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Volumn 34, Issue 8, 2010, Pages 1366-1379

The effects of cholesterol on learning and memory

Author keywords

24S hydroxcholesterol; Alzheimer's disease; Apolipoprotein E; ATP binding cassette transporters; Cholesterol fed rabbit; Classical conditioning; Eyeblink conditioning; Fear conditioning; Low density lipoprotein receptors; Statins; Water maze

Indexed keywords

26 HYDROXYCHOLESTEROL; ABC TRANSPORTER; APOLIPOPROTEIN E; ATORVASTATIN; CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LIVER X RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR; PLACEBO; SIMVASTATIN;

EID: 77954175073     PISSN: 01497634     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neubiorev.2010.04.010     Document Type: Review
Times cited : (88)

References (240)
  • 1
    • 76449103011 scopus 로고    scopus 로고
    • Increased expression of cholesterol transporter ABCA1 is highly correlated with severity of dementia in AD hippocampus
    • Akram A., Schmeidler J., Kastel P., Hof P.R., Haroutunian V. Increased expression of cholesterol transporter ABCA1 is highly correlated with severity of dementia in AD hippocampus. Brain Res. 2010, 1318:167-177.
    • (2010) Brain Res. , vol.1318 , pp. 167-177
    • Akram, A.1    Schmeidler, J.2    Kastel, P.3    Hof, P.R.4    Haroutunian, V.5
  • 2
    • 0035829375 scopus 로고    scopus 로고
    • Methods for behavioural phenotyping of mouse mutants. How to keep the overview
    • Arndt S.S., Surjo D. Methods for behavioural phenotyping of mouse mutants. How to keep the overview. Behav. Brain Res. 2001, 125:39-42.
    • (2001) Behav. Brain Res. , vol.125 , pp. 39-42
    • Arndt, S.S.1    Surjo, D.2
  • 6
    • 75749128612 scopus 로고    scopus 로고
    • Neuropsychological assessment in the diagnosis of Alzheimer's disease
    • Baldwin S., Farias S.T. Neuropsychological assessment in the diagnosis of Alzheimer's disease. Curr. Protocols Neurosci. 2009, 49:1031-1038.
    • (2009) Curr. Protocols Neurosci. , vol.49 , pp. 1031-1038
    • Baldwin, S.1    Farias, S.T.2
  • 7
    • 77955921493 scopus 로고    scopus 로고
    • Brain lipid metabolism, apolipoprotein E and the pathophysiology of Alzheimer's disease
    • in press
    • Bales, K.R. Brain lipid metabolism, apolipoprotein E and the pathophysiology of Alzheimer's disease. Neuropharmacology, in press.
    • Neuropharmacology
    • Bales, K.R.1
  • 8
    • 14744289048 scopus 로고    scopus 로고
    • Blood-brain barrier transport of cytokines: a mechanism for neuropathology
    • Banks W.A. Blood-brain barrier transport of cytokines: a mechanism for neuropathology. Curr. Pharm. Des. 2005, 11:973-984.
    • (2005) Curr. Pharm. Des. , vol.11 , pp. 973-984
    • Banks, W.A.1
  • 9
    • 63649087890 scopus 로고    scopus 로고
    • Biological role of liver X receptors
    • Baranowski M. Biological role of liver X receptors. J. Physiol. Pharmacol. 2008, 59(Suppl. 7):31-55.
    • (2008) J. Physiol. Pharmacol. , vol.59 , Issue.SUPPL. 7 , pp. 31-55
    • Baranowski, M.1
  • 10
    • 40449101922 scopus 로고    scopus 로고
    • Physiologic origins of age-related β-amyloid deposition
    • Beach T.G. Physiologic origins of age-related β-amyloid deposition. Neurodegenerative Dis. 2008, 5:143-145.
    • (2008) Neurodegenerative Dis. , vol.5 , pp. 143-145
    • Beach, T.G.1
  • 11
    • 55449116793 scopus 로고    scopus 로고
    • Brain cholesterol metabolism and neurologic disease
    • Benarroch E.E. Brain cholesterol metabolism and neurologic disease. Neurology 2008, 71:1368-1373.
    • (2008) Neurology , vol.71 , pp. 1368-1373
    • Benarroch, E.E.1
  • 14
    • 33846570982 scopus 로고    scopus 로고
    • Learning decreases Aβ 56 and tau pathology and ameliorates behavioral decline in 3xTg-AD mice
    • Billings L.M., Green K.N., McGaugh J.L., LaFerla F.M. Learning decreases Aβ 56 and tau pathology and ameliorates behavioral decline in 3xTg-AD mice. J. Neurosci. 2007, 27:751-761.
    • (2007) J. Neurosci. , vol.27 , pp. 751-761
    • Billings, L.M.1    Green, K.N.2    McGaugh, J.L.3    LaFerla, F.M.4
  • 15
    • 14644442872 scopus 로고    scopus 로고
    • Intraneuronal Aβ causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice
    • Billings L.M., Oddo S., Green K.N., McGaugh J.L., LeFerla F.M. Intraneuronal Aβ causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice. Neuron 2005, 45:675-688.
    • (2005) Neuron , vol.45 , pp. 675-688
    • Billings, L.M.1    Oddo, S.2    Green, K.N.3    McGaugh, J.L.4    LeFerla, F.M.5
  • 16
    • 0036736781 scopus 로고    scopus 로고
    • Do oxysterols control cholesterol homeostasis?
    • Bjorkhem I. Do oxysterols control cholesterol homeostasis?. J. Clin. Invest. 2002, 110:725-730.
    • (2002) J. Clin. Invest. , vol.110 , pp. 725-730
    • Bjorkhem, I.1
  • 17
    • 66349136255 scopus 로고    scopus 로고
    • Are side-chain oxidized oxysterols regulators also in vivo?
    • Bjorkhem I. Are side-chain oxidized oxysterols regulators also in vivo?. J. Lipid Res. 2009, 50:S213-S218.
    • (2009) J. Lipid Res. , vol.50
    • Bjorkhem, I.1
  • 20
    • 3442887483 scopus 로고    scopus 로고
    • Behavioural profiles of inbred mouse strains used as transgenic backgrounds. I: motor tests
    • Brooks S.P., Pask T., Jones L., Dunnett S.B. Behavioural profiles of inbred mouse strains used as transgenic backgrounds. I: motor tests. Genes Brain Behav. 2004, 3:206-215.
    • (2004) Genes Brain Behav. , vol.3 , pp. 206-215
    • Brooks, S.P.1    Pask, T.2    Jones, L.3    Dunnett, S.B.4
  • 21
    • 58049215490 scopus 로고    scopus 로고
    • Molecular genetics of Alzheimer's disease: an update
    • Brouwers N., Sleegers K., Van Broeckhoven C. Molecular genetics of Alzheimer's disease: an update. Ann. Med. 2008, 18:1-22.
    • (2008) Ann. Med. , vol.18 , pp. 1-22
    • Brouwers, N.1    Sleegers, K.2    Van Broeckhoven, C.3
  • 23
    • 33947589524 scopus 로고    scopus 로고
    • Alzheimer's disease and cholesterol: the fat connection
    • Canevari L., Clark J.B. Alzheimer's disease and cholesterol: the fat connection. Neurochem. Res. 2007, 32:739-750.
    • (2007) Neurochem. Res. , vol.32 , pp. 739-750
    • Canevari, L.1    Clark, J.B.2
  • 24
    • 33748431934 scopus 로고    scopus 로고
    • Lack of LDL receptor aggravates learning deficits and amyloid deposits in Alzheimer transgenic mice
    • Cao D., Fukuchi K., Wan H., Kim H., Li L. Lack of LDL receptor aggravates learning deficits and amyloid deposits in Alzheimer transgenic mice. Neurobiol. Aging 2006, 27:1632-1643.
    • (2006) Neurobiol. Aging , vol.27 , pp. 1632-1643
    • Cao, D.1    Fukuchi, K.2    Wan, H.3    Kim, H.4    Li, L.5
  • 27
    • 50949097728 scopus 로고    scopus 로고
    • Oligomer-specific aβ toxicity in cell models is mediated by selective uptake
    • Chafekar S.M., Baas F., Scheper W. Oligomer-specific aβ toxicity in cell models is mediated by selective uptake. Biochim. Biophys. Acta 2008, 1782:523-531.
    • (2008) Biochim. Biophys. Acta , vol.1782 , pp. 523-531
    • Chafekar, S.M.1    Baas, F.2    Scheper, W.3
  • 29
    • 42649109113 scopus 로고    scopus 로고
    • Caffeine blocks disruption of the blood brain barrier in a rabbit model of Alzheimer's disease
    • Chen X., Gawryluk J.W., Wagener J.F., Ghribi O., Geiger J.D. Caffeine blocks disruption of the blood brain barrier in a rabbit model of Alzheimer's disease. J. Neuroinflamm. 2008, 5:1-14.
    • (2008) J. Neuroinflamm. , vol.5 , pp. 1-14
    • Chen, X.1    Gawryluk, J.W.2    Wagener, J.F.3    Ghribi, O.4    Geiger, J.D.5
  • 31
    • 77249176175 scopus 로고    scopus 로고
    • Dietary cholesterol impairs memory and memory increases brain cholesterol and sulfatide levels
    • Darwish D.S., Wang D., Konat G.W., Schreurs B.G. Dietary cholesterol impairs memory and memory increases brain cholesterol and sulfatide levels. Behav. Neurosci. 2010, 124:115-123.
    • (2010) Behav. Neurosci. , vol.124 , pp. 115-123
    • Darwish, D.S.1    Wang, D.2    Konat, G.W.3    Schreurs, B.G.4
  • 33
    • 65649105035 scopus 로고    scopus 로고
    • Clearance of amyloid-β across the blood-brain barrier: implications for therapies in Alzheimer's disease
    • Deane R., Bell R.D., Sagare A., Zlokovic B.V. Clearance of amyloid-β across the blood-brain barrier: implications for therapies in Alzheimer's disease. CNS Neurol. Disord. Drug Targets 2009, 8:16-30.
