; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; NEUROPROTECTIVE AGENTS; NEUROTOXICITY SYNDROMES; P-GLYCOPROTEIN; P-GLYCOPROTEINS; PHENANTHRENES; PLANT ROOTS; QUINOLINIC ACID; RATS; RATS, SPRAGUE-DAWLEY; SALVIA MILTIORRHIZA; TISSUE DISTRIBUTION; TRITERPENES;

EID: 34249035885     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920007780655441     Document Type: Review

References (36)

1. Alavijeh, M. S.; Chishty, M.; Qaiser, M. Z.; Palmer, A. M. (2005) NeuroRx 2(4), 554-571.
2. Choi, D. W. (1988) Trends Neurosci. 11(10), 465-469.
3. Sztriha, L. K.; Sas, K.; Vecsei, L. (2005) J. Neurol. Sci. 229-230, 163-169.
4. Taylor, E. M. (2002) Clin. Pharmacokinet. 41(2), 81-92.
5. Banks, W. A. (1999) J. Neurovirol. 5(6), 538-555.
6. Borst, P.; Elferink, R. O. (2002) Annu. Rev. Biochem. 71, 537-592.
7. Zhu, Y. Z.; Huang, S. H.; Tan, B. K.; Sun, J.; Whiteman, M.; Zhu, Y. C. (2004) Nat. Prod. Rep. 21(4), 478-489.
8. Zhu, Y.-P. Chinese materia medica: chemistry, pharmacology and applications; Harwood Academic Publishers: Amsterdam, The Netherlands, 1998.
9. Wu, B.; Liu, M.; Zhang, S. (2004) Cochrane Database Syst. Rev. 4, CD004295.
10. Yang, M.; Liu, A.; Guan, S.; Sun, J.; Xu, M.; Guo, D. (2006) Rapid Commun. Mass Spectrom. 20(8), 1266-1280.
11. Gu, M.; Zhang, G.; Su, Z.; Ouyang, F. (2004) J. Chromatogr. A 1041(1-2), 239-243.
12. Don, M. J.; Shen, C. C.; Syu, W. J.; Ding, Y. H.; Sun, C. M. (2006) Phytochemistry 67(5), 497-503.
13. Zhou, L.; Zuo, Z.; Chow, M. S. (2005) J. Clin. Pharmacol. 45(12), 1345-1359.
14. Liu, A. H.; Li, L.; Xu, M.; Lin, Y. H.; Guo, H. Z.; Guo, D. A. (2006) J. Pharm. Biomed Anal. 41(1), 48-56.
15. Ma, L.; Zhang, X.; Guo, H.; Gan, Y. (2006) J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 833(2), 260-263.
16. Adams, J. D.; Wang, R.; Yang, J.; Lien, E. J. (2006) Chin. Med. 1(3), 1-15.
17. Zhang, J.; Huang, M.; Guan, S.; Bi, H. C.; Pan, Y.; Duan, W.; Chan, S. Y.; Chen, X.; Hong, Y. H.; Bian, J. S.; Yang, H. Y.; Zhou, S. (2006) J. Pharmacol. Exp. Ther. 317(3), 1285-1294.
18. Laemmli, U. K. (1970) Nature 227(5259), 680-685.
19. Mosmann, T. (1983) J. Immunol. Methods 65(1-2), 55-63.
20. El Hafny, B.; Cano, N.; Piciotti, M.; Regina, A.; Scherrmann, J. M.; Roux, F. (1997) Biochem. Pharmacol. 53(11), 1735-1742.
21. Zhou, S.; Feng, X.; Kestell, P.; Paxton, J. W.; Baguley, B. C.; Chan, E. (2005) Eur. J. Pharm. Sci. 24(5), 513-524.
22. Tian, Q.; Zhang, J.; Chan, E.; Duan, W.; Zhou, S. F. (2005) Drug Dev. Res. 51(2), 1-18.
23. Takasato, Y.; Rapoport, S. I.; Smith, Q. R. (1984) Am. J. Physiol. 247(3 Pt 2), H484-493.
24. Tamai, I.; Senmaru, M.; Terasaki, T.; Tsuji, A. (1995) Biochem. Pharmacol. 50(11), 1783-1793.
25. Belayev, L.; Alonso, O. F.; Busto, R.; Zhao, W.; Ginsberg, M. D. (1996) Stroke 27(9), 1616-1622; discussion 1623.
26. Altar, C. A.; Dugich-Djordjevic, M.; Armanini, M.; Bakhit, C. (1991) J. Neurosci. 11(3), 828-836.
27. Yamada, K.; Fuji, K.; Nabeshima, T.; Kameyama, T. (1990) Neurosci. Lett. 118(1), 128-131.
28. Zhou, S.; Paxton, J. W.; Kestell, P.; Tingle, M. D. (2001) J. Pharm. Pharmacol. 53(4), 463-471.
29. Gavrieli, Y.; Sherman, Y.; Ben-Sasson, S. A. (1992) J. Cell. Biol. 119(3), 493-501.
30. Cecchelli, R.; Dehouck, B.; Descamps, L.; Fenart, L.; Buee-Scherrer, V. V.; Duhem, C.; Lundquist, S.; Rentfel, M.; Torpier, G.; Dehouck, M. P. (1999) Adv. Drug Deliv. Rev. 36(2-3), 165-178.
31. Roux, F.; Couraud, P.O. (2005) Cell. Mol. Neurobiol. 25(1), 41-58.
32. Schinkel, A. H.; Wagenaar, E.; Mol, C. A.; van Deemter, L. (1996) J. Clin. Invest. 97(11), 2517-2524.
33. Schinkel, A. H.; Wagenaar, E.; van Deemter, L.; Mol, C. A.; Borst, P. (1995) J. Clin. Invest. 96(4), 1698-1705.
34. Hong, M.; Schlichter, L.; Bendayan, R. (2000) J. Pharmacol. Exp. Ther. 292(1), 366-374.
35. Breuer, C.; Wolf, G.; Andrabi, S. A.; Lorenz, P.; Horn, T. F. (2006) Neurosci. Lett. 393(2-3), 113-118.
36. Begley, D. J. (2004) Curr. Pharm. Des. 10(12), 1295-1312.