    • (2009) CNS Neurol. Disord. Drug Targets , vol.8 , pp. 16-30
    • Deane, R.1    Bell, R.D.2    Sagare, A.3    Zlokovic, B.V.4
  • 35
    • 33745268224 scopus 로고    scopus 로고
    • Different conformations of amyloid β induce toxicity by distinct mechanisms in human cortical neurons
    • Despande A., Mina E., Glabe C., Busciglio J. Different conformations of amyloid β induce toxicity by distinct mechanisms in human cortical neurons. J. Neurosci. 2006, 26:6011-6018.
    • (2006) J. Neurosci. , vol.26 , pp. 6011-6018
    • Despande, A.1    Mina, E.2    Glabe, C.3    Busciglio, J.4
  • 36
    • 0024514210 scopus 로고
    • Nimodipine facilitates associative learning in aging rabbits
    • Deyo R.A., Straube K.T., Disterhoft J.F. Nimodipine facilitates associative learning in aging rabbits. Science 1989, 243:809-811.
    • (1989) Science , vol.243 , pp. 809-811
    • Deyo, R.A.1    Straube, K.T.2    Disterhoft, J.F.3
  • 37
    • 47849103782 scopus 로고    scopus 로고
    • Neuroinflammation and synaptic plasticity: theoretical basis for a movel, immune-centred, therapeutic approach to neurological disorders
    • Di Filippo M., Sarchielli P., Picconi B., Calabresi P. Neuroinflammation and synaptic plasticity: theoretical basis for a movel, immune-centred, therapeutic approach to neurological disorders. Trends Pharmacol. Sci. 2008, 29:402-412.
    • (2008) Trends Pharmacol. Sci. , vol.29 , pp. 402-412
    • Di Filippo, M.1    Sarchielli, P.2    Picconi, B.3    Calabresi, P.4
  • 38
    • 64949147821 scopus 로고    scopus 로고
    • Central nervous system: cholesterol turnover, brain development and neurodegeneration
    • Dietschy J.M. Central nervous system: cholesterol turnover, brain development and neurodegeneration. Biol. Chem. 2009, 390:287-293.
    • (2009) Biol. Chem. , vol.390 , pp. 287-293
    • Dietschy, J.M.1
  • 40
    • 3543104951 scopus 로고    scopus 로고
    • Cholesterol metabolism in the central nervous system during early development and in the mature animal
    • Dietschy J.M., Turley S.D. Cholesterol metabolism in the central nervous system during early development and in the mature animal. J. Lipid Res. 2004, 45:1375-1397.
    • (2004) J. Lipid Res. , vol.45 , pp. 1375-1397
    • Dietschy, J.M.1    Turley, S.D.2
  • 42
    • 0037151046 scopus 로고    scopus 로고
    • Accelerated plaque accumulation, associative learning deficits, and up-regulation of α7 nicotinic receptor protein in transgenic mice co-expressing mutant human preseniline 1 and amyloid precursor proteins
    • Dineley K.T., Xia X., Bui D., Sweatt J.D., Zheng H. Accelerated plaque accumulation, associative learning deficits, and up-regulation of α7 nicotinic receptor protein in transgenic mice co-expressing mutant human preseniline 1 and amyloid precursor proteins. J. Biol. Chem. 2002, 277:22768-22780.
    • (2002) J. Biol. Chem. , vol.277 , pp. 22768-22780
    • Dineley, K.T.1    Xia, X.2    Bui, D.3    Sweatt, J.D.4    Zheng, H.5
  • 43
    • 33746098173 scopus 로고    scopus 로고
    • Cholesterol-enriched diet affects spatial learning and synaptic function in hippocampal synapses
    • Dufour F., Liu Q.-Y., Gusev P., Alkon D.L., Atzori M. Cholesterol-enriched diet affects spatial learning and synaptic function in hippocampal synapses. Brain Res. 2006, 1103:88-98.
    • (2006) Brain Res. , vol.1103 , pp. 88-98
    • Dufour, F.1    Liu, Q.-Y.2    Gusev, P.3    Alkon, D.L.4    Atzori, M.5
  • 44
    • 62349118424 scopus 로고    scopus 로고
    • Hippocampal infusion of apolipoprotein E peptides induce long-lasting cognitive impairment
    • Eddins D., Klein R.C., Yakel J.L., Levin E.D. Hippocampal infusion of apolipoprotein E peptides induce long-lasting cognitive impairment. Brain Res. Bull. 2009, 79:111-115.
    • (2009) Brain Res. Bull. , vol.79 , pp. 111-115
    • Eddins, D.1    Klein, R.C.2    Yakel, J.L.3    Levin, E.D.4
  • 47
    • 0030065554 scopus 로고    scopus 로고
    • Impairment of maze learning in rats following long-term glucocorticoid treatments
    • Endo Y., Nishimura J.-I., Kimura F. Impairment of maze learning in rats following long-term glucocorticoid treatments. Neurosci. Lett. 1996, 203:199-202.
    • (1996) Neurosci. Lett. , vol.203 , pp. 199-202
    • Endo, Y.1    Nishimura, J.-I.2    Kimura, F.3
  • 48
    • 0036130129 scopus 로고    scopus 로고
    • Apolipoprotein E affects amyloid formation but not amyloid growth in vitro: mechanistic implications for ApoE4 enhanced amyloid burden and risk for Alzheimer's disease
    • Esler W.P., Marshall J.R., Stimson E.R., Ghilardi J.R., Vinters H.V., Mantyh P.W., Maggio J.E. Apolipoprotein E affects amyloid formation but not amyloid growth in vitro: mechanistic implications for ApoE4 enhanced amyloid burden and risk for Alzheimer's disease. Amyloid: J. Protein Folding Disord. 2002, 9:1-12.
    • (2002) Amyloid: J. Protein Folding Disord. , vol.9 , pp. 1-12
    • Esler, W.P.1    Marshall, J.R.2    Stimson, E.R.3    Ghilardi, J.R.4    Vinters, H.V.5    Mantyh, P.W.6    Maggio, J.E.7
  • 49
    • 67650805429 scopus 로고    scopus 로고
    • Statin-associated adverse cognitive effects: survey results from 171 patients
    • Evans M.A., Golomb B.A. Statin-associated adverse cognitive effects: survey results from 171 patients. Pharmacotherapy 2009, 29:800-811.
    • (2009) Pharmacotherapy , vol.29 , pp. 800-811
    • Evans, M.A.1    Golomb, B.A.2
  • 50
    • 0033958076 scopus 로고    scopus 로고
    • Serum cholesterol, APOE genotype, and the risk of Alzheimer's disease: a population-based study of African Americans
    • Evans R.M., Emsley C.L., Gao S., Sahota A., Hall K.S., Farlow M.R., Hendrie H. Serum cholesterol, APOE genotype, and the risk of Alzheimer's disease: a population-based study of African Americans. Neurology 2000, 54:240-242.
    • (2000) Neurology , vol.54 , pp. 240-242
    • Evans, R.M.1    Emsley, C.L.2    Gao, S.3    Sahota, A.4    Hall, K.S.5    Farlow, M.R.6    Hendrie, H.7
  • 55
    • 32944476331 scopus 로고    scopus 로고
    • Biological markers of age-related memory deficits. Treatment of senescent physiology
    • Foster T.C. Biological markers of age-related memory deficits. Treatment of senescent physiology. CNS Drugs 2006, 20:153-166.
    • (2006) CNS Drugs , vol.20 , pp. 153-166
    • Foster, T.C.1
  • 57
    • 70350778518 scopus 로고    scopus 로고
    • Cholesterol 24-hydroxylase (CYP46A1) polymorphisms are associated with faster cognitive deterioration in Chinese older persons: a two-year follow up study
    • Fu B.Y., Ma S.L., Tang N.L., Tam C.W., Lui V.W., Chiu H.F., Lam L.C. Cholesterol 24-hydroxylase (CYP46A1) polymorphisms are associated with faster cognitive deterioration in Chinese older persons: a two-year follow up study. Int. J. Geriatr. Psychiatry 2009, 24:921-926.
    • (2009) Int. J. Geriatr. Psychiatry , vol.24 , pp. 921-926
    • Fu, B.Y.1    Ma, S.L.2    Tang, N.L.3    Tam, C.W.4    Lui, V.W.5    Chiu, H.F.6    Lam, L.C.7
  • 58
    • 33749161414 scopus 로고    scopus 로고
    • Deposition of iron and β-amyloid plaques is associated with cortical cellular damage in rabbits fed with long-term cholesterol-enriched diets
    • Ghribi O., Golovko M.Y., Larsen B., Schrag M., Murphy E.J. Deposition of iron and β-amyloid plaques is associated with cortical cellular damage in rabbits fed with long-term cholesterol-enriched diets. J. Neurochem. 2006, 99:438-449.
    • (2006) J. Neurochem. , vol.99 , pp. 438-449
    • Ghribi, O.1    Golovko, M.Y.2    Larsen, B.3    Schrag, M.4    Murphy, E.J.5
  • 59
    • 33746299216 scopus 로고    scopus 로고
    • High cholesterol content in neurons increases BACE, β-amyloid, and phosphorylated tau levels in rabbit hippocampus
    • Ghribi O., Larsen B., Schrag M., Herman M.M. High cholesterol content in neurons increases BACE, β-amyloid, and phosphorylated tau levels in rabbit hippocampus. Exp. Neurol. 2006, 200:460-467.
    • (2006) Exp. Neurol. , vol.200 , pp. 460-467
    • Ghribi, O.1    Larsen, B.2    Schrag, M.3    Herman, M.M.4
  • 60
    • 19444372396 scopus 로고    scopus 로고
    • Multiple mechanisms mediate cholesterol-induced synaptogenesis in a CNS neuron
    • Goritz C., Mauch D.H., Pfrieger F.W. Multiple mechanisms mediate cholesterol-induced synaptogenesis in a CNS neuron. Mol. Cell. Neurosci. 2006, 29:190-201.
    • (2006) Mol. Cell. Neurosci. , vol.29 , pp. 190-201
    • Goritz, C.1    Mauch, D.H.2    Pfrieger, F.W.3
  • 62
    • 0034924777 scopus 로고    scopus 로고
    • Pleiotropic effects of statins: do they matter?
    • Gotto A.M., Farmer J.A. Pleiotropic effects of statins: do they matter?. Curr. Opin. Lipidol. 2001, 12:391-394.
    • (2001) Curr. Opin. Lipidol. , vol.12 , pp. 391-394
    • Gotto, A.M.1    Farmer, J.A.2
  • 63
    • 25144501662 scopus 로고    scopus 로고
    • Intraneuronal Aβ accummulation and origin of plaques in Alzheimer's disease
    • Gouras G.K., Almeida C.G., Takahashi R.H. Intraneuronal Aβ accummulation and origin of plaques in Alzheimer's disease. Neurobiol. Aging 2005, 26:1235-1244.
    • (2005) Neurobiol. Aging , vol.26 , pp. 1235-1244
    • Gouras, G.K.1    Almeida, C.G.2    Takahashi, R.H.3
  • 65
    • 34547145226 scopus 로고    scopus 로고
    • Amyloid beta as a regulator of lipid homeostasis
    • Grimm M.O.W., Grimm H.S., Hartmann T. Amyloid beta as a regulator of lipid homeostasis. Trends Mol. Med. 2007, 13:337-344.
    • (2007) Trends Mol. Med. , vol.13 , pp. 337-344
    • Grimm, M.O.W.1    Grimm, H.S.2    Hartmann, T.3
  • 66
    • 15744378392 scopus 로고    scopus 로고
    • Human apoE targeted replacement mouse lines: h-apoE4 and h-apoE3 mice differ on spatial memory performance and avoidance behavior
    • Grootendorst J., Bours A., Vogel E., Kelche C., Sullivan P.M., Dodart J.-C., Bales K., Mathis C. Human apoE targeted replacement mouse lines: h-apoE4 and h-apoE3 mice differ on spatial memory performance and avoidance behavior. Behav. Brain Res. 2005, 159:1-14.
    • (2005) Behav. Brain Res. , vol.159 , pp. 1-14
    • Grootendorst, J.1    Bours, A.2    Vogel, E.3    Kelche, C.4    Sullivan, P.M.5    Dodart, J.-C.6    Bales, K.7    Mathis, C.8
  • 67
  • 68
    • 33847662852 scopus 로고    scopus 로고
    • Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide
    • Haass C., Selkoe D.J. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide. Nat. Rev. Mol. Cell Biol. 2007, 8:101-112.
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 101-112
    • Haass, C.1    Selkoe, D.J.2
  • 71
    • 0034870449 scopus 로고    scopus 로고
    • Behavioral phenotyping of GFAP-ApoE3 and -ApoE4 transgenic mice: ApoE4 mice show profound working memory impairments in the absence of Alzheimer's-like neuropathology
    • Hartman R.E., Wozniak D.F., Nardi A., Olney J.W., Sartorius L., Holtzman D.M. Behavioral phenotyping of GFAP-ApoE3 and -ApoE4 transgenic mice: ApoE4 mice show profound working memory impairments in the absence of Alzheimer's-like neuropathology. Exp. Neurol. 2001, 170:326-344.
    • (2001) Exp. Neurol. , vol.170 , pp. 326-344
    • Hartman, R.E.1    Wozniak, D.F.2    Nardi, A.3    Olney, J.W.4    Sartorius, L.5    Holtzman, D.M.6
  • 72
    • 0028298389 scopus 로고
    • Apolipoprotein E and cholesterol affect neuronal calcium signalling: the possible relationship to β-neurotoxicity
    • Hartmann H., Eckert A., Muller W. Apolipoprotein E and cholesterol affect neuronal calcium signalling: the possible relationship to β-neurotoxicity. Biochem. Biophys. Res. Commun. 1994, 200:1185-1192.
    • (1994) Biochem. Biophys. Res. Commun. , vol.200 , pp. 1185-1192
    • Hartmann, H.1    Eckert, A.2    Muller, W.3
  • 73
    • 0042810567 scopus 로고    scopus 로고
    • Cholesterol, Aβ and Alzheimer's disease
    • Hartmann T. Cholesterol, Aβ and Alzheimer's disease. Trends Neurosci. 2001, 11:S45-S48.
    • (2001) Trends Neurosci. , vol.11
    • Hartmann, T.1
  • 74
    • 33750215920 scopus 로고    scopus 로고
    • Role of amyloid precursor protein, amyloid-β and γ-secretase in cholesterol maintenance
    • Hartmann T. Role of amyloid precursor protein, amyloid-β and γ-secretase in cholesterol maintenance. Neurodegenerative Dis. 2006, 3:305-311.
    • (2006) Neurodegenerative Dis. , vol.3 , pp. 305-311
    • Hartmann, T.1
  • 76
    • 34248368921 scopus 로고    scopus 로고
    • Cholesterol metabolism, apolipoprotein E, adenosine triphosphate-binding cassette transporters, and Alzheimer's disease
    • Hirsch-Reinshagen V., Wellington C.L. Cholesterol metabolism, apolipoprotein E, adenosine triphosphate-binding cassette transporters, and Alzheimer's disease. Curr. Opin. Lipidol. 2007, 18:325-332.
    • (2007) Curr. Opin. Lipidol. , vol.18 , pp. 325-332
    • Hirsch-Reinshagen, V.1    Wellington, C.L.2
  • 78
    • 0036149410 scopus 로고    scopus 로고
    • Gene dose effect of the APOE-e{open}4 allele on plasma HDL cholesterol level in patients with Alzheimer's disease
    • Hoshino T., Kamino K., Matsumoto M. Gene dose effect of the APOE-e{open}4 allele on plasma HDL cholesterol level in patients with Alzheimer's disease. Neurobiol. Aging 2002, 23:41-45.
    • (2002) Neurobiol. Aging , vol.23 , pp. 41-45
    • Hoshino, T.1    Kamino, K.2    Matsumoto, M.3
  • 79
    • 33947593576 scopus 로고    scopus 로고
    • Alzheimer disease - no traget for statin treatment. A mini review
    • Hoyer S., Riederer P. Alzheimer disease - no traget for statin treatment. A mini review. Neurochem. Res. 2007, 32:695-706.
    • (2007) Neurochem. Res. , vol.32 , pp. 695-706
    • Hoyer, S.1    Riederer, P.2
  • 80
    • 74149083432 scopus 로고    scopus 로고
    • Adeno-associated virus gene therapy with cholesterol 24-hydroxylase reduces the amyloid pathology before or after onset of amyloid plaques in mouse models of Alzheimer's disease
    • Hudry E., Van Dam D., Kulik W., De Deyn P.P., Stet F.S., Ahouansou O., Benraiss A., Delacourte A., Bougneres P., Aubourg P., Cartier N. Adeno-associated virus gene therapy with cholesterol 24-hydroxylase reduces the amyloid pathology before or after onset of amyloid plaques in mouse models of Alzheimer's disease. Mol. Therapy 2009, 18:44-53.
    • (2009) Mol. Therapy , vol.18 , pp. 44-53
    • Hudry, E.1    Van Dam, D.2    Kulik, W.3    De Deyn, P.P.4    Stet, F.S.5    Ahouansou, O.6    Benraiss, A.7    Delacourte, A.8    Bougneres, P.9    Aubourg, P.10    Cartier, N.11
  • 83
    • 0029072551 scopus 로고
    • Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer's disease
    • Jarvik G.P., Wijsman E.M., Kukull W.A., Schellenberg G.D., Yu C., Larson E.B. Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer's disease. Neurology 1995, 45:1092-1096.
    • (1995) Neurology , vol.45 , pp. 1092-1096
    • Jarvik, G.P.1    Wijsman, E.M.2    Kukull, W.A.3    Schellenberg, G.D.4    Yu, C.5    Larson, E.B.6
  • 84
    • 38049175023 scopus 로고    scopus 로고
    • Statins: a new insight into their mechanisms of action and consequent pleiotropic effects
    • Jasinska M., Owczarek J., Orszulak-Michalak D. Statins: a new insight into their mechanisms of action and consequent pleiotropic effects. Pharmacol. Rep. 2007, 59:483-499.
    • (2007) Pharmacol. Rep. , vol.59 , pp. 483-499
    • Jasinska, M.1    Owczarek, J.2    Orszulak-Michalak, D.3
  • 85
    • 56949085688 scopus 로고    scopus 로고
    • Regulation of β-amyloid levels in the brain of cholesterol-fed rabbit, a model system for sporadic Alzheimer's disease
    • Jaya Prasanthi R.P., Schommer E., Thomasson S., Thompson A., Feist G., Ghribi O. Regulation of β-amyloid levels in the brain of cholesterol-fed rabbit, a model system for sporadic Alzheimer's disease. Mech. Ageing Dev. 2008, 29:649-655.
    • (2008) Mech. Ageing Dev. , vol.29 , pp. 649-655
    • Jaya Prasanthi, R.P.1    Schommer, E.2    Thomasson, S.3    Thompson, A.4    Feist, G.5    Ghribi, O.6
  • 91
    • 33750996121 scopus 로고    scopus 로고
    • Cholesterol-fed rabbit as a unique model of nonalcoholic, nonobese, non-insulin-resistant fatty liver disease with characteristic fibrosis
    • Kainuma M., Fujimoto M., Sekiya N., Tsuneyama K., Cheng C., Takano Y., Tersawa K., Shimada Y. Cholesterol-fed rabbit as a unique model of nonalcoholic, nonobese, non-insulin-resistant fatty liver disease with characteristic fibrosis. J. Gastroenterol. 2006, 41:971-980.
    • (2006) J. Gastroenterol. , vol.41 , pp. 971-980
    • Kainuma, M.1    Fujimoto, M.2    Sekiya, N.3    Tsuneyama, K.4    Cheng, C.5    Takano, Y.6    Tersawa, K.7    Shimada, Y.8
  • 92
    • 0344404174 scopus 로고    scopus 로고
    • Effect of chronic nimodipine on spatial learning and on long-term potentiation
    • Kane K.A., Robinson G.B. Effect of chronic nimodipine on spatial learning and on long-term potentiation. Behav. Brain Res. 1999, 98:95-101.
    • (1999) Behav. Brain Res. , vol.98 , pp. 95-101
    • Kane, K.A.1    Robinson, G.B.2
  • 94
    • 0022527081 scopus 로고
    • In vivo modulation of brain cholesterol level and learning performance by a novel plant lipid: indication of interactions between hippocampal-cortical cholesterol and learning
    • Kessler A.R., Kessler B., Yehuda S. In vivo modulation of brain cholesterol level and learning performance by a novel plant lipid: indication of interactions between hippocampal-cortical cholesterol and learning. Life Sci. 1986, 38:1185-1192.
    • (1986) Life Sci. , vol.38 , pp. 1185-1192
    • Kessler, A.R.1    Kessler, B.2    Yehuda, S.3
  • 95
    • 68249134074 scopus 로고    scopus 로고
    • The role of apolipoprotein E in Alzheimer's disease
    • Kim J.-H., Basak J.M., Holtzman D.M. The role of apolipoprotein E in Alzheimer's disease. Neuron 2009, 63:287-303.
    • (2009) Neuron , vol.63 , pp. 287-303
    • Kim, J.-H.1    Basak, J.M.2    Holtzman, D.M.3
  • 96
    • 0035983305 scopus 로고    scopus 로고
    • Apolipoprotein E e{open}4 Allele is not associated with the cognitive impairment in community-dwelling normal elderly individuals
    • Kim K.W., Youn J.C., Jhoo J.H., Lee D.Y., Lee K.U., Lee J.H., Woo J.I. Apolipoprotein E e{open}4 Allele is not associated with the cognitive impairment in community-dwelling normal elderly individuals. Int. J. Geriatr. Psychiatry 2002, 17:635-640.
    • (2002) Int. J. Geriatr. Psychiatry , vol.17 , pp. 635-640
    • Kim, K.W.1    Youn, J.C.2    Jhoo, J.H.3    Lee, D.Y.4    Lee, K.U.5    Lee, J.H.6    Woo, J.I.7
  • 97
    • 39749104095 scopus 로고    scopus 로고
    • Role of ATP-binding cassette transporters in brain lipid transport and neurological disease
    • Kim W.S., Weickert C.S., Garner B. Role of ATP-binding cassette transporters in brain lipid transport and neurological disease. J. Neurochem. 2008, 104:1145-1166.
    • (2008) J. Neurochem. , vol.104 , pp. 1145-1166
    • Kim, W.S.1    Weickert, C.S.2    Garner, B.3
  • 100
    • 51349101107 scopus 로고    scopus 로고
    • Ameliorative role of atorvastatin and pitavastatin in L-methionine induced vascular dementia in rats
    • Koladiya R.U., Jaggi A.S., Singh N., Sharma B.K. Ameliorative role of atorvastatin and pitavastatin in L-methionine induced vascular dementia in rats. BMC Pharmacol. 2008, 9:8-14.
    • (2008) BMC Pharmacol. , vol.9 , pp. 8-14
    • Koladiya, R.U.1    Jaggi, A.S.2    Singh, N.3    Sharma, B.K.4
  • 103
    • 0035430622 scopus 로고    scopus 로고
    • Essential role of cholesterol in synaptic plasticity and neuronal degeneration
    • Koudinov A.R., Koudinova N.V. Essential role of cholesterol in synaptic plasticity and neuronal degeneration. FASEB J. 2001, 15:1858-1860.
    • (2001) FASEB J. , vol.15 , pp. 1858-1860
    • Koudinov, A.R.1    Koudinova, N.V.2
  • 104
    • 33846633336 scopus 로고    scopus 로고
    • Aβ oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease
    • Lacor P.N., Buniel M.C., Furlow P.W., Clemente A.S., Velasco P.T., Wood M., Viola K.L., Klein W.L. Aβ oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease. J. Neurosci. 2007, 27:796-807.
    • (2007) J. Neurosci. , vol.27 , pp. 796-807
    • Lacor, P.N.1    Buniel, M.C.2    Furlow, P.W.3    Clemente, A.S.4    Velasco, P.T.5    Wood, M.6    Viola, K.L.7    Klein, W.L.8
  • 105
    • 34250819839 scopus 로고    scopus 로고
    • Intracellular amyloid-β in Alzheimer's disease
    • LaFerla F.M., Green K.N., Oddo S. Intracellular amyloid-β in Alzheimer's disease. Nat. Rev. Neurosci. 2007, 8:499-509.
    • (2007) Nat. Rev. Neurosci. , vol.8 , pp. 499-509
    • LaFerla, F.M.1    Green, K.N.2    Oddo, S.3
  • 106
    • 33749045445 scopus 로고    scopus 로고
    • Amyloid excess in Alzheimer's disease: what is cholesterol to be blamed for?
    • Ledesma M.D., Dotti C.G. Amyloid excess in Alzheimer's disease: what is cholesterol to be blamed for?. FEBS Lett. 2006, 580:5525-5532.
    • (2006) FEBS Lett. , vol.580 , pp. 5525-5532
    • Ledesma, M.D.1    Dotti, C.G.2
  • 110
    • 0345275964 scopus 로고    scopus 로고
    • Association of aortic atherosclerosis with cerebral β-amyloidosis and learning deficits in a mouse model of Alzheimer's disease
    • Li L., Cao D., Garber D.W., Kim H., Fukuchi K. Association of aortic atherosclerosis with cerebral β-amyloidosis and learning deficits in a mouse model of Alzheimer's disease. Am. J. Pathol. 2003, 163:2155-2164.
    • (2003) Am. J. Pathol. , vol.163 , pp. 2155-2164
    • Li, L.1    Cao, D.2    Garber, D.W.3    Kim, H.4    Fukuchi, K.5
  • 111
    • 33846048569 scopus 로고    scopus 로고
    • Simvastatin enhances learning and memory independent of amyloid load in mice
    • Li L., Cao D., Kim H., Lester R., Fukuchi K. Simvastatin enhances learning and memory independent of amyloid load in mice. Ann. Neurol. 2006, 60:729-739.
    • (2006) Ann. Neurol. , vol.60 , pp. 729-739
    • Li, L.1    Cao, D.2    Kim, H.3    Lester, R.4    Fukuchi, K.5
  • 114
    • 0032573097 scopus 로고    scopus 로고
    • Amyloid β peptide alters intracellular vesicle trafficking and cholesterol homeostasis
    • Liu Y., Peterson D.A., Schubert D. Amyloid β peptide alters intracellular vesicle trafficking and cholesterol homeostasis. Proc. Natl. Acad. Sci. U.S.A. 1998, 95:13266-13271.
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 13266-13271
    • Liu, Y.1    Peterson, D.A.2    Schubert, D.3
  • 115
    • 0035826518 scopus 로고    scopus 로고
    • Apolipoprotein E deficiency effects on learning in mice are dependent upon the background strain
    • Lominska C., Levin J.A., Wang J., Sikes J., Kao C., Smith J.D. Apolipoprotein E deficiency effects on learning in mice are dependent upon the background strain. Behav. Brain Res. 2001, 120:23-34.
    • (2001) Behav. Brain Res. , vol.120 , pp. 23-34
    • Lominska, C.1    Levin, J.A.2    Wang, J.3    Sikes, J.4    Kao, C.5    Smith, J.D.6
  • 116
    • 34547098112 scopus 로고    scopus 로고
    • Statins increase neurogenesis in the dentate gyrus, reduce delayed neuronal death in the hippocampal CA3 region, and improve spatial learning in rat after traumatic brain injury
    • Lu D., Qu C., Goussev A., Jiang H., Lu C., Schallert T., Mahmood A., Chen J., Chopp M. Statins increase neurogenesis in the dentate gyrus, reduce delayed neuronal death in the hippocampal CA3 region, and improve spatial learning in rat after traumatic brain injury. J. Neurotrauma 2007, 24:1132-1146.
    • (2007) J. Neurotrauma , vol.24 , pp. 1132-1146
    • Lu, D.1    Qu, C.2    Goussev, A.3    Jiang, H.4    Lu, C.5    Schallert, T.6    Mahmood, A.7    Chen, J.8    Chopp, M.9
  • 117
    • 58549116872 scopus 로고    scopus 로고
    • Trace amounts of copper exacerbate beta amyloid-induced neurotoxicity in the cholesterol-fed mice through TNF-mediated inflammatory pathway
    • Lu J., Wu D.-M., Zheng Y.-L., Sun D.-X., Hu B., Shan Q., Zhang Z.-F., Fan S.-H. Trace amounts of copper exacerbate beta amyloid-induced neurotoxicity in the cholesterol-fed mice through TNF-mediated inflammatory pathway. Brain Behav. Immun. 2009, 23:193-203.
    • (2009) Brain Behav. Immun. , vol.23 , pp. 193-203
    • Lu, J.1    Wu, D.-M.2    Zheng, Y.-L.3    Sun, D.-X.4    Hu, B.5    Shan, Q.6    Zhang, Z.-F.7    Fan, S.-H.8
  • 118
    • 23944501334 scopus 로고    scopus 로고
    • Alzheimer's disease-a dysfunction in cholesterol and lipid metabolism
    • Lukiw W.J., Pappolla M., Pelaez R.P., Bazan N.G. Alzheimer's disease-a dysfunction in cholesterol and lipid metabolism. Cell. Mol. Neurobiol. 2005, 25:475-483.
    • (2005) Cell. Mol. Neurobiol. , vol.25 , pp. 475-483
    • Lukiw, W.J.1    Pappolla, M.2    Pelaez, R.P.3    Bazan, N.G.4
  • 120
    • 0034120932 scopus 로고    scopus 로고
    • Cholesterol-rich diets have different effects on lipid peroxidation, cholesterol oxides, and antioxidant enzymes in rats and rabbits
    • Mahfouz M.M., Kummerow F.A. Cholesterol-rich diets have different effects on lipid peroxidation, cholesterol oxides, and antioxidant enzymes in rats and rabbits. J. Nutr. Biochem. 2000, 11:293-302.
    • (2000) J. Nutr. Biochem. , vol.11 , pp. 293-302
    • Mahfouz, M.M.1    Kummerow, F.A.2
  • 123
    • 0034974216 scopus 로고    scopus 로고
    • Memory performance in healthy elderly without Alzheimer's disease: effects of time and apolipoprotein-E
    • Mayeux R., Small S.A., Tang M.-X., Tycko B., Stern Y. Memory performance in healthy elderly without Alzheimer's disease: effects of time and apolipoprotein-E. Neurobiol. Aging 2001, 22:683-689.
    • (2001) Neurobiol. Aging , vol.22 , pp. 683-689
    • Mayeux, R.1    Small, S.A.2    Tang, M.-X.3    Tycko, B.4    Stern, Y.5
  • 125
    • 0242383360 scopus 로고    scopus 로고
    • Cholesterol, a modulator of membrane-associated aβ-fibrillogenesis
    • McLaurin J., Darabie A.A., Morrison M.R. Cholesterol, a modulator of membrane-associated aβ-fibrillogenesis. Pharmacopsychiatry 2003, 36:S130-S135.
    • (2003) Pharmacopsychiatry , vol.36
    • McLaurin, J.1    Darabie, A.A.2    Morrison, M.R.3
  • 126
    • 42749090738 scopus 로고    scopus 로고
    • Behavioral effects of dietary cholesterol in rats tested in experimental models of mild stress and cognition tasks
    • Micale V., Scapagnini G., Colombrita C., Mazzola C., Alkon D.L., Drago F. Behavioral effects of dietary cholesterol in rats tested in experimental models of mild stress and cognition tasks. Eur. Neuropsychopharmacol. 2008, 18:462-471.
    • (2008) Eur. Neuropsychopharmacol. , vol.18 , pp. 462-471
    • Micale, V.1    Scapagnini, G.2    Colombrita, C.3    Mazzola, C.4    Alkon, D.L.5    Drago, F.6
  • 127
  • 128
    • 0028146356 scopus 로고
    • Cholesterol treatment facilitates spatial learning performance in DBA/2Ibg mice
    • Miller S., Wehner J.M. Cholesterol treatment facilitates spatial learning performance in DBA/2Ibg mice. Pharmacol. Biochem. Behav. 1994, 49:257-261.
    • (1994) Pharmacol. Biochem. Behav. , vol.49 , pp. 257-261
    • Miller, S.1    Wehner, J.M.2
  • 129
    • 0038632272 scopus 로고    scopus 로고
    • Learning and memory deficits in APP transgenic mouse models of amyloid deposition
    • Morgan D. Learning and memory deficits in APP transgenic mouse models of amyloid deposition. Neurochem. Res. 2003, 28:1029-1034.
    • (2003) Neurochem. Res. , vol.28 , pp. 1029-1034
    • Morgan, D.1
  • 130
    • 0021173996 scopus 로고
    • Developments of a water-maze procedure for studying spatial learning in the rat
    • Morris R. Developments of a water-maze procedure for studying spatial learning in the rat. J. Neurosci. Methods 1984, 11:47-60.
    • (1984) J. Neurosci. Methods , vol.11 , pp. 47-60
    • Morris, R.1
  • 134
    • 0038117796 scopus 로고    scopus 로고
    • Correlation between elevated levels of amyloid β-peptide in the brain and cognitive decline
    • Näslund J., Haroutunian V., Mohs R., Davis K.L., Davies P., Greengard P., Buxbaum J.D. Correlation between elevated levels of amyloid β-peptide in the brain and cognitive decline. JAMA 2000, 283:1571-1577.
    • (2000) JAMA , vol.283 , pp. 1571-1577
    • Näslund, J.1    Haroutunian, V.2    Mohs, R.3    Davis, K.L.4    Davies, P.5    Greengard, P.6    Buxbaum, J.D.7
  • 135
    • 0032970348 scopus 로고    scopus 로고
    • Review of preclinical data of calcium channel blockers and atherosclerosis
    • S7-S-11
    • Nayler W.G. Review of preclinical data of calcium channel blockers and atherosclerosis. J. Cardiovasc. Pharmacol. 1999, 33. S7-S-11.
    • (1999) J. Cardiovasc. Pharmacol. , vol.33
    • Nayler, W.G.1
  • 143
    • 62149143598 scopus 로고    scopus 로고
    • Cognition, learning behaviour and hippocampal synaptic plasticity are not disrupted in mice over-expressing the cholesterol transporter ABCG1
    • Parkinson, P.F., Kannangara, T.S., Eadie, B.D., Burgess, B.L., Wellington, C.L., Christie, B.R., 2009. Cognition, learning behaviour and hippocampal synaptic plasticity are not disrupted in mice over-expressing the cholesterol transporter ABCG1. Lipids in Health and Disease 8.
    • (2009) Lipids in Health and Disease , pp. 8
    • Parkinson, P.F.1    Kannangara, T.S.2    Eadie, B.D.3    Burgess, B.L.4    Wellington, C.L.5    Christie, B.R.6
  • 145
    • 33746809372 scopus 로고    scopus 로고
    • Physiological roles for amyloid β peptides
    • Pearson H.A., Peers C. Physiological roles for amyloid β peptides. J. Physiol. (Lond.) 2006, 575:5-10.
    • (2006) J. Physiol. (Lond.) , vol.575 , pp. 5-10
    • Pearson, H.A.1    Peers, C.2
  • 146
    • 70350445259 scopus 로고    scopus 로고
    • No association between cognitive acheivements, academic performance and serum cholesterol concentrations among school-aged children
    • Perry L.A., Stigger C.B., Ainsworth B.E., Zhang J. No association between cognitive acheivements, academic performance and serum cholesterol concentrations among school-aged children. Nutr. Neurosci. 2009, 12:160-166.
    • (2009) Nutr. Neurosci. , vol.12 , pp. 160-166
    • Perry, L.A.1    Stigger, C.B.2    Ainsworth, B.E.3    Zhang, J.4
  • 147
    • 0037230328 scopus 로고    scopus 로고
    • Outsourcing in the brain: do neurons depend on cholesterol delivery by astrocytes?
    • Pfrieger F.W. Outsourcing in the brain: do neurons depend on cholesterol delivery by astrocytes?. BioEssays 2002, 25:72-78.
    • (2002) BioEssays , vol.25 , pp. 72-78
    • Pfrieger, F.W.1
  • 148
    • 34548202219 scopus 로고    scopus 로고
    • Pro-inflammatory cytokines and their effects in the dentate gyrus
    • Pickering M., O'Connor J.J. Pro-inflammatory cytokines and their effects in the dentate gyrus. Prog. Brain Res. 2007, 163:339-354.
    • (2007) Prog. Brain Res. , vol.163 , pp. 339-354
    • Pickering, M.1    O'Connor, J.J.2
  • 149
    • 11444251445 scopus 로고    scopus 로고
    • Apolipoprotein E, cholesterol transport and synthesis in sporadic Alzheimer's disease
    • Poirier J. Apolipoprotein E, cholesterol transport and synthesis in sporadic Alzheimer's disease. Neurobiol. Aging 2005, 26:355-361.
    • (2005) Neurobiol. Aging , vol.26 , pp. 355-361
    • Poirier, J.1
  • 150
    • 28944440029 scopus 로고    scopus 로고
    • A fresh look at an ancient family: emerging roles for low density lipoprotein receptors in synaptic plasticity and memory formation
    • Qiu S., Korwek K.M., Weeber E.J. A fresh look at an ancient family: emerging roles for low density lipoprotein receptors in synaptic plasticity and memory formation. Neurobiol. Learn. Mem. 2006, 85:16-29.
    • (2006) Neurobiol. Learn. Mem. , vol.85 , pp. 16-29
    • Qiu, S.1    Korwek, K.M.2    Weeber, E.J.3
  • 151
    • 0034733890 scopus 로고    scopus 로고
    • 2+ channel blocker amlodipine facilitates learning and memory in mice
    • 2+ channel blocker amlodipine facilitates learning and memory in mice. Eur. J. Pharmacol. 2000, 399:57-63.
    • (2000) Eur. J. Pharmacol. , vol.399 , pp. 57-63
    • Quartermain, D.1
  • 152
    • 0035704606 scopus 로고    scopus 로고
    • Calcium channel antagonists enhance retention of passive avoidance and maze learning in mice
    • Quartermain D., deSoria V.G., Kwan A. Calcium channel antagonists enhance retention of passive avoidance and maze learning in mice. Neurobiol. Learn. Mem. 2001, 75:77-90.
    • (2001) Neurobiol. Learn. Mem. , vol.75 , pp. 77-90
    • Quartermain, D.1    deSoria, V.G.2    Kwan, A.3
  • 153
    • 39749145196 scopus 로고    scopus 로고
    • Translating molecular discoveries into new therapies for atherosclerosis
    • Rader D.J., Daugherty A. Translating molecular discoveries into new therapies for atherosclerosis. Nature 2008, 451:904-913.
    • (2008) Nature , vol.451 , pp. 904-913
    • Rader, D.J.1    Daugherty, A.2
  • 154
    • 0142105914 scopus 로고    scopus 로고
    • Cholesterol: from heart attacks to Alzheimer's disease
    • Raffai R.L., Weisgraber K.H. Cholesterol: from heart attacks to Alzheimer's disease. J. Lipid Res. 2003, 44:1423-1430.
    • (2003) J. Lipid Res. , vol.44 , pp. 1423-1430
    • Raffai, R.L.1    Weisgraber, K.H.2
  • 155
    • 58549104757 scopus 로고    scopus 로고
    • Peripheral arterial disease and cognitive function
    • Rafnsson S.B., Deary I.J., Fowkes F.G. Peripheral arterial disease and cognitive function. Vasc. Med. 2009, 14:51-61.
    • (2009) Vasc. Med. , vol.14 , pp. 51-61
    • Rafnsson, S.B.1    Deary, I.J.2    Fowkes, F.G.3
  • 156
    • 34547315810 scopus 로고    scopus 로고
    • Alzheimer's disease: cholesterol, membrane rafts, isoprenoids and statins
    • Reid P.C., Urano Y., Kodama T., Hamakubo T. Alzheimer's disease: cholesterol, membrane rafts, isoprenoids and statins. J. Cell. Mol. Med. 2007, 11:383-392.
    • (2007) J. Cell. Mol. Med. , vol.11 , pp. 383-392
    • Reid, P.C.1    Urano, Y.2    Kodama, T.3    Hamakubo, T.4
  • 157
    • 0000595349 scopus 로고
    • The relationship of serum cholesterol changes to psychological abilities
    • Reitan R.M., Shipley R.E. The relationship of serum cholesterol changes to psychological abilities. J. Gerontol. 1963, 18:350-357.
    • (1963) J. Gerontol. , vol.18 , pp. 350-357
    • Reitan, R.M.1    Shipley, R.E.2
  • 159
    • 33646361359 scopus 로고    scopus 로고
    • Longitudinal memory performance during normal aging: twin association models of APOE and other Alzheimer candidate genes
    • Reynolds C.A., Prince J.A., Feuk L., Brookes A.J., Gatz M., Pedersen N.L. Longitudinal memory performance during normal aging: twin association models of APOE and other Alzheimer candidate genes. Behav. Genet. 2006, 36:185-194.
    • (2006) Behav. Genet. , vol.36 , pp. 185-194
    • Reynolds, C.A.1    Prince, J.A.2    Feuk, L.3    Brookes, A.J.4    Gatz, M.5    Pedersen, N.L.6
  • 161
    • 76549120194 scopus 로고    scopus 로고
    • Are Aβ and Its derivatives causative agents or innocent bystanders in AD?
    • Robakis N.K. Are Aβ and Its derivatives causative agents or innocent bystanders in AD?. Neurodegenerative Dis. 2010, 7:32-37.
    • (2010) Neurodegenerative Dis. , vol.7 , pp. 32-37
    • Robakis, N.K.1
  • 162
    • 0036827161 scopus 로고    scopus 로고
    • Aβ as a bioflocculant: implications for the amyloid hypothesis of Alzheimer's disease
    • Robinson S.R., Bishop G.M. Aβ as a bioflocculant: implications for the amyloid hypothesis of Alzheimer's disease. Neurobiol. Aging 2002, 23:1051-1072.
    • (2002) Neurobiol. Aging , vol.23 , pp. 1051-1072
    • Robinson, S.R.1    Bishop, G.M.2
  • 165
    • 65549159074 scopus 로고    scopus 로고
    • Carotid artery atherosclerosis. MRI indices of brain ischemia, aging, and cognitive impairment: the Framingham study
    • Romero J.R., Beiser A., Seshardi S., Benjamin J., Polak J.F., Vasan R.S., Au R., DeCarli C., Wolf P.A. Carotid artery atherosclerosis. MRI indices of brain ischemia, aging, and cognitive impairment: the Framingham study. Stroke 2009, 40:1590-1596.
    • (2009) Stroke , vol.40 , pp. 1590-1596
    • Romero, J.R.1    Beiser, A.2    Seshardi, S.3    Benjamin, J.4    Polak, J.F.5    Vasan, R.S.6    Au, R.7    DeCarli, C.8    Wolf, P.A.9
  • 166
    • 66549113526 scopus 로고    scopus 로고
    • Clinical field-strength MRI of amyloid plaques induced by low-level cholesterol feeding in rabbits
    • Ronald J.A., Chen Y., Bernas L., Kizler H.H., Rogers K.A., Hegele R.A., Rutt B.K. Clinical field-strength MRI of amyloid plaques induced by low-level cholesterol feeding in rabbits. Brain 2009, 132:1346-1354.
    • (2009) Brain , vol.132 , pp. 1346-1354
    • Ronald, J.A.1    Chen, Y.2    Bernas, L.3    Kizler, H.H.4    Rogers, K.A.5    Hegele, R.A.6    Rutt, B.K.7
  • 170
    • 0036862315 scopus 로고    scopus 로고
    • Is amyloid β-peptide neurotoxic or neuroprotective and what is its role in the binding of metal ions?
    • Savory J., Ghribi O., Herman M.M. Is amyloid β-peptide neurotoxic or neuroprotective and what is its role in the binding of metal ions?. Neurobiol. Aging 2002, 23:1089-1092.
    • (2002) Neurobiol. Aging , vol.23 , pp. 1089-1092
    • Savory, J.1    Ghribi, O.2    Herman, M.M.3
  • 171
    • 0031593078 scopus 로고    scopus 로고
    • Calcium antagonists and atherosclerosis
    • Schachter M. Calcium antagonists and atherosclerosis. Int. J. Cardiol. 1997, 62:S9-S15.
    • (1997) Int. J. Cardiol. , vol.62
    • Schachter, M.1
  • 172
    • 43049154803 scopus 로고    scopus 로고
    • Effects of cytokines on neuronal excitability
    • Schafers M., Sorkin L. Effects of cytokines on neuronal excitability. Neurosci. Lett. 2008, 437:188-193.
    • (2008) Neurosci. Lett. , vol.437 , pp. 188-193
    • Schafers, M.1    Sorkin, L.2
  • 174
    • 34848853040 scopus 로고    scopus 로고
    • Classical conditioning of the rabbit's nictitating membrane response is a function of the duration of dietary cholesterol
    • Schreurs B.G., Smith-Bell C.A., Darwish D.S., Stankovic G., Sparks D.L. Classical conditioning of the rabbit's nictitating membrane response is a function of the duration of dietary cholesterol. Nutr. Neurosci. 2007, 10:159-168.
    • (2007) Nutr. Neurosci. , vol.10 , pp. 159-168
    • Schreurs, B.G.1    Smith-Bell, C.A.2    Darwish, D.S.3    Stankovic, G.4    Sparks, D.L.5
  • 175
    • 34247555415 scopus 로고    scopus 로고
    • High dietary cholesterol facilitates classical conditioning of the rabbit's nictitating membrane response
    • Schreurs B.G., Smith-Bell C.A., Darwish D.S., Stankovic G., Sparks D.L. High dietary cholesterol facilitates classical conditioning of the rabbit's nictitating membrane response. Nutr. Neurosci. 2007, 10:31-43.
    • (2007) Nutr. Neurosci. , vol.10 , pp. 31-43
    • Schreurs, B.G.1    Smith-Bell, C.A.2    Darwish, D.S.3    Stankovic, G.4    Sparks, D.L.5
  • 177
    • 0346365427 scopus 로고    scopus 로고
    • Cholesterol modifies classical conditioning of the rabbit (Oryctolagus cuniculus) nictitating membrane response
    • Schreurs B.G., Smith-Bell C.A., Lochhead J., Sparks D.L. Cholesterol modifies classical conditioning of the rabbit (Oryctolagus cuniculus) nictitating membrane response. Behav. Neurosci. 2003, 117:1220-1232.
    • (2003) Behav. Neurosci. , vol.117 , pp. 1220-1232
    • Schreurs, B.G.1    Smith-Bell, C.A.2    Lochhead, J.3    Sparks, D.L.4
  • 178
    • 1642386167 scopus 로고    scopus 로고
    • Facilitated acquisition of the classically conditioned eyeblink response in male rats after systemic IL-1β
    • Servatius R.J., Beck K.D. Facilitated acquisition of the classically conditioned eyeblink response in male rats after systemic IL-1β. Integr. Physiol. Behav. Sci. 2003, 38:169-178.
    • (2003) Integr. Physiol. Behav. Sci. , vol.38 , pp. 169-178
    • Servatius, R.J.1    Beck, K.D.2
  • 179
    • 33947314641 scopus 로고    scopus 로고
    • Natural oligomers of the Alzheimer amyloid-β protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway
    • Shankar G.M., Bloodgood B.L., Townsend M., Walsh D.M., Selkoe D.J., Sabatini B.L. Natural oligomers of the Alzheimer amyloid-β protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J. Neurosci. 2007, 27:2866-2875.
    • (2007) J. Neurosci. , vol.27 , pp. 2866-2875
    • Shankar, G.M.1    Bloodgood, B.L.2    Townsend, M.3    Walsh, D.M.4    Selkoe, D.J.5    Sabatini, B.L.6
  • 181
    • 56349160982 scopus 로고    scopus 로고
    • Hypercholesterolemia-induced Aβ accumulation in rabbit brain is associated with alteration in IGF-1 signaling
    • Sharma S., Prasanthi J., Schommer E., Feist G., Ghribi O. Hypercholesterolemia-induced Aβ accumulation in rabbit brain is associated with alteration in IGF-1 signaling. Neurobiol. Dis. 2008, 32:426-432.
    • (2008) Neurobiol. Dis. , vol.32 , pp. 426-432
    • Sharma, S.1    Prasanthi, J.2    Schommer, E.3    Feist, G.4    Ghribi, O.5
  • 182
    • 0035949755 scopus 로고    scopus 로고
    • Cholesterol and Alzheimer's disease: Is there a link?
    • Simons M., Keller P., Dichgans J., Schulz J.B. Cholesterol and Alzheimer's disease: Is there a link?. Neurology 2001, 57:1089-1093.
    • (2001) Neurology , vol.57 , pp. 1089-1093
    • Simons, M.1    Keller, P.2    Dichgans, J.3    Schulz, J.B.4
  • 185
    • 0023782337 scopus 로고
    • Bilateral cerebellar lesions disrupt conditioned eyelid responses in unrestrained rats
    • Skelton R.W. Bilateral cerebellar lesions disrupt conditioned eyelid responses in unrestrained rats. Behav. Neurosci. 1988, 102:586-590.
    • (1988) Behav. Neurosci. , vol.102 , pp. 586-590
    • Skelton, R.W.1
  • 189
    • 66349112615 scopus 로고    scopus 로고
    • Cholesterol-modifying strategies for Alzheimer's disease
    • Solomon A., Kivipelto M. Cholesterol-modifying strategies for Alzheimer's disease. Expert Rev. Neurotherap. 2009, 9:695-709.
    • (2009) Expert Rev. Neurotherap. , vol.9 , pp. 695-709
    • Solomon, A.1    Kivipelto, M.2
  • 190
    • 67749114631 scopus 로고    scopus 로고
    • Midlife serum cholesterol and increased risk of Alzheimer's and vascular dementia three decades later
    • Solomon A., Kivipelto M., Wolozin B., Zhou J., Whitmer R.A. Midlife serum cholesterol and increased risk of Alzheimer's and vascular dementia three decades later. Dement. Geriatr. Cogn. Disord. 2009, 28:75-80.
    • (2009) Dement. Geriatr. Cogn. Disord. , vol.28 , pp. 75-80
    • Solomon, A.1    Kivipelto, M.2    Wolozin, B.3    Zhou, J.4    Whitmer, R.A.5
  • 191
    • 9844226208 scopus 로고    scopus 로고
    • Coronary artery disease, hypertension, ApoE and cholesterol: a link to Alzheimer's disease
    • Sparks D.L. Coronary artery disease, hypertension, ApoE and cholesterol: a link to Alzheimer's disease. Ann. N. Y. Acad. Sci. 1997, 826:128-146.
    • (1997) Ann. N. Y. Acad. Sci. , vol.826 , pp. 128-146
    • Sparks, D.L.1
  • 192
    • 16544362951 scopus 로고    scopus 로고
    • Cholesterol, copper, and accumulation of thioflavine s-reactive Alzheimer's-like amyloid β in rabbit brain
    • Sparks D.L. Cholesterol, copper, and accumulation of thioflavine s-reactive Alzheimer's-like amyloid β in rabbit brain. J. Mol. Neurosci. 2004, 24:97-104.
    • (2004) J. Mol. Neurosci. , vol.24 , pp. 97-104
    • Sparks, D.L.1
  • 193
    • 34147173784 scopus 로고    scopus 로고
    • Cholesterol metabolism and brain amyloidosis: evidence for a role of copper in the clearance of Aβ through the liver
    • Sparks D.L. Cholesterol metabolism and brain amyloidosis: evidence for a role of copper in the clearance of Aβ through the liver. Curr. Alzheimer Res. 2007, 4:165-169.
    • (2007) Curr. Alzheimer Res. , vol.4 , pp. 165-169
    • Sparks, D.L.1
  • 194
    • 0036964776 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitors (statins) in the treatment of Alzheimer's disease and why it would be ill-advised to use one that crosses the blood-brain barrier
    • Sparks D.L., Connor D.J., Browne P.J., Lopez J.E., Sabbagh M.N. HMG-CoA reductase inhibitors (statins) in the treatment of Alzheimer's disease and why it would be ill-advised to use one that crosses the blood-brain barrier. J. Nutr. Health Aging 2002, 6:324-331.
    • (2002) J. Nutr. Health Aging , vol.6 , pp. 324-331
    • Sparks, D.L.1    Connor, D.J.2    Browne, P.J.3    Lopez, J.E.4    Sabbagh, M.N.5
  • 195
    • 33745739157 scopus 로고    scopus 로고
    • Circulating cholesterol levels, apolipoprotein E genotype and dementia severity influence the benefit of atorvastatin treatment in Alzheimer's disease: results of the Alzheimer's Disease Cholesterol-Lowering Treatment (ADCLT) trial
    • Sparks D.L., Connor D.J., Sabbagh M.N., Petersen R.B., Lopez J., Browne P. Circulating cholesterol levels, apolipoprotein E genotype and dementia severity influence the benefit of atorvastatin treatment in Alzheimer's disease: results of the Alzheimer's Disease Cholesterol-Lowering Treatment (ADCLT) trial. Acta Neurol. Scand. 2006, 114:s3-s7.
    • (2006) Acta Neurol. Scand. , vol.114
    • Sparks, D.L.1    Connor, D.J.2    Sabbagh, M.N.3    Petersen, R.B.4    Lopez, J.5    Browne, P.6
  • 197
    • 0034098980 scopus 로고    scopus 로고
    • Alterations of Alzheimer's disease in the cholesterol-fed rabbit, including vascular inflammation. Preliminary observations
    • Sparks D.L., Kuo Y.-M., Roher A.E., Martin T.A., Lukas R.J. Alterations of Alzheimer's disease in the cholesterol-fed rabbit, including vascular inflammation. Preliminary observations. Ann. N. Y. Acad. Sci. 2000, 903:335-344.
    • (2000) Ann. N. Y. Acad. Sci. , vol.903 , pp. 335-344
    • Sparks, D.L.1    Kuo, Y.-M.2    Roher, A.E.3    Martin, T.A.4    Lukas, R.J.5
  • 198
    • 0036967251 scopus 로고    scopus 로고
    • Water quality has a pronounced effect on cholesterol-induced accumulation of Alzheimer amyloid (aβ) in rabbit brain
    • Sparks D.L., Lochhead J., Horstman D., Wagoner T., Martin T. Water quality has a pronounced effect on cholesterol-induced accumulation of Alzheimer amyloid (aβ) in rabbit brain. J. Alzheimer's Dis. 2002, 4:523-529.
    • (2002) J. Alzheimer's Dis. , vol.4 , pp. 523-529
    • Sparks, D.L.1    Lochhead, J.2    Horstman, D.3    Wagoner, T.4    Martin, T.5
  • 200
    • 0028177562 scopus 로고
    • Induction of Alzheimer-like β-amyloid immunoreactivity in the brains of rabbits with dietary cholesterol
    • Sparks D.L., Scheff S.W., Hunsaker J.C., Liu H., Landers T., Gross D.R. Induction of Alzheimer-like β-amyloid immunoreactivity in the brains of rabbits with dietary cholesterol. Exp. Neurol. 1994, 126:88-94.
    • (1994) Exp. Neurol. , vol.126 , pp. 88-94
    • Sparks, D.L.1    Scheff, S.W.2    Hunsaker, J.C.3    Liu, H.4    Landers, T.5    Gross, D.R.6
  • 201
    • 0141702360 scopus 로고    scopus 로고
    • Trace amounts of copper in water induce β-amyloid plaques and learning deficits in a rabbit model of Alzheimer's disease
    • Sparks D.L., Schreurs B.G. Trace amounts of copper in water induce β-amyloid plaques and learning deficits in a rabbit model of Alzheimer's disease. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:11065-11069.
    • (2003) Proc. Natl. Acad. Sci. U.S.A. , vol.100 , pp. 11065-11069
    • Sparks, D.L.1    Schreurs, B.G.2
  • 202
    • 0035012831 scopus 로고    scopus 로고
    • Apolipoprotein E genotype, vascular risk and early cognitive impairment in an African Caribbean population
    • Stewart R., Russ C., Richards M., Brayne C., Lovestone S., Mann A. Apolipoprotein E genotype, vascular risk and early cognitive impairment in an African Caribbean population. Dement. Geriatr. Cogn. Disord. 2001, 12:251-256.
    • (2001) Dement. Geriatr. Cogn. Disord. , vol.12 , pp. 251-256
    • Stewart, R.1    Russ, C.2    Richards, M.3    Brayne, C.4    Lovestone, S.5    Mann, A.6
  • 204
    • 33745109326 scopus 로고    scopus 로고
    • High-dose statin treatment does not alter plasma marker for brain cholesterol metabolism in patients with moderately elevated plasma cholesterol levels
    • Thelen K.M., Laaksonen R., Paiva H., Lehtimaki T., Lutjohann D. High-dose statin treatment does not alter plasma marker for brain cholesterol metabolism in patients with moderately elevated plasma cholesterol levels. J. Clin. Pharmacol. 2006, 46:812-816.
    • (2006) J. Clin. Pharmacol. , vol.46 , pp. 812-816
    • Thelen, K.M.1    Laaksonen, R.2    Paiva, H.3    Lehtimaki, T.4    Lutjohann, D.5
  • 205
    • 45249117903 scopus 로고    scopus 로고
    • High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with the loss of working memory in mice
    • Thirumangalakudi L., Prakasam A., Zhang R., Bimonte-Nelson H.A., Sambamurti K., Kindy M.S., Bhat N.R. High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with the loss of working memory in mice. J. Neurochem. 2008, 106:475-485.
    • (2008) J. Neurochem. , vol.106 , pp. 475-485
    • Thirumangalakudi, L.1    Prakasam, A.2    Zhang, R.3    Bimonte-Nelson, H.A.4    Sambamurti, K.5    Kindy, M.S.6    Bhat, N.R.7
  • 206
    • 0024161847 scopus 로고
    • DBA/2Ibg mice are incapable of cholinergically-based learning in the Morris water maze
    • Upchurch M., Wehner J.M. DBA/2Ibg mice are incapable of cholinergically-based learning in the Morris water maze. Pharmacol. Biochem. Behav. 1988, 29:325-329.
    • (1988) Pharmacol. Biochem. Behav. , vol.29 , pp. 325-329
    • Upchurch, M.1    Wehner, J.M.2
  • 211
    • 0036470760 scopus 로고    scopus 로고
    • Neurotoxic effects of apolipoprotein E4 are mediated via dysregulation of calcium homeostasis
    • Veinbergs I., Everson A., Sagara Y., Masliah E. Neurotoxic effects of apolipoprotein E4 are mediated via dysregulation of calcium homeostasis. J. Neurosci. Res. 2002, 67:379-387.
    • (2002) J. Neurosci. Res. , vol.67 , pp. 379-387
    • Veinbergs, I.1    Everson, A.2    Sagara, Y.3    Masliah, E.4
  • 212
    • 0034513572 scopus 로고    scopus 로고
    • Vitamin E supplementation prevents spatial learning deficits and dendritic alterations in aged apolipoprotein E-deficient mice
    • Veinbergs I., Mallory M., Sagara Y., Masliah E. Vitamin E supplementation prevents spatial learning deficits and dendritic alterations in aged apolipoprotein E-deficient mice. Eur. J. Neurosci. 2000, 12:4541-4546.
    • (2000) Eur. J. Neurosci. , vol.12 , pp. 4541-4546
    • Veinbergs, I.1    Mallory, M.2    Sagara, Y.3    Masliah, E.4
  • 213
    • 34547279579 scopus 로고    scopus 로고
    • Cytokines and neuronal ion channels in health and disease
    • Viviani B., Gardoni F., Marinovich M. Cytokines and neuronal ion channels in health and disease. Int. Rev. Neurobiol. 2007, 82:247-263.
    • (2007) Int. Rev. Neurobiol. , vol.82 , pp. 247-263
    • Viviani, B.1    Gardoni, F.2    Marinovich, M.3
  • 214
    • 0037089805 scopus 로고    scopus 로고
    • Cognitive deficit and development of motor impairment in a mouse model of Niemann-Pick type C disease
    • Voikar V., Rauvala H., Ikonen E. Cognitive deficit and development of motor impairment in a mouse model of Niemann-Pick type C disease. Behav. Brain Res. 2002, 132:1-10.
    • (2002) Behav. Brain Res. , vol.132 , pp. 1-10
    • Voikar, V.1    Rauvala, H.2    Ikonen, E.3
  • 216
    • 34248190279 scopus 로고    scopus 로고
    • Aβ oligomers-a decade of discovery
    • Walsh D.M., Selkoe D.J. Aβ oligomers-a decade of discovery. J. Neurochem. 2007, 101:1172-1184.
    • (2007) J. Neurochem. , vol.101 , pp. 1172-1184
    • Walsh, D.M.1    Selkoe, D.J.2
  • 218
    • 61449177661 scopus 로고    scopus 로고
    • Better memory functioning associated with higher total and low-density lipoprotein cholesterol levels in very elderly subjects without the apolipoprotein e4 allele
    • West R., Beeri M.S., Schmeidler J., Hannigan C.M., Angelo G., Grossman H.T., Rosendorff C., Silverman J.M. Better memory functioning associated with higher total and low-density lipoprotein cholesterol levels in very elderly subjects without the apolipoprotein e4 allele. Am. J. Geriatr. Psychiatry 2008, 16:781-785.
    • (2008) Am. J. Geriatr. Psychiatry , vol.16 , pp. 781-785
    • West, R.1    Beeri, M.S.2    Schmeidler, J.3    Hannigan, C.M.4    Angelo, G.5    Grossman, H.T.6    Rosendorff, C.7    Silverman, J.M.8
  • 219
    • 12744273863 scopus 로고    scopus 로고
    • Midlife cardiovascular risk factors and risk of dementia in late life
    • Whitmer R.A., Sidney S., Selby J., Johnston S.C., Yaffe K. Midlife cardiovascular risk factors and risk of dementia in late life. Neurology 2005, 64:277-281.
    • (2005) Neurology , vol.64 , pp. 277-281
    • Whitmer, R.A.1    Sidney, S.2    Selby, J.3    Johnston, S.C.4    Yaffe, K.5
  • 220
    • 55549132657 scopus 로고    scopus 로고
    • Status of computerized cognitive testing in aging: a systematic review
    • Wild K., Howieson D., Webbe F., Seeyle A., Kaye J. Status of computerized cognitive testing in aging: a systematic review. Alzheimer's Dement. 2008, 4:428-437.
    • (2008) Alzheimer's Dement. , vol.4 , pp. 428-437
    • Wild, K.1    Howieson, D.2    Webbe, F.3    Seeyle, A.4    Kaye, J.5
  • 223
    • 0033772113 scopus 로고    scopus 로고
    • Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors
    • Wolozin B., Kellman W., Celesia G.C., Siegel G. Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors. Arch. Neurol. 2000, 57:1439-1443.
    • (2000) Arch. Neurol. , vol.57 , pp. 1439-1443
    • Wolozin, B.1    Kellman, W.2    Celesia, G.C.3    Siegel, G.4
  • 225
    • 34447628317 scopus 로고    scopus 로고
    • A rabbit model of Alzheimer's disease: valid at neuropathological, cognitive, and therapeutic levels
    • Woodruff-Pak D.S., Agelan A., Del Valle L. A rabbit model of Alzheimer's disease: valid at neuropathological, cognitive, and therapeutic levels. J. Alzheimer's Dis. 2007, 11:371-383.
    • (2007) J. Alzheimer's Dis. , vol.11 , pp. 371-383
    • Woodruff-Pak, D.S.1    Agelan, A.2    Del Valle, L.3
  • 226
    • 0031440589 scopus 로고    scopus 로고
    • Nimodipine ameliorates impaired eyeblink classical conditioning in order rabbits in the long-delay paradigm
    • Woodruff-Pak D.S., Chi J., Li Y.-T., Pak M.H., Fanelli R.J. Nimodipine ameliorates impaired eyeblink classical conditioning in order rabbits in the long-delay paradigm. Neurobiol. Aging 1997, 18:641-649.
    • (1997) Neurobiol. Aging , vol.18 , pp. 641-649
    • Woodruff-Pak, D.S.1    Chi, J.2    Li, Y.-T.3    Pak, M.H.4    Fanelli, R.J.5
  • 227
    • 0038182452 scopus 로고    scopus 로고
    • Brain region-dependent increases in β-amyloid and apolipoprotein E levels in hypercholesterolemic rabbits
    • Wu C.-W., Liao P.-C., Lin C., Kuo C.-J., Chen S.-T., Cehn H.-I., Kuo Y.-M. Brain region-dependent increases in β-amyloid and apolipoprotein E levels in hypercholesterolemic rabbits. J. Neural. Transm. 2003, 110:641-649.
    • (2003) J. Neural. Transm. , vol.110 , pp. 641-649
    • Wu, C.-W.1    Liao, P.-C.2    Lin, C.3    Kuo, C.-J.4    Chen, S.-T.5    Cehn, H.-I.6    Kuo, Y.-M.7
  • 229
    • 36148934982 scopus 로고    scopus 로고
    • Microglial activation in the hippocampus of hypercholesterolemic rabbits occurs independent of increased amyloid production
    • Xue Q.-S., Sparks D.L., Streit W.J. Microglial activation in the hippocampus of hypercholesterolemic rabbits occurs independent of increased amyloid production. J. Neuroinflamm. 2007, 4:20-30.
    • (2007) J. Neuroinflamm. , vol.4 , pp. 20-30
    • Xue, Q.-S.1    Sparks, D.L.2    Streit, W.J.3
  • 230
    • 0036186663 scopus 로고    scopus 로고
    • Serum lipoprotein levels, statin use, and cognitive function in older women
    • Yaffe K., Barret-Connor E., Lin F., Grady D. Serum lipoprotein levels, statin use, and cognitive function in older women. Arch. Neurol. 2002, 59:378-384.
    • (2002) Arch. Neurol. , vol.59 , pp. 378-384
    • Yaffe, K.1    Barret-Connor, E.2    Lin, F.3    Grady, D.4
  • 231
    • 0037010313 scopus 로고    scopus 로고
    • Cholesterol and pathological processes in Alzheimer's disease
    • Yanagisawa K. Cholesterol and pathological processes in Alzheimer's disease. J. Neurosci. Res. 2002, 70:361-366.
    • (2002) J. Neurosci. Res. , vol.70 , pp. 361-366
    • Yanagisawa, K.1
  • 232
    • 0036776991 scopus 로고    scopus 로고
    • Function of β-amyloid in cholesterol transport: a lead to neurotoxicity
    • Yao Z.-X., Papadopoulos V. Function of β-amyloid in cholesterol transport: a lead to neurotoxicity. FASEB J. 2002, 16:1677-1679.
    • (2002) FASEB J. , vol.16 , pp. 1677-1679
    • Yao, Z.-X.1    Papadopoulos, V.2
  • 233
    • 0027500855 scopus 로고
    • Modulation of learning, pain thresholds, and thermoregulation in the rat by preparations of free purified α-linolenic and linoleic acids: determination of the optimal ω3-to-ω6 ratio
    • Yehuda S., Carasso R.L. Modulation of learning, pain thresholds, and thermoregulation in the rat by preparations of free purified α-linolenic and linoleic acids: determination of the optimal ω3-to-ω6 ratio. Proc. Natl. Acad. Sci. U.S.A. 1993, 90:10345-10349.
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 10345-10349
    • Yehuda, S.1    Carasso, R.L.2
  • 234
    • 0031922472 scopus 로고    scopus 로고
    • Modulation of learning and neuronal membrane composition in the rat by essential fatty acid preparation: time-course analysis
    • Yehuda S., Rabinovitz S., Motofsky D.I. Modulation of learning and neuronal membrane composition in the rat by essential fatty acid preparation: time-course analysis. Neurochem. Res. 1998, 23:627-634.
    • (1998) Neurochem. Res. , vol.23 , pp. 627-634
    • Yehuda, S.1    Rabinovitz, S.2    Motofsky, D.I.3
  • 236
    • 0036128465 scopus 로고    scopus 로고
    • Astrocytosis, microgliosis, metallothionein-I-II and amyloid expression in high cholesterol-fed rabbits
    • Zatta P., Zambenedetti P., Stella M.P., Licastro F. Astrocytosis, microgliosis, metallothionein-I-II and amyloid expression in high cholesterol-fed rabbits. J. Alzheimer's Dis. 2002, 4:1-9.
    • (2002) J. Alzheimer's Dis. , vol.4 , pp. 1-9
    • Zatta, P.1    Zambenedetti, P.2    Stella, M.P.3    Licastro, F.4
  • 238
    • 70349757157 scopus 로고    scopus 로고
    • Polar metabolite of cholesterol induces rat cognitive dysfunctions
    • Zhao S., Liao W., Xu N., Xu H., Yu C., Liu X., Li C. Polar metabolite of cholesterol induces rat cognitive dysfunctions. Neuroscience 2009, 164:398-403.
    • (2009) Neuroscience , vol.164 , pp. 398-403
    • Zhao, S.1    Liao, W.2    Xu, N.3    Xu, H.4    Yu, C.5    Liu, X.6    Li, C.7
  • 239
    • 51049104476 scopus 로고    scopus 로고
    • Genetic association between low-density lipoprotein receptor-related protein gene polymorphisms and Alzheimer's disease in Chinese Han population
    • Zhou Y.-T., Zhang Z.-X., Chan P., He X.-M., Tang M.-N., Wu C.-B., Hong Z. Genetic association between low-density lipoprotein receptor-related protein gene polymorphisms and Alzheimer's disease in Chinese Han population. Neurosci. Lett. 2008, 444:109-111.
    • (2008) Neurosci. Lett. , vol.444 , pp. 109-111
    • Zhou, Y.-T.1    Zhang, Z.-X.2    Chan, P.3    He, X.-M.4    Tang, M.-N.5    Wu, C.-B.6    Hong, Z.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.